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Showing 31-60 of 236 results for "p6273" within Papers
Histone deacetylase inhibitor, 2-propylpentanoic acid, increases the chemosensitivity and radiosensitivity of human glioma cell linesin vitro
Cuijie S, et al.
Chinese Medical Journal (English Edition), 125(24), 4338-4343 (2012)
Systematic Review of Randomized Clinical Trials on Safety and Efficacy of Pharmacological and Nonpharmacological Treatments for Retinitis Pigmentosa.
Marta Sacchetti et al.
Journal of ophthalmology, 2015, 737053-737053 (2015-09-05)
Zhi-Feng Xie et al.
Bioorganic & medicinal chemistry letters, 15(21), 4803-4805 (2005-09-06)
A series of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinoline derivatives was synthesized using 6-hydroxy-3,4-dihydro-1H-quinolin-2-one as a starting material. Their anticonvulsant activities were evaluated by the maximal electroshock test (MES test) and the subcutaneous (s.c.) pentylenetetrazol test (scMet test), and their neurotoxicity was evaluated by the
Andrea Cipriani et al.
The Cochrane database of systematic reviews, 10(10), CD003196-CD003196 (2013-10-18)
Bipolar disorder is a recurrent illness that is amongst the top 30 causes of disability worldwide and is associated with significant healthcare costs. In the past, emphasis was placed solely on the treatment of acute episodes of bipolar disorder; recently
Yuanyuan Shi et al.
Bioorganic & medicinal chemistry letters, 17(16), 4491-4494 (2007-06-15)
Valproic (2-propylpentanoic) acid is a commonly used drug in the treatment of bipolar disorder and epilepsy. The molecular mechanism that underlies its clinical efficacy remains controversial and is complicated by the broad range of intracellular effects of valproic acid, including
Martina Korfei et al.
Thorax, 70(11), 1022-1032 (2015-09-12)
Activation and differentiation of fibroblasts into contractile protein-expressing myofibroblasts and their acquired apoptosis-resistant phenotype are critical factors towards the development of idiopathic pulmonary fibrosis (IPF), a fatal disease characterised by distorted pulmonary structure and excessive extracellular matrix (ECM) deposition. The
Maria Lyngaas Torgersen et al.
Blood, 122(14), 2467-2476 (2013-08-24)
The role of autophagy during leukemia treatment is unclear. On the one hand, autophagy might be induced as a prosurvival response to therapy, thereby reducing treatment efficiency. On the other hand, autophagy may contribute to degradation of fusion oncoproteins, as
Fernando Dueñas et al.
BMC veterinary research, 10, 154-154 (2014-07-12)
Mesenchymal stem cells (MSC) are multipotent progenitor cells characterized by their ability to both self-renew and differentiate into tissues of mesodermal origin. The plasticity or transdifferentiation potential of MSC is not limited to mesodermal derivatives, since under appropriate cell culture
Hideki Mutai et al.
PloS one, 10(4), e0124301-e0124301 (2015-04-16)
Various factors that are important for proper hearing have been identified, including serum levels of zinc. Here we investigated whether epigenetic regulatory pathways, which can be modified by environmental factors, could modulate hearing. RT-PCR detected expression of genes encoding DNA
Henry F Duncan et al.
Experimental cell research, 319(10), 1534-1543 (2013-04-09)
Application of histone deacetylase inhibitors (HDACi) to cells epigenetically alters their chromatin structure and induces transcriptional and cellular reparative events. This study investigated the application of two HDACi, valproic acid (VPA) and trichostatin A (TSA) on the induction of repair-associated
John O Hwabejire et al.
The Journal of surgical research, 186(1), 363-370 (2013-10-19)
Valproic acid (VPA) has been shown to improve survival in animal models of hemorrhagic shock at a dose of 300 mg/kg. Our aim was to identify the ideal dose through dose-escalation, split-dosing, and dose de-escalation regimens. Rats were subjected to
O V Burenkova et al.
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 99(2), 212-220 (2013-05-09)
In the brain, histone acetylation underlies both learning and the maintenance of long-term sustained effects of early experience which is further epigenetically inherited. However, the role of acetylation in learning previously has only been studied in adult animals: high level
Heath R Pardoe et al.
Neurology, 80(20), 1895-1900 (2013-04-26)
We hypothesized that total brain volume, white matter volume, and lobar cortical thickness would be different in epilepsy patients. We studied valproate relative to nonvalproate by using patients with epilepsy and healthy controls. Patients with focal intractable epilepsy from a
Jakob Avi Shimshoni et al.
Journal of medicinal chemistry, 50(25), 6419-6427 (2007-11-13)
Valproic acid (VPA) is a major antiepileptic drug (AED); however, its use is limited by two life-threatening side effects: teratogenicity and hepatotoxicity. Several constitutional isomers of VPA and their amide and urea derivatives were synthesized and evaluated in three different
Long-term follow-up for efficacy and safety of treatment of retinitis pigmentosa with valproic acid.
Sheena Bhalla et al.
The British journal of ophthalmology, 97(7), 895-899 (2013-04-23)
The purpose of this study was to determine the long-term efficacy and safety of valproic acid (VPA) treatment in patients with pigmentary retinal dystrophies. A retrospective chart review was conducted on 31 patients with a diagnosis of pigmentary retinal dystrophy
Xiaofei Li et al.
Biochemical and biophysical research communications, 436(2), 259-264 (2013-06-04)
Aspirin and valproic acid (VPA) have been extensively studied for inducing various malignancies growth inhibition respectively, despite their severe side effects. Here, we developed a novel combination by aspirin and VPA on hepatocellular cancer cells (HCCs). The viability of HCC
Annette M Lopez et al.
Emergency medicine clinics of North America, 32(1), 103-125 (2013-11-28)
Toxins such as pharmaceuticals, herbals, foods, and supplements may lead to hepatic damage. This damage may range from nonspecific symptoms in the setting of liver test abnormalities to acute hepatic failure. The majority of severe cases of toxin-induced hepatic injury
Terina N Martinez et al.
Molecular neurodegeneration, 7, 45-45 (2012-09-15)
Dopaminergic (DA) neurons in the ventral midbrain selectively degenerate in Parkinson's disease (PD) in part because their oxidative environment in the substantia nigra (SN) may render them vulnerable to neuroinflammatory stimuli. Chronic inhibition of soluble Tumor Necrosis Factor (TNF) with
J Fisher et al.
Clinical toxicology (Philadelphia, Pa.), 52(1), 63-65 (2013-12-25)
Methylene blue inhibits the nitric oxide-cyclic guanosine monophosphate (NO-cGMP) pathway, decreasing vasodilation and increasing responsiveness to vasopressors. It is reported to improve haemodynamics in distributive shock from various causes including septicaemia and post-cardiac surgery. Reports of use in overdose are
Wolfgang Löscher
CNS drugs, 16(10), 669-694 (2002-09-25)
Since its first marketing as an antiepileptic drug (AED) 35 years ago in France, valproate has become established worldwide as one of the most widely used AEDs in the treatment of both generalised and partial seizures in adults and children.
Simone E Dekker et al.
The Journal of surgical research, 190(1), 312-318 (2014-04-04)
We have previously shown that resuscitation with fresh frozen plasma (FFP) in a large animal model of traumatic brain injury (TBI) and hemorrhagic shock (HS) decreases the size of the brain lesion, and that addition of a histone deacetylase inhibitor
Koji Sugimoto et al.
Anticancer research, 34(7), 3403-3409 (2014-07-02)
Valproic acid (VPA) acts as a specific inhibitor of class I HDACs and it use has been proven to be safe since a long time. In the present study, we investigated the effect of VPA in the combination with pegylated
Faizul Azam et al.
European journal of medicinal chemistry, 44(1), 203-211 (2008-04-09)
A series of N(4)-(naphtha[1,2-d]thiazol-2-yl)semicarbazides were designed and synthesized to meet the structural requirements essential for anticonvulsant activity. Anticonvulsant activity was determined after intraperitoneal (i.p.) administration to mice by maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ)-induced seizure tests and minimal motor
Alessandro Ieraci et al.
Hippocampus, 25(11), 1380-1392 (2015-03-31)
Physical exercise and stressful experiences have been shown to exert opposite effects on behavioral functions and brain plasticity, partly by involving the action of brain-derived neurotrophic factor (BDNF). Although epigenetic modifications are known to play a pivotal role in the
Kihoon Han et al.
Nature, 503(7474), 72-77 (2013-10-25)
Mutations in SHANK3 and large duplications of the region spanning SHANK3 both cause a spectrum of neuropsychiatric disorders, indicating that proper SHANK3 dosage is critical for normal brain function. However, SHANK3 overexpression per se has not been established as a
Eva Juengel et al.
Experimental biology and medicine (Maywood, N.J.), 238(11), 1297-1304 (2013-09-06)
The influence of the histone deacetylase (HDAC)-inhibitor, valproic acid (VPA), on bladder cancer cell adhesion in vitro was investigated in this paper. TCCSUP and RT-112 bladder cancer cells were treated with VPA (0.5 or 1 mM) twice or thrice weekly for 14
Chi-Tso Chiu et al.
Pharmacological reviews, 65(1), 105-142 (2013-01-10)
The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar disorder (BD), a severe mental illness arising from complex interactions between genes and environment that drive deficits in cellular plasticity and resiliency. The therapeutic potential of
A A Kholin
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 113(3), 21-27 (2013-04-25)
Malignant migrating partial seizures in infancy (MMPSI) or Coppola-Dulac syndrome is a rare epilepsy syndrome with the onset in the first 6 months of life, characterized by multiple continuous electroencephalographic and electroclinical focal ictal patterns due to the involvement of
S Bavamian et al.
Molecular psychiatry, 20(5), 573-584 (2015-01-28)
Bipolar disorder (BD) is a heritable neuropsychiatric disorder with largely unknown pathogenesis. Given their prominent role in brain function and disease, we hypothesized that microRNAs (miRNAs) might be of importance for BD. Here we show that levels of miR-34a, which
Michael K Tso et al.
Acta neurochirurgica. Supplement, 120, 81-85 (2014-11-05)
Subarachnoid hemorrhage (SAH) can result in significant brain injury. Valproic acid (VPA), a widely-used anti-epileptic drug, was investigated as a possible neuroprotective drug in a prechiasmatic injection model of SAH in mice. Mice were randomized to the following experimental groups:
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