Q2128

Applied Filters:

Keyword:'Q2128'

Showing 1-30 of 60 results for "Q2128" within Papers

Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors.

Charalambos Kaittanis et al.

The Journal of experimental medicine, 215(1), 159-175 (2017-11-17)

Prostate-specific membrane antigen (PSMA) or folate hydrolase 1 (FOLH1) is highly expressed on prostate cancer. Its expression correlates inversely with survival and increases with tumor grade. However, the biological role of PSMA has not been explored, and its role in

Deleterious GRM1 mutations in schizophrenia.

Mohammed Akli Ayoub et al.

PloS one, 7(3), e32849-e32849 (2012-03-27)

We analysed a phenotypically well-characterised sample of 450 schziophrenia patients and 605 controls for rare non-synonymous single nucleotide polymorphisms (nsSNPs) in the GRM1 gene, their functional effects and family segregation. GRM1 encodes the metabotropic glutamate receptor 1 (mGluR1), whose documented

Predifferentiated GABAergic neural precursor transplants for alleviation of dysesthetic central pain following excitotoxic spinal cord injury.

Jeung Woon Lee et al.

Frontiers in physiology, 3, 167-167 (2012-07-04)

Intraspinal quisqualic acid (QUIS) injury induce (i) mechanical and thermal hyperalgesia, (ii) progressive self-injurious overgrooming of the affected dermatome. The latter is thought to resemble painful dysesthesia observed in spinal cord injury (SCI) patients. We have reported previously loss of

Serotonin-2B receptor antagonism increases the activity of dopamine and glutamate neurons in the presence of selective serotonin reuptake inhibition.

Rami Hamati et al.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 45(12), 2098-2105 (2020-05-31)

Previous research has implicated the serotonin-2B (5-HT2B) receptor as a possible contributor to the antidepressant-like response. Aripiprazole has been successfully used in combination with selective serotonin reuptake inhibitors (SSRIs) in treatment-resistant depression and it, among all receptors, exhibits the highest

Potential for Cell-Transplant Therapy with Human Neuronal Precursors to Treat Neuropathic Pain in Models of PNS and CNS Injury: Comparison of hNT2.17 and hNT2.19 Cell Lines.

Mary J Eaton et al.

Pain research and treatment, 2012, 356412-356412 (2012-05-24)

Effective treatment of sensory neuropathies in peripheral neuropathies and spinal cord injury (SCI) is one of the most difficult problems in modern clinical practice. Cell therapy to release antinociceptive agents near the injured spinal cord is a logical next step

C-fos expression in the rat nucleus basalis upon excitotoxic lesion with quisqualic acid: a study in adult and aged animals.

L Giovannelli et al.

Journal of neural transmission (Vienna, Austria : 1996), 105(8-9), 935-948 (1998-12-30)

A unilateral quisqualic acid lesion was placed in the nucleus basalis magnocellularis of 3- and 24-month-old rats, and the animals were sacrificed at different times post-surgery. The morphology and the number of the cholinergic neurons of the nucleus basalis were

Metabotropic and ionotropic glutamate receptors mediate the modulation of acetylcholine release at the frog neuromuscular junction.

Andrei Tsentsevitsky et al.

Journal of neuroscience research, 95(7), 1391-1401 (2016-10-23)

There is some evidence that glutamate (Glu) acts as a signaling molecule at vertebrate neuromuscular junctions where acetylcholine (ACh) serves as a neurotransmitter. In this study, performed on the cutaneous pectoris muscle of the frog Rana ridibunda, Glu receptor mechanisms

Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine null

Quisqualis indica Improves Benign Prostatic Hyperplasia by Regulating Prostate Cell Proliferation and Apoptosis.

Charith Ub Wijerathne et al.

Biological & pharmaceutical bulletin, 40(12), 2125-2133 (2017-09-26)

Quisqualis indica (QI) has been used for treating disorders such as stomach pain, constipation, and digestion problem. This study was aimed to evaluate the therapeutic efficacy of QI extract on treating benign prostatic hyperplasia (BPH) in LNCaP human prostate cancer

Effects of acute and sustained administration of vortioxetine on the serotonin system in the hippocampus: electrophysiological studies in the rat brain.

Mostafa El Mansari et al.

Psychopharmacology, 232(13), 2343-2352 (2015-02-11)

Vortioxetine is a novel multimodal antidepressant that is a 5-HT1B receptor partial agonist, a 5-HT1A receptor agonist, an inhibitor of the serotonin (5-HT) transporter, and a 5-HT1D, 5-HT3, and 5-HT7 receptor antagonist in vitro. In vivo studies have shown that

Recent advances in the pharmacology of excitatory amino acids.

Watkins, et al.

Neurol. Neurobiol., 24, 19-19 (1987)

Functional induction of the cystine-glutamate exchanger system Xc(-) activity in SH-SY5Y cells by unconjugated bilirubin.

Pablo J Giraudi et al.

PloS one, 6(12), e29078-e29078 (2012-01-05)

We have previously reported that exposure of SH-SY5Y neuroblastoma cells to unconjugated bilirubin (UCB) resulted in a marked up-regulation of the mRNA encoding for the Na(+)-independent cystine∶glutamate exchanger System X(c)(-) (SLC7A11 and SLC3A2 genes). In this study we demonstrate that

Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice.

Marzia Castiglione et al.

Neuropharmacology, 55(4), 560-567 (2008-07-08)

Neural progenitor cells (NPCs) are found in the subventricular zone (SVZ) of the adult brain, a specialized neurogenic niche that might provide a substrate for brain repair after injury. The incomplete knowledge of how NPCs in the niche respond to

Long-term administration of cariprazine increases locus coeruleus noradrenergic neurons activity and serotonin1A receptor neurotransmission in the hippocampus.

Mostafa El Mansari et al.

Journal of psychopharmacology (Oxford, England), 34(10), 1143-1154 (2020-07-21)

Cariprazine, the novel dopamine (DA) D3-preferring D3/D2 and serotonin (5-HT)1A receptor partial agonist, has activity as an adjunctive therapy in major depressive disorder (MDD). This study aims to investigate the effects of chronic cariprazine administration in combination with the selective

Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [H]Glutamate Binding to Rat Synaptic Membranes.

Lisa M Del Valle-Mojica et al.

Evidence-based complementary and alternative medicine : eCAM, 2011, 403591-403591 (2011-05-18)

Although GABA neurotransmission has been suggested as a mechanism for Valeriana officinalis effects, CNS depression can also be evoked by inhibition of ionotropic (iGluR) and metabotropic glutamate receptors (mGluR). In this study, we examined if aqueous valerian extract interacted with

Posttraumatic syringomyelia.

Michael G Fehlings et al.

Journal of neurosurgery. Spine, 14(5), 570-572 (2011-03-11)

Subtype selective kainic acid receptor agonists: discovery and approaches to rational design.

Lennart Bunch et al.

Medicinal research reviews, 29(1), 3-28 (2008-07-16)

(S)-Glutamic acid (Glu) is the major excitatory neurotransmitter in the mammalian central nervous system, activating the plethora of glutamate receptors (GluRs). In broad lines, the GluRs are divided into two major classes: the ionotropic Glu receptors (iGluRs) and the metabotropic

Activation of metabotropic glutamate receptors induces periodic burst firing and concomitant cytosolic Ca2+ oscillations in cerebellar interneurons.

Thibault Collin et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 29(29), 9281-9291 (2009-07-25)

Little is known about the generation of slow rhythms in brain neuronal circuits. Nevertheless, a few studies, both from reconstituted systems and from hippocampal slices, indicate that activation of metabotropic glutamate receptors (mGluRs) could generate such rhythms. Here we show

Medical Laboratory Science : Theory And Practice (1990)

Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation.

Alexander A Nicodemo et al.

Molecular brain, 3, 4-4 (2010-02-26)

Group I metabotropic glutamate receptors (mGluRs) are coupled via Galphaq/11 to the activation of phospholipase Cbeta, which hydrolyzes membrane phospholipids to form inositol 1,4,5 trisphosphate and diacylglycerol. This results in the release of Ca2+ from intracellular stores and the activation

Involvement of ERK2 in traumatic spinal cord injury.

Chen-Guang Yu et al.

Journal of neurochemistry, 113(1), 131-142 (2010-01-14)

Activation of extracellular signal-regulated protein kinase 1/2 (ERK1/2) are implicated in the pathophysiology of spinal cord injury (SCI). However, the specific functions of individual ERK isoforms in neurodegeneration are largely unknown. We investigated the hypothesis that ERK2 activation may contribute

Structural insight into the evolutionary and pharmacologic homology of glutamate carboxypeptidases II and III.

Klara Hlouchova et al.

The FEBS journal, 276(16), 4448-4462 (2009-08-15)

Glutamate carboxypeptidase III (GCPIII) is a metalloenzyme that belongs to the transferrin receptor/glutamate carboxypeptidase II (GCPII; EC 3.4.17.21) superfamily. GCPIII has been studied mainly because of its evolutionary relationship to GCPII, an enzyme involved in a variety of neuropathologies and

Reaction of endogenous progenitor cells in a rat model of posttraumatic syringomyelia.

Jian Tu et al.

Journal of neurosurgery. Spine, 14(5), 573-582 (2011-03-11)

Endogenous stem cells theoretically could replace lost tissue and repair deficits caused by syringes. In this study the authors quantitatively examined 1) whether neural progenitor cells exist in an adult rat model of posttraumatic syringomyelia (PTS); 2) and if so

Structural insight into the pharmacophore pocket of human glutamate carboxypeptidase II.

Cyril Barinka et al.

Journal of medicinal chemistry, 50(14), 3267-3273 (2007-06-15)

Inhibition of glutamate carboxypeptidase II (GCPII) has been shown to be neuroprotective in multiple preclinical models in which dysregulated glutamatergic transmission is implicated. Herein, we report crystal structures of the human GCPII complexed with three glutamate mimetics/derivatives, 2-(phosphonomethyl)pentanedioic acid (2-PMPA)

Agonist-induced internalization of mGluR1alpha is mediated by caveolin.

Yun Hwa Hong et al.

Journal of neurochemistry, 111(1), 61-71 (2009-07-25)

Agonist-induced internalization of metabotropic glutamate receptors (mGluRs) plays an important role in neuronal signaling. Although internalization of mGluRs has been reported to be mediated by clathrin-dependent pathway, studies describing clathrin-independent pathways are emerging. Here, we report that agonist-induced internalization of

The fungal alkaloid Okaramine-B activates an L-glutamate-gated chloride channel from Ixodes scapularis, a tick vector of Lyme disease.

Shogo Furutani et al.

International journal for parasitology. Drugs and drug resistance, 8(2), 350-360 (2018-06-30)

A novel L-glutamate-gated anion channel (IscaGluCl1) has been cloned from the black-legged tick, Ixodes scapularis, which transmits multiple pathogens including the agents of Lyme disease and human granulocytic anaplasmosis. When mRNA encoding IscaGluCl1 was expressed in Xenopus laevis oocytes, we

Optical recordings of Ca2+ signaling activities from identified inner ear cells in cochlear slices and hemicochleae

Xi Lin

Brain Res. Protoc., 11(2) (2003)

Increased [³H]quisqualic acid binding density in the dorsal striatum and anterior insula of alcoholics: A post-mortem whole-hemisphere autoradiography study.

Virpi Laukkanen et al.

Psychiatry research. Neuroimaging, 287, 63-69 (2019-04-17)

The function of group I metabotropic glutamate receptors mGluR1 and mGluR5 is involved in the hyperglutamatergic state caused by chronic alcohol. Preclinical studies suggest that group I mGluR modulation could serve as a novel treatment of alcoholism. Considering the wide

Structural insights into the activation of metabotropic glutamate receptors.

Antoine Koehl et al.

Nature, 566(7742), 79-84 (2019-01-25)

Metabotropic glutamate receptors are family C G-protein-coupled receptors. They form obligate dimers and possess extracellular ligand-binding Venus flytrap domains, which are linked by cysteine-rich domains to their 7-transmembrane domains. Spectroscopic studies show that signalling is a dynamic process, in which

Long-term administration of the antidepressant vilazodone modulates rat brain monoaminergic systems.

Mostafa El Mansari et al.

Neuropharmacology, 99, 696-704 (2015-09-13)

Vilazodone has high affinity for the human 5-hydroxytryptamine1A (h5-HT1A) receptor and for the serotonin transporter (5-HTT). A previous in vivo microdialysis experiment showed that a single administration of vilazodone, dose-dependently increases extracellular 5-HT but not norepinephrine (NE) or dopamine (DA) levels

Page 1 of 2