phr1047

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Showing 1-30 of 436 results for "phr1047" within Papers

The evolutionary dynamics of variant antigen genes in Babesia reveal a history of genomic innovation underlying host-parasite interaction.

Andrew P Jackson et al.

Nucleic acids research, 42(11), 7113-7131 (2014-05-07)

Babesia spp. are tick-borne, intraerythrocytic hemoparasites that use antigenic variation to resist host immunity, through sequential modification of the parasite-derived variant erythrocyte surface antigen (VESA) expressed on the infected red blood cell surface. We identified the genomic processes driving antigenic

Isolation and immortalization of MIP-GFP neurons from the hypothalamus.

Zi Chen Wang et al.

Endocrinology, 155(6), 2314-2319 (2014-03-13)

The mouse insulin I promoter (MIP) construct was developed to eliminate the promoter activity detected with the rat insulin II promoter in specific hypothalamic neurons that may have unintended effects on glucose and energy homeostasis in transgenic models. Thus, the

Arhodomonas sp. strain Seminole and its genetic potential to degrade aromatic compounds under high-salinity conditions.

Sonal Dalvi et al.

Applied and environmental microbiology, 80(21), 6664-6676 (2014-08-26)

Arhodomonas sp. strain Seminole was isolated from a crude oil-impacted brine soil and shown to degrade benzene, toluene, phenol, 4-hydroxybenzoic acid (4-HBA), protocatechuic acid (PCA), and phenylacetic acid (PAA) as the sole sources of carbon at high salinity. Seminole is

Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation.

Ageliki Tsagaratou et al.

Proceedings of the National Academy of Sciences of the United States of America, 111(32), E3306-E3315 (2014-07-30)

The discovery of Ten Eleven Translocation proteins, enzymes that oxidize 5-methylcytosine (5mC) in DNA, has revealed novel mechanisms for the regulation of DNA methylation. We have mapped 5-hydroxymethylcytosine (5hmC) at different stages of T-cell development in the thymus and T-cell

Sesamol-loaded solid lipid nanoparticles for treatment of skin cancer.

T Geetha et al.

Journal of drug targeting, 23(2), 159-169 (2014-10-01)

Abstract Role of reactive oxygen species (ROS) in skin carcinogenesis is well documented. Natural molecules, like sesamol, with marked antioxidant potential can be useful in combating skin cancers. In vitro antiproliferative (using MTT assay) and DNA fragmentation studies in HL

Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats.

Hichem Alimi et al.

General physiology and biophysics, 32(1), 115-127 (2013-03-28)

Rhus tripartitum (sumac) is an Anacardiaceae tree with a wide phytotherapeutic application including the use of its roots in the management of gastric ulcer. In the present study the Rhus tripartitum root barks extract (RTE) was phytochemical studied, in vitro

Comparative in vitro study on magnetic iron oxide nanoparticles for MRI tracking of adipose tissue-derived progenitor cells.

Annika Kasten et al.

PloS one, 9(9), e108055-e108055 (2014-09-23)

Magnetic resonance imaging (MRI) using measurement of the transverse relaxation time (R2*) is to be considered as a promising approach for cell tracking experiments to evaluate the fate of transplanted progenitor cells and develop successful cell therapies for tissue engineering.

Rapid chemiluminescent sandwich enzyme immunoassay capable of consecutively quantifying multiple tumor markers in a sample.

Julie Kim et al.

Talanta, 129, 106-112 (2014-08-17)

Using the role of p-iodophenol in enzyme assay, enhanced 1,1'-oxalyldiimidazole chemiluminescent enzyme immunoassays (ODI-CLEIAs) were developed to consecutively quantify trace levels of triple tumor markers, such as alpha fetoprotein (AFP), carcinoembryonic antigen (CEA), and prostate specific antigen (PSA) in a

Impairment of high-density lipoprotein resistance to lipid peroxidation and adipose tissue inflammation in obesity complicated by obstructive sleep apnea.

Rahul Yadav et al.

The Journal of clinical endocrinology and metabolism, 99(9), 3390-3398 (2014-05-16)

Obstructive sleep apnea (OSA) complicates morbid obesity and is associated with increased cardiovascular disease incidence. An increase in the circulating markers of chronic inflammation and dysfunctional high-density lipoprotein (HDL) occur in severe obesity. The objective of the study was to

Natural genetic variation impacts expression levels of coding, non-coding, and antisense transcripts in fission yeast.

Mathieu Clément-Ziza et al.

Molecular systems biology, 10, 764-764 (2014-11-30)

Our current understanding of how natural genetic variation affects gene expression beyond well-annotated coding genes is still limited. The use of deep sequencing technologies for the study of expression quantitative trait loci (eQTLs) has the potential to close this gap.

Gli regulates MUC5AC transcription in human gastrointestinal cells.

Natsuko Kageyama-Yahara et al.

PloS one, 9(8), e106106-e106106 (2014-08-29)

MUC5AC is a well-known gastric differentiation marker, which has been frequently used for the classification of stomach cancer. Immunohistochemistry revealed that expression of MUC5AC decreases accompanied with increased malignant property of gastric mucosa, which further suggests the importance of MUC5AC

Determination of trace amounts of phenol in river waters by gas chromatography

Rennie.JP

Analyst, 107, 327-330 (1982)

Elevated miR-122 serum levels are an independent marker of liver injury in inflammatory diseases.

Christoph Roderburg et al.

Liver international : official journal of the International Association for the Study of the Liver, 35(4), 1172-1184 (2014-07-22)

Serum concentrations of miR-122 were proposed as a marker for various inflammatory diseases, but the mechanisms driving alterations in miR-122 serum levels are unknown. We analysed miR-122 serum levels and hepatic miR-122 expression in mice after hepatic ischaemia and reperfusion

Macrophage metalloelastase (MMP12) regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase.

Jung-Ting Lee et al.

Endocrinology, 155(9), 3409-3420 (2014-06-11)

Macrophage metalloelastase, a matrix metallopeptidase (MMP12) predominantly expressed by mature tissue macrophages, is implicated in pathological processes. However, physiological functions for MMP12 have not been described. Because mRNA levels for the enzyme increase markedly in adipose tissue of obese mice

Shaping of mesoporous AISBA-15 as cylindrical nano reactor for tertiary butylation of phenol.

Govindasamy Chandrasekar et al.

Journal of nanoscience and nanotechnology, 14(6), 4683-4691 (2014-04-18)

Mesoporous AISBA-15 with different n(Si)/n(Al) ratios (45, 136 and 215) in the powder (P) form were synthesized by hydrothermal technique. The powder materials were shaped into cylindrical extrudates (Ex) by compounding with additives such as bentonite (binder) and methylcellulose (plasticizer).

Degradation of phenol by using magnetic photocatalysts of titania.

Chiung-Fen Chang et al.

Water science and technology : a journal of the International Association on Water Pollution Research, 67(7), 1434-1441 (2013-04-05)

Magnetic TiO2 (MT) composites were prepared and applied to degrading phenol, which is one of the listed priority pollutants. The effects of heat treatment under preparation on the photocatalytic activity of MT composites have been investigated by varying the soaking

Combined treatment with GH and IGF-I: additive effect on cortical bone mass but not on linear bone growth in female rats.

Katja Sundström et al.

Endocrinology, 155(12), 4798-4807 (2014-09-23)

The growth-promoting effect of combined therapy with GH and IGF-I in normal rats is not known. We therefore investigated the efficacy of treatment with recombinant human (rh)GH and/or rhIGF-I on longitudinal bone growth and bone mass in intact, prepubertal, female

Conversion of bone marrow mesenchymal stem cells into type II alveolar epithelial cells reduces pulmonary fibrosis by decreasing oxidative stress in rats.

Kun Huang et al.

Molecular medicine reports, 11(3), 1685-1692 (2014-11-21)

Pulmonary fibrosis is an irreversible chronic progressive fibroproliferative lung disease, which usually has a poor prognosis. Previous studies have confirmed that the transplantation of bone marrow mesenchymal stem cells (MSCs) significantly reduces lung damage in a number of animal models.

Effects of uremic solutes on reactive oxygen species in vitro model systems as a possibility of support the renal function management.

Renata P Assis et al.

BMC nephrology, 16, 50-50 (2015-04-18)

In view of the prevalence of oxidative stress in chronic kidney disease (CKD) patients, the loss of low-molecular-weight biomolecules by hemodialysis and the antioxidant potential of some uremic solutes that accumulate in CKD, we used in vitro model systems to

The effect of glucose concentration and sodium phenylbutyrate treatment on mitochondrial bioenergetics and ER stress in 3T3-L1 adipocytes.

Ross M Tanis et al.

Biochimica et biophysica acta, 1853(1), 213-221 (2014-12-03)

While the 3T3-L1 adipocyte model is routinely used for the study of obesity and diabetes, the mitochondrial respiratory profile in normal versus high glucose has not been examined in detail. We matured adipocytes in normal (5mM) or high (30 mM)

Codon swapping of zinc finger nucleases confers expression in primary cells and in vivo from a single lentiviral vector.

Cécilia Abarrategui-Pontes et al.

Current gene therapy, 14(5), 365-376 (2015-02-18)

Zinc finger nucleases (ZFNs) are promising tools for genome editing for biotechnological as well as therapeutic purposes. Delivery remains a major issue impeding targeted genome modification. Lentiviral vectors are highly efficient for delivering transgenes into cell lines, primary cells and

MicroRNA let-7b suppresses human gastric cancer malignancy by targeting ING1.

X Han et al.

Cancer gene therapy, 22(3), 122-129 (2015-01-24)

MicroRNAs (miRNAs) are important regulators that play key roles in tumorigenesis and tumor progression. In this study, we investigate whether let-7b acts as a tumor suppressor to inhibit invasion and metastasis in gastric cancers. We analyzed the expression of let-7b

Silymarin ameliorates memory deficits and neuropathological changes in mouse model of high-fat-diet-induced experimental dementia.

Neha et al.

Naunyn-Schmiedeberg's archives of pharmacology, 387(8), 777-787 (2014-05-29)

A huge body evidences suggest that obesity is the single great risk factor for the development of dementia. Recently, silymarin, a flavonoid, clinically in use as a hepatoprotectant, has been reported to prevent amyloid beta-induced memory impairment by reducing oxidative

Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption.

Meghan K Rothenberger et al.

Proceedings of the National Academy of Sciences of the United States of America, 112(10), E1126-E1134 (2015-02-26)

Antiretroviral therapy (ART) suppresses HIV replication in most individuals but cannot eradicate latently infected cells established before ART was initiated. Thus, infection rebounds when treatment is interrupted by reactivation of virus production from this reservoir. Currently, one or a few

A previously uncharacterized, nonphotosynthetic member of the Chromatiaceae is the primary CO2-fixing constituent in a self-regenerating biocathode.

Zheng Wang et al.

Applied and environmental microbiology, 81(2), 699-712 (2014-11-16)

Biocathode extracellular electron transfer (EET) may be exploited for biotechnology applications, including microbially mediated O2 reduction in microbial fuel cells and microbial electrosynthesis. However, biocathode mechanistic studies needed to improve or engineer functionality have been limited to a few select

Frequent involvement of chromatin remodeler alterations in gastric field cancerization.

Hideyuki Takeshima et al.

Cancer letters, 357(1), 328-338 (2014-12-03)

A field for cancerization, or a field defect, is formed by the accumulation of genetic and epigenetic alterations in normal-appearing tissues, and is involved in various cancers, especially multiple cancers. Epigenetic alterations are frequently present in chronic inflammation-exposed tissues, but

The novel zinc cluster regulator Tog1 plays important roles in oleate utilization and oxidative stress response in Saccharomyces cerevisiae.

Piyasuda Thepnok et al.

Biochemical and biophysical research communications, 450(4), 1276-1282 (2014-07-08)

Many zinc cluster proteins have been shown to play a role in the transcriptional regulation of glucose-repressible genes during glucose exhaustion and diauxic shift. Here, we studied an additional member of this family called Yer184c (herein called Tog1) for transcriptional

Physiological features of Halomonas lionensis sp. nov., a novel bacterium isolated from a Mediterranean Sea sediment.

Frédéric Gaboyer et al.

Research in microbiology, 165(7), 490-500 (2014-08-03)

A novel halophilic bacterium, strain RHS90(T), was isolated from marine sediments from the Gulf of Lions, in the Mediterranean Sea. Its metabolic and physiological characteristics were examined under various cultural conditions, including exposure to stressful ones (oligotrophy, high pressure and

Transcriptional analysis of South African cassava mosaic virus-infected susceptible and tolerant landraces of cassava highlights differences in resistance, basal defense and cell wall associated genes during infection.

Farhahna Allie et al.

BMC genomics, 15, 1006-1006 (2014-11-22)

Cassava mosaic disease is caused by several distinct geminivirus species, including South African cassava mosaic virus-[South Africa:99] (SACMV). To date, there is limited gene regulation information on viral stress responses in cassava, and global transcriptome profiling in SACMV-infected cassava represents

Genomic microarray analysis on formalin-fixed paraffin-embedded material for uveal melanoma prognostication.

Eugen C Minca et al.

Cancer genetics, 207(7-8), 306-315 (2014-12-03)

Cytogenetic alterations are strong outcome prognosticators in uveal melanoma (UVM). Monosomy 3 (-3) and MYC amplification at 8q24 are commonly tested by fluorescence in situ hybridization (FISH). Alternatively, microarray analysis provides whole genome data, detecting partial chromosome loss, loss of

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