PHR1241

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Showing 1-30 of 187 results for "PHR1241" within Papers

Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells.

Feiran Zhang et al.

Journal of medicinal chemistry, 56(10), 3996-4016 (2013-05-03)

Methionine aminopeptidases (MetAPs), which remove the initiator methionine from nascent peptides, are essential in all organisms. While MetAP2 has been demonstrated to be a therapeutic target for inhibiting angiogenesis in mammals, MetAP1 seems to be vital for cell proliferation. Our

Pharmacological inhibition of dynamin II reduces constitutive protein secretion from primary human macrophages.

Maaike Kockx et al.

PloS one, 9(10), e111186-e111186 (2014-10-28)

Dynamins are fission proteins that mediate endocytic and exocytic membrane events and are pharmacological therapeutic targets. These studies investigate whether dynamin II regulates constitutive protein secretion and show for the first time that pharmacological inhibition of dynamin decreases secretion of

Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA.

S Ishiwata et al.

The Tohoku journal of experimental medicine, 176(1), 61-68 (1995-05-01)

To evaluate the clinical usefulness of serum 1-methyladenosine, several modifications have been made in our previously established inhibition ELISA system. Horseradish peroxidase (HRP) labeled anti-mouse IgG and 3,3',5,5'-tetramethylbenzidine (TMBZ) were used as a secondary antibody and a substrate, respectively. The

Methionine metabolism: major pathways and enzymes involved and strategies for control and diversification of volatile sulfur compounds in cheese.

María Del Carmen Martínez-Cuesta et al.

Critical reviews in food science and nutrition, 53(4), 366-385 (2013-01-17)

For economical reasons and to accommodate current market trends, cheese manufacturers and product developers are increasingly interested in controlling cheese flavor formation and developing new flavors. Due to their low detection threshold and diversity, volatile sulfur compounds (VSCs) are of

Initial clinical sensitivity and acquired resistance to MET inhibition in MET-mutated papillary renal cell carcinoma.

Jennifer R Diamond et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(16), e254-e258 (2013-04-24)

Detection of heterozygotes for homocystinuria. Study of sulphur-containing amino acids in plasma and urine after L-methionine loading.

I B Sardharwalla et al.

Archives of disease in childhood, 49(7), 553-559 (1974-07-01)

GH administration rescues fatty liver regeneration impairment by restoring GH/EGFR pathway deficiency.

A Collin de l'Hortet et al.

Endocrinology, 155(7), 2545-2554 (2014-04-09)

GH pathway has been shown to play a major role in liver regeneration through the control of epidermal growth factor receptor (EGFR) activation. This pathway is down-regulated in nonalcoholic fatty liver disease. Because regeneration is known to be impaired in

Ion-chromatographic determination of carbocisteine in pharmaceuticals based on non-suppressed conductimetric detection

Megoulas NC and Koupparis MA

Journal of Chromatography A, 1026(1-2), 167-174 (2004)

Circulating levels of apelin, glucagon-like peptide and visfatin in hypercholesterolemic-hyperhomocysteinemic guinea-pigs: their relation with NO metabolism.

Zeynep Kusku-Kiraz et al.

Molecular and cellular biochemistry, 400(1-2), 69-75 (2014-11-09)

The aim of this study was to determine the levels of regulatory peptides apelin, glucagon-like peptide (GLP-1) and visfatin in hypercholesterolemic and hyperhomocysteinemic state and to examine their relation with nitric oxide (NO) metabolism. 32 Male guinea pigs were divided

Probing the paramyxovirus fusion (F) protein-refolding event from pre- to postfusion by oxidative footprinting.

Taylor A Poor et al.

Proceedings of the National Academy of Sciences of the United States of America, 111(25), E2596-E2605 (2014-06-14)

To infect a cell, the Paramyxoviridae family of enveloped viruses relies on the coordinated action of a receptor-binding protein (variably HN, H, or G) and a more conserved metastable fusion protein (F) to effect membrane fusion and allow genomic transfer.

Correction of the consequences of mitochondrial 3243A>G mutation in the MT-TL1 gene causing the MELAS syndrome by tRNA import into mitochondria.

Olga Z Karicheva et al.

Nucleic acids research, 39(18), 8173-8186 (2011-07-05)

Mutations in human mitochondrial DNA are often associated with incurable human neuromuscular diseases. Among these mutations, an important number have been identified in tRNA genes, including 29 in the gene MT-TL1 coding for the tRNA(Leu(UUR)). The m.3243A>G mutation was described

Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome.

Kevin Guo et al.

Analytical chemistry, 81(10), 3919-3932 (2009-03-25)

We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be

Acute tryptophan depletion reduces kynurenine levels: implications for treatment of impaired visuospatial memory performance in irritable bowel syndrome.

Paul J Kennedy et al.

Psychopharmacology, 232(8), 1357-1371 (2014-10-24)

A visuospatial episodic memory impairment has recently been identified in irritable bowel syndrome. Increased tryptophan metabolism along the kynurenine pathway has also been reported in irritable bowel syndrome, which may play a role in altered cognitive performance as peripheral kynurenine

Pro-apoptotic and pro-autophagic effects of the Aurora kinase A inhibitor alisertib (MLN8237) on human osteosarcoma U-2 OS and MG-63 cells through the activation of mitochondria-mediated pathway and inhibition of p38 MAPK/PI3K/Akt/mTOR signaling pathway.

Ning-Kui Niu et al.

Drug design, development and therapy, 9, 1555-1584 (2015-03-21)

Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN8237) is a selective Aurora kinase A inhibitor that displays

A case of glioblastoma invasion clearly demonstrated on 11C-methionine positron emission tomography.

Makoto Ohno et al.

Japanese journal of clinical oncology, 43(4), 448-448 (2013-03-28)

Clinical outcome according to the level of preexisting epidermal growth factor receptor T790M mutation in patients with lung cancer harboring sensitive epidermal growth factor receptor mutations.

Youngjoo Lee et al.

Cancer, 120(14), 2090-2098 (2014-04-17)

Epidermal growth factor receptor (EGFR) T790M mutation drives acquired drug resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) in patients with EGFR-mutant lung cancer. However, it was reported that this mutation may exist before drug exposure. The objective of the current

DNA methylation potential: dietary intake and blood concentrations of one-carbon metabolites and cofactors in rural African women.

Paula Dominguez-Salas et al.

The American journal of clinical nutrition, 97(6), 1217-1227 (2013-04-12)

Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were

Alcohol, one-carbon nutrient intake, and risk of colorectal cancer according to tumor methylation level of IGF2 differentially methylated region.

Reiko Nishihara et al.

The American journal of clinical nutrition, 100(6), 1479-1488 (2014-11-21)

Although a higher consumption of alcohol, which is a methyl-group antagonist, was previously associated with colorectal cancer risk, mechanisms remain poorly understood. We hypothesized that excess alcohol consumption might increase risk of colorectal carcinoma with hypomethylation of insulin-like growth factor

Effects of randomized supplementation of methionine or alanine on cysteine and glutathione production during the early phase of treatment of children with edematous malnutrition.

Curtis O Green et al.

The American journal of clinical nutrition, 99(5), 1052-1058 (2014-03-07)

We have shown that a low glutathione concentration and synthesis rate in erythrocytes are associated with a shortage of protein-derived cysteine in children with edematous severe acute malnutrition (SAM). We tested the hypothesis that methionine supplementation may increase protein-derived cysteine

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

Filipe Cabreiro et al.

Cell, 153(1), 228-239 (2013-04-02)

The biguanide drug metformin is widely prescribed to treat type 2 diabetes and metabolic syndrome, but its mode of action remains uncertain. Metformin also increases lifespan in Caenorhabditis elegans cocultured with Escherichia coli. This bacterium exerts complex nutritional and pathogenic

PET in the clinical management of glioma: evidence map.

Takashi Nihashi et al.

AJR. American journal of roentgenology, 200(6), W654-W660 (2013-05-25)

Several studies have assessed PET to complement the anatomic information obtained from other imaging modalities in various clinical contexts for the management of glioma. We constructed an evidence map of clinical evidence on the use of PET in glioma and

[D-methionine as a protector for irradiation-induced oral mucositis and xerostomia].

Masanobu Yoshikawa

Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 141(6), 310-313 (2013-06-12)

Optimization and validation of a chiral GC-MS method for the determination of free D-amino acids ratio in human urine: application to a gestational diabetes mellitus study.

Ma Paz Lorenzo et al.

Journal of pharmaceutical and biomedical analysis, 107, 480-487 (2015-02-14)

Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance with onset or first recognition during pregnancy. It is affecting approximately up to 14% of all pregnancies with an increasing tendency. GDM has been related to relevant short-term and long-term health

Effects of hepatic protein tyrosine phosphatase 1B and methionine restriction on hepatic and whole-body glucose and lipid metabolism in mice.

Emma Katherine Lees et al.

Metabolism: clinical and experimental, 64(2), 305-314 (2014-12-04)

Methionine restriction (MR) and hepatic protein tyrosine phosphatase 1B (PTP1B) knockdown both improve hepatic insulin sensitivity by targeting different proteins within the insulin signaling pathway, as well as diminishing hepatic triglyceride content through decreasing hepatic lipogenesis. We hypothesized that a

Capillary electrophoresis with laser-induced fluorescence detection for studying amino acid uptake by yeast during beer fermentation.

Heidi Turkia et al.

Talanta, 131, 366-371 (2014-10-05)

The amino acid composition of cultivation broth is known to affect the biomass accumulation, productivity, and vitality of yeast during cultivation. A separation method based on capillary electrophoresis with laser-induced fluorescence (LIF) detection was developed for the determination of amino

Endogenous annexin A1 is a novel protective determinant in nonalcoholic steatohepatitis in mice.

Irene Locatelli et al.

Hepatology (Baltimore, Md.), 60(2), 531-544 (2014-03-29)

Annexin A1 (AnxA1) is an effector of the resolution of inflammation and is highly effective in terminating acute inflammatory responses. However, its role in chronic settings is less investigated. Because changes in AnxA1 expression within adipose tissue characterize obesity in

The inflammatory response to sciatic nerve injury in a familial amyloidotic polyneuropathy mouse model.

Goncalves NP, Teixeira-Coelho M, and Saraiva MJ

Experimental Neurology, 257, 76-87 (2014)

Tauroursodeoxycholic acid attenuates progression of steatohepatitis in mice fed a methionine-choline-deficient diet.

Cho EJ, Yoon JH, Kwak MS, et al.

Digestive Diseases and Sciences, 59(7), 1461-1474 (2014)

Reduction of MOPEG levels in cerebrospinal fluid of psychotic women after electroconvulsive treatment.

C Härnryd et al.

Psychopharmacology, 64(2), 131-134 (1979-08-08)

The effect of ECT on concentrations of monoamine metabolites in lumbar CSF of psychotic women with a schizophrenic symptomatology was examined. After a series of ECT there was a significant reduction of the concentration of the major noradrenaline metabolite, MOPEG.

Characterization of homocysteine γ-lyase from submerged and solid cultures of Aspergillus fumigatus ASH (JX006238).

Ashraf S El-Sayed et al.

Journal of microbiology and biotechnology, 23(4), 499-510 (2013-04-10)

Among 25 isolates, Aspergillus fumigatus ASH (JX006238) was identified as a potent producer of homocysteine gamma- lyase. The nutritional requirements to maximize the enzyme yield were optimized under submerged (SF) and solid-state fermentation (SSF) conditions, resulting in a 5.2- and

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