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Showing 1-21 of 21 results for "PLN70" within Papers
Merijn L M Salverda et al.
PLoS genetics, 7(3), e1001321-e1001321 (2011-03-17)
Whether evolution is erratic due to random historical details, or is repeatedly directed along similar paths by certain constraints, remains unclear. Epistasis (i.e. non-additive interaction between mutations that affect fitness) is a mechanism that can contribute to both scenarios. Epistasis
Aarti Kathrani et al.
PloS one, 7(1), e30117-e30117 (2012-01-27)
Single nucleotide polymorphisms (SNP) in the TLR5 gene have been associated with human inflammatory bowel disease (IBD) and animal models of this disease. We recently demonstrated a significant association between three non-synonymous SNPs in the canine TLR5 gene and IBD
Esteban Cruz et al.
Pharmaceutics, 13(11) (2021-11-28)
Protein aggregation constitutes a recurring complication in the manufacture and clinical use of therapeutic monoclonal antibodies (mAb) and mAb derivatives. Antibody aggregates can reduce production yield, cause immunogenic reactions, decrease the shelf-life of the pharmaceutical product and impair the capacity
Martina Herrmann et al.
Applied and environmental microbiology, 75(10), 3127-3136 (2009-03-24)
Communities of ammonia-oxidizing archaea (AOA) and bacteria (AOB) in freshwater sediments and those in association with the root system of the macrophyte species Littorella uniflora, Juncus bulbosus, and Myriophyllum alterniflorum were compared for seven oligotrophic to mesotrophic softwater lakes and
Comparison of three molecular methods for the detection of pilchard herpesvirus in archived paraffin-embedded tissue and frozen tissue.
Crockford M
Diseases of Aquatic Organisms, 82(1), 37-44 (2008)
Genetic determinants of resistance to fusidic acid among clinical bacteremia isolates of Staphylococcus aureus.
Lannergard J
Antimicrobial Agents and Chemotherapy, 53(5), 2059-2065 (2009)
Soudabeh Rad Pour et al.
Scientific reports, 9(1), 12150-12150 (2019-08-23)
Kynurenine pathway (KP) activation by the enzymatic activity of indoleamine 2,3-dioxygenase1 (IDO1) and kynurenine (KYN) production represents an attractive target for reducing tumour progression and improving anti-tumour immunity in multiple cancers. However, immunomodulatory properties of other KP metabolites such as
Jakub Harnoš et al.
Nature communications, 10(1), 1804-1804 (2019-04-20)
Dishevelled (DVL) is the key component of the Wnt signaling pathway. Currently, DVL conformational dynamics under native conditions is unknown. To overcome this limitation, we develop the Fluorescein Arsenical Hairpin Binder- (FlAsH-) based FRET in vivo approach to study DVL
Jian Li et al.
BMC genomics, 10, 223-223 (2009-05-15)
DNA methylation is a widely studied epigenetic mechanism known to correlate with gene repression and genomic stability. Development of sensitive methods for global detection of DNA methylation events is of particular importance. We here describe a technique, called modified methylation-specific
Keiji Ueno et al.
Chemistry Central journal, 5(1), 16-16 (2011-04-06)
We have previously reported on the variation of total fructooligosaccharides (FOS), total inulooligosaccharides (IOS) and inulin in the roots of burdock stored at different temperatures. During storage at 0°C, an increase of FOS as a result of the hydrolysis of
Rosina Pryor et al.
Cell, 178(6), 1299-1312 (2019-09-03)
Metformin is the first-line therapy for treating type 2 diabetes and a promising anti-aging drug. We set out to address the fundamental question of how gut microbes and nutrition, key regulators of host physiology, affect the effects of metformin. Combining
Ky V Hoang et al.
Frontiers in microbiology, 8, 1695-1695 (2017-09-29)
Francisella tularensis (F. tularensis) is the causative agent of tularemia and is classified as a Tier 1 select agent. No licensed vaccine is currently available in the United States and treatment of tularemia is confined to few antibiotics. In this
Masa-aki Yoshida et al.
BMC evolutionary biology, 11, 180-180 (2011-06-28)
Coleoid cephalopods (squids and octopuses) have evolved a camera eye, the structure of which is very similar to that found in vertebrates and which is considered a classic example of convergent evolution. Other molluscs, however, possess mirror, pin-hole, or compound
Isabella Monne et al.
Journal of clinical microbiology, 46(5), 1769-1773 (2008-03-28)
Among the different hemagglutinin (HA) subtypes of avian influenza (AI) viruses, H5, H7, and H9 are of major interest because of the serious consequences for the poultry industry and the increasing frequency of direct transmission of these viruses to humans.
Shree Vidhya Srinivasan et al.
Heliyon, 5(11), e02863-e02863 (2019-12-18)
Pregnancy-associated glycoproteins (PAGs) secreted from conceptus specific trophoblast cells are widely accepted biomarkers of ruminants. Limited information of PAGs in buffalo warrants further investigation for the development of sensitive homologous early pregnancy-specific diagnostic immunoassay. This experiment was thus designed to
SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation.
Mohsen Sarikhani et al.
eLife, 7 (2018-03-06)
Glycogen synthase kinase 3 (GSK3) is a critical regulator of diverse cellular functions involved in the maintenance of structure and function. Enzymatic activity of GSK3 is inhibited by N-terminal serine phosphorylation. However, alternate post-translational mechanism(s) responsible for GSK3 inactivation are
Kelly S Schweitzer et al.
JCI insight, 5(14) (2020-06-24)
Cigarette smoking (CS) and genetic susceptibility determine the risk for development, progression, and severity of chronic obstructive pulmonary diseases (COPD). We posited that an incidental balanced reciprocal chromosomal translocation was linked to a patient's risk of severe COPD. We determined
Timothy A Scott et al.
Cell, 169(3), 442-456 (2017-04-22)
Fluoropyrimidines are the first-line treatment for colorectal cancer, but their efficacy is highly variable between patients. We queried whether gut microbes, a known source of inter-individual variability, impacted drug efficacy. Combining two tractable genetic models, the bacterium E. coli and the nematode C. elegans
Veerle Derous et al.
BMC research notes, 4, 213-213 (2011-06-24)
A number of allele replacement methods can be used to mutate bacterial genes. For instance, the Red recombinase system of phage Lambda has been used very efficiently to inactivate chromosomal genes in E. coli K-12, through recombination between regions of
Cloning and Characterization of Serine-rich Entamoeba histolytica Protein Gene from an Iranian E. histolytica Isolate
Sima Rasti
Pakistan journal of biological sciences: PJBS, 9, 654-658 (2006)
Matthew J Coussens et al.
Journal of visualized experiments : JoVE, (58)(58), doi:10-doi:10 (2012-01-05)
RNA interference (RNAi) is an intrinsic cellular mechanism for the regulation of gene expression. Harnessing the innate power of this system enables us to knockdown gene expression levels in loss of gene function studies. There are two main methods for
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