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Showing 1-30 of 4543 results for "PHR1321" within Papers
Paola Devoto et al.
Addiction biology, 19(4), 612-622 (2013-01-08)
The dopamine-beta-hydroxylase inhibitor nepicastat has been shown to reproduce disulfiram ability to suppress the reinstatement of cocaine seeking after extinction in rats. To clarify its mechanism of action, we examined the effect of nepicastat, given alone or in association with
Jiejun Shi et al.
Nucleic acids research, 42(15), 9730-9739 (2014-08-02)
ATP-dependent chromatin remodeling complexes regulate nucleosome organizations. In Drosophila, gene Brm encodes the core Brahma complex, the ATPase subunit of SWI/SNF class of chromatin remodelers. Its role in modulating the nucleosome landscape in vivo is unclear. In this study, we
Malcolm A Young et al.
Postgraduate medicine, 126(3), 35-46 (2014-06-12)
Chronic kidney disease is frequently present in patients with type 2 diabetes mellitus (T2DM). New therapeutic options in this patient subpopulation are needed. Assess the effect of renal impairment on the pharmacokinetics (PK), efficacy, and safety of albiglutide in single-
Tatsuhiro Masaoka et al.
PloS one, 9(5), e95879-e95879 (2014-05-14)
Recent reports indicate the presence of low grade inflammation in functional gastrointestinal disorders (FGID), in these cases often called "post-inflammatory" FGIDs. However, suitable animal models to study these disorders are not available. The Biobreeding (BB) rat consists of a diabetes-resistant
Almudena Crooke et al.
Current eye research, 40(1), 56-65 (2014-06-04)
We have investigated the effect of melatonin and its analogues on rabbit corneal epithelial wound healing. New Zealand rabbits were anaesthetised and wounds were made by placing Whatman paper discs soaked in n-heptanol on the cornea. Melatonin and analogues (all
Hamid Mahmoud Hashemi et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 73(1), 18-21 (2014-09-25)
Povidone iodine is used primarily as an antiseptic to decrease surgical site infection. Its hemostatic and antiedematous properties in oral surgery also have been investigated recently. A randomized controlled clinical trial was performed in 30 patients undergoing mandibular third molar
Emre Yildirim et al.
Behavioural pharmacology, 26(3), 241-248 (2014-11-27)
Nicotine withdrawal produces cognitive deficits that can predict relapse. Amelioration of these cognitive deficits emerges as a target in current smoking cessation therapies. In rodents, withdrawal from chronic nicotine disrupts contextual fear conditioning (CFC), whereas acute nicotine enhances this hippocampus-specific
Kim Henriksen et al.
Journal of Alzheimer's disease : JAD, 43(4), 1331-1341 (2014-08-30)
Enzyme-generated fragments of tau have been linked to neuronal death and may serve as serum biomarkers of cognitive loss. Two competitive ELISAs detecting an ADAM10-generated fragment (Tau-A) or a caspase-3-generated fragment (Tau-C) were measured in baseline serum samples from patients
Linbin Zhang et al.
PLoS genetics, 11(3), e1005073-e1005073 (2015-03-31)
Biological diversity on Earth depends on the multiplication of species or speciation, which is the evolution of reproductive isolation such as hybrid sterility between two new species. An unsolved puzzle is the exact mechanism(s) that causes two genomes to diverge
Brenda C O'Connell et al.
PloS one, 9(12), e115228-e115228 (2014-12-30)
HSP90 inhibitors are currently undergoing clinical evaluation in combination with antimitotic drugs in non-small cell lung cancer (NSCLC), but little is known about the cellular effects of this novel drug combination. Therefore, we investigated the molecular mechanism of action of
Lykke Blaabjerg et al.
Journal of molecular endocrinology, 53(3), 417-427 (2014-10-18)
During the development of diabetes β-cells are exposed to elevated concentrations of proinflammatory cytokines, TNFα and IL1β, which in vitro induce β-cell death. The class B G-protein-coupled receptors (GPCRs): corticotropin-releasing factor receptor 1 (CRFR1) and CRFR2 are expressed in pancreatic
N Okaniwa et al.
Free radical research, 49(1), 35-44 (2014-10-21)
We reported that deficiency of the eNOS protein exacerbates colitis induced by dextran sodium sulfate (DSS-induced colitis). However, the role of eNOS in colitis remains controversial. Therefore, we studied how over-expression of eNOS affected this inflammatory condition, using vascular endothelial
Eric Lam et al.
Journal of virology, 88(24), 14426-14439 (2014-10-10)
The cGAS/STING DNA sensing complex has recently been established as a predominant pathogen recognition receptor (PRR) for DNA-directed type I interferon (IFN) innate immune activation. Using replication-defective adenovirus vectors and replication-competent wild-type adenovirus, we have modeled the influence of the
Joana Fernandes et al.
PloS one, 9(6), e99958-e99958 (2014-06-25)
Transient global cerebral ischemia induces profound changes in the transcriptome of brain cells, which is partially associated with the induction or repression of genes that influence the ischemic response. However, the mechanisms responsible for the selective vulnerability of hippocampal neurons
Jian-Zhuang Tan et al.
Journal of the science of food and agriculture, 95(1), 126-135 (2014-04-15)
The effects of dietary l-arginine (Arg) on immunosuppression following infectious bursal disease virus (IBDV) inoculation in broiler chickens were evaluated. The design of this study was a 5 × 2 factorial arrangement (n = 5) with five Arg concentrations (starter:
Jieli Li et al.
American journal of physiology. Heart and circulatory physiology, 307(11), H1618-H1625 (2014-09-28)
Mature cardiac myocytes are terminally differentiated, and the heart has limited capacity to replace lost myocytes. Thus adaptation of myocyte size plays an important role in the determination of cardiac function. The hypothesis tested is that regulation of the dynamic
Quan Li et al.
Nature communications, 6, 6183-6183 (2015-01-30)
TAR DNA-binding protein of 43 kDa (TDP-43) and its C-terminal fragment of 25 kDa (CTF25) play critical roles in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. Although the overexpression of TDP-43 in cultured cells and animals results in the production of CTF25
Grace Yim et al.
Chembiochem : a European journal of chemical biology, 15(17), 2613-2623 (2014-09-27)
In this study, a draft genome sequence of Actinoplanes sp. ATCC 53533 was assembled, and an 81-kb biosynthetic cluster for the unusual sulfated glycopeptide UK-68,597 was identified. Glycopeptide antibiotics are important in the treatment of infections caused by Gram-positive bacteria.
Courtney L Williams et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(31), 10402-10414 (2014-08-01)
Stress can reinstate cocaine seeking through an interaction between the stress hormone corticotropin releasing factor (CRF) and glutamate release onto dopamine neurons in the ventral tegmental area (VTA). To better understand the underlying causes, synaptic mechanisms were investigated in brain
David L Veyer et al.
The Journal of general virology, 95(Pt 12), 2757-2768 (2014-08-06)
Vaccinia virus (VACV) is a large dsDNA virus encoding ~200 proteins, several of which inhibit apoptosis. Here, a comparative study of anti-apoptotic proteins N1, F1, B13 and Golgi anti-apoptotic protein (GAAP) in isolation and during viral infection is presented. VACVs
Jincui An et al.
Journal of materials science. Materials in medicine, 26(2), 68-68 (2015-01-30)
Device-related infections have been a big problem for a long time. This paper describes a new method to inhibit bacterial growth on implanted device with tissue-penetrating X-ray radiation, where a thin metallic film deposited on the device is used as
Yun-An A Shen et al.
Nature communications, 5, 4991-4991 (2014-09-27)
The Schwann cell (SC)-axon interface represents a membrane specialization that integrates axonal signals to coordinate cytoskeletal dynamics resulting in myelination. Here we show that LKB1/Par-4 is asymmetrically localized to the SC-axon interface and co-localizes with the polarity protein Par-3. Using
Paul J Toren et al.
Molecular cancer therapeutics, 14(1), 59-69 (2014-10-30)
VT-464 is a novel, nonsteroidal, small-molecule CYP17A1 inhibitor with 17,20-lyase selectivity. This study evaluates the anticancer activity of VT-464 compared with abiraterone (ABI) in castrate-resistant prostate cancer cell lines and xenograft models that are enzalutamide (ENZ)-responsive (C4-2) or ENZ-resistant (MR49C
Yumin Zheng et al.
Nuclear medicine and biology, 41(10), 813-824 (2014-08-30)
(99m)Tc-Teboroxime ([(99m)TcCl(CDO)(CDOH)2BMe]) is a member of the BATO (boronic acid adducts of technetium dioximes) class of (99m)Tc(III) complexes. This study sought to explore the impact of co-ligands on solution stability, heart uptake and myocardial retention of [(99m)Tc(L)(CDO)(CDOH)2BMe] ((99m)Tc-Teboroxime: L=Cl; (99m)Tc-Teboroxime(F):
Magdalena Matusiak et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(5), 1541-1546 (2015-01-22)
The Nlrc4 inflammasome contributes to immunity against intracellular pathogens that express flagellin and type III secretion systems, and activating mutations in NLRC4 cause autoinflammation in patients. Both Naip5 and phosphorylation of Nlrc4 at Ser533 are required for flagellin-induced inflammasome activation
Yong Fang Zhu et al.
Pflugers Archiv : European journal of physiology, 466(7), 1467-1475 (2013-10-09)
Enteric sensory neurons (the AH neurons) play a role in control of gastrointestinal motor activity; AH neuron activation has been proposed to change propulsion into segmentation. We sought to find a mechanism underlying this phenomenon. We formulated the hypothesis that
Natália Corniani et al.
PloS one, 9(7), e103704-e103704 (2014-08-01)
The 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway leads to the synthesis of isopentenyl diphosphate in plastids. It is a major branch point providing precursors for the synthesis of carotenoids, tocopherols, plastoquinone and the phytyl chain of chlorophylls, as well as the hormones
Anna Sankiewicz et al.
Analytical biochemistry, 469, 4-11 (2014-10-15)
We have developed a new method for highly selective determination of the ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) concentration using a surface plasmon resonance imaging (SPRI) technique and two different biosensors. UCH-L1 was captured from a solution by immobilized specific rabbit
Silke Beermann et al.
PloS one, 9(9), e107481-e107481 (2014-09-23)
Histamine (HA) is recognized by its target cells via four G-protein-coupled receptors, referred to as histamine H1-receptor (H1R), H2R, H3R, and H4R. Both H1R and H4R exert pro-inflammatory functions. However, their signal transduction pathways have never been analyzed in a
Lauren Byrd-Leotis et al.
Journal of virology, 89(8), 4504-4516 (2015-02-06)
Influenza A viruses enter host cells through endosomes, where acidification induces irreversible conformational changes of the viral hemagglutinin (HA) that drive the membrane fusion process. The prefusion conformation of the HA is metastable, and the pH of fusion can vary
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