phr1130

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Showing 31-49 of 49 results for "phr1130" within Papers

Conformationally sensitive proximity of extracellular loops 2 and 4 of the γ-aminobutyric acid (GABA) transporter GAT-1 inferred from paired cysteine mutagenesis.

Maram Hilwi et al.

The Journal of biological chemistry, 289(49), 34258-34266 (2014-10-24)

The sodium- and chloride-coupled GABA transporter GAT-1 is a member of the neurotransmitter:sodium:symporters, which are crucial for synaptic transmission. Structural work on the bacterial homologue LeuT suggests that extracellular loop 4 closes the extracellular solvent pathway when the transporter becomes

Depression of excitatory synapses onto parvalbumin interneurons in the medial prefrontal cortex in susceptibility to stress.

Zinaida Perova et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(7), 3201-3206 (2015-02-24)

In response to extreme stress, individuals either show resilience or succumb to despair. The prefrontal cortex (PFC) is required for coping with stress, and PFC dysfunction has been implicated in stress-related mental disorders, including depression. Nevertheless, the mechanisms by which

Copper inclusion in cellulose using sodium D-gluconate complexes.

Hossam E Emam et al.

Carbohydrate polymers, 90(3), 1345-1352 (2012-09-04)

Copper containing cellulose material is of growing interest, e.g. offering alternative in the field of antimicrobials. Solutions of copper d-gluconate complexes (Cu(2+)-DGL) were used to introduce copper ions into a swollen cellulosic matrix. A ligand exchange mechanism forms the chemical

CIEL*a*b* parameters of white dehydrated grapes as quality markers according to chemical composition, volatile profile and mechanical properties.

Luca Rolle et al.

Analytica chimica acta, 732, 105-113 (2012-06-13)

In the oenological sector, the withering process is of particular importance in the production of dry and sweet dessert wines due to the total or partial use of overripe and/or dehydrated grapes. This complex process leads to several changes in

Disruption of a neural microcircuit in the rod pathway of the mammalian retina by diabetes mellitus.

Áurea Castilho et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(13), 5422-5433 (2015-04-04)

Diabetes leads to dysfunction of the neural retina before and independent of classical microvascular diabetic retinopathy, but previous studies have failed to demonstrate which neurons and circuits are affected at the earliest stages. Here, using patch-clamp recording and two-photon Ca(2+)

In vivo two-photon imaging of structural dynamics in the spinal dorsal horn in an inflammatory pain model.

Shinji Matsumura et al.

The European journal of neuroscience, 41(7), 989-997 (2015-02-04)

Two-photon microscopy imaging has recently been applied to the brain to clarify functional and structural synaptic plasticity in adult neural circuits. Whereas the pain system in the spinal cord is phylogenetically primitive and easily exhibits behavioral changes such as hyperalgesia

[Permeability of pannexin 1 channels to large anions].

R A Romanov et al.

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova, 98(12), 1578-1586 (2013-03-07)

It is widely accepted that ATP secretion in diverse cells involves pannexin 1 (Panx1) that functions as an ATP-permeable channel. We analyzed the permeability of Panx1 channels heterologically expressed in HEK-293 cells to a variety of anions, including ATP. As

The efficacy of zinc supplementation in young children with acute lower respiratory infections: a randomized double-blind controlled trial.

Ubaid H Shah et al.

Clinical nutrition (Edinburgh, Scotland), 32(2), 193-199 (2012-09-18)

Acute lower respiratory infections are the most frequent illnesses globally in children less than 5 years old. The aim of this randomized double blind controlled trial is to assess the effectiveness of zinc gluconate supplementation for 2 months period compared

Dimethyl sulfoxide at high concentrations inhibits non-selective cation channels in human erythrocytes.

Oleg A Nardid et al.

General physiology and biophysics, 32(1), 23-32 (2013-03-28)

Dimethyl sulfoxide (DMSO), a by-product of the pulping industry, is widely used in biological research, cryobiology and medicine. On cellular level DMSO was shown to suppress NMDA-AMPA channels activation, blocks Na+ channel activation and attenuates Ca2+ influx (Lu and Mattson

Genes for carbon metabolism and the ToxA virulence factor in Pseudomonas aeruginosa are regulated through molecular interactions of PtxR and PtxS.

Abdelali Daddaoua et al.

PloS one, 7(7), e39390-e39390 (2012-07-31)

Homologs of the transcriptional regulator PtxS are omnipresent in Pseudomonas, whereas PtxR homologues are exclusively found in human pathogenic Pseudomonas species. In all Pseudomonas sp., PtxS with 2-ketogluconate is the regulator of the gluconate degradation pathway and controls expression from

[Item 232--Facial dermatoses: acne].

Annales de dermatologie et de venereologie, 139(11 Suppl), A192-A196 (2012-12-05)

Oral administration of an anti-inflammatory does not compromise the efficacy of intra-testicular injection of zinc gluconate as a contraceptive for dogs.

Erika C S Oliveira et al.

Animal reproduction science, 132(3-4), 207-212 (2012-06-12)

The objective was to determine whether the efficacy of zinc gluconate (Testoblock(®)) as a chemical contraceptive in male dogs was compromised in the presence of metamizole sodium (a nonsteroidal antiinflammatory/analgesic agent). Ten sexually mature mongrel dogs were assigned to two

Aggregation and structural changes of silver carp actomyosin as affected by mild acidification with D-gluconic acid δ-lactone.

Yanshun Xu et al.

Food chemistry, 134(2), 1005-1010 (2012-10-31)

The structural changes and aggregation properties of silver carp actomyosin acidified with d-gluconic acid-δ-lactone (GDL) were investigated. Results showed that silver carp actomyosin underwent aggregation and formation of precipitate as indicated by turbidity and centrifugation coupled electrophoresis analysis. Circular dichroism

Intrinsic neurophysiological properties of hilar ectopic and normotopic dentate granule cells in human temporal lobe epilepsy and a rat model.

A L Althaus et al.

Journal of neurophysiology, 113(4), 1184-1194 (2014-11-28)

Hilar ectopic dentate granule cells (DGCs) are a salient feature of aberrant plasticity in human temporal lobe epilepsy (TLE) and most rodent models of the disease. Recent evidence from rodent TLE models suggests that hilar ectopic DGCs contribute to hyperexcitability

Elevated urine zinc concentration reduces the detection of methamphetamine, cocaine, THC and opiates in urine by EMIT.

Chia-Ni Lin et al.

Journal of analytical toxicology, 37(9), 665-669 (2013-07-12)

Methods for circumventing positive drug tests continue to evolve and are often spread through internet websites reporting on the proposed effectiveness of various adulteration methods. Recent claims of the use of zinc added directly to urine or ingested prior to

The palmitoyl acyltransferase DHHC2 regulates recycling endosome exocytosis and synaptic potentiation through palmitoylation of AKAP79/150.

Kevin M Woolfrey et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(2), 442-456 (2015-01-16)

Phosphorylation and dephosphorylation of AMPA-type ionotropic glutamate receptors (AMPARs) by kinases and phosphatases and interactions with scaffold proteins play essential roles in regulating channel biophysical properties and trafficking events that control synaptic strength during NMDA receptor-dependent synaptic plasticity, such as

Metabolite profiling to characterize disease-related bacteria: gluconate excretion by Pseudomonas aeruginosa mutants and clinical isolates from cystic fibrosis patients.

Volker Behrends et al.

The Journal of biological chemistry, 288(21), 15098-15109 (2013-04-11)

Metabolic footprinting of supernatants has been proposed as a tool for assigning gene function. We used NMR spectroscopy to measure the exometabolome of 86 single-gene transposon insertion mutant strains (mutants from central carbon metabolism and regulatory mutants) of the opportunistic

Evaluation of the suppressive effect on bitter taste of gluconate.

Masataka Narukawa et al.

Bioscience, biotechnology, and biochemistry, 76(12), 2282-2288 (2012-12-12)

Gluconate is used as an additive in a wide range of processed foods. In this study, we investigated its utility as a taste-improving substance. To determine whether it has a suppressive effect on bitter taste, sensory evaluations were performed by

A basic consideration for porcine liver preservation using a novel continuous machine perfusion device.

T Shigeta et al.

Transplantation proceedings, 44(4), 942-945 (2012-05-09)

The aims of this study were to compare extracellular and intracellular-type University of Wisconsin (UW) solutions for liver grafts and to assess oxygenation in this perfusion system. The organ preservation system consisted of 3 circulating systems for the portal vein

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