PHR1428

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Showing 1-30 of 1919 results for "PHR1428" within Papers

Salmonella evades D-amino acid oxidase to promote infection in neutrophils.

Brian R Tuinema et al.

mBio, 5(6), e01886-e01886 (2014-11-27)

Neutrophils engulf and kill bacteria using oxidative and nonoxidative mechanisms. Despite robust antimicrobial activity, neutrophils are impaired in directing Salmonella clearance and harbor viable intracellular bacteria during early stages of infection that can subsequently escape to more-permissive cell types. The

MARQUIS: a multiplex method for absolute quantification of peptides and posttranslational modifications.

Timothy G Curran et al.

Nature communications, 6, 5924-5924 (2015-01-13)

Absolute quantification of protein expression and posttranslational modifications by mass spectrometry has been challenging due to a variety of factors, including the potentially large dynamic range of phosphorylation response. To address these issues, we have developed MARQUIS-Multiplex Absolute Regressed Quantification

Involvement of interleukin-17A-induced hypercontractility of intestinal smooth muscle cells in persistent gut motor dysfunction.

Hirotada Akiho et al.

PloS one, 9(5), e92960-e92960 (2014-05-07)

The etiology of post-inflammatory gastrointestinal (GI) motility dysfunction, after resolution of acute symptoms of inflammatory bowel diseases (IBD) and intestinal infection, is largely unknown, however, a possible involvement of T cells is suggested. Using the mouse model of T cell

Activated-ester-type photocleavable crosslinker for preparation of photodegradable hydrogels using a two-component mixing reaction.

Fumiki Yanagawa et al.

Advanced healthcare materials, 4(2), 246-254 (2014-08-15)

Photodegradable hydrogels have emerged as powerful platforms for studying and directing cellular behavior in a spatiotemporally controlled manner. Photodegradable hydrogels have previously been formed by free radical polymerizations, Michael-type addition reactions, and orthogonal click reactions. Here, an ester-activated photocleavable crosslinker

Significant enhancement of hPrx1 chaperone activity through lysine acetylation.

Yanchao Pan et al.

Chembiochem : a European journal of chemical biology, 15(12), 1773-1776 (2014-08-02)

The reversible acetylation of proteins plays a key role in regulating biological processes, including chromatin remodeling, progression of the cell cycle, and actin nucleation. Human peroxiredoxin 1(hPrx1), one of the most abundant proteins in the cytoplasm, has been shown to

Peripheral prostaglandin E2 prolongs the sensitization of nociceptive dorsal root ganglion neurons possibly by facilitating the synthesis and anterograde axonal trafficking of EP4 receptors.

Bruno St-Jacques et al.

Experimental neurology, 261, 354-366 (2014-06-10)

Prostaglandin E2 (PGE2), a well-known pain mediator enriched in inflamed tissues, plays a pivotal role in the genesis of chronic pain conditions such as inflammatory and neuropathic pain. PGE2-prolonged sensitization of nociceptive dorsal root ganglion (DRG) neurons (nociceptors) may contribute

Co-transplantation of endothelial progenitor cells and pancreatic islets to induce long-lasting normoglycemia in streptozotocin-treated diabetic rats.

Paola Quaranta et al.

PloS one, 9(4), e94783-e94783 (2014-04-16)

Graft vascularization is a crucial step to obtain stable normoglycemia in pancreatic islet transplantation. Endothelial progenitor cells (EPCs) contribute to neoangiogenesis and to the revascularization process during ischaemic events and play a key role in the response to pancreatic islet

In vivo fluorescence imaging and urinary monoamines as surrogate biomarkers of disease progression in a mouse model of pheochromocytoma.

Martin Ullrich et al.

Endocrinology, 155(11), 4149-4156 (2014-08-20)

Pheochromocytoma (PHEO) is a rare but potentially lethal neuroendocrine tumor arising from catecholamine-producing chromaffin cells. Especially for metastatic PHEO, the availability of animal models is essential for developing novel therapies. For evaluating therapeutic outcome in rodent PHEO models, reliable quantification

Collagen gel contraction assay using human bronchial smooth muscle cells and its application for evaluation of inhibitory effect of formoterol.

Yusuke Sakota et al.

Biological & pharmaceutical bulletin, 37(6), 1014-1020 (2014-06-03)

Collagen gel contraction assay is a method for evaluating contraction of cells embedded in collagen gel matrices through measuring the gel size. In the present study, we established a protocol for collagen gel contraction assay using human bronchial smooth muscle

1,25-dihydroxyvitamin D3 causes ADAM10-dependent ectodomain shedding of tumor necrosis factor receptor 1 in vascular smooth muscle cells.

Won Seok Yang et al.

Molecular pharmacology, 87(3), 533-542 (2015-01-04)

1,25-Dihydroxyvitamin D3 (1,25D3) has a potential antiatherosclerotic effect through anti-inflammatory actions. We investigated how 1,25D3 regulates tumor necrosis factor-α (TNF-α)-induced lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) expression in cultured human aortic smooth muscle cells. TNF-α activated Rac1/reactive oxygen species/spleen tyrosine

Direct effect of bevacizumab on glioblastoma cell lines in vitro.

Thomas Simon et al.

Neuromolecular medicine, 16(4), 752-771 (2014-08-13)

Bevacizumab is a humanized monoclonal antibody directed against the pro-angiogenic factor vascular and endothelial growth factor-A (VEGF-A) used in the treatment of glioblastomas. Although most patients respond initially to this treatment, studies have shown that glioblastomas eventually recur. Several non-mutually

Neonatal thymectomy favors Helicobacter pylori-promoted gastric mucosa-associated lymphoid tissue lymphoma lesions in BALB/c mice.

Delphine Chrisment et al.

The American journal of pathology, 184(8), 2174-2184 (2014-06-10)

Neonatal thymectomy in BALB/c mice has been described as a model of gastric mucosa-associated lymphoid tissue (MALT) lymphoma (GML). By using this experimental system, we screened, for the first time to our knowledge, Helicobacter pylori GML-associated strains for their capacity

Cryopreservation of viable human lung tissue for versatile post-thaw analyses and culture.

John E Baatz et al.

In vivo (Athens, Greece), 28(4), 411-423 (2014-07-02)

Clinical trials are currently used to test therapeutic efficacies for lung cancer, infections and diseases. Animal models are also used as surrogates for human disease. Both approaches are expensive and time-consuming. The utility of human biospecimens as models is limited

Shape-shifting 3D protein microstructures with programmable directionality via quantitative nanoscale stiffness modulation.

Mian Rong Lee et al.

Small (Weinheim an der Bergstrasse, Germany), 11(6), 740-748 (2014-09-30)

The ability to shape-shift in response to a stimulus increases an organism's survivability in nature. Similarly, man-made dynamic and responsive "smart" microtechnology is crucial for the advancement of human technology. Here, 10-30 μm shape-changing 3D BSA protein hydrogel microstructures are

SIGNR3-dependent immune regulation by Lactobacillus acidophilus surface layer protein A in colitis.

Yaíma L Lightfoot et al.

The EMBO journal, 34(7), 881-895 (2015-02-11)

Intestinal immune regulatory signals govern gut homeostasis. Breakdown of such regulatory mechanisms may result in inflammatory bowel disease (IBD). Lactobacillus acidophilus contains unique surface layer proteins (Slps), including SlpA, SlpB, SlpX, and lipoteichoic acid (LTA), which interact with pattern recognition

Metallothionein III (MT3) is a putative tumor suppressor gene that is frequently inactivated in pediatric acute myeloid leukemia by promoter hypermethylation.

Yan-Fang Tao et al.

Journal of translational medicine, 12, 182-182 (2014-06-26)

Acute myeloid leukemia (AML) is the second most common form of leukemia in children. Aberrant DNA methylation patterns are a characteristic feature in various tumors, including AML. Metallothionein III (MT3) is a tumor suppresser reported to show promoter hypermethylated in

Spectrum and mechanisms of inflammasome activation by chitosan.

Chelsea L Bueter et al.

Journal of immunology (Baltimore, Md. : 1950), 192(12), 5943-5951 (2014-05-16)

Chitosan, the deacetylated derivative of chitin, can be found in the cell wall of some fungi and is used in translational applications. We have shown that highly purified preparations of chitosan, but not chitin, activate the NOD-like receptor family, pyrin

Exposure to diethylstilbestrol during pregnancy modulates microRNA expression profile in mothers and fetuses reflecting oncogenic and immunological changes.

Narendra P Singh et al.

Molecular pharmacology, 87(5), 842-854 (2015-03-11)

Prenatal exposure to diethylstilbestrol (DES) is known to cause an increased susceptibility to a wide array of clinical disorders in humans. Previous studies from our laboratory demonstrated that prenatal exposure to DES induces thymic atrophy and apoptosis in the thymus.

The absence or overexpression of IL-15 drastically alters breast cancer metastasis via effects on NK cells, CD4 T cells, and macrophages.

Amy Gillgrass et al.

Journal of immunology (Baltimore, Md. : 1950), 193(12), 6184-6191 (2014-10-31)

IL-15 is a cytokine that can affect many immune cells, including NK cells and CD8 T cells. In several tumor models, IL-15 delays primary tumor formation and can prevent or reduce metastasis. In this study, we have employed a model

Muscle-specific Drp1 overexpression impairs skeletal muscle growth via translational attenuation.

T Touvier et al.

Cell death & disease, 6, e1663-e1663 (2015-02-27)

Mitochondrial fission and fusion are essential processes in the maintenance of the skeletal muscle function. The contribution of these processes to muscle development has not been properly investigated in vivo because of the early lethality of the models generated so

Reduced Infectivity in cattle for an outer membrane protein mutant of Anaplasma marginale.

Francy L Crosby et al.

Applied and environmental microbiology, 81(6), 2206-2214 (2015-01-18)

Anaplasma marginale is the causative agent of anaplasmosis in cattle. Transposon mutagenesis of this pathogen using the Himar1 system resulted in the isolation of an omp10 operon insertional mutant referred to as the omp10::himar1 mutant. The work presented here evaluated

Macrophages clear refrigerator storage-damaged red blood cells and subsequently secrete cytokines in vivo, but not in vitro, in a murine model.

Boguslaw S Wojczyk et al.

Transfusion, 54(12), 3186-3197 (2014-07-22)

In mice, refrigerator-stored red blood cells (RBCs) are cleared by extravascular hemolysis and induce cytokine production. To enhance understanding of this phenomenon, we sought to model it in vitro. Ingestion of refrigerator-stored murine RBCs and subsequent cytokine production were studied

Quantification of leakage from large unilamellar lipid vesicles by fluorescence correlation spectroscopy.

Kasper Kristensen et al.

Biochimica et biophysica acta, 1838(12), 2994-3002 (2014-08-20)

Fluorescence correlation spectroscopy (FCS) is a powerful experimental technique that in recent years has found numerous applications for studying biological phenomena. In this article, we scrutinize one of these applications, namely, FCS as a technique for studying leakage of fluorescent

The in vitro apoptotic effects of A248 and A1659, newly synthetic histone deacetylase inhibitors in oral cancer cells.

J-A Shin et al.

Oral diseases, 20(5), 482-489 (2013-07-16)

Histone deacetylase (HDAC) inhibitors represent potential therapeutic agents against various cancers. In this study, we attempt to identify whether newly synthesized HDAC inhibitors, A248 and A1659, can be effective anti-cancer drug candidates for oral cancer. The anti-cancer activities of A248

Viruses infecting marine picoplancton encode functional potassium ion channels.

Fenja Siotto et al.

Virology, 466-467, 103-111 (2014-12-03)

Phycodnaviruses are dsDNA viruses, which infect algae. Their large genomes encode many gene products, like small K(+) channels, with homologs in prokaryotes and eukaryotes. Screening for K(+) channels revealed their abundance in viruses from fresh-water habitats. Recent sequencing of viruses

Identification of predictive factors of response to the BH3-mimetic molecule ABT-737: an ex vivo experiment in human serous ovarian carcinoma.

Stéphanie Lheureux et al.

International journal of cancer, 136(5), E340-E350 (2014-07-30)

Ovarian cancers are addicted to Bcl-xL and Mcl-1, antiapoptotic members of the Bcl-2 family. Bcl-xL can be inhibited by the BH3-mimetic ABT-737. In vitro, ABT-737 can induce apoptosis of cancer cells, and its activity is potentiated by Mcl-1 inactivation. Herein

Neutral polymer micelle carriers with pH-responsive, endosome-releasing activity modulate antigen trafficking to enhance CD8(+) T cell responses.

Salka Keller et al.

Journal of controlled release : official journal of the Controlled Release Society, 191, 24-33 (2014-04-05)

Synthetic subunit vaccines need to induce CD8(+) cytotoxic T cell (CTL) responses for effective vaccination against intracellular pathogens. Most subunit vaccines primarily generate humoral immune responses, with a weaker than desired CD8(+) cytotoxic T cell response. Here, a neutral, pH-responsive

Development of novel electrospun nanofibrous scaffold from P. Ricini And A. Mylitta silk fibroin blend with improved surface and biological properties.

N Panda et al.

Materials science & engineering. C, Materials for biological applications, 48, 521-532 (2015-01-13)

Biomaterials that stimulate cell attachment and proliferation without any surface modification (e.g. RGD coating) provide potent and cost effective scaffold for regenerative medicine. This study assessed the physico-chemical properties and cell supportive potential of a silk fibroin blend scaffold derived

Analogues of etomidate: modifications around etomidate's chiral carbon and the impact on in vitro and in vivo pharmacology.

Ervin Pejo et al.

Anesthesiology, 121(2), 290-301 (2014-04-30)

R-etomidate possesses unique desirable properties but potently suppresses adrenocortical function. Consequently, efforts are being made to define structure-activity relationships with the goal of designing analogues with reduced adrenocortical toxicity. The authors explored the pharmacological impact of modifying etomidate's chiral center

Characterization of niphatenones that inhibit androgen receptor N-terminal domain.

Carmen A Banuelos et al.

PloS one, 9(9), e107991-e107991 (2014-10-01)

Androgen ablation therapy causes a temporary reduction in tumor burden in patients with advanced prostate cancer. Unfortunately the malignancy will return to form lethal castration-recurrent prostate cancer (CRPC). The androgen receptor (AR) remains transcriptionally active in CRPC in spite of

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