Search Within
P6148
Applied Filters:
Keyword:'P6148'
Showing 1-30 of 584 results for "P6148" within Papers
Philip J Johnson et al.
Journal of biomedical materials research. Part A, 92(1), 152-163 (2009-01-24)
The purpose of this study was to evaluate the effects of fibrin scaffolds on subacute rat spinal cord injury (SCI). Long-Evans rats were anesthetized and underwent a dorsal hemisection injury; two weeks later, the injury site was re-exposed, scar tissue
Brian Z Wang et al.
Aging and disease, 10(5), 1058-1074 (2019-10-09)
The global incidence of age-associated neurological diseases is expected to rise with increasingly greying societies. In the aged brain, there is a dramatic decrease in the number of stem cells, which is a main cause for the decrease in brain
James Baye et al.
Biomedical microdevices, 19(3), 59-59 (2017-07-02)
Tumor spheroids are a 3-D tumor model that holds promise for testing cancer therapies in vitro using microfluidic devices. Tailoring the properties of a tumor spheroid is critical for evaluating therapies over a broad range of possible indications. Using human
Elly Sinkala et al.
Methods in molecular biology (Clifton, N.J.), 1346, 1-9 (2015-11-07)
Little headway has been made in single cell protein analysis, aside from tools that rely solely on antibody-probe based detection (i.e., flow cytometry, immunocytochemistry), which are limited by low specificity and multiplexing capabilities. To address these protein analysis gaps, we
Mehdi Hooshmandi et al.
Cell reports, 35(4), 109036-109036 (2021-04-29)
Recent studies have demonstrated that selective activation of mammalian target of rapamycin complex 1 (mTORC1) in the cerebellum by deletion of the mTORC1 upstream repressors TSC1 or phosphatase and tensin homolog (PTEN) in Purkinje cells (PCs) causes autism-like features and
Francesca Morello et al.
Cell reports, 33(2), 108268-108268 (2020-10-15)
Tegmental nuclei in the ventral midbrain and anterior hindbrain control motivated behavior, mood, memory, and movement. These nuclei contain inhibitory GABAergic and excitatory glutamatergic neurons, whose molecular diversity and development remain largely unraveled. Many tegmental neurons originate in the embryonic
Jennifer Schmahl et al.
Genes & development, 22(23), 3255-3267 (2008-12-06)
The platelet-derived growth factor (PDGF) signaling pathway regulates numerous lineages of mesenchymal cell origin during development and in the adult. The transcriptional targets of this pathway have been shown to be required in several PDGF-dependent processes, but the roles of
Laura Tikker et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(45), 8669-8682 (2020-10-14)
Serotonergic neurons in the dorsal raphe (DR) nucleus are associated with several psychiatric disorders including depression and anxiety disorders, which often have a neurodevelopmental component. During embryonic development, GATA transcription factors GATA2 and GATA3 operate as serotonergic neuron fate selectors
Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein.
Rasoul Pourebrahim et al.
Genes & development, 31(18), 1847-1857 (2017-10-13)
Yea Seul Shin et al.
Journal of neurochemistry, 149(2), 269-283 (2019-01-22)
Contributions of damaged mitochondria to neuropathologies have stimulated interest in mitophagy. We investigated triggers of neuronal mitophagy by disruption of mitochondrial energy metabolism in primary neurons. Mitophagy was examined in cultured murine cerebellar granule cells after inhibition of mitochondrial respiratory
Zohreh Jangravi et al.
Journal of proteome research, 14(9), 3492-3502 (2015-07-29)
One of the major objectives of the Human Y Chromosome Proteome Project is to characterize sets of proteins encoded from the human Y chromosome. Lysine (K)-specific demethylase 5D (KDM5D) is located on the AZFb region of the Y chromosome and
Myriam Holl et al.
Biomedicines, 9(2) (2021-02-14)
Peritoneal mucosa of mesothelial cells line the abdominal cavity, surround intestinal organs and the female reproductive organs and are responsible for immunological integrity, organ functionality and regeneration. Peritoneal diseases range from inflammation, adhesions, endometriosis, and cancer. Efficient technologies to isolate
Staining of Membrane Receptors with Fluorescently-labeled DNA Aptamers for Super-resolution Imaging.
Maria Angela Gomes de Castro et al.
Bio-protocol, 7(17), e2541-e2541 (2017-09-05)
One of the most prominent applications of fluorescent super-resolution microscopy is the study of nanodomain arrangements of receptors and the endocytic pathway. Staining methods are becoming crucial for answering questions on the nanoscale, therefore, the use of small and monovalent
Alejandro Maruri et al.
Theriogenology, 119, 143-149 (2018-07-15)
The coculture with somatic cells is an alternative to improve suboptimal in vitro culture (IVC) conditions and promote embryo development. Several cell types have been used for this purpose, but there is no information about using luteal cells in short-term coculture
Jagyeong Oh et al.
Cells, 10(4) (2021-05-01)
Aberrant alternative splicing (AS) is a hallmark of cancer and a potential target for novel anti-cancer therapeutics. Breast cancer-associated AS events are known to be linked to disease progression, metastasis, and survival of breast cancer patients. To identify altered AS
Jonghan Kim et al.
Journal of immunology (Baltimore, Md. : 1950), 182(5), 2583-2589 (2009-02-24)
In adults, the nonclassical MHC class I molecule, FcRn, binds both IgG and albumin and rescues both from a degradative fate, endowing both proteins with high plasma concentrations. FcRn also transports IgG from mother to young during gestation. Anticipating that
Selective accumulation of aggregation-prone proteasome substrates in response to proteotoxic stress.
Florian A Salomons et al.
Molecular and cellular biology, 29(7), 1774-1785 (2009-01-23)
Conditions causing an increase in misfolded or aberrant proteins can impair the activity of the ubiquitin/proteasome system (UPS). This observation is of particular interest, given the fact that proteotoxic stress is closely associated with a large variety of disorders. Although
George K E Umanah et al.
Cell reports, 33(5), 108329-108329 (2020-11-05)
The regulation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking affects multiple brain functions, such as learning and memory. We have previously shown that Thorase plays an important role in the internalization of AMPARs from the synaptic membrane. Here, we show that
Ernesto Cortes et al.
Hepatology (Baltimore, Md.), 69(2), 785-802 (2018-07-29)
Hepatic stellate cells (HSCs) are essential perisinusoidal cells in both healthy and diseased liver. HSCs modulate extracellular matrix (ECM) homeostasis when quiescent, but in liver fibrosis, HSCs become activated and promote excess deposition of ECM molecules and tissue stiffening via
Angela D Morris et al.
Developmental dynamics : an official publication of the American Association of Anatomists, 246(11), 956-962 (2017-06-10)
Spinal motor nerves are essential for relaying information between the central and peripheral nervous systems. Perturbations to cell types that comprise these nerves may impair rapid and efficient transmission of action potentials and alter nerve function. Identifying ultrastructural changes resulting
Hye Young Ryu et al.
Experimental & molecular medicine, 53(3), 369-383 (2021-03-04)
Unc-51-like autophagy activating kinase 1 (ULK1), a mammalian homolog of the yeast kinase Atg1, has an essential role in autophagy induction. In nutrient and growth factor signaling, ULK1 activity is regulated by various posttranslational modifications, including phosphorylation, acetylation, and ubiquitination.
Jihye Han et al.
Autophagy, 12(12), 2326-2343 (2016-10-27)
Severe hepatic inflammation is a common cause of acute or chronic liver disease. Macrophages are one of the key mediators which regulate the progress of hepatic inflammation. Increasing evidence shows that the TAM (TYRO3, AXL and MERTK) family of RTKs
Peng Xiao et al.
Human cell, 34(1), 60-75 (2020-10-12)
Osteoarthritis (OA), which is characterized by articular cartilage degeneration, shows a gradually increasing incidence with age. This study explored the molecular mechanism underlying the proliferation and apoptosis of chondrocytes during OA progression. In this study, chondrocytes were isolated from human
M Lango-Chavarría et al.
International journal of oncology, 50(2), 432-440 (2017-01-20)
Breast cancer ranks first in incidence and mortality in working age women. Cancer initiation and progression relies on accumulation of genetic and epigenetic aberrations that alter cellular processes, among them, epithelial to mesenchymal transition (EMT) denotes particularly aggressive neoplasias given
Zhenyue Tong et al.
Hepatology (Baltimore, Md.), 50(3), 939-947 (2009-08-12)
Connective tissue growth factor (CCN2) is a matricellular protein that is up-regulated in many fibrotic disorders and coexpressed with transforming growth factor beta. CCN2 promotes fibrogenesis and survival in activated hepatic stellate cells, and injured or fibrotic liver contains up-regulated
Ayoze González-Santana et al.
Journal of neurochemistry, 152(3), 299-314 (2019-11-05)
Adrenal chromaffin cells release epinephrine (EPI) and norepinephrine (NE) into the bloodstream as part of the homeostatic response to situations like stress. Here we utilized EPI-deficient mice generated by knocking out (KO) the phenylethanolamine N-methyltransferase (Pnmt) gene. These Pnmt-KO mice
M Kolpen et al.
Clinical and experimental immunology, 177(1), 310-319 (2014-03-13)
Chronic Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) patients is characterized by persisting mucoid biofilms in hypoxic endobronchial mucus. These biofilms are surrounded by numerous polymorphonuclear leucocytes (PMNs), which consume a major part of present molecular oxygen (O(2)) due
Nimantana He et al.
Cytotechnology, 68(6), 2579-2588 (2016-05-20)
In this study, highly purified hair follicle stem cells from Arbas Cashmere goat (gHFSCs) were isolated using enzyme digestion and adhesion to type IV collagen. The biological characteristics of the gHFSCs were identified by morphological observation, growth curve, markers assay
Emily R Moore et al.
Bone, 143, 115738-115738 (2020-11-15)
Bone is a dynamic organ that is continuously modified during development, load-induced adaptation, and fracture repair. Understanding the cellular and molecular mechanisms for natural fracture healing can lead to therapeutics that enhance the quality of newly formed tissue, advance the
Yi-Fan Chen et al.
Scientific reports, 7, 45366-45366 (2017-03-30)
Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect of cancer treatment. No medication has been shown to be effective in the treatment of CIPN. This study aims to integrate the image-based high-content screening, mouse behavior models and mechanistic cell-based
Page 1 of 20