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Showing 1-30 of 81 results for "P8287" within Papers
Brian H Santich et al.
Science translational medicine, 12(534) (2020-03-13)
T cell-bispecific antibodies (BsAbs) couple cytotoxic T lymphocytes to tumor cells, inducing their destruction. Although there are more than 60 classes of BsAbs in development, the relative importance of parameters such as interdomain spacing or spatial configuration is largely unknown.
Lance R Thurlow et al.
Infection and immunity, 77(12), 5551-5557 (2009-10-07)
It has become increasingly difficult to treat infections caused by Enterococcus faecalis due to its high levels of intrinsic and acquired antibiotic resistance. However, few studies have explored the mechanisms that E. faecalis employs to circumvent the host innate immune
James D Allen et al.
Frontiers in immunology, 12, 707339-707339 (2021-09-04)
Each person has a unique immune history to past influenza virus infections. Exposure to influenza viruses early in life establishes memory B cell populations that influence future immune responses to influenza vaccination. Current influenza vaccines elicit antibodies that are typically
Heide Kogelberg et al.
Journal of molecular biology, 382(2), 385-401 (2008-07-29)
The alpha v beta 6 integrin is a promising target for cancer therapy. Its expression is up-regulated de novo on many types of carcinoma where it may activate transforming growth factor-beta1 and transforming growth factor-beta 3, interact with the specific
L Reclaru et al.
Materials science & engineering. C, Materials for biological applications, 45, 411-420 (2014-12-11)
Three super alloy candidates (X1 CrNiMoMnW 24-22-6-3-2 N, NiCr21 MoNbFe 8-3-5 AlTi, CoNiCr 35-20 Mo 10 BTi) for a prolonged contact with skin are evaluated in comparison with two reference austenitic stainless steels 316L and 904L. Several electrochemical parameters were
Rafał Biedroń et al.
PloS one, 10(4), e0123293-e0123293 (2015-04-08)
The initiation of adaptive immune responses to protein antigens has to be preceded by their uptake by antigen presenting cells and intracellular proteolytic processing. Paradoxically, endocytic receptors involved in antigen uptake do not bind the majority of proteins, which may
Yoko Shoji et al.
Human vaccines & immunotherapeutics, 11(1), 118-123 (2014-12-09)
The H1N1 influenza pandemic of 2009 stimulated interest in developing safe and effective subunit influenza vaccines using rapid and cost-effective recombinant technologies that can avoid dependence on hens' eggs supply and live viruses for production. Among alternative approaches to subunit
Ali Emileh et al.
Biochemistry, 53(21), 3403-3414 (2014-05-08)
The HIV-1 gp120 glycoprotein is the main viral surface protein responsible for initiation of the entry process and, as such, can be targeted for the development of entry inhibitors. We previously identified a class of broadly active peptide triazole (PT)
Diana Kouiavskaia et al.
Journal of virological methods, 276, 113785-113785 (2019-11-26)
To address the biosafety and biosecurity concerns related to the manufacture of inactivated polio vaccine (IPV), several manufacturers started producing it from attenuated Sabin strains. Slight immunological differences between wild and attenuated strains create a challenge for testing IPV potency
Yao-An Shen et al.
Cancer letters, 360(1), 39-47 (2015-02-11)
Currently, epithelial ovarian cancer is viewed as a heterogeneous disease with five major histological subtypes. Clear cell carcinoma represents a specific histological subtype of epithelial ovarian cancer that demonstrates more aggressive clinical behavior and drug resistance compared with other subtypes.
Audrey Toinon et al.
Biologicals : journal of the International Association of Biological Standardization, 60, 49-54 (2019-05-21)
The NIH assay is used to assess the potency of rabies vaccine and is currently a key measure required for vaccine release. As this test involves immunization of mice and subsequent viral challenge, efforts are being made to develop alternative
Timothy J Powell et al.
The Journal of general virology, 100(3), 431-445 (2019-02-05)
A non-replicating form of pseudotyped influenza virus, inactivated by suppression of the haemagglutinin signal sequence (S-FLU), can act as a broadly protective vaccine. S-FLU can infect for a single round only, and induces heterotypic protection predominantly through activation of cross-reactive
Gene S Tan et al.
Journal of virology, 88(23), 13580-13592 (2014-09-12)
Due to continuous changes to its antigenic regions, influenza viruses can evade immune detection and cause a significant amount of morbidity and mortality around the world. Influenza vaccinations can protect against disease but must be annually reformulated to match the
Leandro T Kochi et al.
Virulence, 10(1), 734-753 (2019-08-20)
Leptospirosis is a worldwide zoonosis caused by pathogenic species of Leptospira. Leptospires are able to adhere to exposed extracellular matrix in injured tissues and, once in the bloodstream, can survive the attack of the immune system and spread to colonize
Eduardo C Roncolato et al.
Infection and immunity, 83(2), 713-720 (2014-12-03)
Diarrhea and amebic liver abscesses due to invasive Entamoeba histolytica infections are an important cause of morbidity and mortality in the developing world. Entamoeba histolytica adherence and cell migration, two phenotypes linked to virulence, are both aberrant in trophozoites deficient
Matthias Lingemann et al.
Journal of virology, 89(6), 3318-3331 (2015-01-16)
Human parainfluenza virus type 3 (HPIV3), a paramyxovirus, is a major viral cause of severe lower respiratory tract disease in infants and children. The gene-end (GE) transcription signal of the HPIV3 matrix (M) protein gene is identical to those of
S Kansal et al.
British journal of pharmacology, 171(17), 4038-4050 (2014-05-20)
The aim of the present study was to evaluate the immunomodulatory and chemotherapeutic potential of alginate-(SA) coated nanocapsule (NCs) loaded with doxorubicin (SA-NCs-DOX) against visceral leishmaniasis in comparison with nano-emulsions containing doxorubicin (NE-DOX). NE-DOX was prepared using low-energy emulsification methods.
R Mark Jones et al.
Human vaccines & immunotherapeutics, 11(1), 124-132 (2014-12-09)
Malaria transmission blocking vaccines (TBV) directed against proteins expressed on sexual stages of Plasmodium falciparum in the mosquito midgut are considered an effective means to reduce malaria transmission. Antibodies induced by TBV block sporogonic development in the mosquito, and thus
Elizabeth Monreal-Escalante et al.
Molecular biotechnology, 63(5), 424-436 (2021-03-03)
Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Paratuberculosis, a contagious, untreatable, and chronic granulomatous enteritis that results in diarrhea, emaciation, and death in farmed ruminants (i.e., cattle, sheep, and goats). In this study, the Ag85B antigen from
Mei-Ying Liao et al.
International journal of oncology, 46(4), 1788-1800 (2015-02-06)
We have generated a novel monoclonal antibody (mAb), OCAb9-1, which specifically binds to various types of cancer cell lines, but not to normal cells. According to the results of immunoaffinity chromatography, LC-MS/MS analysis, co-immunoprecipitation, and RNA interference studies, the target
Maite Duhalde Vega et al.
International immunopharmacology, 24(2), 377-382 (2015-01-13)
Mice infected with mouse hepatitis virus A59 (MHV-A59) develop autoantibodies (autoAb) to liver and kidney fumarylacetoacetate hydrolase (FAH) with a concomitant enhancement of transaminases and release of alarmins such as uric acid and high-mobility group box protein 1 (HMGB1). Tryptophan
Erin Harberts et al.
Journal of immunology (Baltimore, Md. : 1950), 194(7), 3127-3135 (2015-02-27)
UV radiation (UVR) induces DNA damage, leading to the accumulation of mutations in epidermal keratinocytes and immunosuppression, which contribute to the development of nonmelanoma skin cancer. We reported previously that the TLR4-MyD88 signaling axis is necessary for UV-induced apoptosis. In
Taishi Onodera et al.
Immunity, 54(10), 2385-2398 (2021-09-12)
Potent neutralizing SARS-CoV-2 antibodies often target the spike protein receptor-binding site (RBS), but the variability of RBS epitopes hampers broad neutralization of multiple sarbecoviruses and drifted viruses. Here, using humanized mice, we identified an RBS antibody with a germline VH
Sara Fornera et al.
Analytical biochemistry, 407(2), 293-295 (2010-08-10)
The assay conditions for the spectrophotometric quantification of horseradish peroxidase (HRP) with the chromogenic substrate o-phenylenediamine (OPD) at 25°C in the presence of hydrogen peroxide (H(2)O(2)) were optimized. With [OPD](0)=3.14 mM and [H(2)O(2)](0)=80 μM at pH 7.2, the initial formation
Roland Schmitt et al.
Journal of immunology (Baltimore, Md. : 1950), 193(1), 317-326 (2014-05-23)
IgA nephropathy (IgAN) is characterized by mesangial cell proliferation and extracellular matrix expansion associated with immune deposits consisting of galactose-deficient polymeric IgA1 and C3. We have previously shown that IgA-binding regions of streptococcal M proteins colocalize with IgA in mesangial
Min Mo et al.
Infection and immunity, 76(5), 1837-1847 (2008-02-27)
Attachment of erythrocytes infected by Plasmodium falciparum to receptors of the microvasculature is a major contributor to the pathology and morbidity associated with malaria. Adhesion is mediated by the P. falciparum erythrocyte membrane protein 1 (PfEMP-1), which is expressed at
James D Allen et al.
Scientific reports, 11(1), 4554-4554 (2021-03-04)
While vaccines remain the best tool for preventing influenza virus infections, they have demonstrated low to moderate effectiveness in recent years. Seasonal influenza vaccines typically consist of wild-type influenza A and B viruses that are limited in their ability to
Nicholas Juleff et al.
Journal of virology, 83(8), 3626-3636 (2009-01-30)
The role of T-lymphocyte subsets in recovery from foot-and-mouth disease virus (FMDV) infection in calves was investigated by administering subset-specific monoclonal antibodies. The depletion of circulating CD4(+) or WC1(+) gammadelta T cells was achieved for a period extending from before
Xiaofang Liu et al.
BMC veterinary research, 11, 11-11 (2015-01-28)
Hepatitis E virus (HEV) infection is a significant public health concern in Asia, and swine is an important source of sporadic HEV infection in human. However, no epidemiological data are available regarding HEV infection among the swine or human population
Jae-Keun Park et al.
Nature medicine, 26(8), 1240-1246 (2020-07-01)
The conserved region of influenza hemagglutinin (HA) stalk (or stem) has gained attention as a potent target for universal influenza vaccines1-5. Although the HA stalk region is relatively well conserved, the evolutionarily dynamic nature of influenza viruses6 raises concerns about
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