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Showing 1-30 of 185 results for "P5282" within Papers
Somanna Kollimada et al.
Molecular biology of the cell, 32(18), 1737-1748 (2021-08-20)
The regulation of cellular force production relies on the complex interplay between a well-conserved set of proteins of the cytoskeleton: actin, myosin, and α-actinin. Despite our deep knowledge of the role of these proteins in force production at the molecular
Caroline Stefani et al.
Nature communications, 8, 15839-15839 (2017-06-24)
Transendothelial cell macroaperture (TEM) tunnels control endothelium barrier function and are triggered by several toxins from pathogenic bacteria that provoke vascular leakage. Cellular dewetting theory predicted that a line tension of uncharacterized origin works at TEM boundaries to limit their
Yun Chen et al.
Theriogenology, 156, 107-115 (2020-07-23)
Glutathione peroxidases (GPxs) are regarded as important protectors against oxidative stress. Some members of this protein family were reported to play key roles in protecting sperm against oxidative stress. Whether GPx6 a member of the GPx family also plays a
Le Xie et al.
Neurochemistry international, 128, 196-205 (2019-04-30)
Mutations in the GJB2 gene (which encodes Connexin26 (Cx26)) are the most common cause of non-syndromic deafness. Previous studies showed that an extensive knockout of the Gjb2 gene in cochlear epithelium can cause severe deafness, significant hair cell (HC) loss
N Craig Carville et al.
ACS biomaterials science & engineering, 2(8), 1351-1356 (2016-08-08)
Photodeposition of silver nanoparticles onto chemically patterned lithium niobate having alternating lithium niobate and proton exchanged regions has been previously investigated. Here, the spatially defined photodeposition of gold nanoparticles onto periodically proton exchanged lithium niobate is demonstrated. It is shown
Kai Xu et al.
Frontiers in cell and developmental biology, 9, 637011-637011 (2021-02-23)
Osteopetrosis is a rare inherited bone disease characterized by dysfunction of osteoclasts, causing impaired bone resorption and remodeling, which ultimately leads to increased bone mass and density. Hearing loss is one of the most common complications of osteopetrosis. However, the
Jinar Rostami et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 131, 110788-110788 (2020-11-07)
Growing evidence emphasizes insufficient clearance of pathological alpha-synuclein (αSYN) aggregates in the progression of Parkinson's disease (PD). Consequently, cellular degradation pathways represent a potential therapeutic target. Prolyl oligopeptidase (PREP) is highly expressed in the brain and has been suggested to
The H9C2 cell line and primary neonatal cardiomyocyte cells show similar hypertrophic responses in vitro.
Watkins SJ
In Vitro Cellular & Developmental Biology. Animal, 47(2), 125-131 (2011)
Huiqing Li et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 23(6), 1988-2000 (2009-02-13)
Myofibrillogenesis, the precise assembly of sarcomeric proteins into the highly organized sarcomeres, is essential for muscle cell differentiation and function. Myofibrillogenesis requires proper folding and assembly of newly synthesized sarcomeric proteins. sknac (skeletal naca) is an alternatively spliced isoform of
José Ignacio Valenzuela et al.
Developmental cell, 52(1), 104-117 (2019-12-24)
Ephrins can elicit either contact-mediated cell-cell adhesion or repulsion, depending on the efficiency of the removal of their ligand-receptor complexes from the cell surface, thus controlling tissue morphogenesis and oncogenic development. However, the dynamic of the turnover of newly assembled ephrin-Eph
Simon Stritt et al.
Nature communications, 7, 11097-11097 (2016-03-30)
Mg(2+) plays a vital role in platelet function, but despite implications for life-threatening conditions such as stroke or myocardial infarction, the mechanisms controlling [Mg(2+)]i in megakaryocytes (MKs) and platelets are largely unknown. Transient receptor potential melastatin-like 7 channel (TRPM7) is
Daniel Walcher et al.
Hypertension (Dallas, Tex. : 1979), 51(2), 259-266 (2007-12-26)
Migration of CD4-positive lymphocytes into the vessel wall represents an important step in early atherogenesis. Telmisartan is an angiotensin type 1 receptor (AT1R) blocker with peroxisome proliferator-activated receptor (PPAR)-gamma-activating properties. The present study examined the effect of telmisartan on CD4-positive
Lina Wu et al.
Orphanet journal of rare diseases, 15(1), 74-74 (2020-03-19)
Dubin-Johnson syndrome (DJS) is a rare autosomal recessive disorder characterized by predominantly conjugated hyperbilirubinemia that is caused by pathogenic mutations in the adenosine triphosphate-binding cassette subfamily C member 2 (ABCC2) gene, which encodes multidrug resistance-associated protein 2 (MRP2). However, little
The cAMP-responsive element binding protein (CREB) transcription factor regulates furin expression during human trophoblast syncytialization.
Zhou Z, Wang R, Yang X, et al.
Placenta, 35(11), 907-918 (2014)
Christine T Dinh et al.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology, 38(2), 180-186 (2016-11-30)
Stereotactic radiosurgery for lateral skull base tumors can cause hearing loss when the cochleae are exposed to high doses of single-fraction radiation. Currently, there are no known nondosimetric preventative treatments for radiation-induced ototoxicity. Intratympanic (IT) dexamethasone (DXM), a synthetic steroid
Eric L Van Nostrand et al.
Nature, 583(7818), 711-719 (2020-07-31)
Many proteins regulate the expression of genes by binding to specific regions encoded in the genome1. Here we introduce a new data set of RNA elements in the human genome that are recognized by RNA-binding proteins (RBPs), generated as part
Chenyang Huang et al.
Reproductive biology and endocrinology : RB&E, 15(1), 25-25 (2017-04-01)
Decidualization is a prerequisite for successful implantation and the establishment of pregnancy. A critical role of impaired decidualization in subfertility has been established. In human endometrial stromal cells (hESCs), Krüppel-like factor 12 (KLF12) and Nur77 are novel regulators of decidualization.
Natália Barreto et al.
Cancer cell international, 20(1), 576-576 (2020-12-18)
Glioblastoma (GB) cells have the ability to migrate and infiltrate the normal parenchyma, leading to the formation of recurrent tumors often adjacent to the surgical extraction site. We recently showed that Phoneutria nigriventer spider venom (PnV) has anticancer effects mainly
Bruno Jaime Santacreu et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1866(4), 158888-158888 (2021-01-18)
Collecting duct cells are physiologically subject to the hypertonic environment of the kidney. This condition is necessary for kidney maturation and function but represents a stress condition that requires active strategies to ensure epithelial integrity. Madin-Darby Canine Kidney (MDCK) cells
Shuangshuang Mao et al.
Biofabrication, 12(4), 045014-045014 (2020-07-01)
Towards the development of in vivo-mimicking tumor model for extensive study of tumorigenesis and establishment of personalized therapy, patient-derived primary tumor cells were employed in this work for three-dimensional (3D) bioprinting. Intrahepatic cholangiocarcinoma cells isolated from patient were bioprinted using
Giulia Silvani et al.
Frontiers in bioengineering and biotechnology, 9, 612151-612151 (2021-02-23)
Characterizing mechanical properties of cells is important for understanding many cellular processes, such as cell movement, shape, and growth, as well as adaptation to changing environments. In this study, we explore the mechanical properties of endothelial cells that form the
Chantal Roubinet et al.
Current biology : CB, 31(18), 3973-3983 (2021-07-24)
Although nuclei are the defining features of eukaryotes, we still do not fully understand how the nuclear compartment is duplicated and partitioned during division. This is especially the case for organisms that do not completely disassemble their nuclear envelope upon
Sung-Tae Hong et al.
Nature communications, 7, 12988-12988 (2016-10-01)
Genome stability is essential for all organisms. Translationally controlled tumour protein (TCTP) is a conserved protein associated with cancers. TCTP is involved in multiple intracellular functions, but its role in transcription and genome stability is poorly understood. Here, we demonstrate
Paula K Yu et al.
Translational vision science & technology, 10(1), 29-29 (2021-02-02)
To determine the fidelity of optical coherence tomography angiography (OCTA) techniques by direct comparison of the retinal capillary network images obtained from the same region as imaged by OCTA and high-resolution confocal microscope. Ten porcine eyes were perfused with red
Joan Röhl et al.
Traffic (Copenhagen, Denmark), 20(9), 661-673 (2019-07-13)
Macrophage migration into injured or infected tissue is a key aspect in the pathophysiology of many diseases where inflammation is a driving factor. Membrane-type-1 matrix metalloproteinase (MT1-MMP) cleaves extracellular matrix components to facilitate invasion. Here we show that, unlike the
Han-Qing Liang et al.
Scientific reports, 11(1), 15272-15272 (2021-07-29)
While epigamic traits likely evolve via sexual selection, the mechanism whereby internal sexual dimorphism arises remains less well understood. Seeking clues as to how the internal sexual dimorphism evolved, we compared the abdominal musculature of 41 Drosophila montium group species
Ina Felix et al.
International journal of molecular sciences, 21(9) (2020-05-10)
Some highly metastatic types of breast cancer show decreased intracellular levels of the tumor suppressor protein NME1, also known as nm23-H1 or nucleoside diphosphate kinase A (NDPK-A), which decreases cancer cell motility and metastasis. Since its activity is directly correlated
Xi Cheng et al.
Reproductive biology and endocrinology : RB&E, 15(1), 42-42 (2017-06-05)
A receptive endometrium is essential for maternal-embryonic molecular communication during implantation. However, the specific molecular regulatory mechanisms of the endometrial capacity remain poorly understood. Here, we examined activating transcription factor 3 (ATF3) expression in human endometria and the functional effect
Alireza Tavakolinejad et al.
Biochemical and biophysical research communications, 464(2), 473-479 (2015-07-08)
Alteration in specific inertial conditions can lead to changes in morphology, proliferation, mechanical properties and cytoskeleton of cells. In this report, the effects of hypergravity on morphology of Adipose-Derived Stem Cells (ADSCs) are indicated. ADSCs were repeatedly exposed to discontinuous
Lukas Ded et al.
Reproductive biology and endocrinology : RB&E, 17(1), 109-109 (2019-12-21)
Capacitation involves physiological changes that spermatozoa must undergo in the female reproductive tract or in vitro to obtain the ability to bind, penetrate and fertilize the egg. Up to date, several methods have been developed to characterize this complex biological
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