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Showing 1-30 of 193 results for "P8136" within Papers
Kimi Drobin et al.
Cancers, 12(3) (2020-04-03)
Nearly half of all cancers are treated with radiotherapy alone or in combination with other treatments, where damage to normal tissues is a limiting factor for the treatment. Radiotherapy-induced adverse health effects, mostly of importance for cancer patients with long-term
Adam C Wilkinson et al.
Nature, 571(7763), 117-121 (2019-05-31)
Multipotent self-renewing haematopoietic stem cells (HSCs) regenerate the adult blood system after transplantation1, which is a curative therapy for numerous diseases including immunodeficiencies and leukaemias2. Although substantial effort has been applied to identifying HSC maintenance factors through the characterization of
Emily N Abada et al.
Biomedical microdevices, 20(4), 86-86 (2018-10-07)
While extracorporeal membrane oxygenation (ECMO) is a valuable therapy for patients with lung or heart failure, clinical use of ECMO remains limited due to hemocompatibility concerns with pro-coagulatory hollow fiber membrane geometries. Previously, we demonstrated the feasibility of silicon nanopore
Angela Christina Saleh et al.
Reproductive biology and endocrinology : RB&E, 19(1), 119-119 (2021-08-05)
Exposure to endocrine-disrupting chemicals, such as Bisphenol A (BPA) and Bisphenol S (BPS), is widespread and has negative implications on embryonic development. Preliminary evidence revealed that in women undergoing IVF treatment, urinary BPA levels were associated with low serum anti-Mullerian
G M Bragança et al.
Domestic animal endocrinology, 74, 106518-106518 (2020-07-28)
This study evaluated the role of progesterone (P4) and medroxyprogesterone acetate (MAP) on the molecular status of immature cumulus-oocyte complexes (COCs) and the implications for oocyte quality in sheep. The number of viable COCs per ewe and the rate of
Shailendra B Tallapaka et al.
International journal of pharmaceutics, 565, 242-257 (2019-05-12)
Encapsulation of protein vaccines in biodegradable nanoparticles (NP) increases T-cell expansion after mucosal immunization but requires incorporating a suitable immunostimulant to increase long-lived memory T-cells. EP67 is a clinically viable, host-derived peptide agonist of the C5a receptor that selectively activates
Celina M Checura et al.
Animal reproduction science, 223, 106626-106626 (2020-11-03)
In horses, prostaglandin E2 (PGE2) is produced by embryos around Day 5 post-ovulation; PGE2 functions directly at the oviduct promoting embryo transport into the uterus. Non-surgical collection of horse embryos for cryopreservation is recommended at Day 6.5-7 post-ovulation. It was
Adam C Wilkinson et al.
Nature communications, 12(1), 686-686 (2021-01-31)
CRISPR/Cas9-mediated beta-globin (HBB) gene correction of sickle cell disease (SCD) patient-derived hematopoietic stem cells (HSCs) in combination with autologous transplantation represents a recent paradigm in gene therapy. Although several Cas9-based HBB-correction approaches have been proposed, functional correction of in vivo
Nanostructured poly(vinyl alcohol)/bioactive glass and poly(vinyl alcohol)/chitosan/bioactive glass hybrid scaffolds for biomedical applications
Mansur HS and Costa HS
Chemical Engineering Journal, 137, 72-83 (2008)
Huaqiang Yang et al.
Cell research, 24(4), 464-481 (2014-03-01)
Mutations in the human copper/zinc superoxide dismutase 1 (hSOD1) gene cause familial amyotrophic lateral sclerosis (ALS). It remains unknown whether large animal models of ALS mimic more pathological events seen in ALS patients via novel mechanisms. Here, we report the
Tea Dodig-Crnković et al.
EBioMedicine, 57, 102854-102854 (2020-07-07)
Precision medicine approaches aim to tackle diseases on an individual level through molecular profiling. Despite the growing knowledge about diseases and the reported diversity of molecular phenotypes, the descriptions of human health on an individual level have been far less
Janice P Evans et al.
Methods in molecular biology (Clifton, N.J.), 1818, 163-171 (2018-07-02)
Just as it is important to understand the cell biology of signaling pathways, it is valuable also to understand mechanical forces in cells. The field of mechanobiology has a rich history, including study of cellular mechanics during mitosis and meiosis
Tomonori Nakamura et al.
Nucleic acids research, 43(9), e60-e60 (2015-02-28)
Single-cell mRNA sequencing (RNA-seq) methods have undergone rapid development in recent years, and transcriptome analysis of relevant cell populations at single-cell resolution has become a key research area of biomedical sciences. We here present single-cell mRNA 3-prime end sequencing (SC3-seq)
Rehmani Aniqah Jawad et al.
JPMA. The Journal of the Pakistan Medical Association, 63(12), 1482-1485 (2014-01-09)
To evaluate the results of uterine fibroid embolisation as a treatment option for symptomatic uterine fibroids in the local population. The retrospective study was done at the Department of Diagnostic and Interventional Radiology, Shifa International Hospital, Islamabad, and comprised records
J H Seol et al.
Rhinology, 51(2), 137-142 (2013-05-15)
A number of different nasal packing materials are available for prevention of nasal bleeding after endoscopic sinus surgery. Polyvinyl alcohol (PVA) coated nasal packing is an expandable packing for use in rhinological surgery. This innovative surf- ace treatment helps to
Dan Hoff et al.
International journal of nanomedicine, 8, 703-710 (2013-02-22)
In the present study, the permeability of 11 different iron oxide nanoparticle (IONP) samples (eight fluids and three powders) was determined using an in vitro blood-brain barrier model. Importantly, the results showed that the ferrofluid formulations were statistically more permeable
Mohammad Mujahid Ali Khan et al.
Materials science & engineering. C, Materials for biological applications, 33(4), 2360-2366 (2013-03-19)
The aim of this study was to investigate the preparation of novel membrane and the characterization of their properties. A new class of polyvinyl chloride (PVC) based polyvinyl alcohol Ce(IV) phosphate composite membrane was successfully prepared by solution casting method.
Han Zhu et al.
Biosensors & bioelectronics, 49, 210-215 (2013-06-15)
A novel, facile and green approach for the fabrication of H2O2, glutathione (GSH) and glucose detection biosensor using water-stable PVA and PVA/PEI nanofibers decorated with AgNPs by combining an in situ reduction approach and electrospinning technique has been demonstrated. Small
Satyabrata Das et al.
Nature biotechnology, 38(3), 297-302 (2020-02-26)
The scarcity of donor organs may be addressed in the future by using pigs to grow humanized organs with lower potential for immunological rejection after transplantation in humans. Previous studies have demonstrated that interspecies complementation of rodent blastocysts lacking a
Masahito Tachibana et al.
Nature protocols, 5(6), 1138-1147 (2010-06-12)
In this article, we describe detailed protocols for the isolation and transfer of spindle-chromosomal complexes between mature, metaphase II-arrested oocytes. In brief, the spindle-chromosomal complex is visualized using a polarized microscope and extracted into a membrane-enclosed karyoplast. Chromosomes are then
Kotaro Sasaki et al.
Cell reports, 35(5), 109075-109075 (2021-05-06)
In the early fetal stage, the gonads are bipotent and only later become the ovary or testis, depending on the genetic sex. Despite many studies examining how sex determination occurs from biopotential gonads, the spatial and temporal organization of bipotential
Kazushi Suzuki et al.
Nature communications, 7, 13718-13718 (2016-12-15)
Luminescence imaging has gained attention as a promising bio-imaging modality in situations where fluorescence imaging cannot be applied. However, wider application to multicolour and dynamic imaging is limited by the lack of bright luminescent proteins with emissions across the visible
Andrés Gambini et al.
Developmental cell, 53(5), 545-560 (2020-05-23)
Embryonic genome activation (EGA) is orchestrated by an intrinsic developmental program initiated during oocyte maturation with translation of stored maternal mRNAs. Here, we show that tankyrase, a poly(ADP-ribosyl) polymerase that regulates β-catenin levels, undergoes programmed translation during oocyte maturation and
In Vitro Developmental Competence of In Vitro-Matured Bovine Oocytes Fertilized and Cultured in Completely Defined Media
Keskintepe L and Brackett BG
Biology of Reproduction, 55, 333-339 (1996)
Tomoyuki Yamaguchi et al.
Scientific reports, 8(1), 15289-15289 (2018-10-18)
To study development of the conceptus in xenogeneic environments, we assessed interspecies chimera formation as well as tetraploid complementation between mouse and rat. Overall contribution of donor PSC-derived cells was lower in interspecies chimeras than in intraspecies chimeras, and high
Solmaz Hajizadeh et al.
Journal of chromatography. A, 1274, 6-12 (2013-01-08)
In this work, a new macroporous molecularly imprinted cryogel (MIP composite cryogel) was synthesized by glutaraldehyde cross-linking reaction of poly(vinyl alcohol) (PVA) particles and amino-modified molecularly imprinted core-shell nanoparticles. The MIP core-shell nanoparticles were prepared using propranolol as a template
Tim Waterboer et al.
Clinical chemistry, 51(10), 1845-1853 (2005-08-16)
More than 100 different human papillomaviruses (HPVs) can cause proliferative diseases, many of which are malignant, such as cervical cancer. HPV serology is complex because infection and disease lead to distinct type-specific antibody responses. Using bead-based technology, we have developed
Atchalalt Khurchabilig et al.
Zygote (Cambridge, England), 1-7 (2020-06-03)
The efficiency of in vitro embryo production technologies would be improved by the development of suitable non-invasive biomarkers that allow the selection of good quality cumulus-oocyte complexes (COCs). The present study used whole, single oocyte culture to investigate whether the
Vitor Braga Rissi et al.
Epigenetics, 14(11), 1088-1101 (2019-06-21)
There is growing evidence that histone lysine demethylases (KDMs) play critical roles in the regulation of embryo development. This study investigated if KDM7A, a lysine demethylase known to act on mono-(me1) and di-(me2) methylation of H3K9 and H3K27, participates in
Liuliu Yang et al.
Cell stem cell, 27(1), 125-136 (2020-06-25)
SARS-CoV-2 has caused the COVID-19 pandemic. There is an urgent need for physiological models to study SARS-CoV-2 infection using human disease-relevant cells. COVID-19 pathophysiology includes respiratory failure but involves other organ systems including gut, liver, heart, and pancreas. We present
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