P6001

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Showing 1-30 of 92 results for "P6001" within Papers

Growth of Thin, Anisotropic, π-Conjugated Molecular Films by Stepwise "Click" Assembly of Molecular Building Blocks: Characterizing Reaction Yield, Surface Coverage, and Film Thickness versus Addition Step Number.

Abel T Demissie et al.

Journal of the American Chemical Society, 137(27), 8819-8828 (2015-06-23)

We report the systematic characterization of anisotropic, π-conjugated oligophenyleneimine (OPI) films synthesized using stepwise imine condensation, or "click" chemistry. Film synthesis began with a self-assembled monolayer (SAM) of 4-formylthiophenol or 4-aminothiophenol on Au, followed by repetitive, alternate addition of terephthalaldehyde

Kindlin 3 (FERMT3) is associated with unstable atherosclerotic plaques, anti-inflammatory type II macrophages and upregulation of beta-2 integrins in all major arterial beds.

Niku Oksala et al.

Atherosclerosis, 242(1), 145-154 (2015-07-21)

Kindlins (FERMT) are cytoplasmic proteins required for integrin (ITG) activation, leukocyte transmigration, platelet aggregation and thrombosis. Characterization of kindlins and their association with atherosclerotic plaques in human(s) is lacking. Exploratory microarray (MA) was first performed followed by selective quantitative validation

Investigation of dyeing behavior of oxidative dye in fine structures of the human hair cuticle by nanoscale secondary ion mass spectrometry.

T Kojima et al.

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 21(3), 295-301 (2014-10-18)

In oxidative coloring, the hair cuticle layers are not only the penetration pathway for active ingredients but also one of the most important dyeing regions. The dyeing mechanism of oxidative dyes in fine structures of the cuticle remains unclear. To

Multiple functions of CXCL12 in a syngeneic model of breast cancer.

Sharon A Williams et al.

Molecular cancer, 9, 250-250 (2010-09-21)

A growing body of work implicates chemokines, in particular CXCL12 and its receptors, in the progression and site-specific metastasis of various cancers, including breast cancer. Various agents have been used to block the CXCL12-CXCR4 interaction as a means of inhibiting

Irritant contact dermatitis from a black henna tattoo without sensitization to para-phenylendiamine.

Fabiola Kind et al.

Pediatrics, 131(6), e1974-e1976 (2013-05-22)

Allergic contact dermatitis from nonpermanent black henna tattoos has been frequently reported, particularly in children. Contamination or adulteration of the dyes with para-phenylendiamine has been identified as major cause of active sensitization and elicitation of severe allergic contact dermatitis. Sequelae

In situ evaluation of oxidative stress and immunological parameters as ecotoxicological biomarkers in a novel sentinel species (Mimachlamys varia).

Thomas Milinkovitch et al.

Aquatic toxicology (Amsterdam, Netherlands), 161, 170-175 (2015-02-24)

Although the variegated scallop Mimachlamys varia seems to be a suitable sentinel species for contaminant monitoring, no study has identified biomarkers in this species. In order to fill this gap, this study conducted an in situ biomarker approach. M. varia

Secondary post-geniculate involvement in Leber's hereditary optic neuropathy.

Giovanni Rizzo et al.

PloS one, 7(11), e50230-e50230 (2012-12-05)

Leber's hereditary optic neuropathy (LHON) is characterized by retinal ganglion cell (RGC) degeneration with the preferential involvement of those forming the papillomacular bundle. The optic nerve is considered the main pathological target for LHON. Our aim was to investigate the

Repetitive transcranial magnetic stimulation promotes neural stem cell proliferation via the regulation of MiR-25 in a rat model of focal cerebral ischemia.

Feng Guo et al.

PloS one, 9(10), e109267-e109267 (2014-10-11)

Repetitive transcranial magnetic stimulation (rTMS) has increasingly been studied over the past decade to determine whether it has a therapeutic benefit on focal cerebral ischemia. However, the underlying mechanism of rTMS in this process remains unclear. In the current study

Methods in Enzymology, 24, 161-161 (1972)

Extrapolation of systemic bioavailability assessing skin absorption and epidermal and hepatic metabolism of aromatic amine hair dyes in vitro.

John Manwaring et al.

Toxicology and applied pharmacology, 287(2), 139-148 (2015-06-02)

Approaches to assess the role of absorption, metabolism and excretion of cosmetic ingredients that are based on the integration of different in vitro data are important for their safety assessment, specifically as it offers an opportunity to refine that safety

Unusual localization of allergic contact dermatitis from p-phenylenediamine.

Andrea Bassi et al.

Dermatitis : contact, atopic, occupational, drug, 22(6), 358-358 (2012-06-02)

Glassy carbon electrode modified with horse radish peroxidase/organic nucleophilic-functionalized carbon nanotube composite for enhanced electrocatalytic oxidation and efficient voltammetric sensing of levodopa.

Yalda Shoja et al.

Materials science & engineering. C, Materials for biological applications, 58, 835-845 (2015-10-20)

A novel and selective enzymatic biosensor was designed and constructed for voltammetric determination of levodopa (L-Dopa) in aqueous media (phosphate buffer solution, pH=7). Biosensor development was on the basis of to physically immobilizing of horse radish peroxidase (HRP) as electrochemical

Persistent organic pollutants in a marine bivalve on the Marennes-Oléron Bay and the Gironde Estuary (French Atlantic Coast) - part 2: potential biological effects.

A Luna-Acosta et al.

The Science of the total environment, 514, 511-522 (2015-02-11)

Contaminant effects on defence responses of ecologically and economically important organisms, such as the Pacific oyster Crassostrea gigas, are likely to influence their ability to resist infectious diseases, particularly at the young stages. The aim of this study was to

Patch testing with the textile dyes Disperse Orange 1 and Disperse Yellow 3 and some of their potential metabolites, and simultaneous reactions to para-amino compounds.

Laura Malinauskiene et al.

Contact dermatitis, 67(3), 130-140 (2012-05-26)

It is known that, in vitro, human skin bacteria are able to split disperse azo dyes into the corresponding aromatic amines, some of which are sensitizers in the local lymph node assay. We hypothesize that the molecules of disperse dyes

[Sensitisation to p-Phenylenediamine. Effects of metabolism and individual susceptibility].

R Brans et al.

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 60(1), 26-31 (2008-12-23)

Due to its constant exposure to small molecular weight compounds, the skin is a major target for allergic reactions. Para-phenylenediamine (PPD) is a common and strong contact allergen. Recent studies have revealed new aspects of steps involved in sensitization and

Paraphenylenediamine poisoning.

S C Chaudhary et al.

Nigerian journal of clinical practice, 16(2), 258-259 (2013-04-09)

Hair dye containing paraphenylenediamine (PPD) is widely used in India because of its free availability and low cost. PPD produces local as well as systemic toxic effects when applied topically and/or ingested. It is highly toxic when taken by mouth

Neurodegeneration severity can be predicted from early microglia alterations monitored in vivo in a mouse model of chronic glaucoma.

Alejandra Bosco et al.

Disease models & mechanisms, 8(5), 443-455 (2015-03-11)

Microglia serve key homeostatic roles, and respond to neuronal perturbation and decline with a high spatiotemporal resolution. The course of all chronic CNS pathologies is thus paralleled by local microgliosis and microglia activation, which begin at early stages of the

p-Phenylenediamine allergy: the role of Bandrowski's base

White JML, et al.

Clinical and Experimental Allergy, 36(10), 1289-1293 (2006)

Telomerase biogenesis requires a novel Mex67 function and a cytoplasmic association with the Sm7 complex.

Yulia Vasianovich et al.

eLife, 9 (2020-10-24)

The templating RNA is the core of the telomerase reverse transcriptase. In Saccharomyces cerevisiae, the complex life cycle and maturation of telomerase includes a cytoplasmic stage. However, timing and reason for this cytoplasmic passage are poorly understood. Here, we use

TMIE Defines Pore and Gating Properties of the Mechanotransduction Channel of Mammalian Cochlear Hair Cells.

Christopher L Cunningham et al.

Neuron, 107(1), 126-143 (2020-04-29)

TMC1 and TMC2 (TMC1/2) have been proposed to form the pore of the mechanotransduction channel of cochlear hair cells. Here, we show that TMC1/2 cannot form mechanotransduction channels in cochlear hair cells without TMIE. TMIE binds to TMC1/2, and a

Yanala Sandeep Reddy et al.

Renal failure, 34(7), 880-884 (2012-06-12)

We studied paraphenylenediamine (PPD)-related acute kidney injury (AKI) in 81 patients and also in albino rats experimentally. In the patients' group AKI was found in 32.7%. Of them, 81.4% needed dialysis support. The overall mortality was 25.9%. In experimental rats

Evaluation of non-radioactive endpoints of ex vivo local lymph node assay-BrdU to investigate select contact sensitizers.

Ozge Cemiloglu Ulker et al.

Journal of immunotoxicology, 10(1), 1-8 (2012-06-28)

The present study sought to verify the utility of the non-radioactive endpoints LLNA BrdU (5-bromo-2'-deoxyuridine) ex vivo incorporation and cytokine release using auricular lymph node cells isolated from BALB/c mice topically treated with a strong (formaldehyde or p-phenylene-diamine [PPD]), moderate

In vitro evaluation of the sensitization potential of weak contact allergens using Langerhans-like dendritic cells and autologous T cells

Rougier N, et al.

Toxicology, 145(1), 73-82 (2000)

Identification and quantification of para-phenylenediamine in a temporary black henna tattoo

Brancaccio RR, et al.

American Journal of Contact Dermatitis : Official Journal of the American Contact Dermatitis Society, 13(1), 15-18 (2002)

Hematopathology in Sprague-Dawley rats following sub-chronic topical application of para-phenylenediamine.

Manuj Kr Bharali et al.

Bulletin of environmental contamination and toxicology, 89(4), 712-717 (2012-08-14)

The aim of the present study was to analyze the hematological profile of male SD rats treated topically with aqueous solution of para-phenylenediamine (PPD), a component of almost all hair dye formulations. The rats were painted with different concentration of

The mitosis-regulating and protein-protein interaction activities of astrin are controlled by aurora-A-induced phosphorylation.

Shao-Chih Chiu et al.

American journal of physiology. Cell physiology, 307(5), C466-C478 (2014-07-11)

Cells display dramatic morphological changes in mitosis, where numerous factors form regulatory networks to orchestrate the complicated process, resulting in extreme fidelity of the segregation of duplicated chromosomes into two daughter cells. Astrin regulates several aspects of mitosis, such as

Mabel Lum et al.

International journal of medical microbiology : IJMM, 304(5-6), 530-541 (2014-04-24)

Shigella infection in epithelial cells induces cell death which is accompanied by mitochondrial dysfunction. In this study the role of the mitochondrial fission protein, Drp1 during Shigella infection in HeLa cells was examined. Significant lactate dehydrogenase (LDH) release was detected

Contact dermatitis to hair dye: an update.

Sanjeev Handa et al.

Indian journal of dermatology, venereology and leprology, 78(5), 583-590 (2012-09-11)

Exposure to hair dyes has long been known as a significant risk factor for development of allergic contact dermatitis among the exposed population as these lead to severe eczema of face and upper trunk in the consumer and hand eczema

Transdermal penetration behaviour of drugs: CART-clustering, QSPR and selection of model compounds.

Bram Baert et al.

Bioorganic & medicinal chemistry, 15(22), 6943-6955 (2007-09-11)

A set of 116 structurally very diverse compounds, mainly drugs, was characterized by 1630 molecular descriptors. The biological property modelled in this study was the transdermal permeability coefficient logK(p). The main objective was to find a limited set of suitable

N-Acetylation of p-aminobenzoic acid and p-phenylenediamine in primary porcine urinary bladder epithelial cells and in the human urothelial cell line 5637.

Wolfram Föllmann et al.

Journal of toxicology and environmental health. Part A, 75(19-20), 1206-1215 (2012-09-22)

N-Acetyltransferases (NAT) are important enzymes in the metabolism of certain carcinogenic arylamines, as N-acetylation decreases or prevents their bioactivation via N-hydroxylation. To study such processes in the bladder, cell culture models may be used, but metabolic competence needs to be

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