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Showing 1-30 of 40 results for "P5555" within Papers
An Zhou et al.
Pharmaceutical development and technology, 19(6), 743-747 (2013-08-28)
This study investigated the potential of targeted intestinal lymphatic transport of puerarin via a lipid formulation approach. Three formulations of PEG nanoemulsion, nanosuspension and an oil suspension containing puerarin were examined with the lymph-cannulated anaesthetized rat model. Plasma and lymph
Ka H Wong et al.
Journal of pharmaceutical and biomedical analysis, 84, 5-13 (2013-06-20)
The aims of the study were to differentiate Pueraria lobata from its related species Pueraria thomsonii and to examine the raw herbal material used in manufacturing kudzu root granules using partial least square discriminant analysis (PLS-DA). Sixty-four raw materials of
Lin Gu et al.
Pharmaceutical development and technology, 18(5), 1051-1057 (2012-02-07)
The potential of polyamidoamine (PAMAM) dendrimers as solubility enhancers and oral drug delivery system was well known. Herein, we investigated the possibility of PAMAM dendrimers for promoting the solubility and oral bioavailability of puerarin. In the present study, the effect
HPLC method for the determination and pharmacokinetic studies on puerarin in cerebral ischemia reperfusion rat plasma after intravenous administration of puerariae radix isoflavone
Yan B, et al.
Journal of Pharmaceutical and Biomedical Analysis, 37(2), 297-301 (2005)
Zhen-Gui Huang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 38(3), 381-385 (2013-05-15)
To explore the effect of puerarin combined with felodipine on the mRNA and protein expression of apelin and APJ in renal tissue of renovascular hypertensive rat. Sixty-two Sprague-Dawley rats were used, of which 8 rats were randomly chosen as sham-operation
Eisuke Kato et al.
Bioorganic & medicinal chemistry letters, 20(15), 4333-4336 (2010-07-08)
Chemical treatment of diabetes mellitus is widely studied and controlling of blood glucose level is the main course of therapy. In type 2 diabetes mellitus, insulin resistance is the major problem. An isoflavone C-glucoside, puerarin (1), is known to enhance
Q Wang et al.
The Cochrane database of systematic reviews, (3)(3), CD004196-CD004196 (2006-07-21)
Puerarin is extracted from the Chinese herb puerariae lobata. Many users of Chinese herbal medicine believe that puerarin has positive effects in the treatment of coronary heart disease (CHD). In recent years puerarin injection has been widely used to treat
Xin-Li Liang et al.
Journal of ethnopharmacology, 144(3), 677-682 (2012-10-23)
Angelicae Dahurica (Hoffm.)Benth.& Hook.f.ex Franch.&Sav combined with Pueraria labota (Willd.)Ohwi has been widely used as herb-pairs in traditional Chinese medicine (TCM) for utilization of antipyretic analgesic and anti-inflammatory drugs, and modern pharmacological studies have shown that application compatibility of the
Qi Wang et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 912, 33-37 (2012-12-19)
In the paper, we presented a magnetic solid-phase extraction (MSPE) method based on C(18)-functionalized magnetic silica nanoparticles for the analysis of puerarin in rat plasma. The approach involves two steps including synthesis of magnetic solid-phase sorbents and bioanalysis. The synthesized
Wen Cheng et al.
PloS one, 7(9), e45529-e45529 (2012-10-03)
Puerarin is a major isoflavonoid compound extracted from Radix puerariae. It has a weak estrogenic action by binding to estrogen receptors (ERs). In our early clinical practice to treat endometriosis, a better therapeutic effect was achieved if the formula of
Xin-Yi Liu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(22), 3391-3394 (2013-02-05)
To detect the stability of PEGylated puerarin (PEG-PUE), in order to provide experimental basis for storage conditions of PEGylated puerarin. First, a method for determining the content of PEG-PUE was established. Next, a system study was conducted for the stability
Jing-Hua Peng et al.
The Journal of pharmacology and experimental therapeutics, 344(3), 646-654 (2013-01-02)
Puerarin, an isoflavone component extracted from Kudzu (Pueraria lobata), has been demonstrated to alleviate alcohol-related disorders. Our study examined whether puerarin ameliorates chronic alcoholic liver injury through inhibition of endotoxin gut leakage, the subsequent Kupffer cell activation, and endotoxin receptors
Y Tan et al.
The Cochrane database of systematic reviews, (1)(1), CD004955-CD004955 (2008-02-07)
Puerarin, a form of herbal medicine, is widely used in the treatment of acute ischaemic stroke in China. To assess the efficacy and safety of puerarin in patients with acute ischaemic stroke. We searched the Cochrane Stroke Group Trials Register
Jie-Ping Fan et al.
Food chemistry, 135(4), 2299-2306 (2012-09-18)
Ionic liquid (IL) based ultrasonic assisted extraction (ILUAE) was developed for the effective extraction of puerarin from Radix Puerariae Lobatae (RPL). The ILUAE parameters including the type of ILs, IL concentration, RPL amount, ultrasonic power and time were optimized by
Lei Wang et al.
PloS one, 14(6), e0218490-e0218490 (2019-06-25)
Growing evidence indicates that the gut microbiota plays a significant role in the pathophysiological processes of obesity and its related metabolic symptoms in the host. Puerarin, an active ingredient in the root of Pueraria lobate has been suggested to have
Ying Deng et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(19), 2960-2963 (2012-12-29)
To study the effect of phenformin hydrochloride that may be illegally added in traditional Chinese medicine preparations on the pharmacokinetics of puerarin in rats. Rats were randomly divided into the single pueraria group and the phenformin hydrochloride combined with pueraria
Qin Wang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(11), 1677-1681 (2012-09-22)
To investigate the distribution process of puerarin contained in Zige freeze-dried powder injection in rat liver and kidney and the safety of Zige freeze-dried powder injection. Rats were divided into the Zige freeze-dried powder injection group and the puerarin freeze-dried
Jeevan K Prasain et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 20(1), 17-23 (2012-11-06)
The incidence of type 2 diabetes and metabolic disease is rapidly increasing, but effective therapies for their prevention and treatment have been poorly tolerated or minimally effective. In this study, chronic administration of kudzu root extract (8 months, 0.2%, w/w
Hai-quan Tao et al.
Naunyn-Schmiedeberg's archives of pharmacology, 386(1), 61-70 (2012-11-30)
It is well known that puerarin attenuates ischemia-reperfusion injury and promotes function recovery of ischemic region. However, due to its reverse physiochemical properties, puerarin does not easily cross the blood-brain barrier. The aim of the present study is to create
Ran Yin et al.
Journal of pharmaceutical and biomedical analysis, 72, 127-133 (2012-11-14)
A rapid, sensitive and selective ultra-fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS) method for the simultaneous determination of three active flavonoid glycosides: luteolin-7-O-gentiobioside, luteolin-7-O-β-D-glucoside and luteolin-7-O-β-D-glucuronide in beagle dog plasma was developed and validated. Puerarin was used as internal standard (IS).
Fang-Rong Chang et al.
Journal of natural products, 68(7), 971-973 (2005-07-26)
The transgenic Arabidopsis plant system, pER8-GFP, may be used as a powerful tool in searching for natural estrogen-agonists/antagonists. Among selected plant extracts and natural products, the method was able to distinguish active extracts (e.g., Glycine max and Pueraria lobata) and
Benguo Liu et al.
Journal of agricultural and food chemistry, 60(51), 12501-12507 (2012-12-12)
Puerarin is a natural isoflavone, found in the Chinese medicinal plant Ge-gen, with many reported health-promoting properties. However, its low water solubility impedes its application in pharmaceutical and functional food products. This study explores the formation of inclusion complex between
Jia-Wei Wang et al.
The Journal of surgical research, 186(1), 328-337 (2013-10-02)
A wealth of evidence has suggested that oxidative stress is involved in the secondary brain injury after traumatic brain injury (TBI). Recently, numerous in vivo and in vitro studies were reported that puerarin could inhibit oxidative stress through the activation
Jin Yu et al.
Evidence-based complementary and alternative medicine : eCAM, 2015, 269138-269138 (2015-03-31)
Objective. To explore the effects of puerarin to treat endometriosis (EMT) model rats and the possible regulatory mechanisms. Methods. EMT model rats were surgically induced by autotransplantion of endometrial tissues. The appropriate dosage of puerarin to treat EMT model rats
Xueming Wu et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 935, 70-74 (2013-08-21)
A method of using high-speed counter-current chromatography (HSCCC) was established for preparative isolation and purification of puerarin glycosides from the crude sample after enzymatic glycosylation of puerarin. Four fructosyl puerarins were successfully purified for the first time by HSCCC with
Lin Wang et al.
Human & experimental toxicology, 32(2), 172-185 (2013-01-15)
Puerarin (PU), a natural flavonoid, has been reported to possess anti-oxidative and anti-inflammatory activities. In the present study, female Sprague-Dawley rats received lead (Pb) nitrate (300 mg/L, via drinking water) and/or PU (400 mg/kg/day, orally) to investigate the protective effects of PU
Qin Wang et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 36(10), 1402-1405 (2011-08-16)
Puerarin injection has been widely used for the treatment of cardiac/cerebral blood vascular diseases. The clinical statistical investigation had confirmed that puerarin injection can induce acute intravascular hemolysis, which effected the use of puerarin injection seriously. The review was focus
Mei Ji et al.
The Journal of steroid biochemistry and molecular biology, 138, 421-426 (2013-08-03)
Puerarin, a phytoestrogen with a weak estrogenic effect, binds to estrogen receptors, thereby competing with 17β-estradiol and producing an anti-estrogenic effect. In our early clinical practice to treat endometriosis, a better therapeutic effect was achieved if the formula of traditional
Yancai Wang et al.
International journal of pharmaceutics, 441(1-2), 728-735 (2012-10-24)
The present study aims to evaluate the anticancer activity of puerarin nanosuspensions in human colon cancer HT-29 cell line in vitro and in vivo. Puerarin nanosuspensions were prepared by the high-pressure homogenization (HPH) technique. The HT-29 cells were incubated with
Jian-Jun Hu et al.
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 37(20), 3112-3116 (2013-01-15)
To observe the effect of pretreatment with puerarin on activation of LPS -induced RAW264. 7 cells and secretory cytokines, and discuss its anti-inflammatory mechanism. Well-grown RAW264. 7 cells in the exponential phase were collected and randomly divided them into the
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