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Showing 1-30 of 85 results for "P5295" within Papers
G Justus Hofmeyr et al.
The Cochrane database of systematic reviews, 6(6), CD001064-CD001064 (2012-06-15)
Piracetam is thought to promote the metabolism of brain cells when they are hypoxic. It has been used to prevent adverse effects of fetal distress. The objective of this review was to assess the effects of piracetam for suspected fetal
Ahmed H Ahmed et al.
Journal of medicinal chemistry, 53(5), 2197-2203 (2010-02-19)
Glutamate receptors are the most prevalent excitatory neurotransmitter receptors in the vertebrate central nervous system and are important potential drug targets for cognitive enhancement and the treatment of schizophrenia. Allosteric modulators of AMPA receptors promote dimerization by binding to a
Przemyslaw M Mrozikiewicz et al.
Acta pharmaceutica (Zagreb, Croatia), 64(2), 223-232 (2014-06-11)
There are a number of compounds that can modify the activity of ABC (ATP-binding cassette) and SLC (solute carrier) transporters in the blood-brain barrier (BBB). The aim of this study was to investigate the effect of natural and synthetic substances
Piracetam and vinpocetine ameliorate rotenone-induced Parkinsonism in rats
Zaitone SA, et al.
International Journal of Pharmaceutics, 44(6), 774-774 (2012)
J Gallinat et al.
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 34(9), 520-527 (1999-10-30)
Delirium is a serious postoperative complication after general anaesthesia. The incidence is estimated to be about 10-15%. In the case of additional risk factors, such as old age, previously existing cerebral-vasculous and psychic deficiencies, and anaesthesia of long duration the
Kenji Inaba et al.
The journal of trauma and acute care surgery, 74(3), 766-771 (2013-02-22)
Brain Trauma Foundation guidelines recommend seizure prophylaxis for preventing early posttraumatic seizure (PTS). Phenytoin (PHE) is commonly used. Despite a paucity of data in traumatic brain injury, levetiracetam (LEV) has been introduced as a potential replacement, which is more costly
K Tajima et al.
Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 116(4), 209-214 (2000-11-21)
Myoclonus is defined as shock-like, brief involuntary abnormal movements in muscle jerking caused by external stimuli; and it arises from progressive myoclonus epilepsy, post-anoxic encephalopathy and Alzheimer's disease, causing disabling symptoms. It is a rare syndrome but very difficult to
Levetiracetam: a possible new inducer of toxic epidermal necrolysis and Stevens-Johnson syndrome in 2 cases.
Tu Anh Duong et al.
JAMA dermatology, 149(1), 113-115 (2013-01-18)
Iu I Hubs'kyĭ et al.
Ukrains'kyi biokhimichnyi zhurnal (1999 ), 84(5), 89-96 (2013-01-25)
Under modelling of brain ischemia in rats the antioxidant and cerebroprotective action of new N-,S-chinazolone derivative--compound NC-224 has been established. The compensation of pathobiochemical abnormalities in the system "LPO-antioxidant protection" is observed, indicators of carbohydrate metabolism and energy-supply, and morpho-functional
Qingtao Gao et al.
Neurochemical research, 40(7), 1438-1447 (2015-05-23)
In our previous study, we demonstrated that nodakenin, a coumarin compound isolated from Angelica decursiva, ameliorates learning and memory impairments induced by scopolamine. In the present study, we investigated the effects of nodakenin on the cognitive function in the normal
Fulvio Gualtieri et al.
Current pharmaceutical design, 8(2), 125-138 (2002-01-29)
Cognition enhancers are drugs able to facilitate attentional abilities and acquisition, storage and retrieval of information, and to attenuate the impairment of cognitive functions associated with head traumas, stroke, age and age-related pathologies. Development of cognition enhancers is still a
Jason T Connor et al.
Journal of clinical epidemiology, 66(8 Suppl), S130-S137 (2013-07-17)
We present a novel Bayesian adaptive comparative effectiveness trial comparing three treatments for status epilepticus that uses adaptive randomization with potential early stopping. The trial will enroll 720 unique patients in emergency departments and uses a Bayesian adaptive design. The
Dong Wook Kim et al.
Epilepsia, 54(10), e146-e149 (2013-08-29)
Although it is well documented that long-term therapy with older antiepileptic drugs (AEDs) leads to an increase in risk for atherosclerosis, there has been only limited information regarding the vascular risk in patients who are treated with new AEDs. We
Levetiracetam-associated acute pancreatitis in an adolescent with autism: a case report.
Daniel M Almeida et al.
Pancreas, 42(1), 177-178 (2012-12-21)
Thomas Bleck et al.
Epilepsia, 54 Suppl 6, 89-92 (2013-09-06)
Benzodiazepine-refractory status epilepticus (established status epilepticus, ESE) is a relatively common emergency condition with several widely used treatments. There are no controlled, randomized, blinded clinical trials to compare the efficacy and tolerability of currently available treatments for ESE. The ESE
Bong Su Kang et al.
Epileptic disorders : international epilepsy journal with videotape, 15(3), 302-310 (2013-08-29)
To evaluate the long-term efficacy and safety of levetiracetam based on a large population of patients in a tertiary epilepsy centre. All patients who received levetiracetam at the Seoul National University Hospital between January 2007 and March 2009 were evaluated.
Elisabetta Martini et al.
Journal of medicinal chemistry, 54(7), 2512-2516 (2011-03-09)
A series of cis and trans 3,7-diazabicyclo[4.3.0]nonan-8-ones has been synthesized and tested for their ability to revert scopolamine-induced amnesia in the mouse passive-avoidance test. The racemates of the most potent compounds 4 and 7 were separated and tested, but no
M M Asadullaev et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 112(10), 24-27 (2012-12-20)
Sixty patients were randomized to treatment with cytoflavin (n=30) or nootropil (n=30). Patients of the main group received cytoflavin along with standard treatment for correction of hemodynamics. The treatment scheme was as follows: intravenous injections during 10 days, tablets -
Partha Palit et al.
Journal of ethnopharmacology, 159, 274-284 (2014-12-03)
Gelsemium sempervirens (L.) J.St.-Hil is a herb used for the treatment of various neuroses in both homeopathic and Ayurvedic systems. The present study examines whether Gelsemium reconstituted tincture can protect against scopolamine induced cognitive discrepancies in amnesic mouse model. In
Measurement and correlation for the solubilities of cinnarizine, pentoxifylline, and piracetam in supercritical carbon dioxide
Lee, C, et al.
Fluid Phase Equilibria, 367(1), 182-187 (2014)
A A Noorbala et al.
Journal of clinical pharmacy and therapeutics, 24(5), 369-374 (1999-12-03)
There is a growing interest in investigating the role of glutamate receptors in the pathophysiology of schizophrenia. Indeed, the hyperdopaminergic theory of schizophrenia can explain only the positive symptoms of schizophrenia, whereas the glutamate hypothesis may provide a more comprehensive
Nitin K Sethi et al.
Drug metabolism and drug interactions, 28(2), 123-124 (2013-02-20)
Levetiracetam is a commonly used broad-spectrum anticonvulsant efficacious in both partial and generalized seizures. It has an extremely favorable side effect profile with few drug-drug interactions, low potential for hematological and hepatic toxicity, and thus has rapidly become the preferred
Marta Maschio et al.
Epileptic disorders : international epilepsy journal with videotape, 14(4), 388-397 (2012-12-19)
An open pilot study to evaluate the effect of pregabalin (PGB) as add-on therapy on seizure control, quality of life, and anxiety in patients with brain tumour-related epilepsy (BTRE). We recruited 25 consecutive patients with BTRE and uncontrolled seizures. At
[Current possibilities of the correction of oxidative stress in acute brain ischaemia].
E I Chukanova et al.
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 112(11), 79-82 (2013-02-05)
G J Hofmeyr et al.
The Cochrane database of systematic reviews, (2)(2), CD001064-CD001064 (2000-05-05)
Piracetam is thought to promote the metabolism of brain cells when they are hypoxic. It has been used to prevent adverse effects of fetal distress. The objective of this review was to assess the effects of piracetam for suspected fetal
Phenytoin or levetiracetam for seizure prophylaxis in TBI.
Larissa DeDea
JAAPA : official journal of the American Academy of Physician Assistants, 25(12), 11-11 (2013-04-23)
Eugen Trinka et al.
Journal of neurology, neurosurgery, and psychiatry, 84(10), 1138-1147 (2012-08-31)
To compare the effectiveness of levetiracetam (LEV) with extended-release sodium valproate (VPA-ER) and controlled-release carbamazepine (CBZ-CR) as monotherapy in patients with newly diagnosed epilepsy. This unblinded, randomised, 52-week superiority trial (NCT00175903) recruited patients (≥16 years of age) with ≥2 unprovoked
A A Al Hajeri et al.
The Cochrane database of systematic reviews, (2)(2), CD006111-CD006111 (2007-04-20)
Sickle cell disease is one of the most common genetic disorders. Sickle cell crises in which irregular and dehydrated cells contribute to blocking of blood vessels are characterised by episodes of pain. Treatment is mainly supportive and symptomatic. In vitro
Sawsan A Zaitone et al.
Indian journal of pharmacology, 44(6), 774-779 (2012-12-19)
To evaluate the neuroprotective effect of the nootropic drugs, piracetam (PIR) and vinpocetine (VIN), in rotenone-induced Parkinsonism in rats. Sixty male rats were divided into 6 groups of 10 rats each. The groups were administered vehicle, control (rotenone, 1.5 mg/kg/48
B Barrera-Bailón et al.
Epilepsy & behavior : E&B, 28(3), 413-425 (2013-07-23)
Epilepsy modeling is essential for understanding the basic mechanisms of the epileptic process. The Genetic Audiogenic Seizure Hamster (GASH:Sal) exhibits generalized tonic-clonic seizures of genetic origin in response to sound stimulation and is currently being validated as a reliable model
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