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Showing 31-60 of 111 results for "P8765" within Papers
J L Brown et al.
Acta physiologica (Oxford, England), 220(2), 275-288 (2016-11-04)
PGC-1α4 is a novel regulator of muscle hypertrophy; however, there is limited understanding of the regulation of its expression and role in many (patho)physiological conditions. Therefore, our purpose was to elicit signalling mechanisms regulating gene expression of Pgc1α4 and examine
Wenjun Mou et al.
Cancer letters, 358(2), 115-123 (2014-12-03)
Transcriptional factor Sox2 promotes tumor metastasis; however its regulatory effect on tumor-associated macrophages (TAMs, M2 phenotype) has not been defined. This study disclosed concomitant expression of TAMs marker-CD163 with SOX2 in human breast cancer and showed that Sox2 in breast
Chun-Fa Huang et al.
Toxicology letters, 214(1), 33-45 (2012-08-23)
Exposure to mercury can lead to several injuries in mammals, including immune system dysfunction, and pyrrolidine dithiocarbamate (PDTC), as a metal chelator and antioxidant, has been indicated to increase the cytotoxic effects of toxic metals. However, the toxicological effects and
Xiu Dong et al.
Journal of Asian natural products research, 14(11), 1008-1019 (2013-01-04)
Previous study proved that norcantharidin (NCTD) could exert its anticancer activity in a variety of malignant cell lines, including human cervical carcinoma HeLa cells. In this study, we found that NCTD-activated p38 mitogen-activated protein kinase (p38 MAPK)-nuclear transcription factor kappa
Judith Sylvester et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 30(3), 563-574 (2012-07-27)
We investigated the unknown molecular mechanisms of Interleukin-1 (IL-1β)-induced cartilage aggrecan degeneration by aggrecanase (ADAMTS-A Disintegrin And Metalloproteinase with ThromboSpondin motifs) in human articular chondrocytes, a model mimicking human arthritis. Chondrocytes were pretreated with various pharmacological inhibitors and then stimulated
Xiujuan Wang et al.
Biochemistry and biophysics reports, 35, 101497-101497 (2023-08-03)
Spinal cord injury (SCI) is an incurable central nervous system impairment that lack of efficient treatment. Exosomes derived from mesenchymal stem cells (MSCs) are widely applied in disease treatment. This work aimed to determine the promising therapeutic effects of MSC-derived
Hao-Nan Li et al.
Journal of neuroinflammation, 18(1), 150-150 (2021-07-07)
Our recent studies have identified that the red nucleus (RN) dual-directionally modulates the development and maintenance of mononeuropathic pain through secreting proinflammatory and anti-inflammatory cytokines. Here, we further explored the action of red nucleus IL-33 in the early development of
Hongkun Zhu et al.
Cell cycle (Georgetown, Tex.), 19(15), 1941-1951 (2020-07-04)
Curcumin alleviates septic acute kidney injury (SAKI); however, the underlying mechanism remained unclear. To explore this, SAKI cell model and mice model were conducted by using LPS and cecal ligation and puncture (CLP), respectively. Cell counting kit-8 (CCK-8) and enzyme-linked
Ye Wang et al.
Neuroscience letters, 535, 128-133 (2013-01-19)
Cardiac sympathetic hyperinnervation after myocardial infarction (MI) is associated with a high incidence of lethal arrhythmia. However, the mechanisms of nerve sprouting induced by MI are unclear. In this study, we showed a nuclear factor-κB (NF-κB) signaling pathway involved in
Chang-Hee Kang et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(12), 4270-4276 (2012-09-15)
Since the anti-inflammatory effect of caffeine is unclear in microglial cells, we performed whether caffeine attenuates the expression of pro-inflammatory mediators in lipopolysaccharide (LPS)-stimulated BV2 microglial cells. Caffeine substantially suppressed the LPS-induced pro-inflammatory mediators nitric oxide (NO), prostaglandin E(2) (PGE(2))
The mTORC2/Akt/NF?B pathway-mediated activation of TRPC6 participates in adriamycin-induced podocyte apoptosis.
Zhang H T, et al.
Cellular Physiology and Biochemistry, 40(5), 1079-1093 (2016)
Zheng-Qian Li et al.
Biochemical and biophysical research communications, 438(4), 628-634 (2013-08-13)
Although much recent evidence has demonstrated that neuroinflammation contributes to volatile anesthetic-induced cognitive deficits, there are few existing mechanistic explanations for this inflammatory process. This study was conducted to investigate the effects of the volatile anesthetic isoflurane on canonical nuclear
Short-Term TERT Inhibition Impairs Cellular Proliferation via a Telomere Length-Independent Mechanism and Can Be Exploited as a Potential Anticancer Approach.
Amin, et al.
Cancers, 15 (2023)
Yasuhiro Horita et al.
Bioorganic & medicinal chemistry letters, 21(3), 899-903 (2011-01-15)
The present study was undertaken to optimize the anti-tubercular activity of 2-acetamido-2-deoxy-β-D-glucopyranosyl N,N-dimethyldithiocarbamate (OCT313, Glc-NAc-DMDC), a lead compound previously reported by us. Structural modifications of OCT313 included the replacements of the DMDC group at C-1 by pyrrolidine dithiocarbamate (PDTC) and
Electron transport chain inhibitors induce microglia activation through enhancing mitochondrial reactive oxygen species production
Ye J, et al.
Experimental Cell Research, 340(2), 315-326 (2016)
A S Dos Passos et al.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment, 29(11), 1689-1695 (2012-08-01)
A pre-concentration procedure with solid-phase extraction was developed for the determination of arsenic (As) in chicken feed using hydride generation atomic absorption spectrometry (HG-AAS). The procedure was based on the sorption of As(III) ions as complexes with ammonium pyrrolidine dithiocarbamate
Yu-Wen Huang et al.
Aging, 12(10), 9475-9488 (2020-05-20)
Chondrosarcomas are well known for their resistance to chemotherapeutic agents, including cisplatin, which is commonly used in chondrosarcomas. Amphiregulin (AR), a ligand of epidermal growth factor receptor (EGFR), plays an important role in drug resistance. We therefore sought to determine
Man Zhang et al.
Cellular signalling, 53, 304-315 (2018-11-08)
The ruminal mucosal epithelium can secrete defensins, which play a key role in innate and adaptive immunity and are considered potential replacements for antibiotics. Of these, sheep β-defensin-1 (SBD-1) is one of the most potent molecules produced by ovine ruminal
Yuanyuan Zhang et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 10(7), e2206958-e2206958 (2023-01-03)
Development of abdominal aortic aneurysms (AAA) enhances lesion group-2 innate lymphoid cell (ILC2) accumulation and blood IL5. ILC2 deficiency in Rorafl/fl Il7rCre/+ mice or induced ILC2 depletion in Icosfl-DTR-fl/+ Cd4Cre/+ mice expedites AAA growth, increases lesion inflammation, but leads to
Darine Villela et al.
Life sciences, 94(2), 122-129 (2013-11-19)
The circadian rhythm in mammalian pineal melatonin secretion is modulated by norepinephrine (NE) released at night. NE interaction with β1-adrenoceptors activates PKA that phosphorylates the transcription factor CREB, leading to the transcription and translation of the arylalkylamine-N-acetyltransferase (AANAT) enzyme. Several
Alexandre D Andrade et al.
Andrology, 12(5), 1024-1037 (2024-03-18)
Region-specific immune environments in the epididymis influence the immune responses to uropathogenic Escherichia coli (UPEC) infection, a relevant cause of epididymitis in men. Toll-like receptors (TLRs) are essential to orchestrate immune responses against bacterial infections. The epididymis displays region-specific inflammatory
Chien-Huang Liao et al.
International journal of medical sciences, 21(1), 107-122 (2024-01-03)
NF-κB activation is pivotal for the excess inflammation causing the critical condition and mortality of respiratory viral infection patients. This study was aimed to evaluate the effect of a banana plant extract (BPE) on suppressing NF-κB activity and acute lung
Weirong Wang et al.
Experimental cell research, 319(10), 1523-1533 (2013-04-23)
The ligand-activated transcription factor peroxisome proliferator-activated receptor-α (PPARα) participates in the regulation of cellular inflammation. More recent studies indicated that sirtuin1 (SIRT1), a NAD(+)-dependent deacetylase, regulates the inflammatory response in adipocytes. However, whether the role of PPARα in inflammation is
Rijun Gui et al.
Talanta, 94, 257-262 (2012-05-23)
A near-infrared-emitting CdTe/CdS core/shell quantum dots (QDs)-based photoluminescence (PL) sensor was designed and applied for highly selective and sensitive detection of Cd(2+). This sensor was based on a PL "OFF-ON" mode. First, the addition of ammonium pyrrolidine dithiocarbamate (APDC) led
Giovanni Cimmino et al.
European journal of pharmacology, 885, 173422-173422 (2020-08-07)
Epidemiologic studies have clearly demonstrated the correlation existing between Vitamin D (Vit. D) deficiency and increased risk of developing cardiovascular disease, suggesting that it might have a protective role in this clinical setting. Although many experimental studies have investigated the
Shaoqing Xu et al.
Journal of neurochemistry, 145(4), 312-322 (2018-01-10)
Loss of function mutations of DJ-1 (PARK7) have been linked to the pathogenesis of Parkinson's disease. Antioxidative stress is one of the multi-protective functions of DJ-1, and oxidation of cysteine 106 has been proposed to regulate the protective activity of
Xinghua Guo et al.
International journal of rheumatic diseases, 15(3), 322-329 (2012-06-20)
After the onset of rheumatoid arthritis (RA), fibroblast-like synoviocytes (RA-FLS) which are specialized types of fibroblasts, become tumor-like, keeping their ability to increase proliferation and invasion. The mechanism of their tumor-like growth is unclear. Fractalkine (FKN), also called CX3CL1, plays
An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells
Lukiw WJ, et al.
The Journal of Biological Chemistry, 283(46), 31315-31322 (2008)
Zhi Wang et al.
Experimental neurology, 249, 74-82 (2013-09-03)
Brain injury due to birth asphyxia is the major cause of death and long-term disabilities in newborns. We determined whether intranasal pyrrolidine dithiocarbamate (PDTC) could provide neuroprotection in neonatal rats after brain hypoxia-ischemia (HI). Seven-day old male and female Sprague-Dawley
Parisa Yazdizadeh Shotorbani et al.
American journal of physiology. Renal physiology, 318(3), F673-F682 (2020-01-28)
Overproduction of extracellular matrix proteins, including fibronectin by mesangial cells (MCs), contributes to diabetic nephropathy. Inhibitor of myogenic differentiation family isoform a (I-mfa) is a multifunctional cytosolic protein functioning as a transcriptional modulator or plasma channel protein regulator. However, its
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