PHR1000

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Showing 1-30 of 973 results for "PHR1000" within Papers

Electrochemical biosensor based on glucose oxidase encapsulated within enzymatically synthesized poly(1,10-phenanthroline-5,6-dione).

Hakan Ciftci et al.

Colloids and surfaces. B, Biointerfaces, 123, 685-691 (2014-12-03)

This study is focused on the investigation of electrocatalytic effect of glucose oxidase (GOx) immobilized on the graphite rod (GR) electrode. The enzyme modified electrode was prepared by encapsulation of immobilized GOx within enzymatically formed poly(1,10-phenanthroline-5,6-dione) (pPD) film. The electrochemical

Attenuation of allergic immune response phenotype by mannosylated egg white in orally induced allergy in BALB/c mice.

Prithy Rupa et al.

Journal of agricultural and food chemistry, 62(39), 9479-9487 (2014-09-13)

Food allergies are attributed to an imbalance in immune response to ubiquitous antigens. A previous study demonstrated that mannose glycation (mannosylation) of ovalbumin decreased allergenicity in vivo. The proposed research targets mannosylation of various common allergens that may help prevent

Evidence from studies in rodents and in isolated adipocytes that agonists of the chemerin receptor CMKLR1 may be beneficial in the treatment of type 2 diabetes.

Edward T Wargent et al.

PeerJ, 3, e753-e753 (2015-02-24)

The literature is unclear on whether the adipokine chemerin has pro- or anti-inflammatory properties or plays any role in the aetiology of type 2 diabetes or obesity. To address these questions, and in particular the potential of agonists or antagonists

The novel GLP-1-gastrin dual agonist ZP3022 improves glucose homeostasis and increases β-cell mass without affecting islet number in db/db mice.

Louise S Dalbøge et al.

The Journal of pharmacology and experimental therapeutics, 350(2), 353-360 (2014-06-07)

Antidiabetic treatments aiming to preserve or even to increase β-cell mass are currently gaining increased interest. Here we investigated the effect of chronic treatment with the novel glucagon-like peptide-1 (GLP-1)-gastrin dual agonist ZP3022 (HGEGTFTSDLSKQMEEEAVRLFIEWLKN-8Ado-8Ado-YGWLDF-NH2) on glycemic control, β-cell mass and

Improved vascular engraftment and graft function after inhibition of the angiostatic factor thrombospondin-1 in mouse pancreatic islets.

Johan Olerud et al.

Diabetes, 57(7), 1870-1877 (2008-04-19)

Insufficient development of a new intra-islet capillary network after transplantation may be one contributing factor to the failure of islet grafts in clinical transplantation. The present study tested the hypothesis that the angiostatic factor thrombospondin-1 (TSP-1), which is normally present

High concentration of insulin promotes apoptosis of primary cultured rat ovarian granulosa cells via its increase in extracellular HMGB1.

Xiao-Rong Ni et al.

Reproductive sciences (Thousand Oaks, Calif.), 22(3), 271-277 (2014-09-18)

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting women of reproductive age. Insulin resistance/hyperinsulinemia is a prevalent finding in women with PCOS, which indicates that insulin resistance/hyperinsulinemia may be an important player in the pathogenesis of the PCOS.

Extracellular DNA release confers heterogeneity in Candida albicans biofilm formation.

Ranjith Rajendran et al.

BMC microbiology, 14, 303-303 (2014-12-06)

Biofilm formation by Candida albicans has shown to be highly variable and is directly associated with pathogenicity and poor clinical outcomes in patients at risk. The aim of this study was to test the hypotheses that the extracellular DNA release

Effects of environmental parameters on the dual-species biofilms formed by Escherichia coli O157:H7 and Ralstonia insidiosa, a strong biofilm producer isolated from a fresh-cut produce processing plant.

Nancy T Liu et al.

Journal of food protection, 78(1), 121-127 (2015-01-13)

Biofilm-forming bacteria resident to food processing facilities are a food safety concern due to the potential of biofilms to harbor foodborne bacterial pathogens. When cultured together, Ralstonia insidiosa, a strong biofilm former frequently isolated from produce processing environments, has been

The crosstalk between TLR2 and NOD2 in Aspergillus fumigatus keratitis.

Jiayin Wu et al.

Molecular immunology, 64(2), 235-243 (2015-01-01)

Innate immunity is considered to be critical in the pathogenesis of fungal keratitis. Pattern recognition receptors (PRRs) recognize conserved microbial structures called pathogen-associated molecular patterns (PAMPS), thereby initiating the innate immunity. Toll-like receptors (TLRs) and nucleotide-binding oligomerization domain (NOD)-like receptors

The combination of zinc and glibenclamide limits cardiovascular complications in diabetic rats via multiple mechanisms.

Hala Attia et al.

Pakistan journal of pharmaceutical sciences, 28(2), 499-508 (2015-03-03)

Cardiovascular complications have become a major cause of mortality for diabetic patients. Glibenclamide is an effective hypoglycemic agent, but failed to alleviate diabetic complications. This study aimed to evaluate whether the addition of zinc to glibenclamide could mitigate such complications.

Functional molecular imaging of tumors by chemical exchange saturation transfer MRI of 3-O-Methyl-D-glucose.

Michal Rivlin et al.

Magnetic resonance in medicine, 72(5), 1375-1380 (2014-09-23)

To evaluate the feasibility to detect tumors and metastases by the chemical exchange saturation transfer (CEST) MRI technique using 3-O-Methyl-D-glucose (3OMG), a nonmetabolizable derivative of glucose that is taken up rapidly and preferentially by tumors and is entirely excreted by

The diamidine DB75 targets the nucleus of Plasmodium falciparum.

Anne E Purfield et al.

Malaria journal, 8, 104-104 (2009-05-16)

DB289, [2,5-bis(4-amidinophenyl)furan bis-O-methylamidoxime], is a broad spectrum anti-parasitic compound which has been shown to be effective against malaria in recent clinical trials. DB75, [2,5-bis(4-amidinophenyl)furan], is the active metabolite of this drug. The objective of this study was to determine the

Production, HPLC analysis, and in situ apoptotic activities of swainsonine toward lepidopteran, Sf-21 cell line.

Digar Singh et al.

Biotechnology progress, 30(5), 1196-1205 (2014-07-22)

Swainsonine, a secondary metabolite from Metarhizium anisopliae has been extensively studied in the complementary areas of therapeutics and toxicology. This work aims to develop a simple UV-HPLC method of analyses for swainsonine in Metarhizium fermentation broth and to explore its

Obstructive apneas induce early release of mesenchymal stem cells into circulating blood.

Alba Carreras et al.

Sleep, 32(1), 117-119 (2009-02-05)

To investigate whether noninvasive application of recurrent airway obstructions induces early release of mesenchymal stem cells into the circulating blood in a rat model of obstructive sleep apnea. Prospective controlled animal study. University laboratory. Twenty male Sprague-Dawley rats (250-300 g).

Glucose-coated superparamagnetic iron oxide nanoparticles prepared by metal vapour synthesis are electively internalized in a pancreatic adenocarcinoma cell line expressing GLUT1 transporter.

Daniele Barbaro et al.

PloS one, 10(4), e0123159-e0123159 (2015-04-16)

Iron oxide nanoparticles (IONP) can have a variety of biomedical applications due to their visualization properties through Magnetic Resonance Imaging (MRI) and heating with radio frequency or alternating magnetic fields. In the oncological field, coating IONP with organic compounds to

Cord blood serum-based eye drops: the impact of donor haematological and obstetric factors on the variability of epidermal growth factor levels.

Piera Versura et al.

Blood transfusion = Trasfusione del sangue, 12 Suppl 1, s44-s50 (2013-10-15)

Cord blood serum (CBS)-based eye drops are successfully used in corneal epithelial wound healing and are prepared to supply a known amount of epidermal growth factor (EGF). Product standardisation includes expensive EGF dosage in all cord blood (CB) units. The

Hemin improves insulin sensitivity in skeletal muscle in high fat-fed mice.

Tae-Jin Ju et al.

Journal of pharmacological sciences, 126(2), 115-125 (2014-10-25)

The present study examined whether hemin could prevent the development of high-fat diet-induced insulin resistance in the liver and skeletal muscle using a hyperinsulinemic-euglycemic clamp. A four-week high-fat feeding to mice increased the body weight, fat mass, and plasma levels

Discovery of Chromatin-Associated Proteins via Sequence-Specific Capture and Mass Spectrometric Protein Identification in Saccharomyces cerevisiae.

Julia Kennedy-Darling et al.

Journal of proteome research, 13(8), 3810-3825 (2014-07-08)

DNA-protein interactions play critical roles in the control of genome expression and other fundamental processes. An essential element in understanding how these systems function is to identify their molecular components. We present here a novel strategy, Hybridization Capture of Chromatin

cspA influences biofilm formation and drug resistance in pathogenic fungus Aspergillus fumigatus.

Zhongqi Fan et al.

BioMed research international, 2015, 960357-960357 (2015-03-31)

The microbial cell wall plays a crucial role in biofilm formation and drug resistance. cspA encodes a repeat-rich glycophosphatidylinositol-anchored cell wall protein in the pathogenic fungus Aspergillus fumigatus. To determine whether cspA has a significant impact on biofilm development and

Correlation of (18)F-FDG avid volumes on pre-radiation therapy and post-radiation therapy FDG PET scans in recurrent lung cancer.

Nadya Shusharina et al.

International journal of radiation oncology, biology, physics, 89(1), 137-144 (2014-04-15)

To investigate the spatial correlation between high uptake regions of 2-deoxy-2-[(18)F]-fluoro-D-glucose positron emission tomography ((18)F-FDG PET) before and after therapy in recurrent lung cancer. We enrolled 106 patients with inoperable lung cancer into a prospective study whose primary objectives were

Hypermethylation of Cox5a promoter is associated with mitochondrial dysfunction in skeletal muscle of high fat diet-induced insulin resistant rats.

Ying-ying Gong et al.

PloS one, 9(12), e113784-e113784 (2014-12-02)

High-fat diet (HFD) is an environmental factor that contributes to the pathogenesis of obesity and type 2 diabetes. A number of genes influencing oxidative phosphorylation (OXPHOS) were found to be downregulated in skeletal muscle of humans and rats treated with

Human endogenous retrovirus-K(II) envelope induction protects neurons during HIV/AIDS.

Rakesh K Bhat et al.

PloS one, 9(7), e97984-e97984 (2014-07-06)

Human endogenous retroviruses (HERVs) are differentially expressed depending on the cell type and physiological circumstances. HERV-K has been implicated in the pathogenesis of several diseases although the functional consequences of its expression remain unknown. Human immunodeficiency virus (HIV) infection causes

Dietary calcium concentration and cereals differentially affect mineral balance and tight junction proteins expression in jejunum of weaned pigs.

Barbara U Metzler-Zebeli et al.

The British journal of nutrition, 113(7), 1019-1031 (2015-03-13)

Ca plays an essential role in bone development; however, little is known about its effect on intestinal gene expression in juvenile animals. In the present study, thirty-two weaned pigs (9·5 (SEM 0·11) kg) were assigned to four diets that differed

Beta cell regeneration after single-round immunological destruction in a mouse model.

Jason M Tonne et al.

Diabetologia, 58(2), 313-323 (2014-10-24)

Achieving a better understanding of beta cell regeneration after immunological destruction is crucial for the development of immunotherapy approaches for type 1 diabetes. In previous type 1 diabetes models, sustained immune activation eliminates regenerating beta cells, thus limiting the study

Triterpene glycosides and other polar constituents of shea (Vitellaria paradoxa) kernels and their bioactivities.

Jie Zhang et al.

Phytochemistry, 108, 157-170 (2014-12-03)

The MeOH extract of defatted shea (Vitellaria paradoxa; Sapotaceae) kernels was investigated for its constituents, and fifteen oleanane-type triterpene acids and glycosides, two steroid glucosides, two pentane-2,4-diol glucosides, seven phenolic compounds, and three sugars, were isolated. The structures of five

Elevated dopamine induces minimal hepatic encephalopathy by activation of astrocytic NADPH oxidase and astrocytic protein tyrosine nitration.

Saidan Ding et al.

The international journal of biochemistry & cell biology, 55, 252-263 (2014-09-16)

We previously demonstrated that dopamine (DA) overload may be a key mechanism behind development of minimal hepatic encephalopathy (MHE) in rats. It has been shown that low-grade cerebral oedema and oxidative stress play important roles in the pathogenesis of MHE.

Acid-catalysed glucose dehydration in the gas phase: a mass spectrometric approach.

Andreina Ricci et al.

Journal of mass spectrometry : JMS, 50(1), 228-234 (2015-01-21)

Understanding on a molecular level the acid-catalysed decomposition of the sugar monomers from hemicellulose and cellulose (e.g. glucose, xylose), the main constituent of lignocellulosic biomass is very important to increase selectivity and reaction yields in solution, key steps for the development

Expulsion of Trichuris muris is associated with increased expression of angiogenin 4 in the gut and increased acidity of mucins within the goblet cell.

Riccardo D'Elia et al.

BMC genomics, 10, 492-492 (2009-10-27)

Trichuris muris in the mouse is an invaluable model for infection of man with the gastrointestinal nematode Trichuris trichiura. Three T. muris isolates have been studied, the Edinburgh (E), the Japan (J) and the Sobreda (S) isolates. The S isolate

Regulation of glucose homeostasis using radiogenetics and magnetogenetics in mice.

Ingo B Leibiger et al.

Nature medicine, 21(1), 14-16 (2015-01-09)

Vinpocetine attenuates neointimal hyperplasia in diabetic rat carotid arteries after balloon injury.

Ke Wang et al.

PloS one, 9(5), e96894-e96894 (2014-05-14)

Diabetes exacerbates abnormal vascular smooth muscle cell (VSMC) accumulation in response to arterial wall injury. Vinpocetine has been shown to improve vascular remolding; however, little is known about the direct effects of vinpocetine on vascular complications mediated by diabetes. The

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