PHR1372

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Showing 1-30 of 3291 results for "PHR1372" within Papers

Multifunctional nanoparticles for prostate cancer therapy.

Shantanu S Chandratre et al.

AAPS PharmSciTech, 16(1), 98-107 (2014-09-06)

The relapse of cancer after first line therapy with anticancer agents is a common occurrence. This recurrence is believed to be due to the presence of a subpopulation of cells called cancer stem cells in the tumor. Therefore, a combination

Analysis of triterpenoids and phytosterols in vegetables by thin-layer chromatography coupled to tandem mass spectrometry.

Katerina Naumoska et al.

Journal of chromatography. A, 1381, 229-238 (2015-01-20)

Three TLC methods were used for an initial screening of some common plant triterpenoids and phytosterols in cuticular wax extracts of different vegetables (zucchini, eggplant, tomato, red pepper, mangold, spinach, lettuce, white-colored radicchio di Castelfranco, raddichio Leonardo, white cabbage, red

Preparative separation and identification of novel subsidiary colors of the color additive D&C Red No. 33 (Acid Red 33) using spiral high-speed counter-current chromatography.

Adrian Weisz et al.

Journal of chromatography. A, 1380, 120-129 (2015-01-17)

Three low-level subsidiary color impurities (A, B, and C) often present in batches of the color additive D&C Red No. 33 (R33, Acid Red 33, Colour Index No. 17200) were separated from a portion of R33 by spiral high-speed counter-current

Comprehensive Metabolomic, Lipidomic and Microscopic Profiling of Yarrowia lipolytica during Lipid Accumulation Identifies Targets for Increased Lipogenesis.

Kyle R Pomraning et al.

PloS one, 10(4), e0123188-e0123188 (2015-04-24)

Yarrowia lipolytica is an oleaginous ascomycete yeast that accumulates large amounts of lipids and has potential as a biofuel producing organism. Despite a growing scientific literature focused on lipid production by Y. lipolytica, there remain significant knowledge gaps regarding the

A 44-year-old woman with metabolic acidosis, high anion gap, and delayed neurologic deterioration.

Abhay Vakil et al.

Chest, 147(1), e18-e21 (2015-01-07)

A 44-year-old woman was brought to the ED from John F. Kennedy International Airport. The patient was returning with her son from a 3-month visit to Bangladesh. Her journey started with a 4-h flight from Dhaka, Bangladesh to Dubai, United

Unsaturated free fatty acids: a potential biomarker panel for early detection of gastric cancer.

Yaping Zhang et al.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 19(8), 667-673 (2014-10-31)

Changes in the levels of free fatty acids (FFAs) are closely associated with physiological status. Serum levels of C16:1, C18:3, C18:2, C18:1, C20:4, and C22:6 in 164 gastric cancer (GC) patients and 111 benign gastric disease (BGD) patients were significantly

LC-MS/MS bioanalysis of loratadine (Claritin) in dried blood spot (DBS) samples collected by subjects in a clinical research study.

Wenkui Li et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 983-984, 117-124 (2015-02-04)

A high-performance liquid chromatography-tandem mass spectrometric (LC-MS/MS) method has been developed and validated for the quantitative analysis of loratadine, an H1 histamine antagonist, in human dried blood spot (DBS) samples following a single self-administered 10 or 20mg oral dose. The

Topical analgesic, anti-inflammatory and antioxidant properties of Oxybaphus nyctagineus: phytochemical characterization of active fractions.

Árpád Könczöl et al.

Journal of ethnopharmacology, 155(1), 776-784 (2014-06-20)

Oxybaphus nyctagineus (Michx.) Sweet has traditionally been used by several Native American tribes predominantly as a topical anti-inflammatory and analgesic agent. To evaluate the antioxidant, analgesic and anti-inflammatory activity of the extracts prepared from the aerial parts of Oxybaphus nyctagineus

Determination of tapentadol and tapentadol-O-glucuronide in human serum samples by UPLC-MS/MS.

Vera Hillewaert et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 981-982, 40-47 (2015-01-21)

Tapentadol is a novel, centrally acting analgesic with 2 mechanisms of action, MOR agonism and noradrenaline (NA) reuptake inhibition in a single molecule. It is the first member of a new therapeutic class, MOR-NRI. A high throughput liquid chromatography-tandem mass

Determination of pharmaceuticals in sewage sludge and biochar from hydrothermal carbonization using different quantification approaches and matrix effect studies.

C Vom Eyser et al.

Analytical and bioanalytical chemistry, 407(3), 821-830 (2014-08-08)

Producing valuable biochar from waste materials using thermal processes like hydrothermal carbonization (HTC) has gained attention in recent years. However, the fate of micropollutants present in these waste sources have been neglected, although they might entail the risk of environmental

The influence of residual water on the secondary structure and crystallinity of freeze-dried fibrinogen.

Verena Wahl et al.

International journal of pharmaceutics, 484(1-2), 95-102 (2015-02-24)

The purpose of this work was to investigate the influence of water content on the secondary structure of a freeze-dried protein (fibrinogen) after a storage period of two weeks. To that end, attenuated reflectance Fourier transformed infrared (ATR-FTIR) and Raman

Simultaneous quantitative determination of microcystin-LR and its glutathione metabolites in rat liver by liquid chromatography-tandem mass spectrometry.

Xiaochun Guo et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 963, 54-61 (2014-06-16)

The roles of glutathione (GSH) and cysteine (Cys) in the detoxification of Microcystin-LR (MC-LR) have recently become a popular area of research. However, lacking analysis methods for MC-LR-GSH and MC-LR-Cys (two main GSH pathway metabolites) in mammals, elucidation of the

Gene silencing of Rac1 with RNA interference mediated by ultrasound and microbubbles in human LoVo cells: evaluation of cell invasion inhibition and metastatic.

Fang Nie et al.

Journal of drug targeting, 23(4), 380-386 (2015-02-13)

The objective of this study was to assess the change of cytoskeleton and cell cycle in LoVo (human colorectal cancer) cell via gene silencing of Rac1 with RNA interference mediated by microbubble (SonoVue) and ultrasound (US). The compound of plasmid

Transient and persistent metabolomic changes in plasma following chronic cigarette smoke exposure in a mouse model.

Charmion I Cruickshank-Quinn et al.

PloS one, 9(7), e101855-e101855 (2014-07-10)

Cigarette smoke exposure is linked to the development of a variety of chronic lung and systemic diseases in susceptible individuals. Metabolomics approaches may aid in defining disease phenotypes, may help predict responses to treatment, and could identify biomarkers of risk

Implementing visible 473 nm photodissociation in a Q-Exactive mass spectrometer: towards specific detection of cysteine-containing peptides.

Marion Girod et al.

The Analyst, 139(21), 5523-5530 (2014-09-10)

Improvement of the fragmentation specificity may streamline data processing of bottom-up proteomic experiments by drastically reducing either the amount of MS/MS data to process in the discovery phase or the detection of interfering signals in targeted quantification. Photodissociation at appropriate

Synthesis and evaluation of candidate PET radioligands for corticotropin-releasing factor type-1 receptors.

Nicholas J Lodge et al.

Nuclear medicine and biology, 41(6), 524-535 (2014-05-06)

A radioligand for measuring the density of corticotropin-releasing factor subtype-1 receptors (CRF1 receptors) in living animal and human brain with positron emission tomography (PET) would be a useful tool for neuropsychiatric investigations and the development of drugs intended to interact

The efficiency of conventional microscopic selection is comparable to the hyaluronic acid binding method in selecting spermatozoa for male infertility patients.

Meng-Ting Huang et al.

Taiwanese journal of obstetrics & gynecology, 54(1), 48-53 (2015-02-14)

To evaluate if hyaluronic acid (HA)-bound spermatozoa surpassed conventional microscopy-selected spermatozoa in the status of sperm DNA integrity by acridine orange (AO) fluorescence staining. Spermatozoa obtained from couples with indication for the intracytoplasmic sperm injection (ICSI) procedure due to male

Solid lipid nanoparticles of anticancer drug andrographolide: formulation, in vitro and in vivo studies.

Rabea Parveen et al.

Drug development and industrial pharmacy, 40(9), 1206-1212 (2013-07-06)

Diterpenoidal anti-cancer drug andrographolide (AD) was encapsulated into solid lipid nanoparticle (SLN) because of poor aqueous solubility and high lipophilicity. AD-SLNs were prepared by solvent injection method and characterized for droplet size, surface morphology, zeta potential, etc. In vitro drug

Identification of 2-aminothiazolobenzazepine metabolites in human, rat, dog, and monkey microsomes by ion-molecule reactions in linear quadrupole ion trap mass spectrometry.

Minli Zhang et al.

Drug metabolism and disposition: the biological fate of chemicals, 43(3), 358-366 (2014-12-31)

2-Aminothiazolobenzazepine (2-ATBA), 7-[(1-methyl-1H-pyrazol-4-yl)methyl]-6,7,8,9-tetrahydro-5H-[1,3]thiazolo[4,5-h][3]benzazepin-2-amine, is a D2 partial agonist that has demonstrated antipsychotic effects in a rodent in vivo efficacy model. The metabolite profile showed that 2-ATBA is mainly metabolized by oxidation. However, identification of the oxidation site(s) in the 2-aminothiazole

Detection of previously unknown fumonisin P analogue mycotoxins in a Fusarium verticillioides culture by high-performance liquid chromatography-electrospray ionization time-of-flight and ion trap mass spectrometry.

Tibor Bartók et al.

Journal of chromatographic science, 52(6), 508-513 (2013-06-12)

Five previously unknown fumonisin mycotoxins (iso-FP1, iso-FP(2,3a), iso-FP(2,3b), FP4 and iso-FP4) and three previously described FP analogues (FP(1-3)) were detected in a solid rice culture inoculated with Fusarium verticillioides. The fumonisins were characterized by high-performance liquid chromatography-electrospray ionization time-of-flight mass

Metabolomic profiling of serum in the progression of Alzheimer's disease by capillary electrophoresis-mass spectrometry.

Raúl González-Domínguez et al.

Electrophoresis, 35(23), 3321-3330 (2014-08-20)

There is high interest in the discovery of early diagnostic biomarkers of Alzheimer's disease, for which metabolomics exhibits a great potential. In this work, a metabolomic approach based on ultrafiltration and analysis by CE-MS has been used to obtain representative

Nitazoxanide, an antiviral thiazolide, depletes ATP-sensitive intracellular Ca(2+) stores.

Omodele Ashiru et al.

Virology, 462-463, 135-148 (2014-06-28)

Nitazoxanide (NTZ) inhibits influenza, Japanese encephalitis, hepatitis B and hepatitis C virus replication but effects on the replication of other members of the Flaviviridae family has yet to be defined. The pestivirus bovine viral diarrhoea virus (BVDV) is a surrogate

Development of a validated stability-indicating HPTLC method for rufinamide in bulk and its pharmaceutical dosage form.

Apexa Patel et al.

Journal of chromatographic science, 52(10), 1294-1301 (2013-12-04)

A sensitive, selective, precise and stability indicating a high-performance thin layer chromatographic method for the analysis of rufinamide (Rf) in bulk drug and its formulations was developed and validated. The method employed thin layer chromatography aluminum plates precoated with silica

Activation of muscarinic receptors in rat parotid acinar cells induces AQP5 trafficking to nuclei and apical plasma membrane.

Gota Cho et al.

Biochimica et biophysica acta, 1850(4), 784-793 (2015-01-21)

The subcellular distribution of aquaporin-5 (AQP5) in rat parotid acinar cells in response to muscarinic acetylcholine receptor (mAChR) activation remains unclear. Immunoconfocal and immunoelectron microscopy were used to visualize the distribution of AQP5 in parotid acinar cells. Western blotting was

The Moon as a recorder of organic evolution in the early solar system: a lunar regolith analog study.

Richard Matthewman et al.

Astrobiology, 15(2), 154-168 (2015-01-24)

The organic record of Earth older than ∼3.8 Ga has been effectively erased. Some insight is provided to us by meteorites as well as remote and direct observations of asteroids and comets left over from the formation of the Solar System.

Group V secreted phospholipase A2 is upregulated by IL-4 in human macrophages and mediates phagocytosis via hydrolysis of ethanolamine phospholipids.

Julio M Rubio et al.

Journal of immunology (Baltimore, Md. : 1950), 194(7), 3327-3339 (2015-03-01)

Studies on the heterogeneity and plasticity of macrophage populations led to the identification of two major polarization states: classically activated macrophages or M1, induced by IFN-γ plus LPS, and alternatively activated macrophages, induced by IL-4. We studied the expression of

Differential contribution of monocytes to heart macrophages in steady-state and after myocardial infarction.

Timo Heidt et al.

Circulation research, 115(2), 284-295 (2014-05-03)

Macrophages populate the steady-state myocardium. Previously, all macrophages were thought to arise from monocytes; however, it emerged that, in several organs, tissue-resident macrophages may self-maintain through local proliferation. Our aim was to study the contribution of monocytes to cardiac-resident macrophages

Improved permeability of acyclovir: optimization of mucoadhesive liposomes using the phospholipid vesicle-based permeation assay.

Elenaz Naderkhani et al.

Journal of pharmaceutical sciences, 103(2), 661-668 (2014-01-08)

The antiviral drug acyclovir (ACV) suffers from poor solubility both in lipophilic and hydrophilic environment, leading to low and highly variable bioavailability. To overcome these limitations, this study aimed at designing mucoadhesive ACV-containing liposomes to improve its permeability. Liposomes were

Aberrant neuronal differentiation and inhibition of dendrite outgrowth resulting from endoplasmic reticulum stress.

Koichi Kawada et al.

Journal of neuroscience research, 92(9), 1122-1133 (2014-04-12)

Neural stem cells (NSCs) play an essential role in development of the central nervous system. Endoplasmic reticulum (ER) stress induces neuronal death. After neuronal death, neurogenesis is generally enhanced to repair the damaged regions. However, it is unclear whether ER

Exploring the potential association between brominated diphenyl ethers, polychlorinated biphenyls, organochlorine pesticides, perfluorinated compounds, phthalates, and bisphenol A in polycystic ovary syndrome: a case-control study.

Sara J Vagi et al.

BMC endocrine disorders, 14, 86-86 (2014-10-29)

Polycystic Ovary Syndrome (PCOS) is an endocrine-metabolic disorder that affects approximately 6-10% of women of child-bearing age. Although preliminary studies suggest that certain pollutants may act as endocrine disruptors in animals, little is known about their potential association with PCOS.

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