phr1372

Applied Filters:

Keyword:'phr1372'

Showing 31-60 of 3291 results for "phr1372" within Papers

Epithelial cells expressing cytokeratins-19 and bone marrow micrometastases in patients with breast cancer at the time of primary surgery: clinical outcome during long-term follow-up.

Yovcho P Yovtchev et al.

Breast cancer (Tokyo, Japan), 21(5), 590-597 (2012-10-30)

To evaluate the detection of epithelial cells in bone marrow of breast cancer patients as an indicator of metastatic disease. Between 2001 and 2005, bone marrow biopsies were taken from 79 breast cancer patients during primary surgery. Specimens were stained

Cleaning up blood samples using a modified "QuEChERS" procedure for the determination of drugs of abuse and benzodiazepines by UPLC-MSMS(☆).

Luca Anzillotti et al.

Forensic science international, 243, 99-106 (2014-06-08)

The "QuEChERS" (quick, easy, cheap, effective, rugged, and safe) dispersive SPE (dSPE) method is an emerging sample preparation technique that is becoming increasingly popular in the area of multi-residue pesticide analysis in food and agricultural products. A simplified QuEChERS extraction

Acrylamide and 5-hydroxymethylfurfural formation in reconstituted potato chips during frying.

YuTian Miao et al.

Journal of food science and technology, 51(12), 4005-4011 (2014-12-06)

In our present paper, the effect of water activity and processing conditions in reconstituted potato chips was considered as a model to investigate the changes of acrylamide (AA) and 5-hydroxymethylfurfural (HMF). The results suggested that the formation of AA and

Facilitated preparation of bioconjugatable zwitterionic quantum dots using dual-lipid encapsulation.

Robert Shrake et al.

Journal of colloid and interface science, 437, 140-146 (2014-10-15)

Zwitterionic quantum dots prepared through incorporated zwitterionic ligands on quantum dot surfaces, are being paid significant attention in biomedical applications because of their excellent colloidal stability across a wide pH and ionic strength range, antifouling surface, good biocompatibility, etc. In

In vitro inhibition of herpes simplex virus type 1 replication by Mentha suaveolens essential oil and its main component piperitenone oxide.

Livia Civitelli et al.

Phytomedicine : international journal of phytotherapy and phytopharmacology, 21(6), 857-865 (2014-03-19)

Several essential oils exert in vitro activity against bacteria and viruses and, among these latter, herpes simplex virus type 1 (HSV-1) is known to develop resistance to commonly used antiviral agents. Thus, the effects of the essential oil derived from

Proteomic characterization of human coronary thrombus in patients with ST-segment elevation acute myocardial infarction.

Sergio Alonso-Orgaz et al.

Journal of proteomics, 109, 368-381 (2014-07-30)

Acute myocardial infarction with ST-segment elevation (STEMI) initiates with intraluminal thrombosis and results in total occlusion of the coronary artery. To date, characterization of the coronary thrombus proteome in STEMI patients has not been yet accomplished. Therefore, we aimed to

Method development and validation of olprinone in human plasma by HPLC coupled with ESI-MS-MS: application to a pharmacokinetic study.

Hongbo Wang et al.

Journal of chromatographic science, 52(5), 400-405 (2013-05-22)

A simple, specific and highly sensitive assay using liquid chromatography-tandem mass spectrometry with electrospray ionization was developed for the determination of olprinone in human plasma. Following the addition of codeine as an internal standard and simple liquid-liquid extraction with ethyl

A validated method for quantification of efavirenz in dried blood spots using high-performance liquid chromatography-mass spectrometry.

Alieu B Amara et al.

Therapeutic drug monitoring, 37(2), 220-228 (2014-08-28)

Efavirenz (EFV) is one of the preferred components of first-line antiretroviral treatment. EFV is characterized by a long plasma half-life (40-55 hours) with large interpatient variability, which raises the potential for individualization of therapy. Analyses of EFV levels in plasma

Hair analysis for long-term monitoring of buprenorphine intake in opiate withdrawal.

Valentina Pirro et al.

Therapeutic drug monitoring, 36(6), 796-807 (2014-04-10)

Buprenorphine (BUP) is a psychoactive pharmaceutical drug largely used to treat opiate addiction. Short-term therapeutic monitoring is supported by toxicological analysis of blood and urine samples, whereas long-term monitoring by means of hair analysis is rarely used. Aim of this

Enhancing Terpene yield from sugars via novel routes to 1-deoxy-d-xylulose 5-phosphate.

James Kirby et al.

Applied and environmental microbiology, 81(1), 130-138 (2014-10-19)

Terpene synthesis in the majority of bacterial species, together with plant plastids, takes place via the 1-deoxy-d-xylulose 5-phosphate (DXP) pathway. The first step of this pathway involves the condensation of pyruvate and glyceraldehyde 3-phosphate by DXP synthase (Dxs), with one-sixth

Calcium montmorillonite clay reduces AFB1 and FB1 biomarkers in rats exposed to single and co-exposures of aflatoxin and fumonisin.

Nicole J Mitchell et al.

Journal of applied toxicology : JAT, 34(7), 795-804 (2013-11-07)

Aflatoxins (AFs) and fumonisins (FBs) can co-contaminate foodstuffs and have been associated with hepatocellular and esophageal carcinomas in humans at high risk for exposure. One strategy to reduce exposure (and toxicity) from contaminated foodstuffs is the dietary inclusion of a

Development of simplified HPLC methods for the detection of counterfeit antimalarials in resource-restraint environments.

Ludwig Hoellein et al.

Journal of pharmaceutical and biomedical analysis, 98, 434-445 (2014-07-13)

Regular quality control and post-marketing surveillance of pharmaceuticals has been a critical challenge for countries of the developing world ever since. Counterfeit and substandard medicines are widely distributed and the real extent of their prevalence still remains unknown. Compendial protocols

Effects of mixing procedure itself on the structure, viscosity, and spreadability of white petrolatum and salicylic acid ointment and the skin permeation of salicylic acid.

Shuji Kitagawa et al.

Chemical & pharmaceutical bulletin, 63(1), 43-48 (2014-11-18)

White petrolatum is a mixture of solid and liquid hydrocarbons and its structure can be affected by shear stress. Thus, it might also induce changes in its rheological properties. In this study, we used polarization microscopy to investigate how different

A cadherin switch underlies malignancy in high-grade gliomas.

I Appolloni et al.

Oncogene, 34(15), 1991-2002 (2014-05-27)

Although the infiltrative behavior of malignant gliomas is one of their most critical aspects, the mechanisms underlying it have not yet been elucidated. To migrate in the brain parenchyma, malignant glioma cells need to bypass the cell-cell contact inhibitory signals.

TIMP-1 inhibition of occludin degradation in Caco-2 intestinal cells: a potential protective role in necrotizing enterocolitis.

Amir Bein et al.

Pediatric research, 77(5), 649-655 (2015-02-11)

Necrotizing enterocolitis (NEC), a common intestinal disease affecting premature infants, is a major cause of morbidity and mortality. Previous reports indicate an upregulation of intestinal matrix metalloproteinases (MMPs) activity that may play key roles on the higher permeability of the

Glucose-dependent insulinotropic polypeptide-mediated signaling pathways enhance apical PepT1 expression in intestinal epithelial cells.

Steven D Coon et al.

American journal of physiology. Gastrointestinal and liver physiology, 308(1), G56-G62 (2014-11-08)

We have shown recently that glucose-dependent insulinotropic polypeptide (GIP), but not glucagon-like peptide 1 (GLP-1) augments H(+) peptide cotransporter (PepT1)-mediated peptide absorption in murine jejunum. While we observed that inhibiting cAMP production decreased this augmentation of PepT1 activity by GIP

Effects of the triple monoamine uptake inhibitor amitifadine on pain-related depression of behavior and mesolimbic dopamine release in rats.

Laurence L Miller et al.

Pain, 156(1), 175-184 (2015-01-20)

Pain-related depression of behavior and mood is a key therapeutic target in the treatment of pain. Clinical evidence suggests a role for decreased dopamine (DA) signaling in pain-related depression of behavior and mood. Similarly, in rats, intraperitoneal injection of dilute

Knockdown of toll-like receptor 4 inhibits human NSCLC cancer cell growth and inflammatory cytokine secretion in vitro and in vivo.

Dan Li et al.

International journal of oncology, 45(2), 813-821 (2014-06-04)

Toll-like receptor 4 (TLR4)-mediated signaling has been implicated in tumor cell invasion, survival and metastasis in several types of cancers. However, the expression of TLR4 in patients with non-small cell lung cancer (NSCLC) and its biological function in the development

RHAMM deficiency disrupts folliculogenesis resulting in female hypofertility.

Huaibiao Li et al.

Biology open, 4(4), 562-571 (2015-03-10)

The postnatal mammalian ovary contains the primary follicles, each comprising an immature oocyte surrounded by a layer of somatic granulosa cells. Oocytes reach meiotic and developmental competence via folliculogenesis. During this process, the granulosa cells proliferate massively around the oocyte

Positive effects of soy lecithin-derived phosphatidylserine plus phosphatidic acid on memory, cognition, daily functioning, and mood in elderly patients with Alzheimer's disease and dementia.

Margret I Moré et al.

Advances in therapy, 31(12), 1247-1262 (2014-11-22)

We report previously unpublished, early pilot studies performed with a brain-health food supplement containing a proprietary blend of 100 mg phosphatidylserine (PS) and 80 mg phosphatidic acid (PA) produced from soy lecithin. Serum analysis after single PS+PA ingestion was performed in healthy

Investigations into the decomposition of aminoacyl-substituted monosaccharide scaffolds from a drug discovery library.

Q Q He et al.

Organic & biomolecular chemistry, 13(13), 4070-4079 (2015-03-05)

This study investigated the unexpected decomposition and associated intermediates of compound 1, a specific member of a drug discovery library based on a monosaccharide scaffold. LC/MS and NMR spectroscopic analyses indicated that, under acidic conditions, 1 can be converted into

Direct enantioseparation of underivatized aliphatic 3-hydroxyalkanoic acids with a quinine-based zwitterionic chiral stationary phase.

Federica Ianni et al.

Journal of chromatography. A, 1363, 101-108 (2014-04-15)

While aliphatic 2-hydroxyalkanoic acids have been more or less successfully enantioseparated with various chiral stationary phases by HPLC and GC, analogous applications on underivatized aliphatic 3-hydroxyalkanoic acids are completely absent in the scientific literature. With the aim of closing this

Antinociceptive, anti-inflammatory and gastroprotective effects of a hydroalcoholic extract from the leaves of Eugenia punicifolia (Kunth) DC. in rodents.

Rosanna T Basting et al.

Journal of ethnopharmacology, 157, 257-267 (2014-10-15)

An ethnopharmacological survey indicated that leaves from Eugenia punicifolia (Kunth) DC. (Myrtaceae) are popularly used as a natural therapeutic agent to treat pain and inflammation. The overall objective of the present study was to evaluate the antinociceptive, anti-inflammatory and gastroprotective

Localization of ginsenosides in the rhizome and root of Panax ginseng by laser microdissection and liquid chromatography-quadrupole/time of flight-mass spectrometry.

Zhitao Liang et al.

Journal of pharmaceutical and biomedical analysis, 105, 121-133 (2014-12-30)

The root and rhizome of Panax ginseng C.A. Mey, known as ginseng, is a commonly used medicinal plant. Ginsenosides are the major active components responsible for the tonic effects of this herb. Here, the combination of laser microdissection and ultra-high

Nest building is impaired in the Ts65Dn mouse model of Down syndrome and rescued by blocking 5HT2a receptors.

H Craig Heller et al.

Neurobiology of learning and memory, 116, 162-171 (2014-12-03)

Down syndrome (DS) has an incidence of about 1/700 births, and is therefore the most common cause of cognitive and behavioral impairments in children. Recent studies on mouse models of DS indicate that a number of pharmacotherapies could be beneficial

⁹⁹mTc-labeled single-domain antibody EG2 in targeting epidermal growth factor receptor: an in-vitro and mouse model in-vivo study.

Chongjiao Li et al.

Nuclear medicine communications, 36(5), 452-460 (2015-01-16)

The aim of this study was to explore the targeting ability and metabolic characteristics of the technetium-99m-labeled single-domain antibody (⁹⁹mTc-sdAb) EG2 targeting epidermal growth factor receptor (EGFR) through an in-vitro and in-vivo study. The sdAb EG2 was radiolabeled with Tc

Transdermal delivery of forskolin from emulsions differing in droplet size.

Elżbieta Sikora et al.

Colloids and surfaces. B, Biointerfaces, 126, 541-545 (2015-01-27)

The skin permeation of forskolin, a diterpene isolated from Coleus forsholii, was studied using oil in water (O/W) emulsions as delivery formulations and also an oil solution for comparative purposes. Two forskolin-loaded emulsions of water/Brij 72:Symperonic A7/Miglyol 812:Isohexadecane, at 0.075

Evaluation of clinical and cytogenetic parameters in rheumatoid arthritis patients for effective diagnosis.

R Chandirasekar et al.

Clinica chimica acta; international journal of clinical chemistry, 439, 77-83 (2014-10-14)

Rheumatoid arthritis is the commonest inflammatory joint disease, affecting nearly 1% of the adult population worldwide. Early and accurate diagnosis and prognosis of rheumatoid arthritis (RA) have become increasingly important. In the present study, we aimed to elucidate the relationships

Endometrial apical glycoproteomic analysis reveals roles for cadherin 6, desmoglein-2 and plexin b2 in epithelial integrity.

H Singh et al.

Molecular human reproduction, 21(1), 81-94 (2014-09-23)

Implantation failure is one of the major causes of infertility and remains a major barrier to assisted reproduction success. Initial receptivity to implantation is regulated by the endometrial luminal epithelium under maternal hormonal control. Identification of epithelial cell surface components

WNT Agonist Decreases Tissue Damage and Improves Renal Function After Ischemia-Reperfusion.

Michael Kuncewitch et al.

Shock (Augusta, Ga.), 43(3), 268-275 (2014-12-17)

Renal ischemia-reperfusion (IR) injury (IRI) after shock states or transplantation causes tissue damage and delayed graft function, respectively. The Wnt/β-catenin signaling pathway plays a critical role in nephrogenesis. We therefore hypothesized that pharmacological activation of the Wnt/β-catenin signaling by the

Page 2 of 110