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Showing 31-60 of 111 results for "P8765" within Papers

miR-144-3p ameliorates the progression of osteoarthritis by targeting IL-1β: Potential therapeutic implications.

Yen-You Lin et al.

Journal of cellular physiology, 236(10), 6988-7000 (2021-03-28)

The pro-inflammatory cytokine interleukin 1 beta (IL-1β) plays a critical role in osteoarthritis (OA) disease pathogenesis. MicroRNA (miRNA) activity is related to inflammation in OA and some miRNAs specifically regulate IL-mediated degradation of cartilage type II collagen. Previous studies have

PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1.

Lin Wang et al.

Nature communications, 10(1), 746-746 (2019-02-16)

Excessive or uncontrolled release of proinflammatory cytokines caused by severe viral infections often results in host tissue injury or even death. Phospholipase C (PLC)s degrade phosphatidylinositol-4, 5-bisphosphate (PI(4,5)P2) lipids and regulate multiple cellular events. Here, we report that PLCβ2 inhibits

AhR and CYP1B1 Control Oxygen Effects on Bone Marrow Progenitor Cells: The Enrichment of Multiple Olfactory Receptors as Potential Microbiome Sensors.

Michele C Larsen et al.

International journal of molecular sciences, 24(23) (2023-12-09)

Polycyclic aromatic hydrocarbon (PAH) pollutants and microbiome products converge on the aryl hydrocarbon receptor (AhR) to redirect selective rapid adherence of isolated bone marrow (BM) cells. In young adult mice, Cyp1b1-deficiency and AhR activation by PAH, particularly when prolonged by

HTRA1 promotes transdifferentiation of normal fibroblasts to cancer-associated fibroblasts through activation of the NF-κB/bFGF signaling pathway in gastric cancer.

Hongxue Wu et al.

Biochemical and biophysical research communications, 514(3), 933-939 (2019-05-16)

Cancer-associated fibroblasts comprise the major stromal cell populations in gastric cancer, which is a significant contributor to cancer-related death worldwide. As a member of the serine protease family, HTRA1 is reportedly involved in malignant transformation of various tumor types. In

Expression of Sox2 in breast cancer cells promotes the recruitment of M2 macrophages to tumor microenvironment.

Wenjun Mou et al.

Cancer letters, 358(2), 115-123 (2014-12-03)

Transcriptional factor Sox2 promotes tumor metastasis; however its regulatory effect on tumor-associated macrophages (TAMs, M2 phenotype) has not been defined. This study disclosed concomitant expression of TAMs marker-CD163 with SOX2 in human breast cancer and showed that Sox2 in breast

PGC-1α4 gene expression is suppressed by the IL-6-MEK-ERK 1/2 MAPK signalling axis and altered by resistance exercise, obesity and muscle injury.

J L Brown et al.

Acta physiologica (Oxford, England), 220(2), 275-288 (2016-11-04)

PGC-1α4 is a novel regulator of muscle hypertrophy; however, there is limited understanding of the regulation of its expression and role in many (patho)physiological conditions. Therefore, our purpose was to elicit signalling mechanisms regulating gene expression of Pgc1α4 and examine

Caffeine suppresses lipopolysaccharide-stimulated BV2 microglial cells by suppressing Akt-mediated NF-κB activation and ERK phosphorylation.

Chang-Hee Kang et al.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(12), 4270-4276 (2012-09-15)

Since the anti-inflammatory effect of caffeine is unclear in microglial cells, we performed whether caffeine attenuates the expression of pro-inflammatory mediators in lipopolysaccharide (LPS)-stimulated BV2 microglial cells. Caffeine substantially suppressed the LPS-induced pro-inflammatory mediators nitric oxide (NO), prostaglandin E(2) (PGE(2))

Sodium Propionate Relieves LPS-Induced Inflammation by Suppressing the NF-ĸB and MAPK Signaling Pathways in Rumen Epithelial Cells of Holstein Cows.

Chenxu Zhao et al.

Toxins, 15(7) (2023-07-28)

Subacute ruminal acidosis (SARA) is a prevalent disease in intensive dairy farming, and the rumen environment of diseased cows acidifies, leading to the rupture of gram-negative bacteria to release lipopolysaccharide (LPS). LPS can cause rumentitis and other complications, such as

Astrocyte elevated gene-1 promotes progression of cervical squamous cell carcinoma by inducing epithelial-mesenchymal transition via Wnt signaling.

Enlin Song et al.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 25(3), 345-355 (2015-02-20)

The aim of this study was to investigate the association of astrocyte elevated gene-1 (AEG-1) with epithelial-mesenchymal transition of cervical squamous cell carcinoma (CSCC) and the underlying mechanisms. The expression of proteins was determined by immunohistochemistry in tissues. Overexpression and

Toll-like receptor 4 signaling in osteoblasts is required for load-induced bone formation in mice.

Rajpar, et al.

iScience, 26, 106304-106304 (2023)

Red nucleus IL-33 facilitates the early development of mononeuropathic pain in male rats by inducing TNF-α through activating ERK, p38 MAPK, and JAK2/STAT3.

Hao-Nan Li et al.

Journal of neuroinflammation, 18(1), 150-150 (2021-07-07)

Our recent studies have identified that the red nucleus (RN) dual-directionally modulates the development and maintenance of mononeuropathic pain through secreting proinflammatory and anti-inflammatory cytokines. Here, we further explored the action of red nucleus IL-33 in the early development of

Curcumin attenuates inflammation and cell apoptosis through regulating NF-κB and JAK2/STAT3 signaling pathway against acute kidney injury.

Hongkun Zhu et al.

Cell cycle (Georgetown, Tex.), 19(15), 1941-1951 (2020-07-04)

Curcumin alleviates septic acute kidney injury (SAKI); however, the underlying mechanism remained unclear. To explore this, SAKI cell model and mice model were conducted by using LPS and cecal ligation and puncture (CLP), respectively. Cell counting kit-8 (CCK-8) and enzyme-linked

Myocardial infarction induces sympathetic hyperinnervation via a nuclear factor-κB-dependent pathway in rabbit hearts.

Ye Wang et al.

Neuroscience letters, 535, 128-133 (2013-01-19)

Cardiac sympathetic hyperinnervation after myocardial infarction (MI) is associated with a high incidence of lethal arrhythmia. However, the mechanisms of nerve sprouting induced by MI are unclear. In this study, we showed a nuclear factor-κB (NF-κB) signaling pathway involved in

Interleukin-1 induction of aggrecanase gene expression in human articular chondrocytes is mediated by mitogen-activated protein kinases.

Judith Sylvester et al.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 30(3), 563-574 (2012-07-27)

We investigated the unknown molecular mechanisms of Interleukin-1 (IL-1β)-induced cartilage aggrecan degeneration by aggrecanase (ADAMTS-A Disintegrin And Metalloproteinase with ThromboSpondin motifs) in human articular chondrocytes, a model mimicking human arthritis. Chondrocytes were pretreated with various pharmacological inhibitors and then stimulated

Anxiolytic effects of polydatin through the blockade of neuroinflammation in a chronic pain mouse model.

Shao-Yu Guan et al.

Molecular pain, 16, 1744806919900717-1744806919900717 (2020-01-23)

Inflammatory cytokine-induced expression of MASTL is involved in hepatocarcinogenesis by regulating cell cycle progression.

Liye Cao et al.

Oncology letters, 17(3), 3163-3172 (2019-03-15)

Microtubule associated serine/threonine kinase-like (MASTL) is the functional mammalian ortholog of Greatwall kinase (Gwl), which was originally discovered in Drosophila. Gwl is an essential kinase for accurate chromosome condensation and mitotic progression, and inhibits protein phosphatase 2A (PP2A), which subsequently

Pyrrolidine dithiocarbamate as an effector and trigger in ischemia-reperfusion injury in adipocutaneous flaps in rats.

Andreas Dacho et al.

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale, 41(3), 176-182 (2012-07-06)

Immune and inflammatory responses and the regulation of cellular events seem to be major factors in ischemia-reperfusion (I/R) injury. The inhibition of nuclear transcription factor κB (NF-κB) by pyrrolidine dithiocarbamate (PDTC) shows beneficial effects in animal models in various diseases

Activation of the canonical nuclear factor-κB pathway is involved in isoflurane-induced hippocampal interleukin-1β elevation and the resultant cognitive deficits in aged rats.

Zheng-Qian Li et al.

Biochemical and biophysical research communications, 438(4), 628-634 (2013-08-13)

Although much recent evidence has demonstrated that neuroinflammation contributes to volatile anesthetic-induced cognitive deficits, there are few existing mechanistic explanations for this inflammatory process. This study was conducted to investigate the effects of the volatile anesthetic isoflurane on canonical nuclear

Inhibition of Polyinosinic-Polycytidylic Acid-Induced Acute Pulmonary Inflammation and NF-κB Activation in Mice by a Banana Plant Extract.

Chien-Huang Liao et al.

International journal of medical sciences, 21(1), 107-122 (2024-01-03)

NF-κB activation is pivotal for the excess inflammation causing the critical condition and mortality of respiratory viral infection patients. This study was aimed to evaluate the effect of a banana plant extract (BPE) on suppressing NF-κB activity and acute lung

PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway.

Weirong Wang et al.

Experimental cell research, 319(10), 1523-1533 (2013-04-23)

The ligand-activated transcription factor peroxisome proliferator-activated receptor-α (PPARα) participates in the regulation of cellular inflammation. More recent studies indicated that sirtuin1 (SIRT1), a NAD(+)-dependent deacetylase, regulates the inflammatory response in adipocytes. However, whether the role of PPARα in inflammation is

Umbilical mesenchymal stem cell-derived exosomes promote spinal cord functional recovery through the miR-146b/TLR4 -mediated NF-κB p65 signaling pathway in rats.

Xiujuan Wang et al.

Biochemistry and biophysics reports, 35, 101497-101497 (2023-08-03)

Spinal cord injury (SCI) is an incurable central nervous system impairment that lack of efficient treatment. Exosomes derived from mesenchymal stem cells (MSCs) are widely applied in disease treatment. This work aimed to determine the promising therapeutic effects of MSC-derived

p38-NF-κB-promoted mitochondria-associated apoptosis and G2/M cell cycle arrest in norcantharidin-treated HeLa cells.

Xiu Dong et al.

Journal of Asian natural products research, 14(11), 1008-1019 (2013-01-04)

Previous study proved that norcantharidin (NCTD) could exert its anticancer activity in a variety of malignant cell lines, including human cervical carcinoma HeLa cells. In this study, we found that NCTD-activated p38 mitogen-activated protein kinase (p38 MAPK)-nuclear transcription factor kappa

Pyrrolidine dithiocarbamate augments Hg(2+)-mediated induction of macrophage cell death via oxidative stress-induced apoptosis and necrosis signaling pathways.

Chun-Fa Huang et al.

Toxicology letters, 214(1), 33-45 (2012-08-23)

Exposure to mercury can lead to several injuries in mammals, including immune system dysfunction, and pyrrolidine dithiocarbamate (PDTC), as a metal chelator and antioxidant, has been indicated to increase the cytotoxic effects of toxic metals. However, the toxicological effects and

A near-infrared-emitting CdTe/CdS core/shell quantum dots-based OFF-ON fluorescence sensor for highly selective and sensitive detection of Cd2+.

Rijun Gui et al.

Talanta, 94, 257-262 (2012-05-23)

A near-infrared-emitting CdTe/CdS core/shell quantum dots (QDs)-based photoluminescence (PL) sensor was designed and applied for highly selective and sensitive detection of Cd(2+). This sensor was based on a PL "OFF-ON" mode. First, the addition of ammonium pyrrolidine dithiocarbamate (APDC) led

Vitamin D inhibits Tissue Factor and CAMs expression in oxidized low-density lipoproteins-treated human endothelial cells by modulating NF-κB pathway.

Giovanni Cimmino et al.

European journal of pharmacology, 885, 173422-173422 (2020-08-07)

Epidemiologic studies have clearly demonstrated the correlation existing between Vitamin D (Vit. D) deficiency and increased risk of developing cardiovascular disease, suggesting that it might have a protective role in this clinical setting. Although many experimental studies have investigated the

Parkinson's disease-related DJ-1 modulates the expression of uncoupling protein 4 against oxidative stress.

Shaoqing Xu et al.

Journal of neurochemistry, 145(4), 312-322 (2018-01-10)

Loss of function mutations of DJ-1 (PARK7) have been linked to the pathogenesis of Parkinson's disease. Antioxidative stress is one of the multi-protective functions of DJ-1, and oxidation of cysteine 106 has been proposed to regulate the protective activity of

Fractalkine stimulates cell growth and increases its expression via NF-κB pathway in RA-FLS.

Xinghua Guo et al.

International journal of rheumatic diseases, 15(3), 322-329 (2012-06-20)

After the onset of rheumatoid arthritis (RA), fibroblast-like synoviocytes (RA-FLS) which are specialized types of fibroblasts, become tumor-like, keeping their ability to increase proliferation and invasion. The mechanism of their tumor-like growth is unclear. Fractalkine (FKN), also called CX3CL1, plays

An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells

Lukiw WJ, et al.

The Journal of Biological Chemistry, 283(46), 31315-31322 (2008)

Intranasal pyrrolidine dithiocarbamate decreases brain inflammatory mediators and provides neuroprotection after brain hypoxia-ischemia in neonatal rats.

Zhi Wang et al.

Experimental neurology, 249, 74-82 (2013-09-03)

Brain injury due to birth asphyxia is the major cause of death and long-term disabilities in newborns. We determined whether intranasal pyrrolidine dithiocarbamate (PDTC) could provide neuroprotection in neonatal rats after brain hypoxia-ischemia (HI). Seven-day old male and female Sprague-Dawley

Inhibitor of myogenic differentiation family isoform a, a new positive regulator of fibronectin production by glomerular mesangial cells.

Parisa Yazdizadeh Shotorbani et al.

American journal of physiology. Renal physiology, 318(3), F673-F682 (2020-01-28)

Overproduction of extracellular matrix proteins, including fibronectin by mesangial cells (MCs), contributes to diabetic nephropathy. Inhibitor of myogenic differentiation family isoform a (I-mfa) is a multifunctional cytosolic protein functioning as a transcriptional modulator or plasma channel protein regulator. However, its

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