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Showing 1-30 of 126 results for "P7527" within Papers
Ivan D Tarandovskiy et al.
PloS one, 8(2), e55688-e55688 (2013-02-14)
Thrombin generation assay is a convenient and widely used method for analysis of the blood coagulation system status. Thrombin generation curve (TGC) is usually bell-shaped with a single peak, but there are exceptions. In particular, TGC in platelet-rich plasma (PRP)
Pierre Costa et al.
Drugs, 72(17), 2243-2254 (2012-11-23)
The global burden of erectile dysfunction (ED) is increasing. It is estimated that 8-19% of men in Europe have ED and that by 2025 the prevalence of ED worldwide will reach 322 million. The gold standard therapy for ED is
Jun Takahashi et al.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 18(2), 208-215 (2012-12-04)
Quality of life (QOL) is a concern for patients with lumbar spinal stenosis (LSS). In this study, QOL was examined using the 5-item EuroQol (EQ-5D). QOL and activities of daily living (ADL) were surveyed for 91 patients who visited 18
Kelly A Brant et al.
American journal of respiratory cell and molecular biology, 49(1), 105-113 (2013-03-26)
Numerous epidemiological studies have linked exposure to particulate matter (PM) air pollution with acute respiratory infection and chronic respiratory and cardiovascular diseases. We have previously shown that soluble nickel (Ni), a common component of PM, alters the release of CXC
R Urciuoli et al.
The Cochrane database of systematic reviews, (2)(2), CD001784-CD001784 (2004-04-24)
Erectile dysfunction (ED), the inability to achieve or maintain an erection sufficient for satisfactory sexual activity, is one of the most common sexual dysfunctions in men. ED may have a dramatic impact on the quality of life of many men
Claire M Ervin et al.
Reviews on recent clinical trials, 8(1), 9-22 (2012-11-08)
Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders and it is characterized by episodes of abdominal pain and altered bowel functions. The specific bowel disturbances of diarrhea, constipation or an alternation between the two defines the
Yanming Fan et al.
Coronary artery disease, 26(8), 671-677 (2015-08-13)
The aim of this study was to explore whether intravenous administration of liposomal prostaglandin E1 (lipo-PGE1) can reduce the incidence of periprocedural myocardial injury (PMI) in patients with unstable angina undergoing an elective percutaneous coronary intervention (PCI). In this randomized-controlled
Li-Ping Kang et al.
Phytochemistry, 107, 182-189 (2014-08-31)
Sixteen steroidal saponins, including seven previously unreported compounds, were isolated from Tribulus terrestris. The structures of the saponins were established using 1D and 2D NMR spectroscopy, mass spectrometry, and chemical methods. They were identified as: 26-O-β-d-glucopyranosyl-(25R)-furost-4-en-2α,3β,22α,26-tetrol-12-one (terrestrinin C), 26-O-β-d-glucopyranosyl-(25R)-furost-4-en-22α,26-diol-3,12-dione (terrestrinin
Zhichao Liu et al.
PLoS computational biology, 7(12), e1002310-e1002310 (2011-12-24)
Drug-induced liver injury (DILI) is a significant concern in drug development due to the poor concordance between preclinical and clinical findings of liver toxicity. We hypothesized that the DILI types (hepatotoxic side effects) seen in the clinic can be translated
Masayuki Hashiguchi et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 124(6), 321-332 (2004-06-01)
To study the effectiveness for the treatment of intermittent claudication (IC) of three drugs with antiplatelet effects, cilostazol, beraprost sodium, and prostaglandin E(1) (PGE(1)), by using a systemic review of literature and a meta-analysis. A search was undertaken for studies
Maryam Doroudi et al.
The Journal of steroid biochemistry and molecular biology, 145, 65-74 (2014-09-30)
1α,25(OH)2D3 regulates osteoblasts and chondrocytes via its membrane-associated receptor, protein disulfide isomerase A3 (Pdia3) in caveolae. 1α,25(OH)2D3 binding to Pdia3 leads to phospholipase-A2 (PLA2)-activating protein (PLAA) activation, stimulating cytosolic PLA2 and resulting in prostaglandin E2 (PGE2) release and PKCα activation
[Prostaglandin E1: results and perspectives in clinical practice].
N G Guseva
Klinicheskaia meditsina, 79(2), 4-10 (2001-06-23)
Lourdes Santana et al.
Journal of medicinal chemistry, 51(21), 6740-6751 (2008-10-07)
The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared and assayed 33 coumarin derivatives
Ilaria Lucca et al.
Revue medicale suisse, 8(365), 2327-2330 (2013-01-22)
Obesity concerns more than 200 million people in the world, with an increasing prevalence in western countries. It is closely related to multiple medical conditions, such as diabetes and hypertension. It was recently shown that testosterone deficiency syndrome and erectile
Tongyun Chen et al.
The Journal of thoracic and cardiovascular surgery, 147(4), 1362-1367 (2013-11-21)
To compare the therapeutic efficacy of recombinant human brain natriuretic peptide and prostaglandin E1 in the treatment of pulmonary hypertension after mitral valve replacement. Sixty patients with postoperative pulmonary hypertension were divided randomly into 3 groups that received saline, prostaglandin
Practical aspects of prostaglandin E1 before and after solid organ transplantation.
H Müller et al.
Advances in experimental medicine and biology, 433, 9-12 (1997-01-01)
Vikram Khanna et al.
Platelets, 26(7), 689-692 (2015-03-04)
In addition to adenosine diphosphate (ADP), a number of platelet function tests including the VerifyNow P2Y12 assay (VN-P2Y12) employ prostaglandin E1 (PGE1) to improve specificity for P2Y12 blockade by mitigating the contribution of the P2Y1 pathway on ADP-mediated platelet aggregation.
Eric S Schiffhauer et al.
American journal of physiology. Lung cellular and molecular physiology, 304(5), L324-L331 (2013-01-15)
Multiple sodium and chloride channels on the apical surface of nasal epithelial cells contribute to periciliary fluid homeostasis, a function that is disrupted in patients with cystic fibrosis (CF). Among these channels is the chloride channel CLCN2, which has been
O Gottschalk et al.
Scandinavian journal of rheumatology, 43(5), 356-363 (2014-05-16)
The use of statins in the prevention and treatment of cardiovascular diseases is well established. Their use as anti-inflammatory and immunomodulatory agents in the treatment of rheumatoid arthritis (RA) has also been investigated, with several clinical and experimental studies indicating
Alprostadil in impotence.
M J Artoux et al.
DICP : the annals of pharmacotherapy, 25(4), 363-366 (1991-04-01)
Marcello Gomide et al.
The Journal of thoracic and cardiovascular surgery, 146(5), 1146-1151 (2013-10-17)
Preoperative comorbidities (PCMs) are known risk factors for Norwood stage I (NW1). We tested the hypothesis that short-term bilateral pulmonary arterial banding (bPAB) before NW1 could improve the prognosis of these high-risk patients. From January 2006 to October 2011, 17
Leah Armon et al.
Fertility and sterility, 102(3), 885-890 (2014-07-27)
To characterize the nature of the human oocyte-derived chemoattractant. Laboratory in vitro study. Academic research institute. Ten healthy sperm donors. Oocyte-conditioned media from women undergoing IVF treatment because of male factor infertility. Sperm samples were processed by the migration-sedimentation technique. Oocyte-conditioned
[Efficacy and perspectives of use of vasaprostan (prostaglandin E1) in rheumatology].
N G Gusev
Terapevticheskii arkhiv, 74(5), 85-88 (2002-06-29)
Robert C De Lisle
BMC gastroenterology, 12, 156-156 (2012-11-08)
Lubiprostone is a synthetic bicyclic fatty acid derivative of prostaglandin E1 (PGE1) used for chronic constipation. The best known action of lubiprostone is simulation of Cl- dependent fluid secretion. In a mouse model of the genetic disease cystic fibrosis, we
A P Lea et al.
Drugs & aging, 8(1), 56-74 (1996-01-01)
Intracavernous alprostadil (synthetic prostaglandin E1) is a vasodilating agent which acts by relaxing the smooth muscles of the corpus cavernosum and by increasing the diameter of cavernous arteries; this leads to erection. Following intracavernous administration, alprostadil is either locally metabolised
[Prostaglandin E1, E2 and their metabolites].
H Shio
Nihon rinsho. Japanese journal of clinical medicine, 57 Suppl, 724-727 (2000-01-15)
Long-term prostaglandin E1 infusion for newborns with critical congenital heart disease
Aykanat A, et al.
Pediatric Cardiology, 37(1), 131-134 (2016)
Swimming through the gut: implications of fluid transport on the microbiome.
Sean P Colgan
Digestive diseases and sciences, 58(3), 602-603 (2013-01-31)
Raymond A Costabile et al.
Expert opinion on pharmacotherapy, 9(8), 1421-1429 (2008-05-14)
Erectile dysfunction is a disease affecting millions of men over the age of 40. Alprostadil, a synthetic form of prostaglandin E(1), was introduced almost three decades ago, and is today considered an alternative treatment for erectile dysfunction. The purpose of
Th Weiss
VASA. Zeitschrift fur Gefasskrankheiten, 32(4), 187-192 (2003-12-26)
Mode of action of prostaglandin E1 in the treatment of peripheral arterial disease. Prostaglandin E1 has been used for the first time in the treatment of peripheral arterial occlusive disease 30 years ago. Although widely used, the exact mechanism of
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