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Showing 1-25 of 25 results for "PC177L" within Papers
Rebecca L Lowery et al.
International journal of molecular sciences, 22(4) (2021-03-07)
While microglia have been established as critical mediators of synaptic plasticity, the molecular signals underlying this process are still being uncovered. Increasing evidence suggests that microglia utilize these signals in a temporally and regionally heterogeneous manner. Subsequently, it is necessary
Anthony S Castanza et al.
Cerebral cortex (New York, N.Y. : 1991), 31(10), 4808-4824 (2021-05-21)
Human AUTS2 mutations are linked to a syndrome of intellectual disability, autistic features, epilepsy, and other neurological and somatic disorders. Although it is known that this unique gene is highly expressed in developing cerebral cortex, the molecular and developmental functions
R Ye et al.
Genes, brain, and behavior, 13(3), 261-275 (2014-01-11)
Presynaptic serotonin (5-hydroxytryptamine, 5-HT) transporters (SERT) regulate 5-HT signaling via antidepressant-sensitive clearance of released neurotransmitter. Polymorphisms in the human SERT gene (SLC6A4) have been linked to risk for multiple neuropsychiatric disorders, including depression, obsessive-compulsive disorder and autism. Using BXD recombinant
K G Commons
Journal of chemical neuroanatomy, 38(4), 273-281 (2009-05-27)
The serotonergic dorsal raphe nucleus (DR) is an area enriched with cell bodies and axons containing the third vesicular glutamate transporter, VGLUT3. However, the role of VGLUT3-containing axons in modulating activity of serotonin (5-HT) neurons within the DR remains poorly
Diana K Sarko et al.
The Journal of comparative neurology, 519(1), 64-74 (2010-12-02)
Northern grasshopper mice (Onychomys leucogaster) are among the most highly carnivorous rodents in North America. Because predatory mammals may have specialization of senses used to detect prey, we investigated the organization of sensory areas within grasshopper mouse neocortex and quantified
Andrea Forero et al.
Frontiers in cellular neuroscience, 11, 307-307 (2017-10-12)
Background: During early prenatal stages of brain development, serotonin (5-HT)-specific neurons migrate through somal translocation to form the raphe nuclei and subsequently begin to project to their target regions. The rostral cluster of cells, comprising the median and dorsal raphe
Rebecca L Lowery et al.
Glia, 65(11), 1744-1761 (2017-08-25)
Microglia have recently been implicated as key regulators of activity-dependent plasticity, where they contribute to the removal of inappropriate or excess synapses. However, the molecular mechanisms that mediate this microglial function are still not well understood. Although multiple studies have
S Nullmeier et al.
The European journal of neuroscience, 33(4), 689-698 (2011-01-14)
Heterozygous reeler mice (HRM), haploinsufficient for reelin, have been proposed to be a genetic mouse model of schizophrenia. Beside behavioural similarities, HRM also demonstrate several neuroanatomical traits similar to patients suffering from schizophrenia. In the present study using immunocytochemical procedures
Nafsika Poulia et al.
The European journal of neuroscience, 52(1), 2681-2693 (2019-10-19)
Cannabinoid administration during adolescence affects various physiological processes, such as motor and affective response, cognitive-related functions and modulates neurotransmitter activity. Literature remains scant concerning the parallel examination of the effects of adolescent escalating low-dose Δ9 -tetrahydrocannabinol (Δ9 -THC) on the
Arnauld Belmer et al.
Brain structure & function, 222(3), 1297-1314 (2016-08-04)
Serotonin neurons arise from the brainstem raphe nuclei and send their projections throughout the brain to release 5-HT which acts as a modulator of several neuronal populations. Previous electron microscopy studies in rats have morphologically determined the distribution of 5-HT
Martin Sauvageau et al.
eLife, 2, e01749-e01749 (2014-01-02)
Many studies are uncovering functional roles for long noncoding RNAs (lncRNAs), yet few have been tested for in vivo relevance through genetic ablation in animal models. To investigate the functional relevance of lncRNAs in various physiological conditions, we have developed
Daniel G Ehlinger et al.
The European journal of neuroscience, 46(8), 2416-2425 (2017-09-19)
Polymorphism in the gene CACNA1C, encoding the pore-forming subunit of Cav1.2 L-type calcium channels, has one of the strongest genetic linkages to schizophrenia, bipolar disorder and major depressive disorder: psychopathologies in which serotonin signaling has been implicated. Additionally, a gain-of-function
M Bonn et al.
Brain structure & function, 218(2), 421-435 (2012-04-25)
Pharmacobehavioral studies in experimental animals, and imaging studies in humans, indicate that serotonergic transmission in the amygdala plays a key role in emotional processing, especially for anxiety-related stimuli. The lateral and basolateral amygdaloid nuclei receive a dense serotonergic innervation in
Ibrahim M Shokry et al.
BMC pharmacology & toxicology, 20(1), 47-47 (2019-08-07)
MDMA causes serotonin (5-HT) syndrome immediately after administration and serotonergic injury in a few days or weeks. However, a serotonin syndrome is not always followed by serotonergic injury, indicating different mechanisms responsible for two adverse effects. The goal of present
Amin Zahrai et al.
Translational psychiatry, 10(1), 334-334 (2020-10-02)
Chronic treatment with fluoxetine (FLX) is required for its antidepressant effects, but the role of serotonin (5-HT) axonal plasticity in FLX action is unknown. To address this, we examined mice with a stroke in the left medial prefrontal cortex (mPFC)
Alex Crocker-Buque et al.
Human molecular genetics, 25(18), 4052-4061 (2016-07-29)
Genetic mutations known to cause intellectual disabilities (IDs) are concentrated in specific sets of genes including both those encoding synaptic proteins and those expressed during early development. We have characterized the effect of genetic deletion of Dlg3, an ID-related gene
Coralie Berthoux et al.
EMBO molecular medicine, 12(5), e10605-e10605 (2020-04-25)
Cannabis abuse during adolescence confers an increased risk for developing later in life cognitive deficits reminiscent of those observed in schizophrenia, suggesting common pathological mechanisms that remain poorly characterized. In line with previous findings that revealed a role of 5-HT6
Arnauld Belmer et al.
Frontiers in cellular neuroscience, 13, 193-193 (2019-05-28)
A subpopulation of raphe 5-HT neurons expresses the vesicular glutamate transporter VGLUT3 with the co-release of glutamate and serotonin proposed to play a pivotal role in encoding reward- and anxiety-related behaviors. Serotonin axons are identifiable by immunolabeling of either serotonin
Dominik K Biezonski et al.
Journal of neurochemistry, 112(4), 951-962 (2009-12-17)
3,4-Methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a popular recreational drug used worldwide. This study aimed to determine the effects of this compound on the expression of nerve terminal serotonergic markers in rats. Experiment 1 investigated MDMA-induced changes in levels of the serotonin
Yue-Ping Guo et al.
Autism research : official journal of the International Society for Autism Research, 10(1), 66-77 (2016-08-02)
The inbred mouse strain BTBR T+ Itpr3tf /J (BTBR) is studied as a model of idiopathic autism because they are less social and more resistant to change than other strains. Forebrain serotonin receptors and the response to serotonin drugs are
Maya Schiller et al.
Immunity, 54(5), 1022-1036 (2021-05-02)
The sympathetic nervous system is composed of an endocrine arm, regulating blood adrenaline and noradrenaline, and a local arm, a network of fibers innervating immune organs. Here, we investigated the impact of the local arm of the SNS in an
Sabrina Zechel et al.
eLife, 5 (2016-12-10)
Neocortical GABAergic interneuron migration and thalamo-cortical axon (TCA) pathfinding follow similar trajectories and timing, suggesting they may be interdependent. The mechanisms that regulate the radial dispersion of neocortical interneurons are incompletely understood. Here we report that disruption of TCA innervation
Ran Ye et al.
Frontiers in synaptic neuroscience, 7, 20-20 (2016-01-23)
The neurotransmitter serotonin [5-hydroxytryptamine (5-HT)] modulates many key brain functions including those subserving sensation, emotion, reward, and cognition. Efficient clearance of 5-HT after release is achieved by the antidepressant-sensitive 5-HT transporter (SERT, SLC6A4). To identify novel SERT regulators, we pursued
Gregorio L Galiñanes et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(8), 2496-2509 (2009-02-27)
Altered corticostriatal information processing associated with early dopamine systems dysfunction may contribute to attention deficit/hyperactivity disorder (ADHD). Mice with neonatal dopamine-depleting lesions exhibit hyperactivity that wanes after puberty and is reduced by psychostimulants, reminiscent of some aspects of ADHD. To
Bo Wang et al.
Autophagy, 14(5), 796-811 (2017-11-04)
Mammalian ULK1 (unc-51 like kinase 1) and ULK2, Caenorhabditis elegans UNC-51, and Drosophila melanogaster Atg1 are serine/threonine kinases that regulate flux through the autophagy pathway in response to various types of cellular stress. C. elegans UNC-51 and D. melanogaster Atg1
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