PHR1098

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Showing 1-30 of 429 results for "PHR1098" within Papers

Biorelevant media resistant co-culture model mimicking permeability of human intestine.

Delphine Antoine et al.

International journal of pharmaceutics, 481(1-2), 27-36 (2015-01-21)

Cell culture models are currently used to predict absorption pattern of new compounds and formulations in the human gastro-intestinal tract (GIT). One major drawback is the lack of relevant apical incubation fluids allowing mimicking luminal conditions in the GIT. Here

Clonorchis sinensis ferritin heavy chain triggers free radicals and mediates inflammation signaling in human hepatic stellate cells.

Qiang Mao et al.

Parasitology research, 114(2), 659-670 (2014-11-22)

Clonorchiasis, caused by direct and continuous contact with Clonorchis sinensis, is associated with hepatobiliary damage, inflammation, periductal fibrosis, and the development of cholangiocarcinoma. Hepatic stellate cells respond to liver injury through production of proinflammatory mediators which drive fibrogenesis; however, their

Expression of endoplasmic reticulum stress markers GRP78 and CHOP induced by oxidative stress in blue light-mediated damage of A2E-containing retinal pigment epithelium cells.

Jingyang Feng et al.

Ophthalmic research, 52(4), 224-233 (2014-11-18)

Age-related lipofuscin N-retinylidene-N-retinylethanolamine (A2E) accumulated in human retinal pigment epithelium (RPE) cells confers susceptibility to blue light-mediated damage, which represents one pathogenesis of age-related macular degeneration. This study investigated the expression of 2 best-characterized endoplasmic reticulum (ER) stress markers, glucose-related

Exercise ameliorates cognition impairment due to restraint stress-induced oxidative insult and reduced BDNF level.

Dong-Ho Kwon et al.

Biochemical and biophysical research communications, 434(2), 245-251 (2013-03-29)

We assessed whether chronic treadmill exercise attenuated restraint stress-induced cognition impairment. Although serum corticosterone was not significantly altered by exercise, the restraint-induced increases in hippocampal malondialdehyde (MDA) and 4-hydroxynonenal (HNE) were reduced by chronic exercise. The exercise paradigm also reversed

Hyperglycemia induces Toll-like receptor-2 and -4 expression and activity in human microvascular retinal endothelial cells: implications for diabetic retinopathy.

Uthra Rajamani et al.

Journal of diabetes research, 2014, 790902-790902 (2015-01-23)

Diabetic retinopathy (DR) causes visual impairment in working age adults and hyperglycemia-mediated inflammation is central in DR. Toll-like receptors (TLRs) play a key role in innate immune responses and inflammation. However, scanty data is available on their role in DR.

Myeloid-derived suppressor cells are involved in lysosomal acid lipase deficiency-induced endothelial cell dysfunctions.

Ting Zhao et al.

Journal of immunology (Baltimore, Md. : 1950), 193(4), 1942-1953 (2014-07-09)

The underlying mechanisms that lysosomal acid lipase (LAL) deficiency causes infiltration of myeloid-derived suppressor cells (MDSCs) in multiple organs and subsequent inflammation remain incompletely understood. Endothelial cells (ECs), lining the inner layer of blood vessels, constitute barriers regulating leukocytes transmigration

Alessandro Ghezzo et al.

PloS one, 9(11), e113111-e113111 (2014-11-25)

Down Syndrome (DS) is characterised by premature aging and an accelerated decline of cognitive functions in the vast majority of cases. As the life expectancy of DS persons is rapidly increasing, this decline is becoming a dramatic health problem. The

Inhibition of VDAC1 prevents Ca²⁺-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages.

Haibo Chen et al.

Apoptosis : an international journal on programmed cell death, 19(12), 1712-1726 (2014-10-25)

Ultrasound combined with endogenous protoporphyrin IX derived from 5-aminolevulinic acid (ALA-SDT) is known to induce apoptosis in multiple cancer cells and macrophages. Persistent retention of macrophages in the plaque has been implicated in the pathophysiology and progression of atherosclerosis. Here

Prevention of acute renal failure post-contrast imaging in cardiology: a randomized study.

N Alessandri et al.

European review for medical and pharmacological sciences, 17 Suppl 1, 13-21 (2013-04-26)

The contrast-induced nephropathy (CIN) is the third most common cause of acute renal failure (ARF) and the worsening in a pre-existing chronic renal failure (CRF), with a foreseeable increase of morbidity, mortality, length of the stay in hospital and, as

Oligodendroglial maturation is dependent on intracellular protein shuttling.

Peter Göttle et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(3), 906-919 (2015-01-23)

Multiple sclerosis is an autoimmune disease of the CNS resulting in degeneration of myelin sheaths and loss of oligodendrocytes, which means that protection and electrical insulation of axons and rapid signal propagation are impaired, leading to axonal damage and permanent

CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation.

Nina Bertaux-Skeirik et al.

PLoS pathogens, 11(2), e1004663-e1004663 (2015-02-07)

The cytotoxin-associated gene (Cag) pathogenicity island is a strain-specific constituent of Helicobacter pylori (H. pylori) that augments cancer risk. CagA translocates into the cytoplasm where it stimulates cell signaling through the interaction with tyrosine kinase c-Met receptor, leading cellular proliferation.

Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease.

Grace Chen et al.

Blood, 123(24), 3818-3827 (2014-03-13)

Sickle cell disease (SCD) is characterized by recurring episodes of vascular occlusion in which neutrophil activation plays a major role. The disease is associated with chronic hemolysis with elevated cell-free hemoglobin and heme. The ensuing depletion of heme scavenger proteins

Involvement of endoplasmic reticulum stress in all-trans-retinal-induced retinal pigment epithelium degeneration.

Jie Li et al.

Toxicological sciences : an official journal of the Society of Toxicology, 143(1), 196-208 (2014-10-22)

Excess accumulation of endogenous all-trans-retinal (atRAL) contributes to degeneration of the retinal pigment epithelium (RPE) and photoreceptor cells, and plays a role in the etiologies of age-related macular degeneration (AMD) and Stargardt's disease. In this study, we reveal that human

A mouse model of peripheral postischemic dysesthesia: involvement of reperfusion-induced oxidative stress and TRPA1 channel.

Atsushi Sasaki et al.

The Journal of pharmacology and experimental therapeutics, 351(3), 568-575 (2014-09-18)

Peripheral postischemic dysesthesia was examined behaviorally in mice and we investigated the underlying molecular mechanism with a focus on oxidative stress. Hind-paw ischemia was induced by tight compression of the ankle with a rubber band, and reperfusion was achieved by

Differential regulation of pregnancy associated plasma protein-A in human coronary artery endothelial cells and smooth muscle cells.

Cheryl A Conover et al.

Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society, 18(3), 213-220 (2007-10-16)

Pregnancy-associated plasma protein-A (PAPP-A), a metalloproteinase that serves to modulate local insulin-like growth factor (IGF) action, is upregulated in atherosclerotic plaque. However, little is known about the cellular mechanisms underlying this elevated PAPP-A. To continue study of PAPP-A expression and

The antisenescence effect of trans-cinnamaldehyde on adipose-derived stem cells.

Karthyayani Rajamani et al.

Cell transplantation, 24(3), 493-507 (2015-02-06)

As assuring cell quality is an essential parameter for the success of stem cell therapy, the impact of various senescence-inducing stress signals, and strategies to circumvent them, has been an important area of focus in stem cell research. The aim

Arsenic augments the uptake of oxidized LDL by upregulating the expression of lectin-like oxidized LDL receptor in mouse aortic endothelial cells.

Ekhtear Hossain et al.

Toxicology and applied pharmacology, 273(3), 651-658 (2013-10-23)

Although chronic arsenic exposure is a well-known risk factor for cardiovascular diseases, including atherosclerosis, the molecular mechanism underlying arsenic-induced atherosclerosis remains obscure. Therefore, this study aimed to elucidate this molecular mechanism. We examined changes in the mRNA level of the

Killing mechanism of stable N-halamine cross-linked polymethacrylamide nanoparticles that selectively target bacteria.

Michal Natan et al.

ACS nano, 9(2), 1175-1188 (2015-01-21)

Increased resistance of bacteria to disinfection and antimicrobial treatment poses a serious public health threat worldwide. This has prompted the search for agents that can inhibit both bacterial growth and withstand harsh conditions (e.g., high organic loads). In the current

Unsuspected pyocyanin effect in yeast under anaerobiosis.

Rana Barakat et al.

MicrobiologyOpen, 3(1), 1-14 (2013-12-07)

The blue-green phenazine, Pyocyanin (PYO), is a well-known virulence factor produced by Pseudomonas aeruginosa, notably during cystic fibrosis lung infections. It is toxic to both eukaryotic and bacterial cells and several mechanisms, including the induction of oxidative stress, have been

Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress.

Shuying Shen et al.

Chemico-biological interactions, 218, 28-41 (2014-05-08)

Malignant gliomas are the most common primary brain tumors, and novel ways of treating gliomas are urgently needed. Ursolic acid (UA), a pentacyclic triterpenoid, has been reported to exhibit promising antitumor activity. Here, we evaluated the effects of UA on

Anti-rheumatic agent auranofin induced apoptosis in chronic myeloid leukemia cells resistant to imatinib through both Bcr/Abl-dependent and -independent mechanisms.

Xin Chen et al.

Oncotarget, 5(19), 9118-9132 (2014-09-07)

Resistance to Imatinib mesylate (IM) is an emerging problem for patients with chronic myelogenous leukemia (CML). T315I mutation in the Bcr-Abl is the predominant mechanism of the acquired resistance to IM and second generation tyrosine kinase inhibitors (TKI). Therefore it

Zinc sulfide nanoparticles selectively induce cytotoxic and genotoxic effects on leukemic cells: involvement of reactive oxygen species and tumor necrosis factor alpha.

Sandeep Kumar Dash et al.

Journal of applied toxicology : JAT, 34(11), 1130-1144 (2014-01-31)

The aim of the present study was to develop zinc sulfide nanoparticles (ZnS NPs) and to study their cytotoxicity against the KG-1A (human acute myeloid leukemia) cell line. ZnS NPs were synthesized using the pyrolytic method and characterized by X-ray

The anticancer agent di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes prosurvival autophagy by two mechanisms: persistent induction of autophagosome synthesis and impairment of lysosomal integrity.

Elaine Gutierrez et al.

The Journal of biological chemistry, 289(48), 33568-33589 (2014-10-11)

Autophagy functions as a survival mechanism during cellular stress and contributes to resistance against anticancer agents. The selective antitumor and antimetastatic chelator di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) causes lysosomal membrane permeabilization and cell death. Considering the integral role of lysosomes in autophagy

Spectrophotometric determination of N-acetyl-L-cysteine and N-(2-mercaptopropionyl)-glycine in pharmaceutical preparations.

Kukoc-Modun L and Radic N

International Journal of Analytical Chemistry, 2011(1-2), 191-199 (2011)

Inhaled birch pollen extract induces airway hyperresponsiveness via oxidative stress but independently of pollen-intrinsic NADPH oxidase activity, or the TLR4-TRIF pathway.

Karim H Shalaby et al.

Journal of immunology (Baltimore, Md. : 1950), 191(2), 922-933 (2013-06-19)

Oxidative stress in allergic asthma may result from oxidase activity or proinflammatory molecules in pollens. Signaling via TLR4 and its adaptor Toll-IL-1R domain-containing adapter inducing IFN-β (TRIF) has been implicated in reactive oxygen species-mediated acute lung injury and in Th2

Evidence of a new dechlorinated ochratoxin A derivative formed in opossum kidney cell cultures after pretreatment by modulators of glutathione pathways: correlation with DNA-adduct formation.

Virginie Faucet-Marquis et al.

Molecular nutrition & food research, 50(6), 530-542 (2006-05-04)

Ochratoxin A (OTA), a nephrotoxic mycotoxin probably implicated in human Balkan endemic nephropathy and associated urothelial tumors, induces renal carcinomas in rodents and nephrotoxicity in pigs. OTA induces DNA-adduct formation, but the structure of the adducts and their role in

Effect of a nutrient mixture on matrix metalloproteinase-9 dimers in various human cancer cell lines.

M W Roomi et al.

International journal of oncology, 44(3), 986-992 (2014-01-01)

Strong clinical and experimental evidence demonstrates association of elevated levels of matrix metalloproteinase MMP-9 with cancer progression, metastasis and shortened patient survival, as it plays a key role in tumor cell invasion and metastasis by digesting the basement membrane and

N-acetylcysteine alleviates the meconium-induced acute lung injury.

D Mokra et al.

Advances in experimental medicine and biology, 832, 59-67 (2014-10-11)

Meconium aspiration in newborns causes lung inflammation and injury, which may lead to meconium aspiration syndrome (MAS). In this study, the effect of the antioxidant N-acetylcysteine on respiratory and inflammatory parameters were studied in a model of MAS. Oxygen-ventilated rabbits

Eupafolin inhibits PGE2 production and COX2 expression in LPS-stimulated human dermal fibroblasts by blocking JNK/AP-1 and Nox2/p47(phox) pathway.

Ming-Horng Tsai et al.

Toxicology and applied pharmacology, 279(2), 240-251 (2014-06-27)

Eupafolin, a major active component found in the methanol extracts of Phyla nodiflora, has been used to treat inflammation of skin. We examined its effects on cyclooxygenase-2 (COX-2) expression in LPS-treated human dermal fibroblasts. Lipopolysaccharide (LPS) significantly increased prostaglandin-E2 (PGE2)

Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and mitochondrial dysfunction.

Muhammad Khan et al.

BioMed research international, 2013, 719858-719858 (2013-03-28)

Signal transducer and activator of transcription 3 (STAT3) constitutively expresses in human liver cancer cells and has been implicated in apoptosis resistance and tumorigenesis. Alantolactone, a sesquiterpene lactone, has been shown to possess anticancer activities in various cancer cell lines.

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