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Showing 1-30 of 111 results for "p8765" within Papers
Anna E Montegudo et al.
The Journal of surgical research, 179(1), e149-e155 (2012-05-09)
Hemorrhagic shock is a life threatening condition characterized by diminishing organ function. The aim of this study was to determine whether an effective pyrrolidine dithiocarbamate (PDTC) treatment protocol could be established to decrease organ dysfunction and mortality in a lethal
Ju Guo et al.
Journal of cellular biochemistry (2018-11-13)
Cyadox, a new derivative of quinoxalines, has been ascertained as an antibiotic with significant growth promoting, low poison, quick absorption, swift elimination, brief residual period, and noncumulative effect. Seven differential expressed genes, including Insulin-like Growth Factor-1 ( IGF-1), Epidermal Growth
Penny E Reid et al.
Molecular cancer, 8, 49-49 (2009-07-17)
Angiogenesis, the sprouting of capillaries from existing blood vessels, is central to tumour growth and progression, however the molecular regulation of this process remains to be fully elucidated. The secreted glycoprotein osteoprotegerin (OPG) is one potential pro-angiogenic factor, and clinical
Xiaohong Xu et al.
BMC nephrology, 22(1), 218-218 (2021-06-11)
Adiponectin is an adipocytokine that plays a key regulatory role in glucose and lipid metabolism in obesity. The prevalence of obesity has led to an increase in the incidence of obesity-related glomerulopathy (ORG). This study aimed to identify the protective
Huashan Huang et al.
International journal of molecular medicine, 45(6), 1864-1874 (2020-03-19)
Sonic hedgehog (Shh) is pivotally important in embryonic and adult blood vessel development and homeostasis. However, whether Shh is involved in atherosclerosis and plays a role in endothelial apoptosis induced by oxidized low‑density lipoprotein (ox‑LDL) has not been reported. The
Naeemullah et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 154, 157-163 (2015-11-02)
An innovative and simple miniaturized solid phase microextraction (M-SPME) method, was developed for preconcentration and determination of silver(I) in the fresh and waste water samples. For M-SPME, a micropipette tip packed with activated carbon cloth (ACC) as sorbent, in a
Hong Feng et al.
Experimental physiology, 98(3), 784-795 (2012-10-30)
Interaction of peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) with other cellular signalling pathways plays an important role in training-induced mitochondrial adaptations. The purpose of this study was to examine whether pyrolidine dithiocarbamate (PDTC), a nuclear factor-κB inhibitor and antioxidant, and
Brijesh K Garg et al.
PloS one, 14(4), e0214942-e0214942 (2019-04-05)
α7 Nicotinic acetylcholine receptors (nAChRs) reportedly reduce inflammation by blocking effects of the important pro-inflammatory transcription factor, nuclear factor kappa-light chain-enhancer of B cells (NFκB). The α7 nAChR partial agonist GTS-21 reduces secretion of pro-inflammatory cytokines including interleukin-6 (IL6) and
Chuanzong Qi et al.
International immunopharmacology, 87, 106812-106812 (2020-07-25)
Organic cation transporter 1/2 (OCTN1/2) play important roles in the transport of drugs related to pulmonary inflammatory diseases. Nevertheless, the involvement of inflammation induced by cigarette smoke extract (CSE) combined with lipopolysaccharide (LPS) in the regulation of OCTN1/2 is not
Weiwei Wang et al.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 147(6), 1012-1019 (2012-09-14)
To elucidate the functions of nuclear factor kappa B (NF-κB) in mucin hypersecretion in allergic rhinitis (AR), we examined the in vivo effects of an NF-κB inhibitor, ammonium pyrrolidine dithiocarbamate (PDTC), on mucin 5 subtype AC (MUC5AC) expression in the
Soichiro Ikeda et al.
Scientific reports, 9(1), 9850-9850 (2019-07-10)
Ca2+/calmodulin-dependent protein kinase II (CaMKII) and nuclear factor-kappa B (NF-κB) play crucial roles in pathogenesis of doxorubicin (DOX)-induced cardiomyopathy. Their activities are regulated by intracellular Ca2+. We hypothesized that blockade of L-type Ca2+ channel (LTCC) could attenuate DOX-induced cardiomyopathy by
Yasser Majeed et al.
Scientific reports, 9(1), 6316-6316 (2019-04-21)
Angiosarcomas are highly aggressive tumors of endothelial origin, which carry a poor prognosis. Fenofibrate is a hypolipidemic drug, which acts by activating the transcription factor PPARα. It has also been widely reported to have 'anti-cancer' activity. The current study investigated
Pyrrolidine dithiocarbamate inhibits NF-kappa B mobilization and TNF production in human monocytes.
Ziegler-Heitbrock HW, et al.
Journal of Immunology, 151(12), 6986-6993 (1993)
Lirong Zhu et al.
The Korean journal of pain, 34(1), 47-57 (2021-01-01)
Lumbar disc herniation (LDH) is a common cause of radicular pain, but the mechanism is not clear. In this study, we investigated the engagement of toll-like receptor 4 (TLR4) and the nuclear factor-kappa B (NF-κB) in radicular pain and its
Reduction of neutrophil activity decreases early microvascular injury after subarachnoid haemorrhage
Friedrich V, et al.
Journal of Neuroinflammation, 8(1), 103-103 (2011)
Junchen Li et al.
Frontiers in cell and developmental biology, 9, 643525-643525 (2021-07-13)
Tumor growth and metastasis are responsible for breast cancer-related mortality. Andrographolide (Andro) is a traditional anti-inflammatory drug used in the clinic that inhibits NF-κB activation. Recently, Andro has been found in the treatment of various cancers. Andro inhibits breast cell
Serhat Döker et al.
Talanta, 103, 123-129 (2012-12-04)
A miniaturized solid phase extraction procedure has been developed for ultra-trace determination of inorganic arsenic species. Arsenic(III) as pyrrolidinedithiocarbamate complex was selectively adsorbed on 30 mg poly(hydroxyethyl methacrylate) (PHEMA) micro beads, which is simply packed into a micro-pipette-tip. The adsorbed
Marcelo Gomes Granja et al.
Cellular and molecular neurobiology, 35(5), 689-701 (2015-02-16)
Interleukin-4 (IL-4) is a pleiotropic cytokine that regulates several phenomena, among them survival and differentiation of neuronal and glial cells. The aim of this work was to investigate the effect of IL-4 on the cholinergic differentiation of neonatal rat retinal
Zhongwei Cao et al.
Cancer cell international, 14(1), 86-86 (2014-10-10)
Many studies support that chemokine (C-X-C motif) ligand 1 (CXCL1) regulate tumor epithelial-stromal interactions involving in tumor growth and invasion. However, limited studies have been conducted on the expression and function of the CXCL1 gene in hepatocellular carcinoma (HCC). The
Short-Term TERT Inhibition Impairs Cellular Proliferation via a Telomere Length-Independent Mechanism and Can Be Exploited as a Potential Anticancer Approach.
Amin, et al.
Cancers, 15 (2023)
Yasuhiro Horita et al.
Bioorganic & medicinal chemistry letters, 21(3), 899-903 (2011-01-15)
The present study was undertaken to optimize the anti-tubercular activity of 2-acetamido-2-deoxy-β-D-glucopyranosyl N,N-dimethyldithiocarbamate (OCT313, Glc-NAc-DMDC), a lead compound previously reported by us. Structural modifications of OCT313 included the replacements of the DMDC group at C-1 by pyrrolidine dithiocarbamate (PDTC) and
Electron transport chain inhibitors induce microglia activation through enhancing mitochondrial reactive oxygen species production
Ye J, et al.
Experimental Cell Research, 340(2), 315-326 (2016)
A S Dos Passos et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(11), 1689-1695 (2012-08-01)
A pre-concentration procedure with solid-phase extraction was developed for the determination of arsenic (As) in chicken feed using hydride generation atomic absorption spectrometry (HG-AAS). The procedure was based on the sorption of As(III) ions as complexes with ammonium pyrrolidine dithiocarbamate
Yu-Wen Huang et al.
Aging, 12(10), 9475-9488 (2020-05-20)
Chondrosarcomas are well known for their resistance to chemotherapeutic agents, including cisplatin, which is commonly used in chondrosarcomas. Amphiregulin (AR), a ligand of epidermal growth factor receptor (EGFR), plays an important role in drug resistance. We therefore sought to determine
Man Zhang et al.
Cellular signalling, 53, 304-315 (2018-11-08)
The ruminal mucosal epithelium can secrete defensins, which play a key role in innate and adaptive immunity and are considered potential replacements for antibiotics. Of these, sheep β-defensin-1 (SBD-1) is one of the most potent molecules produced by ovine ruminal
Yuanyuan Zhang et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10(7), e2206958-e2206958 (2023-01-03)
Development of abdominal aortic aneurysms (AAA) enhances lesion group-2 innate lymphoid cell (ILC2) accumulation and blood IL5. ILC2 deficiency in Rorafl/fl Il7rCre/+ mice or induced ILC2 depletion in Icosfl-DTR-fl/+ Cd4Cre/+ mice expedites AAA growth, increases lesion inflammation, but leads to
Darine Villela et al.
Life sciences, 94(2), 122-129 (2013-11-19)
The circadian rhythm in mammalian pineal melatonin secretion is modulated by norepinephrine (NE) released at night. NE interaction with β1-adrenoceptors activates PKA that phosphorylates the transcription factor CREB, leading to the transcription and translation of the arylalkylamine-N-acetyltransferase (AANAT) enzyme. Several
Alexandre D Andrade et al.
Andrology, 12(5), 1024-1037 (2024-03-18)
Region-specific immune environments in the epididymis influence the immune responses to uropathogenic Escherichia coli (UPEC) infection, a relevant cause of epididymitis in men. Toll-like receptors (TLRs) are essential to orchestrate immune responses against bacterial infections. The epididymis displays region-specific inflammatory
The mTORC2/Akt/NF?B pathway-mediated activation of TRPC6 participates in adriamycin-induced podocyte apoptosis.
Zhang H T, et al.
Cellular Physiology and Biochemistry, 40(5), 1079-1093 (2016)
Liping Xue et al.
Oncology research, 27(5), 557-564 (2018-05-18)
Because of the characteristics of high invasiveness, relapse, and poor prognosis, the management of malignant gliomas has always been a great challenge. Nod-like receptor (NLR) family pyrin domain containing 3 (NLRP3) is a crucial component of the NLRP3 inflammasome, a
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