phr1242

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Showing 31-60 of 234 results for "phr1242" within Papers

Enhanced anticancer activity of a protein phosphatase 2A inhibitor on chemotherapy and radiation in head and neck squamous cell carcinoma.

Dong-wang Zhu et al.

Cancer letters, 356(2 Pt B), 773-780 (2014-12-03)

The aim of this study is to eliminate more cancer cells by promoting them from quiescence into cell cycle or by changing their molecular events, leading them to be sensitive to radiation or chemotherapy. Protein phosphatase 2A plays an important

Optimization and validation of a chiral GC-MS method for the determination of free D-amino acids ratio in human urine: application to a gestational diabetes mellitus study.

Ma Paz Lorenzo et al.

Journal of pharmaceutical and biomedical analysis, 107, 480-487 (2015-02-14)

Gestational Diabetes Mellitus (GDM) is defined as glucose intolerance with onset or first recognition during pregnancy. It is affecting approximately up to 14% of all pregnancies with an increasing tendency. GDM has been related to relevant short-term and long-term health

Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease.

Takashi Abe et al.

Journal of neuroscience research, 70(3), 447-450 (2002-10-23)

To investigate the possible role of oxidative RNA damage in the pathogenesis of Alzheimer's disease (AD), the concentrations of the oxidative stress marker 8-hydroxyguanosine (8-OHG) were measured in the cerebrospinal fluid (CSF) and the serum of patients with AD and

Clinical outcome according to the level of preexisting epidermal growth factor receptor T790M mutation in patients with lung cancer harboring sensitive epidermal growth factor receptor mutations.

Youngjoo Lee et al.

Cancer, 120(14), 2090-2098 (2014-04-17)

Epidermal growth factor receptor (EGFR) T790M mutation drives acquired drug resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs) in patients with EGFR-mutant lung cancer. However, it was reported that this mutation may exist before drug exposure. The objective of the current

Mechanism of chemical activation of sodium chloride in the presence of amino acids.

Anja K K Rahn et al.

Food chemistry, 166, 301-308 (2014-07-24)

Sodium chloride has been shown to promote chlorination of glycerol during thermal processing. However, the detailed mechanism of this reaction is not well understood. Preliminary experiments have indicated that the reaction mixture should contain an amino acid and it should

Significance of αThr-349 in the catalytic sites of Escherichia coli ATP synthase.

Zulfiqar Ahmad et al.

Biochemistry, 53(47), 7376-7385 (2014-11-07)

This paper describes the role of α-subunit VISIT-DG sequence residue αThr-349 in the catalytic sites of Escherichia coli F1Fo ATP synthase. X-ray structures show the highly conserved αThr-349 in the proximity (2.68 Å) of the conserved phosphate binding residue βR182

Akt kinase targets the association of CBP with histone H3 to regulate the acetylation of lysine K18.

Yan Liu et al.

FEBS letters, 587(7), 847-853 (2013-02-26)

CREB binding protein (CBP) is an acetyltransferase that plays an important role in many biological processes. Here, we show that Akt phosphorylates CBP at threonine 1871 and suppresses its acetyltransferase activity by impeding the binding of CBP to histone H3

Supplemental glycine and threonine effects on performance, intestinal mucosa development, and nutrient utilization of growing broiler chickens.

I C Ospina-Rojas et al.

Poultry science, 92(10), 2724-2731 (2013-09-21)

A study was conducted to evaluate Gly requirements in low-CP diets with different levels of digestible (dig) Thr, and their effects on performance, intestinal mucosal development, and nutrient utilization of broiler chickens from 21 to 35 d age. A total

Glycerophosphocholine is elevated in cerebrospinal fluid of Alzheimer patients.

Anna Walter et al.

Neurobiology of aging, 25(10), 1299-1303 (2004-10-07)

Experimental and clinical studies give evidence for breakdown of membrane phospholipids during neurodegeneration. In the present study, we measured the levels of glycerophosphocholine (GPCh), phosphocholine (PCh), and choline, that is, water-soluble metabolites of phosphatidylcholine (PtdCho), in human cerebrospinal fluid (CSF).

Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells.

Manish Tandon et al.

Breast cancer research : BCR, 16(1), R16-R16 (2014-02-01)

The Runt-related transcription factor Runx2 is critical for skeletal development but is also aberrantly expressed in breast cancers, and promotes cell growth and invasion. A de-regulated serine/threonine kinase Akt signaling pathway is implicated in mammary carcinogenesis and cell survival; however

MEKK2 kinase association with 14-3-3 protein regulates activation of c-Jun N-terminal kinase.

Adi E Matitau et al.

The Journal of biological chemistry, 288(39), 28293-28302 (2013-08-22)

MEKK2 (MAP/ERK kinase kinase-2) is a serine/threonine kinase that belongs to the MEKK/STE11 family of MAP kinase kinase kinases (MAP(3)Ks). MEKK2 integrates stress and mitogenic signals to the activation of NF-κB, JNK1/2, p38, and ERK5 pathways. We have found that

A novel ATP-generating machinery to counter nitrosative stress is mediated by substrate-level phosphorylation.

Christopher Auger et al.

Biochimica et biophysica acta, 1850(1), 43-50 (2014-10-12)

It is well-known that elevated amounts of nitric oxide and other reactive nitrogen species (RNS) impact negatively on the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. These perturbations severely compromise O2-dependent energy production. While bacteria are known to adapt to

Dietary threonine requirement of Pekin ducks from 15 to 35 days of age based on performance, yield, serum natural antibodies, and intestinal mucin secretion.

Q Zhang et al.

Poultry science, 93(8), 1972-1980 (2014-06-07)

A study was conducted to establish the dietary Thr requirement of Pekin ducks from 15 to 35 d of age. Experimental diets were formulated to contain 0.55, 0.60, 0.65, 0.75, and 0.85% Thr (0.57, 0.60, 0.64, 0.72, and 0.80% on

Consequences of a deficit in vitamin B6 biosynthesis de novo for hormone homeostasis and root development in Arabidopsis.

Svetlana Boycheva et al.

Plant physiology, 167(1), 102-117 (2014-12-06)

Vitamin B(6) (pyridoxal 5'-phosphate) is an essential cofactor of many metabolic enzymes. Plants biosynthesize the vitamin de novo employing two enzymes, pyridoxine synthase1 (PDX1) and PDX2. In Arabidopsis (Arabidopsis thaliana), there are two catalytically active paralogs of PDX1 (PDX1.1 and

Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes.

Serge Viatchenko-Karpinski et al.

Journal of molecular and cellular cardiology, 76, 247-256 (2014-09-25)

An increase of late Na(+) current (INaL) in cardiac myocytes can raise the cytosolic Na(+) concentration and is associated with activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and alterations of mitochondrial metabolism and Ca(2+) handling by sarcoplasmic reticulum (SR). We

PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway.

A Tsuchiya et al.

The Journal of endocrinology, 220(1), 49-59 (2013-10-31)

Insulin stimulated translocation of the glucose transporter GLUT4 from the cytosol to the plasma membrane in a concentration (1 nM-1 μM)-dependent manner and increased glucose uptake in 3T3-L1 adipocytes. Insulin-induced GLUT4 translocation to the cell surface was prevented by the

Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1.

Asataro Yamamoto et al.

The FEBS journal, 280(20), 5145-5159 (2013-08-21)

Superoxide production by Nox1, a member of the Nox family NAPDH oxidases, requires expression of its regulatory soluble proteins Noxo1 (Nox organizer 1) and Noxa1 (Nox activator 1) and is markedly enhanced upon cell stimulation with phorbol 12-myristate 13-acetate (PMA)

Comparison of serum and urinary levels of modified nucleoside, 1-methyladenosine, in cancer patients using a monoclonal antibody-based inhibition ELISA.

S Ishiwata et al.

The Tohoku journal of experimental medicine, 176(1), 61-68 (1995-05-01)

To evaluate the clinical usefulness of serum 1-methyladenosine, several modifications have been made in our previously established inhibition ELISA system. Horseradish peroxidase (HRP) labeled anti-mouse IgG and 3,3',5,5'-tetramethylbenzidine (TMBZ) were used as a secondary antibody and a substrate, respectively. The

Initial clinical sensitivity and acquired resistance to MET inhibition in MET-mutated papillary renal cell carcinoma.

Jennifer R Diamond et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(16), e254-e258 (2013-04-24)

Capillary electrophoresis with laser-induced fluorescence detection for studying amino acid uptake by yeast during beer fermentation.

Heidi Turkia et al.

Talanta, 131, 366-371 (2014-10-05)

The amino acid composition of cultivation broth is known to affect the biomass accumulation, productivity, and vitality of yeast during cultivation. A separation method based on capillary electrophoresis with laser-induced fluorescence (LIF) detection was developed for the determination of amino

Phosphorylation-specific prolyl isomerization: is there an underlying theme?

Gerburg Wulf et al.

Nature cell biology, 7(5), 435-441 (2005-05-04)

The prolyl isomerase Pin1 is a conserved enzyme that is intimately involved in diverse biological processes and pathological conditions such as cancer and Alzheimer's disease. By catalysing cis-trans interconversion of certain motifs containing phosphorylated serine or threonine residues followed by

Group I metabotropic glutamate receptor-mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking.

Heath D Schmidt et al.

Addiction biology, 20(2), 285-296 (2014-02-11)

Emerging evidence indicates that type I metabotropic glutamate receptors (mGluRs) in the nucleus accumbens play a critical role in cocaine seeking. The present study sought to determine the role of accumbens core mGluR1, mGluR5 and protein kinase C (PKC) in

Synthetic N- and O-glycosyl derivatives of L-asparagine, L-serine, and L-threonine.

H G Garg et al.

Advances in carbohydrate chemistry and biochemistry, 43, 135-201 (1985-01-01)

Oxidative stress induces phosphorylation of neuronal NOS in cardiomyocytes through AMP-activated protein kinase (AMPK).

Rekha Kar et al.

Biochemical and biophysical research communications, 459(3), 393-397 (2015-03-04)

Neuronal nitric oxide synthase (nNOS) plays a critical role in regulating cardiomyocyte function. nNOS was reported to decrease superoxide production in the myocardium by inhibiting the function of xanthine oxidoreductase. However, the effect of oxidative stress on nNOS in cardiomyocytes

Construction of L-lysine-, L-threonine-, and L-isoleucine-overproducing strains of Corynebacterium glutamicum.

H Sahm et al.

Annals of the New York Academy of Sciences, 782, 25-39 (1996-05-15)

The gram-negative bacterium Corynebacterium glutamicum is used for the industrial production of amino acids, for example, of L-glutamate and L-lysine. By cloning and expressing the various genes of the L-lysine pathway in C. glutamicum, we would demonstrate that an increase

Urine levels of N-[9-(beta-D-ribofuranosyl)purin-6-ylcarbamoyl]-L-threonine, N6-(delta 2-isopentenyl)adenosine, and 2'-O-methylguanosine as determined by radioimmunoassay for normal subjects and cancer patients.

B S Vold et al.

Cancer research, 42(12), 5265-5269 (1982-12-01)

Radioimmunoassays (RIA) are presented for the evaluation of the levels of the following three modified nucleosides in human urine: 2'-O-methylguanosine (Gm), N6-(delta 2-isopentenyl)adenosine (i6A), and N-[9-(beta-D-ribofuranosyl)purin-6-ylcarbamoyl]-L-threonine (t6A). Competitive inhibition of the RIA was provided by 2 to 10 microliters of

Structural biology. Structural basis for Notch1 engagement of Delta-like 4.

Vincent C Luca et al.

Science (New York, N.Y.), 347(6224), 847-853 (2015-02-24)

Notch receptors guide mammalian cell fate decisions by engaging the proteins Jagged and Delta-like (DLL). The 2.3 angstrom resolution crystal structure of the interacting regions of the Notch1-DLL4 complex reveals a two-site, antiparallel binding orientation assisted by Notch1 O-linked glycosylation.

Differential 12C-/13C-isotope dansylation labeling and fast liquid chromatography/mass spectrometry for absolute and relative quantification of the metabolome.

Kevin Guo et al.

Analytical chemistry, 81(10), 3919-3932 (2009-03-25)

We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be

Development of phosphatase inhibitor-1 peptides acting as indirect activators of phosphatase 1.

Hannieh Sotoud et al.

Naunyn-Schmiedeberg's archives of pharmacology, 388(3), 283-293 (2014-11-25)

Phosphatase inhibitor-1 (I-1) inhibits the catalytic subunit of protein phosphatase type 1 (PP1c) in its protein kinase A (PKA)-phosphorylated form (I-1(P)). It thereby amplifies PKA signaling, which, in the heart, mediates both beneficial (acute) and adverse (chronic) effects of catecholamines.

Diphenyl ditelluride-induced cell cycle arrest and apoptosis: a relation with topoisomerase I inhibition.

Patrícia M Jorge et al.

Basic & clinical pharmacology & toxicology, 116(3), 273-280 (2014-08-30)

The diphenyl ditelluride (DPDT) is a prototype for the development of new biologically active molecules. In previous studies, DPDT showed an elevated cytotoxicity in Chinese hamster fibroblast (V79) cells but the mechanisms for reduction of cell viability still remain unknown.

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