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Showing 1-30 of 54 results for "PHR1265" within Papers
James J DiNicolantonio et al.
The American journal of cardiology, 113(3), 565-569 (2013-12-18)
A systematic review and meta-analysis was performed to evaluate the effects of carvedilol versus metoprolol on the incidence of postoperative atrial fibrillation in patients undergoing coronary artery bypass grafting in randomized controlled trials. Ovid MEDLINE, PubMed, CENTRAL, and Excepta Medica
James J DiNicolantonio et al.
Expert review of cardiovascular therapy, 10(1), 13-25 (2011-12-14)
β-Blockers are a standard of care in many clinical settings such as acute myocardial infarction, heart failure and patients at risk for a coronary event. However, not all β-blockers are the same and they vary in properties such as lipophilicity
Tonino Stati et al.
Journal of cardiovascular pharmacology, 64(1), 21-27 (2014-03-14)
Recent results indicate that the reduction of β-adrenergic signaling impairs angiogenesis under ischemic conditions. Because angiogenesis may occur in the absence of ischemia, it remains to be determined whether and how β-adrenergic signaling regulates angiogenesis, which develops under normoxic conditions.
Congjie Pan et al.
Journal of chromatography. A, 1388, 207-216 (2015-03-03)
Homochiral metal-organic frameworks (MOFs) are promising as porous stationary phase for open-tubular capillary electrochromatography (OT-CEC) enantioseparation owing to their fine-tuned pore sizes and large surface areas. In this work, the homochiral MOF AlaZnCl was successfully coated on the inner wall
Gonçalo C Pereira et al.
Current pharmaceutical design, 17(20), 2113-2129 (2011-07-02)
Mitochondria have long been involved in several cellular processes beyond its role in energy production. The importance of this organelle for cardiac tissue homeostasis has been greatly investigated and its impairment can lead to cell death and consequent organ failure.
F S Zarudyĭ et al.
Eksperimental'naia i klinicheskaia farmakologiia, 73(1), 40-43 (2010-02-27)
Unique stereochemistry of the third-generation beta-adrenoblockers is a basis of advantages of the new drugs such as carvedilol. Data on the stereochemistry beta-adrenoblockers and the influence of their optical activity on the pharmacological effects of related drugs are presented. Main
Carol Chen-Scarabelli et al.
American journal of cardiovascular drugs : drugs, devices, and other interventions, 12(6), 391-401 (2012-10-16)
β-Adrenergic receptor antagonists (β-blockers) have been recognized for their cardioprotective properties, prompting use of these pharmacologic agents to become more mainstream in acute myocardial infarction (AMI) and congestive heart failure (CHF). Despite their popularity as a class, the ability to
Attila Balogh et al.
Journal of pharmaceutical sciences, 104(5), 1767-1776 (2015-03-13)
Melt blowing (MB) was investigated to prepare a fast dissolving fibrous drug-loaded solid dispersion and compared with solvent-based electrospinning (SES) and melt electrospinning (MES). As a conventional solvent-free technique coupled with melt extrusion and using a high-speed gas stream, MB
Panagiotis C Stafylas et al.
Vascular health and risk management, 4(1), 23-30 (2008-07-17)
Although beta-blockers have been previously shown to effectively reduce blood pressure (BP) and have been used for hypertension treatment for over 40 years, their effect on cardiovascular morbidity and mortality in hypertensive patients remains controversial and its use in uncomplicated
Randall P Sharp et al.
The Annals of pharmacotherapy, 42(4), 564-571 (2008-03-28)
To examine the evidence regarding the impact of carvedilol on the serum lipid profile. Searches in MEDLINE and International Pharmaceutical Abstracts (1966-December 2007) were conducted. Search terms included carvedilol, cholesterol, lipids, hyperlipidemia, and beta-blockers. Published studies and case reports that
Dhiraj Tripathi et al.
European journal of gastroenterology & hepatology, 22(8), 905-911 (2010-01-23)
Carvedilol is a potent noncardioselective beta-blocker, with weak vasodilating properties because of alpha 1 blockade. A reduction in both intrahepatic and portocollateral resistance contribute to enhanced effects on portal pressure. There are 10 published hemodynamic studies involving 168 patients investigating
Vanessa Machado et al.
Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology, 27(10), 1277-1296 (2009-01-31)
The myocardium is a tissue rich in mitochondria, which are of great importance in the maintenance of cardiac function. Carvedilol is a non-selective beta-blocker which, besides its neuroprotective and vasculoprotective properties, has cardioprotective and antioxidant effects. The number of patients
Kamla Pathak et al.
Clinical pharmacokinetics, 54(4), 325-357 (2015-02-11)
The delivery of drugs through the oral route is regarded as most optimal to achieve desired therapeutic effects and patient compliance. However, poor pharmacokinetic profiles of oral drug candidates remains an area of concern, and approaches to enhance their bioavailability
Jaekyu Shin et al.
The American journal of medicine, 126(9), 805-810 (2013-08-24)
Large randomized trials have reported mixed results regarding the risk of bradycardia between metoprolol and carvedilol. We compared the incidence of emergent bradycardia (measured by an emergency department visit or hospitalization due to bradycardia) for patients initiating metoprolol and carvedilol.
HPLC Method Development and Validation of S (-)-Carvedilol from API and Formulations
Swetha E, et al.
American Journal of Analytical Chemistry, 6(05), 437-437 (2015)
Hamdan Al-Ghamdi
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association, 17(2), 155-158 (2011-03-05)
Variceal bleeding is a major event in the natural history of end-stage liver disease with a subsequent high mortality rate. Non-selective β-blockers are currently the drugs of choice for preventing first variceal bleeding. Endoscopic rubber band ligation of high risk
Achiral-chiral LC/LC-FLD coupling for determination of carvedilol in plasma samples for bioequivalence purposes
Medvedovici A, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 850(1-2), 327-335 (2007)
Jaleh Varshosaz et al.
Pharmaceutical development and technology, 19(5), 605-617 (2013-08-14)
Carvedilol used in cardiovascular diseases has systemic bioavailability of 25-35%. The objective of this study was production of lectin-modified poly(ethylene-co-vinyl acetate) (PEVA) as mucoadhesive nanoparticles to enhance low oral bioavailability of carvedilol. Nanoparticles were prepared by the emulsification-solvent evaporation method
Olav R de Peuter et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(10), 1733-1739 (2013-08-24)
Carvedilol, a nonselective β-blocker, may be more effective than the selective β-blocker metoprolol in reducing the risk of thromboembolic events in heart failure. The aim of this study was, first, to assess whether there is a differential response in cardiac
Nicola Vitulano et al.
Journal of cardiovascular medicine (Hagerstown, Md.), 14(9), 673-676 (2009-12-10)
In this report we describe the case of a 56-year-old man with a medical history of onset of asthenia, palpitations and dyspnoea for mild efforts. After a negative ergometric test for myocardial ischaemia and 24-h Holter monitoring showing frequent ventricular
Li Yue-Chun et al.
Current pharmaceutical design, 18(12), 1620-1624 (2012-03-27)
Carvedilol is a nonselective β-blocker with α1-adrenergic blocking and antioxidant properties. A number of preclinical experiments and clinical trials have demonstrated that carvedilol provides prominent benefit in heart failure. However, less research has been done in the area of animal
Lan Wang et al.
Neurochemical research, 39(9), 1733-1740 (2014-06-22)
Oxidative stress is closely related to the pathogenesis of neurodegenerative disorders such as Parkinson's disease. Carvedilol, a nonselective β-adrenergic receptor blocker with pleiotropic activity has been shown to exert neuroprotective effect due to its antioxidant property. However, the neuroprotective mechanism
Inappropriate implantable defibrillator shocks: an adverse outcome that can be prevented.
Merritt H Raitt
Journal of the American College of Cardiology, 62(15), 1351-1352 (2013-06-19)
Adrian J Stanley et al.
Journal of hepatology, 61(5), 1014-1019 (2014-06-24)
Rebleeding after an initial oesophageal variceal haemorrhage remains a significant problem despite therapy with band ligation, non-selective β-blockers or a combination of these. Carvedilol is a vasodilating non-selective β-blocker with alpha-1 receptor and calcium channel antagonism. A recent study has
Gregg C Fonarow
Expert review of cardiovascular therapy, 7(5), 483-498 (2009-05-08)
Carvedilol is a beta(1)- and beta(2)-adrenergic receptor antagonist with additional vasodilatory alpha(1)-blocking properties. Carvedilol was shown to be more efficacious than a traditional beta-blocker for treating heart failure and improving myocardial function. Carvedilol is the only agent in its class
Quantification of carvedilol in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry: application to bioequivalence study
do Carmo Borges NC, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 822(1-2), 253-262 (2005)
J Wikstrand et al.
Journal of internal medicine, 275(2), 134-143 (2013-10-15)
The four pivotal beta-blocker trials in heart failure (HF) had different inclusion criteria, making comparison difficult without patient stratifying. The aim of this study was to compare, in similar patients, the effects of bisoprolol, metoprolol controlled release/extended release (CR/XL), carvedilol
James T Pearson et al.
Clinical science (London, England : 1979), 135(2), 327-346 (2021-01-23)
A high salt intake exacerbates insulin resistance, evoking hypertension due to systemic perivascular inflammation, oxidative-nitrosative stress and endothelial dysfunction. Angiotensin-converting enzyme inhibitor (ACEi) and angiotensin receptor blockers (ARBs) have been shown to abolish inflammation and redox stress but only partially
Alexandros Briasoulis et al.
The American journal of cardiology, 115(8), 1111-1115 (2015-02-25)
Long-term treatment with appropriate doses of carvedilol or metoprolol is currently recommended for patients with heart failure with reduced ejection fraction (HFrEF) to decrease the risk of death, hospitalizations, and patients' symptoms. It remains unclear if the β blockers used
Editorial comment.
Henry H Woo
Urology, 82(3), 665-665 (2013-08-31)
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