Search Within
PHR1241
Applied Filters:
Keyword:'PHR1241'
Showing 1-30 of 187 results for "PHR1241" within Papers
Seok-Min Kang et al.
Clinical biochemistry, 44(4), 293-299 (2010-12-21)
We sought to identify metabolic pathways characterizing human heart failure (HF) using ¹NMR based urinary metabolomic analysis in conjunction with multivariate statistics. Patients with systolic HF of ischemic origin (n=15) and healthy controls (n=20) participated in this study. Patients with
Yuta Ishizuka et al.
Journal of neurochemistry, 127(1), 66-77 (2013-07-12)
Growth factors and nutrients, such as amino acids and glucose, regulate mammalian target of rapamycin complex 1 (mTORC1) signaling and subsequent translational control in a coordinated manner. Brain-derived neurotrophic factor (BDNF), the most prominent neurotrophic factor in the brain, activates
A case of glioblastoma invasion clearly demonstrated on 11C-methionine positron emission tomography.
Makoto Ohno et al.
Japanese journal of clinical oncology, 43(4), 448-448 (2013-03-28)
Ning-Kui Niu et al.
Drug design, development and therapy, 9, 1555-1584 (2015-03-21)
Osteosarcoma (OS) is the most common malignant bone tumor occurring mostly in children and adolescents between 10 and 20 years of age with poor response to current therapeutics. Alisertib (ALS, MLN8237) is a selective Aurora kinase A inhibitor that displays
Adrian Drazic et al.
Biochimica et biophysica acta, 1844(8), 1367-1382 (2014-01-15)
Sulfur-containing amino acids such as cysteine and methionine are particularly vulnerable to oxidation. Oxidation of cysteine and methionine in their free amino acid form renders them unavailable for metabolic processes while their oxidation in the protein-bound state is a common
Mark G Jones et al.
Clinica chimica acta; international journal of clinical chemistry, 361(1-2), 150-158 (2005-07-05)
Previous work by others have suggested the occurrence of one or more chemical or metabolic 'markers' for ME/CFS including specific amino acids and organic acids and a number of unidentified compounds (CFSUM1, CFSUM2). We have shown elsewhere that CFSUM1 is
Paul J Kennedy et al.
Psychopharmacology, 232(8), 1357-1371 (2014-10-24)
A visuospatial episodic memory impairment has recently been identified in irritable bowel syndrome. Increased tryptophan metabolism along the kynurenine pathway has also been reported in irritable bowel syndrome, which may play a role in altered cognitive performance as peripheral kynurenine
Olga Z Karicheva et al.
Nucleic acids research, 39(18), 8173-8186 (2011-07-05)
Mutations in human mitochondrial DNA are often associated with incurable human neuromuscular diseases. Among these mutations, an important number have been identified in tRNA genes, including 29 in the gene MT-TL1 coding for the tRNA(Leu(UUR)). The m.3243A>G mutation was described
Taylor A Poor et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(25), E2596-E2605 (2014-06-14)
To infect a cell, the Paramyxoviridae family of enveloped viruses relies on the coordinated action of a receptor-binding protein (variably HN, H, or G) and a more conserved metastable fusion protein (F) to effect membrane fusion and allow genomic transfer.
Kevin Guo et al.
Analytical chemistry, 81(10), 3919-3932 (2009-03-25)
We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be
Ronald O Ball et al.
The Journal of nutrition, 136(6 Suppl), 1682S-1693S (2006-05-17)
Sulfur amino acid metabolism has been receiving increased attention because of the link to chronic diseases such as cardiovascular disease, Alzheimer's disease, and diabetes. In addition, the role of cysteine and optimal intakes for physiological substrates such as glutathione are
Youngjoo Lee et al.
Cancer, 120(14), 2090-2098 (2014-04-17)
Epidermal growth factor receptor (EGFR) T790M mutation drives acquired drug resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) in patients with EGFR-mutant lung cancer. However, it was reported that this mutation may exist before drug exposure. The objective of the current
Paula Dominguez-Salas et al.
The American journal of clinical nutrition, 97(6), 1217-1227 (2013-04-12)
Animal models show that periconceptional supplementation with folic acid, vitamin B-12, choline, and betaine can induce differences in offspring phenotype mediated by epigenetic changes in DNA. In humans, altered DNA methylation patterns have been observed in offspring whose mothers were
Maaike Kockx et al.
PloS one, 9(10), e111186-e111186 (2014-10-28)
Dynamins are fission proteins that mediate endocytic and exocytic membrane events and are pharmacological therapeutic targets. These studies investigate whether dynamin II regulates constitutive protein secretion and show for the first time that pharmacological inhibition of dynamin decreases secretion of
Adrian Drazic et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(23), 9493-9498 (2013-05-22)
Oxidant-mediated antibacterial response systems are broadly used to control bacterial proliferation. Hypochlorite (HOCl) is an important component of the innate immune system produced in neutrophils and specific epithelia. Its antimicrobial activity is due to damaging cellular macromolecules. Little is known
Ma Paz Lorenzo et al.
Journal of pharmaceutical and biomedical analysis, 107, 480-487 (2015-02-14)
Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance with onset or first recognition during pregnancy. It is affecting approximately up to 14% of all pregnancies with an increasing tendency. GDM has been related to relevant short-term and long-term health
Ashraf S El-Sayed et al.
Journal of microbiology and biotechnology, 23(4), 499-510 (2013-04-10)
Among 25 isolates, Aspergillus fumigatus ASH (JX006238) was identified as a potent producer of homocysteine gamma- lyase. The nutritional requirements to maximize the enzyme yield were optimized under submerged (SF) and solid-state fermentation (SSF) conditions, resulting in a 5.2- and
The inflammatory response to sciatic nerve injury in a familial amyloidotic polyneuropathy mouse model.
Goncalves NP, Teixeira-Coelho M, and Saraiva MJ
Experimental Neurology, 257, 76-87 (2014)
Barbara E Hasek et al.
Diabetes, 62(10), 3362-3372 (2013-06-27)
Dietary methionine restriction (MR) produces an integrated series of biochemical and physiological responses that improve biomarkers of metabolic health, limit fat accretion, and enhance insulin sensitivity. Using transcriptional profiling to guide tissue-specific evaluations of molecular responses to MR, we report
Fang Yang et al.
Biochimica et biophysica acta, 1837(10), 1674-1683 (2014-05-20)
How animals coordinate cellular bioenergetics in response to stress conditions is an essential question related to aging, obesity and cancer. Elongation factor 4 (EF4/LEPA) is a highly conserved protein that promotes protein synthesis under stress conditions, whereas its function in
Irene Locatelli et al.
Hepatology (Baltimore, Md.), 60(2), 531-544 (2014-03-29)
Annexin A1 (AnxA1) is an effector of the resolution of inflammation and is highly effective in terminating acute inflammatory responses. However, its role in chronic settings is less investigated. Because changes in AnxA1 expression within adipose tissue characterize obesity in
Reiko Nishihara et al.
The American journal of clinical nutrition, 100(6), 1479-1488 (2014-11-21)
Although a higher consumption of alcohol, which is a methyl-group antagonist, was previously associated with colorectal cancer risk, mechanisms remain poorly understood. We hypothesized that excess alcohol consumption might increase risk of colorectal carcinoma with hypomethylation of insulin-like growth factor
Tauroursodeoxycholic acid attenuates progression of steatohepatitis in mice fed a methionine-choline-deficient diet.
Cho EJ, Yoon JH, Kwak MS, et al.
Digestive Diseases and Sciences, 59(7), 1461-1474 (2014)
Victor Stollar et al.
PloS one, 8(3), e60504-e60504 (2013-04-02)
SVlm21 is a mutant of Sindbis virus which was isolated by serial passage of virus in mosquito cells maintained in low-methionine medium; it therefore has a low-methionine-resistant (LMR) phenotype. This phenotype requires mutations at nts 319 and 321; these mutations
Geumsoo Kim et al.
Biochimica et biophysica acta, 1840(2), 901-905 (2013-05-08)
Cysteine and methionine are the two sulfur containing amino acids in proteins. While the roles of protein-bound cysteinyl residues as endogenous antioxidants are well appreciated, those of methionine remain largely unexplored. We summarize the key roles of methionine residues in
Ion-chromatographic determination of carbocisteine in pharmaceuticals based on non-suppressed conductimetric detection
Megoulas NC and Koupparis MA
Journal of Chromatography A, 1026(1-2), 167-174 (2004)
Feiran Zhang et al.
Journal of medicinal chemistry, 56(10), 3996-4016 (2013-05-03)
Methionine aminopeptidases (MetAPs), which remove the initiator methionine from nascent peptides, are essential in all organisms. While MetAP2 has been demonstrated to be a therapeutic target for inhibiting angiogenesis in mammals, MetAP1 seems to be vital for cell proliferation. Our
A Collin de l'Hortet et al.
Endocrinology, 155(7), 2545-2554 (2014-04-09)
GH pathway has been shown to play a major role in liver regeneration through the control of epidermal growth factor receptor (EGFR) activation. This pathway is down-regulated in nonalcoholic fatty liver disease. Because regeneration is known to be impaired in
Detection of heterozygotes for homocystinuria. Study of sulphur-containing amino acids in plasma and urine after L-methionine loading.
I B Sardharwalla et al.
Archives of disease in childhood, 49(7), 553-559 (1974-07-01)
María Del Carmen Martínez-Cuesta et al.
Critical reviews in food science and nutrition, 53(4), 366-385 (2013-01-17)
For economical reasons and to accommodate current market trends, cheese manufacturers and product developers are increasingly interested in controlling cheese flavor formation and developing new flavors. Due to their low detection threshold and diversity, volatile sulfur compounds (VSCs) are of
Page 1 of 7