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Showing 1-30 of 184 results for "P5282" within Papers
Na N Guan et al.
British journal of pharmacology, 172(16), 4024-4037 (2015-04-29)
We have described a urothelium-dependent release of PGD2 -like activity which had inhibitory effects on the motility of guinea pig urinary bladder. Here, we have pharmacologically characterized the receptors involved and localized the sites of PGD2 formation and of its
Kailin Yang et al.
Frontiers in pharmacology, 12, 601846-601846 (2021-07-13)
Background: Clinical research found that Hedysarum Multijugum Maxim.-Chuanxiong Rhizoma Compound (HCC) has definite curative effect on cerebral ischemic diseases, such as ischemic stroke and cerebral ischemia-reperfusion injury (CIR). However, its mechanism for treating cerebral ischemia is still not fully explained.
Flora De Conto et al.
Molecular and cellular biochemistry, 437(1-2), 185-201 (2017-07-27)
Viruses depend on cellular machinery to efficiently replicate. The host cytoskeleton is one of the first cellular systems hijacked by viruses in order to ensure their intracellular transport and promote the development of infection. Our previous results demonstrated that stable
Aaron Ions Gardner et al.
The Journal of biological chemistry, 296, 100650-100650 (2021-04-12)
Most patients with cystic fibrosis (CF) suffer from acute and chronic pulmonary infections with bacterial pathogens, which often determine their life quality and expectancy. Previous studies have demonstrated a downregulation of the acid ceramidase in CF epithelial cells resulting in
Hao Hu et al.
Experimental and therapeutic medicine, 21(5), 412-412 (2021-03-23)
Vasodilator-stimulated phosphoprotein (VASP) is essential for osteoclast differentiation, and reduced VASP expression results in depressed osteoclast differentiation. Previously, we demonstrated the importance of VASP and Ras-related C3 botulinum toxin substrate 1 interactions in osteosarcoma cell migration and metastasis using Mg-63
H Huang et al.
Atherosclerosis, 235(1), 213-222 (2014-05-27)
Deletion of inducible nitric oxide synthase (iNOS) in apolipoprotein E knockout mice was shown to mitigate the extent of arteriosclerosis. Oxidized low density lipoprotein (oxLDL) inhibits macrophage migration and traps foam cells, possibly through a mechanism involving oxidative stress. Here
Quan Liu et al.
Nanoscale, 12(38), 19939-19952 (2020-09-30)
Tumor vaccines are a promising form of cancer immunotherapy, but difficulties such as neo-antigen identification, activation of immune cells, and tumor infiltration prevent their clinical breakthrough. Interestingly, nanotechnology-based photothermal therapy (PTT) has great potential to overcome these barriers. Previous studies
Timothy H Scott-Taylor et al.
Clinical immunology (Orlando, Fla.), 175, 1-9 (2016-11-20)
Peripheral monocytes from patients with common variable immunodeficiency (CVID) had on average a 2 fold greater tendency to form giant cells in medium without additional cytokines. Giant cell formation was faster and 3 to 5 fold higher in most CVID
Yuan Zhou et al.
International journal of molecular sciences, 16(6), 12345-12359 (2015-06-04)
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease caused by mutations in the NF1 tumor suppressor gene, which affect approximately 1 out of 3000 individuals. Patients with NF1 suffer from a range of malignant and nonmalignant manifestations such as
Baojia Zheng et al.
Frontiers in cellular and infection microbiology, 10, 477-477 (2020-10-06)
Dengue virus (DENV) continues to be a major public health problem. DENV infection will cause mild dengue and severe dengue. Severe dengue is clinically manifested as serious complications, including dengue hemorrhagic fever and/or dengue shock syndrome (DHF/DSS), which is mainly
Hong Lu et al.
Toxicological sciences : an official journal of the Society of Toxicology, 103(1), 35-45 (2008-02-26)
The liver-specific importer organic anion transporting polypeptide 1b2 (Oatp1b2, Slco1b2, also known as Oatp4 and Lst-1) and its human orthologs OATP1B1/1B3 transport a large variety of chemicals. Oatp1b2-null mice were engineered by homologous recombination and their phenotype was characterized. Oatp1b2
Jessica Bouvière et al.
Tissue engineering. Part A, 25(23-24), 1667-1676 (2019-05-08)
Although skeletal muscle is capable of complete recovery after an injury, specific situations require support or acceleration of this process, such as in the elderly and athletes, respectively. Skeletal muscle regeneration is due to muscle stem cells (MuSCs) that undergo
Tuğba Kotil et al.
Zygote (Cambridge, England), 26(4), 319-325 (2018-10-04)
SummaryDigyny, the presence of a third pronucleus due to the failure of second polar body extrusion, is problematic after intracytoplasmic sperm injection (ICSI) practices. Mitochondria have critical roles such as production of adenosine triphosphate (ATP) and regulation of Ca2+ homeostasis
Yan-Chao Li et al.
Brain research, 1392, 54-61 (2011-04-05)
The primary afferent neurons are enriched for F-actin in the peripheries, giving rise to ring-like appearances when stained with fluorescence probes for actin. A variety of data, mainly obtained from in vitro experiments, suggested that the satellite cell (SC) envelopes
N Craig Carville et al.
Journal of biomedical materials research. Part A, 103(8), 2540-2548 (2014-12-17)
In this work, the influence of substrate surface charge on in vitro osteoblast cell proliferation on ferroelectric lithium niobate (LN) crystal surfaces is investigated. LN has a spontaneous polarization along the z-axis and is thus characterized by positive and negative
Andrea Palamidessi et al.
Nature materials, 18(11), 1252-1263 (2019-07-25)
During wound repair, branching morphogenesis and carcinoma dissemination, cellular rearrangements are fostered by a solid-to-liquid transition, known as unjamming. The biomolecular machinery behind unjamming and its pathophysiological relevance remain, however, unclear. Here, we study unjamming in a variety of normal
Francesca Farina et al.
The EMBO journal, 38(11) (2019-04-25)
Cells going through mitosis undergo precisely timed changes in cell shape and organisation, which serve to ensure the fair partitioning of cellular components into the two daughter cells. These structural changes are driven by changes in actin filament and microtubule
Jinghan Wang et al.
Neuroscience letters, 592, 42-47 (2015-03-10)
Sperm-associated antigen 6 (Spag6) gene, which encodes an axonemal protein (SPAG6), ubiquitously expresses in tissue and organs containing ciliated cells. The present work was to investigate whether SPAG6 expressed in cochlear hair cells and, if so, to explore the presumable
Silvia Grasso et al.
Cell death and differentiation, 27(2), 790-807 (2019-07-10)
Neuroblastoma is the most common extra-cranial pediatric solid tumor, responsible for 13-15% of pediatric cancer death. Its intrinsic heterogeneity makes it difficult to target for successful therapy. The adaptor protein p140Cap/SRCIN1 negatively regulates tumor cell features and limits breast cancer
Fluorescent phallotoxin, a tool for the visualization of cellular actin.
Wulf E
Proceedings of the National Academy of Sciences of the USA, 76(9), 4498-4502 (1979)
John Ong et al.
Scientific reports, 10(1), 12429-12429 (2020-07-28)
Albumin-based hydrogels are increasingly attractive in tissue engineering because they provide a xeno-free, biocompatible and potentially patient-specific platform for tissue engineering and drug delivery. The majority of research on albumin hydrogels has focused on bovine serum albumin (BSA), leaving human
Xue Bai et al.
Frontiers in cell and developmental biology, 9, 659486-659486 (2021-04-06)
Sudden sensorineural hearing loss (SSNHL) is a common emergency in the world. Increasing evidence of imbalance of oxidant-antioxidant were found in SSNHL patients. Steroids combined with antioxidants may be a potential strategy for the treatment of SSNHL. In cochlear explant
Alena-Svenja Wagner et al.
Biomedical materials (Bristol, England), 12(4), 045003-045003 (2017-04-21)
Herein, we aim to elucidate osteogenic effects of two silica-based xerogels with different degrees of bioactivity on human bone-derived mesenchymal stromal cells by means of scanning electron microscopy, quantitative PCR enhanced osteogenic effects and the formation of an extracellular matrix
Paulina Nastały et al.
Nature communications, 11(1), 2122-2122 (2020-05-03)
Cell polarity refers to the intrinsic asymmetry of cells, including the orientation of the cytoskeleton. It affects cell shape and structure as well as the distribution of proteins and organelles. In migratory cells, front-rear polarity is essential and dictates movement
Yan-Chao Li et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 57(8), 741-751 (2009-04-15)
The organization of F-actin in the ventricular system has been reported to display pronounced regional differences with respect to shape, size, and development. However, the real roles played by F-actin in these cells cannot be understood unless the precise localization
Zhilong Wang et al.
Cell death & disease, 12(4), 387-387 (2021-04-14)
Decidualization is a complex process involving cellular proliferation and differentiation of the endometrial stroma and is required to establish and support pregnancy. Dysregulated decidualization has been reported to be a critical cause of recurrent implantation failure (RIF). In this study
Kahia Messaoudi et al.
Nature communications, 8(1), 1786-1786 (2017-11-28)
Thrombocytopenia is a major side effect of a new class of anticancer agents that target histone deacetylase (HDAC). Their mechanism is poorly understood. Here, we show that HDAC6 inhibition and genetic knockdown lead to a strong decrease in human proplatelet
Miaomiao Han et al.
Neuroscience letters, 600, 164-170 (2015-06-15)
Polybrene is widely used to enhance viral transduction; however, little is known about the utility thereof, in enhancing lentiviral transduction of cochlear cells. In the present study, we examined the cytotoxic effects of polybrene, and the further effects thereof, on
Nesrine Bouhrira et al.
Biofabrication, 12(2), 025020-025020 (2019-11-19)
The effect of disturbed flow profiles on the endothelium have been studied extensively in systemic vasculature, but less is known about the response of the blood-brain barrier (BBB) to these flow regimes. Here we investigate the effect of disturbed flow
Hao Yuan Kueh et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(43), 16531-16536 (2008-10-22)
We report here that actin filaments in vitro exist in two populations with significantly different shrinkage rates. Newly polymerized filaments shrink rapidly, primarily from barbed ends, at 1.8/s, but as they age they switch to a stable state that shrinks
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