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Showing 1-30 of 661 results for "PHR1101" within Papers
Nicola Ciliberti et al.
Phytopathology, 105(3), 325-333 (2014-10-30)
The effect of temperature and wetness duration on infection of Vitis vinifera inflorescences (from "inflorescence clearly visible" to "end of flowering" stages) and young berry clusters (at "fruit swelling" and "berries groat-sized" stages) by Botrytis cinerea was investigated. Artificial inoculations
Daniela Michlmayr et al.
Journal of virology, 88(17), 9553-9567 (2014-06-06)
The encephalitic response to viral infection requires local chemokine production and the ensuing recruitment of immune and inflammatory leukocytes. Accordingly, chemokine receptors present themselves as plausible therapeutic targets for drugs aimed at limiting encephalitic responses. However, it remains unclear which
Jef Stappaerts et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 90, 1-7 (2015-01-17)
The aim of this study was to evaluate the intestinal disposition of abiraterone acetate, an ester prodrug of the anticancer agent abiraterone. Stability of the prodrug and solubility and dissolution characteristics of both abiraterone and abiraterone acetate were monitored in
Kaitlyn E Moore et al.
Biochimica et biophysica acta, 1839(12), 1395-1403 (2014-02-25)
The dynamic modification of histone proteins by lysine methylation has emerged over the last decade as a key regulator of chromatin functions. In contrast, our understanding of the biological roles for lysine methylation of non-histone proteins has progressed more slowly.
Anneli Julander et al.
Environment international, 73, 243-251 (2014-10-11)
Electrical and electronic waste (e-waste) contains multiple toxic metals. However, there is currently a lack of exposure data for metals on workers in formal recycling plants. The objective of this study was to evaluate workers' exposure to metals, using biomarkers
Jee-Yeon Hwang et al.
Journal of molecular biology, 426(20), 3454-3466 (2014-08-12)
The gene silencing transcription factor REST [repressor element 1 silencing transcription factor]/NRSF (neuron-restrictive silencer factor) actively represses a large array of coding and noncoding neuron-specific genes important to synaptic plasticity including miR-132. miR-132 is a neuron-specific microRNA and plays a
Edward Rockenstein et al.
Brain : a journal of neurology, 137(Pt 5), 1496-1513 (2014-03-26)
In Parkinson's disease and dementia with Lewy bodies, α-synuclein aggregates to form oligomers and fibrils; however, the precise nature of the toxic α-synuclein species remains unclear. A number of synthetic α-synuclein mutations were recently created (E57K and E35K) that produce
Kazuyuki Miyamoto et al.
Journal of molecular neuroscience : MN, 54(3), 370-379 (2014-06-09)
The production of reactive oxygen species (ROS) and the resulting oxidative stress in mice in response to a controlled cortical impact (CCI) are typical exacerbating factors associated with traumatic brain injury (TBI). Pituitary adenylate cyclase-activating polypeptide 38 (PACAP38) is a
Lipeng Han et al.
Journal of food protection, 76(5), 912-918 (2013-05-07)
Ne-Carboxymethyllysine (CML), a representative of advanced glycation end products (AGEs), is commonly found in food and is considered a potential hazard to human health. Food scientists have begun to investigate the formation of CML in food processes. As the understanding
Nicholas A Bedard et al.
The Journal of arthroplasty, 29(10), 1961-1969 (2014-06-19)
Long term total hip arthroplasty follow-up has demonstrated bearing surface wear and failure of fixation as the major modes of failure. The purpose of this study was to evaluate the minimum 10year results of a third generation cementless acetabular component
Takumi Yamane et al.
Bioscience, biotechnology, and biochemistry, 79(2), 185-189 (2014-11-25)
The effects of modern dressings on inflammation, which represent the earliest phase of wound healing, are poorly understood. We investigated the effects of modern hydrocellular foam dressings (HCFs) on wound healing and on the gene expression levels of the inflammatory
Danielle E Fortune et al.
Infection and immunity, 82(8), 3186-3198 (2014-05-21)
Decorin-binding protein A (DbpA) of Borrelia burgdorferi mediates bacterial adhesion to heparin and dermatan sulfate associated with decorin. Lysines K82, K163, and K170 of DbpA are known to be important for in vitro interaction with decorin, and the DbpA structure
Jingming Li et al.
Journal of diabetes research, 2015, 963289-963289 (2015-04-14)
NADPH oxidase 4 (Nox4) is a major isoform of NADPH oxidase in retinal endothelial cells. Our previous study suggests that upregulation of Nox4 in retinal endothelial cells contributes to retinal vascular leakage in diabetes. In the current study, we investigated
Mei-Ying Liao et al.
International journal of oncology, 46(4), 1788-1800 (2015-02-06)
We have generated a novel monoclonal antibody (mAb), OCAb9-1, which specifically binds to various types of cancer cell lines, but not to normal cells. According to the results of immunoaffinity chromatography, LC-MS/MS analysis, co-immunoprecipitation, and RNA interference studies, the target
Kei Kimura et al.
Applied and environmental microbiology, 81(3), 1120-1131 (2014-12-03)
Recent studies have suggested that diatom viruses are an important factor affecting diatom population dynamics, which in turn are important in considering marine primary productivity. The marine planktonic diatom Chaetoceros tenuissimus Meunier is a cosmopolitan species and often causes blooms
Faruk Turgay et al.
Journal of atherosclerosis and thrombosis, 22(3), 313-326 (2015-03-05)
Paraoxonase-1 (PON1) is an antiatherosclerotic enzyme located on high-density lipoprotein (HDL). The effects of anaerobic exercise on PON1 activity are unknown. Here we investigated the effects of anaerobic judo training on three different activities of same PON1 enzyme (TDPON1), including
Yasuo Uchida et al.
Drug metabolism and disposition: the biological fate of chemicals, 42(10), 1719-1726 (2014-07-26)
The purpose of this study was to demonstrate experimentally that alterations of in vivo transporter function at the blood-brain barrier (BBB) in disease and during pharmacotherapy can be reconstructed from in vitro data based on our established pharmacoproteomic concept of
Abderrahmane Kaidi et al.
Nature, 498(7452), 70-74 (2013-05-28)
The detection of DNA lesions within chromatin represents a critical step in cellular responses to DNA damage. However, the regulatory mechanisms that couple chromatin sensing to DNA-damage signalling in mammalian cells are not well understood. Here we show that tyrosine
Erika L Pfaunmiller et al.
Journal of chromatography. A, 1366, 92-100 (2014-09-30)
One-site immunometric assays that utilize affinity microcolumns were developed and evaluated for the analysis of protein biomarkers. This approach used labeled antibodies that were monitored through on-line fluorescence or near-infrared (NIR) fluorescence detection. Human serum albumin (HSA) was utilized as
Liang Ma et al.
Cell research, 25(1), 24-38 (2014-10-25)
Cells communicate with each other through secreting and releasing proteins and vesicles. Many cells can migrate. In this study, we report the discovery of migracytosis, a cell migration-dependent mechanism for releasing cellular contents, and migrasomes, the vesicular structures that mediate
Oday Alsarraf et al.
Experimental eye research, 127, 124-131 (2014-07-30)
Neuroretinal ischemic injury contributes to several degenerative diseases in the eye and the resulting pathogenic processes involving a series of necrotic and apoptotic events. This study investigates the time and extent of changes in acetylation, and whether this influences function
Dragana Mutavdžić Pavlović et al.
Talanta, 131, 99-107 (2014-10-05)
The molecularly imprinted polymers (MIPs) with sulfaguanidine as a template, methacrylic acid, 4-vinylpyridine, and 2-hydroxyethyl methacrylate as functional monomers, ethylene glycol dimethacrylate as a cross-linker and 2,2'-azobis-isobutyronitrile as an initiator have been prepared through the cross-link reaction of polymerization. Solid-phase
Characterization of THB1, a Chlamydomonas reinhardtii truncated hemoglobin: linkage to nitrogen metabolism and identification of lysine as the distal heme ligand.
Johnson EA, Rice SL, Preimesberger MR, et al.
Biochemistry, 53(28), 4573-4589 (2014)
Dan-ju Tso et al.
Journal of molecular biology, 426(10), 2112-2129 (2014-03-25)
The G-loop is a 10-residue glycine-rich loop that protrudes from the surface of the mature bacteriophage HK97 capsid at the C-terminal end of the long backbone helix of major capsid protein subunits. The G-loop is essential for assembly, is conserved
Thomas H King et al.
PloS one, 9(7), e101904-e101904 (2014-07-23)
Chronic hepatitis B infection (CHB) is characterized by sub-optimal T cell responses to viral antigens. A therapeutic vaccine capable of restoring these immune responses could potentially improve HBsAg seroconversion rates in the setting of direct acting antiviral therapies. A yeast-based
Toshie Takahashi et al.
Lipids, 49(9), 905-917 (2014-08-12)
It has been recognized that human hair lipids play crucial roles in the integrity of cells and matrices, while the details of distribution and structure of the minor lipids are hardly known. Here we investigated the lipids at the hair
Qian-Qian Li et al.
Physiology & behavior, 139, 482-490 (2014-12-08)
Acupuncture has beneficial effects in vascular dementia (VaD) patients. The underlying mechanism, however, remains unknown. The present study was designed to investigate whether the cAMP/PKA/CREB cascade is involved in the mechanism of acupuncture in cerebral multi-infarction rats. In this study
Zhengzhao Liu et al.
Cancer cell, 26(1), 106-120 (2014-07-16)
In selective autophagy, receptors are central for cargo selection and delivery. However, it remains yet unclear whether and how multiple autophagy receptors might form complex and function concertedly to control autophagy. Optineurin (OPTN), implicated genetically in glaucoma and amyotrophic lateral
Takahiro Murai et al.
Xenobiotica; the fate of foreign compounds in biological systems, 44(11), 996-1008 (2014-06-10)
1. The biotransformation and disposition of tivantinib in humans, dogs and rats was examined after a single oral administration of [(14)C]tivantinib. Tivantinib constituted no more than one-third of the plasma radioactivity in all species, demonstrating significant contribution of the metabolites
Tetsuya Imamura et al.
International journal of urology : official journal of the Japanese Urological Association, 21(10), 1051-1058 (2014-05-09)
This study determined if muscarinic receptors could mediate the cold stress-induced detrusor overactivity induced in type 2 diabetes mellitus rats. Ten-week-old female Goto-Kakizaki diabetic rats (n = 12) and Wister Kyoto non-diabetic rats (n = 12) were maintained on a high-fat diet for 4 weeks. Cystometric
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