PHR1242

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Showing 31-60 of 234 results for "PHR1242" within Papers

Phosphoacceptors threonine 162 and serines 170 and 178 within the carboxyl-terminal RRRS/T motif of the hepatitis B virus core protein make multiple contributions to hepatitis B virus replication.

Jaesung Jung et al.

Journal of virology, 88(16), 8754-8767 (2014-05-23)

Phosphorylation of serines 157, 164, and 172 within the carboxyl-terminal SPRRR motif of the hepatitis B virus (HBV) core (C) protein modulates HBV replication at multiple stages. Threonine 162 and serines 170 and 178, located within the carboxyl-terminal conserved RRRS/T

Modulation of the intestinal environment, innate immune response, and barrier function by dietary threonine and purified fiber during a coccidiosis challenge in broiler chicks.

E L Wils-Plotz et al.

Poultry science, 92(3), 735-745 (2013-02-26)

Coccidiosis is a major contributor to economic losses in the poultry industry due to its detrimental effects on growth performance and nutrient utilization. We hypothesized that the combined effects of supplemental dietary Thr and purified fiber may modulate the intestinal

Differential effects of familial parkinson mutations in LRRK2 revealed by a systematic analysis of autophosphorylation.

Shogo Kamikawaji et al.

Biochemistry, 52(35), 6052-6062 (2013-08-09)

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been identified in pedigrees of autosomal-dominant familial Parkinson's disease (PARK8). It has been shown that the kinase activity of LRRK2 is required for its neuronal toxicity, although how familial Parkinson

Activity-dependent phosphorylation of MeCP2 threonine 308 regulates interaction with NCoR.

Daniel H Ebert et al.

Nature, 499(7458), 341-345 (2013-06-19)

Rett syndrome (RTT) is an X-linked human neurodevelopmental disorder with features of autism and severe neurological dysfunction in females. RTT is caused by mutations in methyl-CpG-binding protein 2 (MeCP2), a nuclear protein that, in neurons, regulates transcription, is expressed at

The role of Misshapen NCK-related kinase (MINK), a novel Ste20 family kinase, in the IRES-mediated protein translation of human enterovirus 71.

Shi Yun Leong et al.

PLoS pathogens, 11(3), e1004686-e1004686 (2015-03-10)

Human Enterovirus 71 (EV71) commonly causes Hand, Foot and Mouth Disease in young children, and occasional occurrences of neurological complications can be fatal. In this study, a high-throughput cell-based screening on the serine/threonine kinase siRNA library was performed to identify

Mechanism of chemical activation of sodium chloride in the presence of amino acids.

Anja K K Rahn et al.

Food chemistry, 166, 301-308 (2014-07-24)

Sodium chloride has been shown to promote chlorination of glycerol during thermal processing. However, the detailed mechanism of this reaction is not well understood. Preliminary experiments have indicated that the reaction mixture should contain an amino acid and it should

The anaerobic degradation of L-serine and L-threonine in enterobacteria: networks of pathways and regulatory signals.

G Sawers

Archives of microbiology, 171(1), 1-5 (1998-12-31)

The mechanisms controlling the biosynthesis and degradation of l-serine and l-threonine are remarkably complex. Their metabolism forms a network of pathways linking several amino acids, central primary metabolites such as pyruvate, oxaloacetate and 3-phosphoglycerate, and C1 metabolism. Studies on the

Prediction of serine/threonine phosphorylation sites in bacteria proteins.

Zhengpeng Li et al.

Advances in experimental medicine and biology, 827, 275-285 (2014-11-13)

As a critical post-translational modification, phosphorylation plays important roles in regulating various biological processes, while recent studies suggest that phosphorylation in bacteria is also critical for functional signaling transduction. Since identification of phosphorylation substrates and sites is fundamental for understanding

Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients.

Anna Walter et al.

Neurobiology of aging, 25(10), 1299-1303 (2004-10-07)

Experimental and clinical studies give evidence for breakdown of membrane phospholipids during neurodegeneration. In the present study, we measured the levels of glycerophosphocholine (GPCh), phosphocholine (PCh), and choline, that is, water-soluble metabolites of phosphatidylcholine (PtdCho), in human cerebrospinal fluid (CSF).

[Role of serine/threonine and tyrosine protein phosphatases in command Helix lucorum neurons at the cellular correlate of habituation].

A S Pivovarov et al.

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova, 63(2), 256-268 (2013-07-23)

Effects of some inhibitors of serine/threonine and tyrosine protein phosphatases on the depression and spontaneous recovery of the acetylcholine-induced inward current (ACh-current) in command Helix neurons of defensive behavior at the cellular correlate of habituation were investigated. The following drugs

Proton-nuclear-magnetic-resonance studies of serum, plasma and urine from fasting normal and diabetic subjects.

J K Nicholson et al.

The Biochemical journal, 217(2), 365-375 (1984-01-15)

Resonances for the ketone bodies 3-D-hydroxybutyrate, acetone and acetoacetate are readily detected in serum, plasma and urine samples from fasting and diabetic subjects by 1H n.m.r. spectroscopy at 400 MHz. Besides the simultaneous observation of metabolites, the major advantage of

Supplemental glycine and threonine effects on performance, intestinal mucosa development, and nutrient utilization of growing broiler chickens.

I C Ospina-Rojas et al.

Poultry science, 92(10), 2724-2731 (2013-09-21)

A study was conducted to evaluate Gly requirements in low-CP diets with different levels of digestible (dig) Thr, and their effects on performance, intestinal mucosal development, and nutrient utilization of broiler chickens from 21 to 35 d age. A total

Reduction of MOPEG levels in cerebrospinal fluid of psychotic women after electroconvulsive treatment.

C Härnryd et al.

Psychopharmacology, 64(2), 131-134 (1979-08-08)

The effect of ECT on concentrations of monoamine metabolites in lumbar CSF of psychotic women with a schizophrenic symptomatology was examined. After a series of ECT there was a significant reduction of the concentration of the major noradrenaline metabolite, MOPEG.

Children with severe asthma have unique oxidative stress-associated metabolomic profiles.

Anne M Fitzpatrick et al.

The Journal of allergy and clinical immunology, 133(1), 258-261 (2013-12-29)

Significance of αThr-349 in the catalytic sites of Escherichia coli ATP synthase.

Zulfiqar Ahmad et al.

Biochemistry, 53(47), 7376-7385 (2014-11-07)

This paper describes the role of α-subunit VISIT-DG sequence residue αThr-349 in the catalytic sites of Escherichia coli F1Fo ATP synthase. X-ray structures show the highly conserved αThr-349 in the proximity (2.68 Å) of the conserved phosphate binding residue βR182

Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA.

S Ishiwata et al.

The Tohoku journal of experimental medicine, 176(1), 61-68 (1995-05-01)

To evaluate the clinical usefulness of serum 1-methyladenosine, several modifications have been made in our previously established inhibition ELISA system. Horseradish peroxidase (HRP) labeled anti-mouse IgG and 3,3',5,5'-tetramethylbenzidine (TMBZ) were used as a secondary antibody and a substrate, respectively. The

Initial clinical sensitivity and acquired resistance to MET inhibition in MET-mutated papillary renal cell carcinoma.

Jennifer R Diamond et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(16), e254-e258 (2013-04-24)

[Regulation of receptor tyrosine kinases by Ser/Thr phosphorylation].

Yue Zhou et al.

Seikagaku. The Journal of Japanese Biochemical Society, 85(6), 462-468 (2013-07-24)

Identification of ubiquitin-modified lysine residues and novel phosphorylation sites on eukaryotic initiation factor 2B epsilon.

Alexander P Tuckow et al.

Biochemical and biophysical research communications, 436(1), 41-46 (2013-05-28)

Eukaryotic initiation factor 2Bε (eIF2Bε) plays a critical role in the initiation of mRNA translation and its expression and guanine nucleotide exchange activity are major determinants of the rate of protein synthesis. In this work we provide evidence that the

Cyclin-dependent kinase five mediates activation of lung xanthine oxidoreductase in response to hypoxia.

Bo S Kim et al.

PloS one, 10(4), e0124189-e0124189 (2015-04-02)

Xanthine oxidoreductase (XOR) is involved in oxidative metabolism of purines and is a source of reactive oxygen species (ROS). As such, XOR has been implicated in oxidant-mediated injury in multiple cardiopulmonary diseases. XOR enzyme activity is regulated, in part, via

Enhanced anticancer activity of a protein phosphatase 2A inhibitor on chemotherapy and radiation in head and neck squamous cell carcinoma.

Dong-wang Zhu et al.

Cancer letters, 356(2 Pt B), 773-780 (2014-12-03)

The aim of this study is to eliminate more cancer cells by promoting them from quiescence into cell cycle or by changing their molecular events, leading them to be sensitive to radiation or chemotherapy. Protein phosphatase 2A plays an important

Optimization and validation of a chiral GC-MS method for the determination of free D-amino acids ratio in human urine: application to a gestational diabetes mellitus study.

Ma Paz Lorenzo et al.

Journal of pharmaceutical and biomedical analysis, 107, 480-487 (2015-02-14)

Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance with onset or first recognition during pregnancy. It is affecting approximately up to 14% of all pregnancies with an increasing tendency. GDM has been related to relevant short-term and long-term health

Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease.

Takashi Abe et al.

Journal of neuroscience research, 70(3), 447-450 (2002-10-23)

To investigate the possible role of oxidative RNA damage in the pathogenesis of Alzheimer's disease (AD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) were measured in the cerebrospinal fluid (CSF) and the serum of patients with AD and

Roles of serine and threonine residues of mumps virus P protein in viral transcription and replication.

Adrian Pickar et al.

Journal of virology, 88(8), 4414-4422 (2014-02-07)

Mumps virus (MuV), a paramyxovirus containing a negative-sense nonsegmented RNA genome, is a human pathogen that causes an acute infection with symptoms ranging from parotitis to mild meningitis and severe encephalitis. Vaccination against mumps virus has been effective in reducing

Synthetic N- and O-glycosyl derivatives of L-asparagine, L-serine, and L-threonine.

H G Garg et al.

Advances in carbohydrate chemistry and biochemistry, 43, 135-201 (1985-01-01)

Clinical outcome according to the level of preexisting epidermal growth factor receptor T790M mutation in patients with lung cancer harboring sensitive epidermal growth factor receptor mutations.

Youngjoo Lee et al.

Cancer, 120(14), 2090-2098 (2014-04-17)

Epidermal growth factor receptor (EGFR) T790M mutation drives acquired drug resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) in patients with EGFR-mutant lung cancer. However, it was reported that this mutation may exist before drug exposure. The objective of the current

Group I metabotropic glutamate receptor-mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking.

Heath D Schmidt et al.

Addiction biology, 20(2), 285-296 (2014-02-11)

Emerging evidence indicates that type I metabotropic glutamate receptors (mGluRs) in the nucleus accumbens play a critical role in cocaine seeking. The present study sought to determine the role of accumbens core mGluR1, mGluR5 and protein kinase C (PKC) in

Oxidative stress induces phosphorylation of neuronal NOS in cardiomyocytes through AMP-activated protein kinase (AMPK).

Rekha Kar et al.

Biochemical and biophysical research communications, 459(3), 393-397 (2015-03-04)

Neuronal nitric oxide synthase (nNOS) plays a critical role in regulating cardiomyocyte function. nNOS was reported to decrease superoxide production in the myocardium by inhibiting the function of xanthine oxidoreductase. However, the effect of oxidative stress on nNOS in cardiomyocytes

Construction of L-lysine-, L-threonine-, and L-isoleucine-overproducing strains of Corynebacterium glutamicum.

H Sahm et al.

Annals of the New York Academy of Sciences, 782, 25-39 (1996-05-15)

The gram-negative bacterium Corynebacterium glutamicum is used for the industrial production of amino acids, for example, of L-glutamate and L-lysine. By cloning and expressing the various genes of the L-lysine pathway in C. glutamicum, we would demonstrate that an increase

Urine levels of N-[9-(beta-D-ribofuranosyl)purin-6-ylcarbamoyl]-L-threonine, N6-(delta 2-isopentenyl)adenosine, and 2'-O-methylguanosine as determined by radioimmunoassay for normal subjects and cancer patients.

B S Vold et al.

Cancer research, 42(12), 5265-5269 (1982-12-01)

Radioimmunoassays (RIA) are presented for the evaluation of the levels of the following three modified nucleosides in human urine: 2'-O-methylguanosine (Gm), N6-(delta 2-isopentenyl)adenosine (i6A), and N-[9-(beta-D-ribofuranosyl)purin-6-ylcarbamoyl]-L-threonine (t6A). Competitive inhibition of the RIA was provided by 2 to 10 microliters of

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