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Showing 31-60 of 2737 results for "PHR1320" within Papers
Karl B Scheidweiler et al.
Analytical and bioanalytical chemistry, 407(3), 883-897 (2014-09-17)
Clandestine laboratories constantly produce new synthetic cannabinoids to circumvent legislative scheduling efforts, challenging and complicating toxicological analysis. Sundstrom et al. (Anal Bioanal Chem 405(26):8463-8474, [9]) and Kronstrand et al. (Anal Bioanal Chem 406(15):3599-3609, [10]) published nontargeted liquid chromatography, high-resolution, quadrupole/time-of-flight
Indra Singh et al.
Phytochemistry, 108, 57-66 (2014-10-11)
Rice seedlings grown under 50 μM cadmium alone or in combination with 5 μM methyl jasmonate were investigated for Cd-induced oxidative injury at 3, 7 and 10 days of treatment. MeJA treatments alone did not have any significant change in
Xue Qiao et al.
Journal of chromatography. A, 1358, 252-260 (2014-07-16)
Ergostanes are major bioactive constituents of the medicinal mushroom Antrodia camphorata. These tetracyclic triterpenoids usually occur as 25R/S epimeric pairs, which renders their chromatographic separation difficult. In this study, we used analytical supercritical-fluid chromatography (SFC) to separate seven pairs of
Norma Angélica Galicia Canales et al.
Oncology letters, 8(2), 939-947 (2014-07-11)
The present study aimed to analyze sera proteins in females with cervical intraepithelial neoplasia, grade III (CIN III) and in healthy control females, in order to identify a potential biomarker which detects lesions that have a greater probability of cervical
Giuseppe Cannazza et al.
Journal of chromatography. A, 1363, 216-225 (2014-06-18)
A stopped-flow HPLC method was developed to evaluate configurational and chemical stability of pharmaceutical compounds employing immobilized artificial membranes (IAM) column to simulate conditions that pharmaceutical compounds will meet in vivo. The method was applied to recent developed chiral 5-arylbenzothiadiazine
Marie Meyer-Monath et al.
Analytical and bioanalytical chemistry, 406(30), 7785-7797 (2014-11-10)
Meconium is the earliest stool of newborns. It is a complex matrix that reflects the degree of fetal exposure to environmental pollutants. To investigate exposure to xenobiotics, an analytical method was developed to identify and quantify some pesticides and their
Haiwei Gu et al.
The Analyst, 140(8), 2726-2734 (2015-02-24)
Amino acids play essential roles in both metabolism and the proteome. Many studies have profiled free amino acids (FAAs) or proteins; however, few have connected the measurement of FAA with individual amino acids in the proteome. In this study, we
Jeffrey D Serrill et al.
Biochemical pharmacology, 93(3), 251-265 (2014-12-17)
Apoptolidin A was first isolated as a secondary metabolite of a Nocardiopsis sp. and is the founding member of a family of potential selective cancer cell toxins. We now report the isolation, production and pharmacological characterization of apoptolidins A and
Gregori B Romero et al.
International journal of pharmaceutics, 482(1-2), 54-60 (2014-12-03)
Industrial concentrates of hesperidin nanocrystals (5.0% nominal concentration) were produced applying the smartCrystal(®) combination technology of wet bead milling and subsequent high pressure homogenization. Stabilization was performed by Kolliphor(®) P 188, preservation by Euxyl PE 9010 and glycerol. Physical and
Tsuyoshi Yamamoto et al.
Organic & biomolecular chemistry, 13(12), 3757-3765 (2015-02-19)
High scalability of a novel bicyclic nucleoside building block, amido-bridged nucleic acid (AmNA), to diversify pharmacokinetic properties of therapeutic antisense oligonucleotides is described. N2'-functionalization of AmNA with a variety of hydrophobic groups is straightforward. Combinations of these modules display similar
Susana Sadler Simões et al.
Forensic science international, 243, 117-125 (2014-08-16)
An UPLC-MS/MS method using ESI+ionization and MRM was developed and fully validated according to international guidelines for the qualitative and quantitative analysis of nine synthetic cannabinoids and/or their metabolites in urine samples (1mL). Prior to extraction the samples were subjected
Haider A J Al Lawati et al.
Luminescence : the journal of biological and chemical luminescence, 29(8), 1148-1153 (2014-05-02)
A highly sensitive, rapid and economical method for the determination of amlodipine (AM) in biological fluids was developed using a peroxyoxalate chemiluminescence (CL) system in a lab-on-a-chip device. Peroxyoxalate-CL is an indirect type of CL that allows the detection of
Sharan Bobbala et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 975, 45-51 (2014-12-02)
Monophosphoryl lipid A (MPL) and Quil A are two immunological adjuvants commonly used in vaccines. At present no simple, validated methods for the quantification of Quil A and MPL have been previously reported therefore the aim of the current study
Matthew W Bernart
Journal of AOAC International, 98(1), 94-97 (2015-04-11)
The citrus-derived bioactive monoterpene limonene is an important industrial commodity and fragrance constituent. An RP isocratic elution C18 ultra-HPLC (UHPLC) method using a superficially porous stationary phase and photodiode array (PDA) detector has been developed for determining the limonene content
A Vinayagam et al.
Indian journal of pharmaceutical sciences, 77(1), 91-95 (2015-03-15)
Four major compounds were separated and identified from the methanol extracts of Nerium indicum flowers (Arali) using HPLC and mass spectral data. Through mass data, the chemical structures were elucidated as: trans5-O-caffeoylquinic acid (1), quercetin-3-O- rutinoside (2), luteolin-5-O-rutinoside (3) and
Zbynek Dzuman et al.
Analytica chimica acta, 863, 29-40 (2015-03-04)
A new reliable and highly sensitive method based on high performance liquid chromatographic (HPLC) separation and high resolution tandem mass spectrometric detection (HRMS/MS) has been developed and validated for determination of 323 pesticide residues, 55 mycotoxins, and 11 plant toxins
Christian Lanshoeft et al.
Analytical and bioanalytical chemistry, 406(22), 5413-5423 (2014-06-25)
A sensitive and ultra-fast method utilizing the laser diode thermal desorption ion source using atmospheric pressure chemical ionization coupled to tandem mass spectrometry (LDTD-APCI-MS/MS) was developed for the quantitative analysis of BKM120, an investigational anticancer drug in human plasma. Samples
Jonans Tusiimire et al.
Analytical and bioanalytical chemistry, 407(13), 3627-3635 (2015-03-10)
There is a growing interest in the potential of bee venom in cosmetics as a rejuvenating agent. Products currently on the market do not specify exactly their content of bee venom (BV). Therefore, we developed a method for the detection
Tanya Q Shang et al.
Journal of pharmaceutical sciences, 103(7), 1967-1978 (2014-05-21)
A highly robust hydrophilic interaction liquid chromatography (HILIC) method that involves both fluorescence and mass spectrometric detection was developed for profiling and characterizing enzymatically released and 2-aminobenzamide (2-AB)-derivatized mAb N-glycans. Online HILIC/mass spectrometry (MS) with a quadrupole time-of-flight mass spectrometer
Jan Soukup et al.
Journal of chromatography. A, 1374, 102-111 (2014-12-30)
Excess adsorption of water from aqueous acetonitrile mobile phases was investigated on 16 stationary phases using the frontal analysis method and coulometric Karl-Fischer titration. The stationary phases include silica gel and silica-bonded phases with different polarities, octadecyl and cholesterol, phenyl
Luc Alexis Leuthold et al.
Analytical chemistry, 87(4), 2068-2071 (2015-01-22)
Hematocrit (Hct) is one of the most critical issues associated with the bioanalytical methods used for dried blood spot (DBS) sample analysis. Because Hct determines the viscosity of blood, it may affect the spreading of blood onto the filter paper.
Martin Mangstl et al.
Dalton transactions (Cambridge, England : 2003), 43(26), 10033-10039 (2014-05-29)
A new synthesis route for phosphates in an organic solvent at low temperatures is presented. The synthesis was done by dispersing a nitrate salt and phosphorus pentoxide in dimethyl sulfoxide. The synthesis can be performed under water-free conditions and yielded
Chao Hong et al.
International journal of pharmaceutics, 477(1-2), 251-260 (2014-12-03)
Although myricetin has various pharmacological applications, it shows low oral bioavailability (<10%) in rats due to its poor aqueous solubility. To overcome this issue, myricetin nanosuspensions were developed and the effects of stabilizers were investigated. Based on the particle size
Xiaoyan Gao et al.
PloS one, 9(6), e100017-e100017 (2014-06-19)
Shuang-huang-lian injection (SHLI) is a famous Chinese patent medicine, which has been wildly used in clinic for the treatment of acute respiratory tract infection, pneumonia, influenza, etc. The existing randomized controlled trial (RCT) studies suggested that SHLI could afford a
Kristi S Thompson et al.
Journal of analytical toxicology, 38(8), 507-512 (2014-09-14)
Zolpidem is a nonbenzodiazepine sedative hypnotic drug used for the short-term treatment of insomnia. While quite effective in producing sedation, zolpidem has potentially hazardous side effects when put in the context of complex tasks. Therefore, to more fully understand the
Kyu Hwan Shim et al.
International journal of nanomedicine, 9 Suppl 2, 207-215 (2015-01-08)
A multitude of nanoparticles, such as titanium oxide (TiO2), zinc oxide, aluminum oxide, gold oxide, silver oxide, iron oxide, and silica oxide, are found in many chemical, cosmetic, pharmaceutical, and electronic products. Recently, SiO2 nanoparticles were shown to have an
Robert Jirásko et al.
Analytical and bioanalytical chemistry, 406(19), 4601-4610 (2014-05-21)
The combination of ultrahigh-resolution mass spectrometry imaging (UHRMSI) and ultrahigh-performance liquid chromatography coupled with tandem mass spectrometry (UHPLC/MS/MS) was used for the identification and the spatial localization of atorvastatin (AT) and its metabolites in rat tissues. Ultrahigh-resolution and high mass
Lei Li et al.
Nature communications, 5, 5469-5469 (2014-11-29)
Cancer results from processes prone to selective pressure and dysregulation acting along the sequence-to-phenotype continuum DNA → RNA → protein → disease. However, the extent to which cancer is a manifestation of the proteome is unknown. Here we present an
Stephen R Groskreutz et al.
Journal of chromatography. A, 1354, 65-74 (2014-06-30)
Solvent-based on-column focusing is a powerful and well known approach for reducing the impact of pre-column dispersion in liquid chromatography. Here we describe an orthogonal temperature-based approach to focusing called temperature-assisted on-column solute focusing (TASF). TASF is founded on the
Fuyou Du et al.
Analytica chimica acta, 845, 45-52 (2014-09-10)
In this publication, a novel solid phase microextraction (SPME) coating functionalized with a DNA aptamer for selective enrichment of a low abundance protein from diluted human plasma is described. This approach is based on the covalent immobilization of an aptamer
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