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Showing 31-60 of 86 results for "phr1075" within Papers
Fatmanur Tuğcu-Demiröz et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 62, 105-110 (2014-06-03)
The aim of the present study was to develop a method for water flux reabsorption measurement in Doluisio's Perfusion Technique based on the use of phenol red as a non-absorbable marker and to validate it by comparison with gravimetric procedure.
Ulcerogenic and intestinal motility/transit stimulating actions of nevirapine in albino Wistar rats.
Elizabeth Bassey Umoren et al.
Journal of physiology and biochemistry, 69(3), 547-557 (2013-03-29)
The antiretroviral is a non-nucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1. This study was undertaken to investigate the effect of nevirapine (NVP) administration on gastric acid secretion, pepsin secretion, mucosal secretion, intestinal motility, and transit using apparently
Wei Guo et al.
Environmental toxicology and pharmacology, 38(3), 901-912 (2014-12-03)
This study aimed to identify the specific cytochrome P450 (CYP450) enzymes involved in the metabolism of dipfluzine hydrochloride using the combination of a chemical inhibition study, a correlation analysis and a panel of recombinant rat CYP450 enzymes. The incubation of
Noah Scheinfeld
Dermatology online journal, 9(2), 4-4 (2003-03-18)
Cimetidine, approved by the FDA for inhibition of gastric acid secretion, has been advocated for a number of dermatological diseases. The cutaneous uses and immunological effects of cimetidine have been actively studied over the past few years, and this review
Tzu-Kai Lin et al.
The Journal of investigative dermatology, 133(2), 469-478 (2012-09-28)
Systemic antagonists of the histamine type 1 and 2 receptors (H1/2r) are widely used as anti-pruritics and central sedatives, but demonstrate only modest anti-inflammatory activity. Because many inflammatory dermatoses result from defects in cutaneous barrier function, and because keratinocytes express
Jamie Merves et al.
PloS one, 10(2), e0114831-e0114831 (2015-02-28)
Eosinophilic Esophagitis (EoE) is a chronic allergic disorder, whose pathobiology is incompletely understood. Histamine-producing cells including mast cells and basophils have been implicated in EoE. However, very little is currently known about the role of histamine and histamine receptor (HR)
Hong Wei et al.
Pharmacological research, 90, 58-66 (2014-10-12)
Among brain structures receiving efferent projections from the histaminergic tuberomammillary nucleus is the pontine locus coeruleus (LC) involved in descending noradrenergic control of pain. Here we studied whether histamine in the LC is involved in descending regulation of neuropathic hypersensitivity.
Xiaofeng Bao et al.
Nuclear medicine and biology, 39(8), 1128-1136 (2012-08-18)
Rhodamine-123 is a known substrate for the efflux transporter, P-glycoprotein (P-gp). We wished to assess whether rhodamine-123 might serve as a useful substrate for developing probes for imaging efflux transporters in vivo with positron emission tomography (PET). For this purpose
A Kumar
DICP : the annals of pharmacotherapy, 24(3), 289-295 (1990-03-01)
Suppressor T lymphocytes possess histamine2 (H2) receptors and contribute significantly to the function of the immune system. Experimentally, cimetidine, an H2-receptor antagonist, has been shown to enhance a variety of immunologic functions both in vivo and in vitro because of
V Barbounis et al.
Anticancer research, 16(1), 545-547 (1996-01-01)
Castleman's disease is a rare benign condition of uncertain etiology, with several forms. It is postulated that a dysregulated inflammatory response may play a role in the pathogenesis of this disease. We report on a case of Castleman's disease treated
Jeppe Schjerning et al.
American journal of physiology. Heart and circulatory physiology, 304(8), H1094-H1102 (2013-02-12)
In arterioles, aldosterone counteracts the rapid dilatation (recovery) following depolarization-induced contraction. The hypothesis was tested that this effect of aldosterone depends on cyclooxygenase (COX)-derived products and/or nitric oxide (NO) synthase (NOS) inhibition. Recovery of the response to high K(+) was
Liping Li et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(7), 1227-1234 (2014-04-30)
Nitidine chloride (NC), a quaternary ammonium alkaloid, has numerous pharmacological effects, such as anticancer activity. However, it was found that NC also has hepatocellular toxicity. Because organic cation transporters 1 and 3 (OCT1 and OCT3) might mediate the influx of
Ryan J Schutte et al.
Journal of neurophysiology, 112(4), 903-912 (2014-05-09)
Hundreds of mutations in the SCN1A sodium channel gene confer a wide spectrum of epileptic disorders, requiring efficient model systems to study cellular mechanisms and identify potential therapeutic targets. We recently demonstrated that Drosophila knock-in flies carrying the K1270T SCN1A
Amal Lamraoui et al.
Inflammation, 37(5), 1689-1704 (2014-05-27)
The inflammatory response caused by scorpion venoms is a key event in the pathogenesis of scorpion envenomation. This response was assessed in the cardiac, pulmonary, and gastric tissues of envenomed mice. The results reveal an increase of permeability in cardiac
Simultaneous determination of moxifloxacin and H2 receptor antagonist in pharmaceutical dosage formulations by RP-HPLC: application to in vitro drug interactions
Sultana N, et al.
Quimica nova, 34(4), 683-688 (2011)
J P Harcourt et al.
International journal of pediatric otorhinolaryngology, 51(2), 109-113 (2000-01-05)
Effective adjuvant treatment for recurrent respiratory papillomatosis (RRP) is at present limited to alpha-interferon, which may have significant side effects including rebound growth of papillomata following its withdrawal, is given by injection and is expensive. High dose cimetidine is known
Hye Ja Lee et al.
The international journal of biochemistry & cell biology, 44(12), 2124-2128 (2012-09-15)
Vitiligo is a progressive depigmenting disorder. Histamine has been shown to induce melanogenesis via histamine receptor 2, suggesting the possibility of histamine as a repigmenting agent for the treatment of vitiligo. However, the role and signaling mechanism of histamine are
Kristine H Kurtz et al.
Microcirculation (New York, N.Y. : 1994), 21(7), 593-605 (2014-04-08)
This study investigated the roles of the H1 and H2 histamine receptors, NO synthase, and sGC cyclase in histamine-induced modulation of rat mesenteric collecting lymphatic pumping. Isolated rat mesenteric collecting lymphatics were treated with 1- to 100-μM histamine. Histamine receptors
P San Miguel et al.
Virchows Archiv : an international journal of pathology, 430(3), 261-263 (1997-03-01)
A case of carcinoma in the breast of a male patient with a chronic gastric ulcer is described. The patient had received cimetidine for 17 years. Histological examination of an excisional biopsy showed lobular in situ and infiltrating carcinoma. In
Imre Laszlo Szabó et al.
Current pharmaceutical design, 19(1), 84-89 (2012-09-06)
Actions of various drugs have been tested on the gastric acid basal secretion and on the drug (Indomethacin)- induced gastric mucosal damage; however their physiological and pharmacological mechanisms have not been compared. The effects of capsaicinoids, atropine, cimetidine, omeprazole, famotidine
Duo-Yu Wu et al.
Asian Pacific journal of tropical medicine, 5(10), 831-833 (2012-10-10)
To evaluate the clinical effects of psychological interventions and drug therapy against peptic ulcer. 96 patients with peptic ulcer were divided into control group with Tagamet 800 mg per evening p.o. and trial group with psychological intervention on the basis
Miyuki Fukuda et al.
Journal of pharmacological sciences, 126(3), 230-242 (2014-10-25)
Intracranial aneurysm (IA) and aortic dissection are both complications of hypertension and characterized by degeneration of the media. Given the involvement of prostaglandin F2α and its receptor, FP, in extracellular matrix remodeling in a mouse model of pulmonary fibrosis, here
[Endocrine effect of cimetidine].
I I Dedov et al.
Klinicheskaia meditsina, 71(2), 11-16 (1993-01-01)
Yisheng Zheng et al.
Molecular immunology, 54(1), 74-83 (2012-12-12)
Cimetidine, a histamine type-2 receptor antagonist, is known to inhibit the growth of several tumors in human and animals, however the mechanism of action underlying this effect remains largely unknown. Here, in the mice model of 3LL lung tumor, cimetidine
Hiroshi Satoh et al.
Digestive diseases and sciences, 58(10), 2840-2849 (2013-06-15)
The effects of feeding conditions (fasted or fed) and dietary fiber (DF) in the diet on gastrointestinal (GI) damage induced by aspirin (ASA) were examined in cats. Plain ASA (P-ASA, 20 mg/kg) or one enteric-coated ASA tablet (EC-ASA, containing 100
A F Shinn
Drug safety, 7(4), 245-267 (1992-07-01)
The excellent efficacy and tolerability profiles of H2-antagonists have established these agents as the leading class of antiulcer drugs. Attention has been focused on drug interactions with H2-antagonists as a means of product differentiation and because many patients are receiving
Xiaoping Xie et al.
Human vaccines & immunotherapeutics, 10(6), 1688-1699 (2014-03-20)
Previously, we have reported that either CIM or PZQ, 2 clinical drugs, could be used to develop as adjuvants on HBV DNA vaccine to elicit both humoral and cellular immune responses. Here, we demonstrate that combinations of CIM and PZQ
M A Sa'adah et al.
European neurology, 42(1), 23-26 (1999-07-08)
Two cases of optic neuropathy associated with cimetidine therapy are reported. Recovery occurred in both after drug withdrawal. Rechallenge with the same agent totally reproduced the condition in the first case. Cimetidine exerts an unequivocal toxicity on the central and
Renata Longhini et al.
Journal of anatomy, 222(2), 239-247 (2012-12-04)
It has been demonstrated that histamine interferes with the recruitment, formation and activity of osteoclasts via H(1)- and H(2)-receptors. Cimetidine is a H(2)-receptor antagonist used for treatment of gastric ulcers that seems to prevent bone resorption. In this study, a
Christian A Fernandez et al.
The Journal of pharmacology and experimental therapeutics, 352(3), 541-551 (2015-01-13)
A murine model was developed that recapitulates key features of clinical hypersensitivity to Escherichia coli asparaginase. Sensitized mice developed high levels of anti-asparaginase IgG antibodies and had immediate hypersensitivity reactions to asparaginase upon challenge. Sensitized mice had complete inhibition of
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