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Showing 1-30 of 60 results for "P5296" within Papers
Qin Wang et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 38(5), 791-801 (2013-01-11)
Morphine is the most efficacious and widely prescribed treatment for pain. However, it decreases the total amount of deep sleep and rapid eye movement sleep in humans. Acute morphine administration at low doses causes wakefulness in animal models. To clarify
Kate M Wassum et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(5), 1591-1599 (2011-02-04)
The decision to perform, or not perform, actions known to lead to a rewarding outcome is strongly influenced by the current incentive value of the reward. Incentive value is largely determined by the affective experience derived during previous consumption of
Maria Domenica Sanna et al.
Pain, 156(7), 1265-1275 (2015-03-26)
Accumulating evidence suggests that opioid analgesics can lead to paradoxical sensitization to pain when delivered in different administration patterns. Although opioid tolerance-induced hyperalgesia is largely studied, little is known about the mechanisms underlying acute ultra-low-dose morphine hyperalgesia. Activation of spinal
Eriko Someya et al.
European journal of pharmacology, 803, 124-129 (2017-03-28)
Opioids contribute to the regulation of cerebral vascular tone. The purpose of this study was to examine the effects of herkinorin, a non-opioid μ-opioid receptor agonist derived from salvinorin A, on blood vessels in the rat retina and to investigate
Enrica Bianchi et al.
Journal of neurochemistry, 111(1), 171-180 (2009-08-07)
Although alterations in micro-opioid receptor (microOR) signaling mediate excitatory effects of opiates in opioid tolerance, the molecular mechanism for the excitatory effect of acute low dose morphine, as it relates to microOR coupling, is presently unknown. A pronounced coupling of
Wenjin Ji et al.
Experimental and therapeutic medicine, 4(3), 503-506 (2012-11-28)
Endothelin B receptor agonists exert antipruritic effects on itching induced via endothelin-1 (ET-1) and compound 48/80. Peripheral µ- and κ-opioid receptors (MORs and KORs, respectively) are reported to be involved in the anti-nociceptive properties triggered by ET(B) agonists. Therefore, we
Géraldine De Muylder et al.
PLoS neglected tropical diseases, 10(12), e0005234-e0005234 (2016-12-31)
Host-directed therapies (HDTs) constitute promising alternatives to traditional therapy that directly targets the pathogen but is often hampered by pathogen resistance. HDT could represent a new treatment strategy for leishmaniasis, a neglected tropical disease caused by the obligate intracellular parasite
He-Min Yang et al.
Frontiers in systems neuroscience, 14, 51-51 (2020-08-28)
Aim: To examine the effects of fentanyl, a potent mu-opioid receptor (MOR) agonist, on-air puff-evoked responses in Purkinje cells (PCs), and molecular layer interneurons (MLIs) using in vivo patch-clamp recordings in anesthetized mice. Methods: Male mice 6-8 weeks-old were anesthetized
Andrew C Eschenroeder et al.
Glia, 60(1), 125-136 (2011-10-18)
Although the classical function of myelin is the facilitation of saltatory conduction, this membrane and the oligodendrocytes, the cells that make myelin in the central nervous system (CNS), are now recognized as important regulators of plasticity and remodeling in the
Heike L Rittner et al.
PLoS pathogens, 5(4), e1000362-e1000362 (2009-04-04)
In inflammation, pain is regulated by a balance of pro- and analgesic mediators. Analgesic mediators include opioid peptides which are secreted by neutrophils at the site of inflammation, leading to activation of opioid receptors on peripheral sensory neurons. In humans
Claudia Herrera Tambeli et al.
Brain research, 1464, 24-29 (2012-06-20)
Ascending nociceptive control is a novel spino-striato-rostral ventral medulla pain modulation pathway that mediates heterosegmental pain-induced analgesia, i.e., noxious stimulus-induced antinociception. In this study, we used the dorsal immobility response in rats as a model of the defensive responses. We
Garrett J Gross et al.
American journal of physiology. Heart and circulatory physiology, 298(6), H2201-H2207 (2010-04-20)
We previously demonstrated that several epoxyeicosatrienoic acids (EETs) produce reductions in myocardial infarct size in rats and dogs. Since a recent study demonstrated the release of opioids in mediating the antinociceptive effect of 14,15-EET, we hypothesized that endogenous opioids may
Melih Ö Celik et al.
JCI insight, 5(4) (2020-02-28)
IL-4 is a pleiotropic antiinflammatory cytokine, which can be neuroprotective after nervous system injury. The beneficial actions of IL-4 are thought to result from the blunting of action of inflammatory mediators, such as proinflammatory cytokines. Here, we demonstrate that IL-4
Laurie-Anne Roeckel et al.
Scientific reports, 7(1), 10406-10406 (2017-09-06)
Opiates are potent analgesics but their clinical use is limited by side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH). The Opiates produce analgesia and other adverse effects through activation of the mu opioid receptor (MOR) encoded by the Oprm1
Eugen V Khomula et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(36), 7061-7073 (2019-07-14)
Opioid-induced hyperalgesia (OIH) is a serious adverse event produced by opioid analgesics. Lack of an in vitro model has hindered study of its underlying mechanisms. Recent evidence has implicated a role of nociceptors in OIH. To investigate the cellular and
Nina T Lichtenberg et al.
The European journal of neuroscience, 45(3), 381-387 (2016-11-20)
Environmental reward-predictive stimuli can retrieve from memory a specific reward expectation that allows them to motivate action and guide choice. This process requires the basolateral amygdala (BLA), but little is known about the signaling systems necessary within this structure. Here
Marcelo L Silva et al.
Life sciences, 93(20), 742-754 (2013-09-26)
The anterior pretectal nucleus (APtN) and electroacupuncture (EA) activate descending mechanisms to modulate nociceptive inputs in the spinal dorsal horn. This study examines qualitatively whether mechanisms in the APtN participate in the EA-induced analgesia in rats. The tail-flick test was
Ruth Drdla-Schutting et al.
Pain, 160(12), 2819-2828 (2019-08-23)
Opioids are the most powerful analgesics available to date. However, they may also induce adverse effects including paradoxical opioid-induced hyperalgesia. A mechanism that might underlie opioid-induced hyperalgesia is the amplification of synaptic strength at spinal C-fibre synapses after withdrawal from
Nicoletta Galeotti et al.
The journal of pain : official journal of the American Pain Society, 11(2), 149-159 (2009-12-01)
The antinociceptive profile of St. John's Wort (SJW) was investigated in mice in a condition of acute thermal and chemical pain, together with the mechanism that might underlie this effect. A dried extract of SJW induced a prolonged antinociception that
Neuroadaptation of GABAergic transmission in the central amygdala during chronic morphine treatment.
Michal Bajo et al.
Addiction biology, 16(4), 551-564 (2010-12-25)
We investigated possible alterations of pharmacologically-isolated, evoked GABA(A) inhibitory postsynaptic potentials (eIPSPs) and miniature GABA(A) inhibitory postsynaptic currents (mIPSCs) in the rat central amygdala (CeA) elicited by acute application of µ-opioid receptor (MOR) agonists (DAMGO and morphine; 1 µM) and
Céline Heinl et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(46), 16748-16756 (2011-11-18)
In addition to analgesia, opioids may also produce paradoxical pain amplification [opioid-induced hyperalgesia (OIH)] either on abrupt withdrawal or during continuous long-term application. Here, we assessed antinociceptive and pronociceptive effects of three clinically used opioids at C-fiber synapses in the
G T C Wong et al.
Acta anaesthesiologica Scandinavica, 54(4), 510-518 (2009-11-03)
Ischemic pre- or post-conditioning of the heart has been shown to involve opioid receptors. Remifentanil, an ultra-short-acting selective mu opioid receptor agonist in clinical use, pre-conditions the rat heart against ischemia-reperfusion injury. This study investigates whether remifentanil post-conditioning is also
Central effects of the potent and highly selective mu opioid antagonist D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2 (CTOP) in mice.
Gulya K
European Journal of Pharmacology, 150(3), 355-360 (1988)
Opioids inhibit visceral afferent activation of catecholamine neurons in the solitary tract nucleus.
R J Cui et al.
Neuroscience, 222, 181-190 (2012-07-17)
Brainstem A2/C2 catecholamine (CA) neurons within the solitary tract nucleus (NTS) influence many homeostatic functions, including food intake, stress, respiratory and cardiovascular reflexes. They also play a role in both opioid reward and withdrawal. Injections of opioids into the NTS
Vinod Tiwari et al.
Anesthesiology, 124(3), 706-720 (2016-01-13)
Opioids have long been regarded as the most effective drugs for the treatment of severe acute and chronic pain. Unfortunately, their therapeutic efficacy and clinical utility have been limited because of central and peripheral side effects. To determine the therapeutic
Cooperative regulation of anxiety and panic-related defensive behaviors in the rat periaqueductal grey matter by 5-HT1A and ?-receptors.
Roncon CM
Journal of Psychopharmacology, 27(12), 1141-1148 (2013)
Heidi Kemppainen et al.
Alcoholism, clinical and experimental research, 36(2), 286-293 (2011-09-08)
Striatopallidal medium spiny neurons have been viewed as a final common path for drug reward and the ventral pallidum as an essential convergent point for hedonic and motivational signaling in the brain. The medium spiny neurons are GABAergic, but they
Jesse J DiCello et al.
Cellular and molecular gastroenterology and hepatology, 9(3), 465-483 (2019-11-24)
Functional interactions between the mu opioid receptor (MOR) and delta opioid receptor (DOR) represent a potential target for novel analgesics and may drive the effects of the clinically approved drug eluxadoline for the treatment of diarrhea-predominant irritable bowel syndrome. Although
Carlo O Martinez et al.
Neurobiology of learning and memory, 96(2), 207-217 (2011-05-17)
The medial and lateral perforant path projections to the hippocampal CA3 region display distinct mechanisms of long-term potentiation (LTP) induction, N-methyl-d-aspartate (NMDA) and opioid receptor dependent, respectively. However, medial and lateral perforant path projections to the CA3 region display associative
Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala.
Narita M
Neuropsychopharmacology, 31(4), 739-750 (2006)
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