PHR1347

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Showing 1-30 of 184 results for "PHR1347" within Papers

Role of Mitofusin-2 in mitochondrial localization and calcium uptake in skeletal muscle.

Alina Ainbinder et al.

Cell calcium, 57(1), 14-24 (2014-12-06)

As muscle contraction requires ATP and Ca(2+), skeletal muscle function is highly dependent on communication between two major intracellular organelles: mitochondria and sarcoplasmic reticulum (SR). In adult skeletal muscle, mitochondria located within the I-band of the sarcomere are connected to

Study of the Structure-Function-Stability Relationships in Yeast D-amino Acid Oxidase: Hydrophobization of Alpha-Helices.

I V Golubev et al.

Acta naturae, 6(3), 76-88 (2014-10-29)

Hydrophobization of alpha-helices is one of the general approaches used for improving the thermal stability of enzymes. A total of 11 serine residues located in alpha-helices have been found based on multiple alignments of the amino acid sequences of D-amino

Fosfomycin tromethamine. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy as a single-dose oral treatment for acute uncomplicated lower urinary tract infections.

S S Patel et al.

Drugs, 53(4), 637-656 (1997-04-01)

Fosfomycin tromethamine is a phosphonic acid bactericidal agent with in vitro activity against most urinary tract pathogens. It is particularly active against Escherichia coli, and Citrobacter, Enterobacter, Klebsiella, Serratia and Enterococcus spp. There appears to be little cross-resistance between fosfomycin

A novel pH/light-triggered surface for DNA adsorption and release.

Gökçen Birlik Demirel

Chemphyschem : a European journal of chemical physics and physical chemistry, 15(8), 1693-1699 (2014-03-22)

A simple strategy for the immobilization of Cy3-labeled single strand DNA (Cy3-ssDNA) on a Si(001) surface and its release under control of both light and pH stimuli is presented. In order to prepare a dual pH/light-triggered surface, positively chargeable azobenzene

Human CD4+ CD39+ regulatory T cells produce adenosine upon co-expression of surface CD73 or contact with CD73+ exosomes or CD73+ cells.

P J Schuler et al.

Clinical and experimental immunology, 177(2), 531-543 (2014-04-23)

While murine CD4(+) CD39(+) regulatory T cells (T(reg)) co-express CD73 and hydrolyze exogenous (e) adenosine triphosphate (ATP) to immunosuppressive adenosine (ADO), surface co-expression of CD73 on human circulating CD4(+) CD39(+) T(reg) is rare. Therefore, the ability of human T(reg) to

Anti-inflammatory, anticholinesterase and antioxidant activity of leaf extracts of twelve plants used traditionally to alleviate pain and inflammation in South Africa.

J P Dzoyem et al.

Journal of ethnopharmacology, 160, 194-201 (2014-12-06)

Oxidative stress and inflammatory conditions are among the pathological features associated with the central nervous system in Alzheimer׳s disease. Traditionally, medicinal plants have been used to alleviate inflammation, pains and also other symptoms possibly associated with Alzheimer׳s disease. Therefore, the

Multifunctional activity of polyphenolic compounds associated with a potential for Alzheimer's disease therapy from Ecklonia cava.

Byoung Wook Choi et al.

Phytotherapy research : PTR, 29(4), 549-553 (2015-02-03)

Five polyphenols were isolated and purified from a brown alga Ecklonia cava. These compounds showed diverse biological activities such as antioxidative, antiinflammatory, and enzyme inhibitory activities. This led us to investigate the potential of these compounds as Alzheimer's disease drugs.

Effects of protein type and composition on postprandial markers of skeletal muscle anabolism, adipose tissue lipolysis, and hypothalamic gene expression.

Christopher Brooks Mobley et al.

Journal of the International Society of Sports Nutrition, 12, 14-14 (2015-03-21)

We examined the acute effects of different dietary protein sources (0.19 g, dissolved in 1 ml of water) on skeletal muscle, adipose tissue and hypothalamic satiety-related markers in fasted, male Wistar rats (~250 g). Oral gavage treatments included: a) whey protein concentrate (WPC

Improvement of derivatized amino acid detection sensitivity in micellar electrokinetic capillary chromatography by means of acid-induced pH-mediated stacking technique.

Szymon Dziomba et al.

Analytical and bioanalytical chemistry, 406(26), 6713-6721 (2014-08-26)

Derivatization is a frequently used sample preparation procedure applicable to the enhancement of analyte detection sensitivity. Amino acids mostly require derivatization prior to electrophoretic or chromatographic analysis, especially if spectrophotometric detection is used. This study presents an on-line preconcentration technique

Potassium channel Kv1.3 is highly expressed by microglia in human Alzheimer's disease.

Srikant Rangaraju et al.

Journal of Alzheimer's disease : JAD, 44(3), 797-808 (2014-11-02)

Recent genetic studies suggest a central role for innate immunity in Alzheimer's disease (AD) pathogenesis, wherein microglia orchestrate neuroinflammation. Kv1.3, a voltage-gated potassium channel of therapeutic relevance in autoimmunity, is upregulated by activated microglia and mediates amyloid-mediated microglial priming and

Effect of glycyrrhetinic acid on lipid raft model at the air/water interface.

Seiichi Sakamoto et al.

Biochimica et biophysica acta, 1848(2), 434-443 (2014-12-03)

To investigate an interfacial behavior of the aglycon of glycyrrhizin (GC), glycyrrhetinic acid (GA), with a lipid raft model consisting of equimolar ternary mixtures of N-palmitoyl sphingomyelin (PSM), dioleoylphosphatidylcholine (DOPC), and cholesterol (CHOL), Langmuir monolayer techniques were systematically conducted. Surface

Detection of microRNA in tumor cells using exonuclease III and graphene oxide-regulated signal amplification.

Rong-Cing Huang et al.

ACS applied materials & interfaces, 6(24), 21780-21787 (2014-04-16)

In this study, we developed a label-free, ultrasensitive graphene oxide (GO)-based probe for the detection of oligonucleotides by laser desorption/ionization mass spectrometry (LDI-MS). On the basis of simple π-π stacking and electrostatic interactions between rhodamine 6G (R6G) and GO, we

A Pseudomonas fluorescens type 6 secretion system is related to mucoidy, motility and bacterial competition.

Victorien Decoin et al.

BMC microbiology, 15, 72-72 (2015-04-18)

Pseudomonas fluorescens strain MFE01 secretes in abundance two Hcp proteins (haemolysin co-regulated proteins) Hcp1 and Hcp2, characteristic of a functional type 6 secretion system. Phenotypic studies have shown that MFE01 has antibacterial activity against a wide range of competitor bacteria

Novel free-paclitaxel-loaded redox-responsive nanoparticles based on a disulfide-linked poly(ethylene glycol)-drug conjugate for intracellular drug delivery: synthesis, characterization, and antitumor activity in vitro and in vivo.

Xingxing Chuan et al.

Molecular pharmaceutics, 11(10), 3656-3670 (2014-09-11)

To address the obstacles facing cancer chemotherapeutics, including toxicity, side effects, water insolubility, and lack of tumor selectivity, a novel stimuli-responsive drug-delivery system was developed based on paclitaxel-loaded poly(ethylene glycol)-disulfide-paclitaxel conjugate nanoparticles (PEG-SS-PTX/PTX NPs). The formulation emphasizes several benefits, including

Transport of L-glutamine, L-alanine, L-arginine and L-histidine by the neuron-specific Slc38a8 (SNAT8) in CNS.

Maria G A Hägglund et al.

Journal of molecular biology, 427(6 Pt B), 1495-1512 (2014-12-03)

Glutamine transporters are important for regulating levels of glutamate and GABA in the brain. To date, six members of the SLC38 family (SNATs) have been characterized and functionally subdivided them into System A (SNAT1, SNAT2 and SNAT4) and System N

Morphine sulfate, transdermal fentanyl citrate and ketorolac tromethamine: effects on postoperative pulmonary function.

H H Mason

American journal of critical care : an official publication, American Association of Critical-Care Nurses, 2(1), 61-64 (1993-01-01)

The physiological effects of morphine sulfate and fentanyl citrate on postoperative pulmonary function demonstrate varying degrees of respiratory depression related to dose, route of administration and pre-existing pathologies. Current postoperative analgesic therapies that include concomitant use of narcotic agonists and

Synaptic vesicle glycoprotein 2A modulates vesicular release and calcium channel function at peripheral sympathetic synapses.

Christian Vogl et al.

The European journal of neuroscience, 41(4), 398-409 (2014-12-09)

Synaptic vesicle glycoprotein (SV)2A is a transmembrane protein found in secretory vesicles and is critical for Ca(2+) -dependent exocytosis in central neurons, although its mechanism of action remains uncertain. Previous studies have proposed, variously, a role of SV2 in the

Ketorolac tromethamine.

G T Jay

Connecticut medicine, 55(5), 288-290 (1991-05-01)

Multianalyte determination of the kinetic rate constants of drug-cyclodextrin supermolecules by high performance affinity chromatography.

Caifen Wang et al.

Journal of chromatography. A, 1359, 287-295 (2014-07-30)

The kinetics of the dissociation is fundamental to the formation and the in vivo performance of cyclodextrin supramolecules. The individual determination of the apparent dissociation rate constant (kd,app) using high performance affinity chromatography (HPAC) is a tedious process requiring numerous

Congenital sucrase-isomaltase deficiency: identification of a common Inuit founder mutation.

Julien L Marcadier et al.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 187(2), 102-107 (2014-12-03)

Congenital sucrase-isomaltase deficiency is a rare hereditary cause of chronic diarrhea in children. People with this condition lack the intestinal brush-border enzyme required for digestion of di- and oligosaccharides, including sucrose and isomaltose, leading to malabsorption. Although the condition is

Phosphodiesterase 5 inhibitors augment UT-15C-stimulated ATP release from erythrocytes of humans with pulmonary arterial hypertension.

Elizabeth A Bowles et al.

Experimental biology and medicine (Maywood, N.J.), 240(1), 121-127 (2014-08-16)

Both prostacyclin analogs and phosphodiesterase 5 (PDE5) inhibitors are effective treatments for pulmonary arterial hypertension (PAH). In addition to direct effects on vascular smooth muscle, prostacyclin analogs increase cAMP levels and ATP release from healthy human erythrocytes. We hypothesized that

The histone deacetylase Rpd3/Sin3/Ume6 complex represses an acetate-inducible isoform of VTH2 in fermenting budding yeast cells.

Igor Stuparevic et al.

FEBS letters, 589(8), 924-932 (2015-03-03)

The tripartite Rpd3/Sin3/Ume6 complex represses meiotic isoforms during mitosis. We asked if it also controls starvation-induced isoforms. We report that VTH1/VTH2 encode acetate-inducible isoforms with extended 5'-regions overlapping antisense long non-coding RNAs. Rpd3 and Ume6 repress the long isoform of

Synthesis, crystal structure and antiproliferative activity of Cu(II) nalidixic acid-DACH conjugate: comparative in vitro DNA/RNA binding profile, cleavage activity and molecular docking studies.

Farukh Arjmand et al.

European journal of medicinal chemistry, 81, 76-88 (2014-05-16)

Nalidixic acid-DACH conjugate Cu(II) molecular entity, 1 was synthesized, thoroughly characterized by spectroscopic techniques (FT-IR, EPR and ESI-MS) and single crystal X-ray diffraction technique as a potential chemotherapeutic drug candidate for cancer oncology. Complex 1 was found to be a

Determination of hyaluronan molecular mass distribution in human breast milk.

Han Yuan et al.

Analytical biochemistry, 474, 78-88 (2015-01-13)

Hyaluronan (HA) in human milk mediates host responses to microbial infection via TLR4- and CD44-dependent signaling. Signaling by HA is generally size specific. Because pure HA with average molecular mass (M) of 35 kDa can elicit a protective response in

Production of in-vitro refolded and highly antigenic SAG1 for development of a sensitive and specific Toxoplasma IgG ELISA.

Mojgan Allahyari et al.

Journal of immunological methods, 416, 157-166 (2014-12-02)

Recombinant antigens are increasingly applied to replace native antigens in serological tests. Surface antigen 1 (SAG1) is a highly immunogenic antigen and probably represents the most explored and used antigen of Toxoplasma gondii for development of serological test kits. The

Reduction of molecular leaching from a gel matrix for the precisely controlled release of encapsulated molecules by light stimulus.

Takaki Amamoto et al.

Chemical & pharmaceutical bulletin, 62(7), 649-653 (2014-07-06)

We have developed a general method for controlling molecular functions using a photodegradable hydrogel; gels containing molecules made from such materials are capable of release and activation by light stimulus. As the elimination of molecular leaching from the gel before

Development of the follicular basement membrane during human gametogenesis and early folliculogenesis.

A Marijne Heeren et al.

BMC developmental biology, 15, 4-4 (2015-01-22)

In society, there is a clear need to improve the success rate of techniques to restore fertility. Therefore a deeper knowledge of the dynamics of the complex molecular environment that regulates human gametogenesis and (early) folliculogenesis in vivo is necessary.

Renoprotective mechanisms of chlorogenic acid in cisplatin-induced kidney injury.

Robert Domitrović et al.

Toxicology, 324, 98-107 (2014-07-22)

The aim of this study was to investigate the renoprotective activity of chlorogenic acid (CA) in a murine model of cisplatin (CP)-induced kidney injury. Male BALB/cN mice were gavaged daily with CA at 3, 10 and 30mg/kg for two successive

Modeling and robust pooling design of a preparative cation-exchange chromatography step for purification of monoclonal antibody monomer from aggregates.

Niklas Borg et al.

Journal of chromatography. A, 1359, 170-181 (2014-08-03)

This study has implemented and calibrated a model that describes the separation of the monomer of monoclonal antibodies from the dimer and larger oligomers on preparative-scale using cation-exchange chromatography. A general rate model with temperature dependent diffusion was coupled to

Capturing and identification of differentially expressed fucome by a gel free and label free approach.

Chanida Puangpila et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 989, 112-121 (2015-03-31)

This research reports a proof-of-concept that describes an instrumental approach that is gel free and label free at both the separation and mass spectrometry ends for the capturing and identification of differentially expressed proteins (DEPs) in diseases, e.g., cancers. The

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