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Showing 1-30 of 65 results for "R101" within Papers
Ruth Prieto-Montero et al.
Sensors (Basel, Switzerland), 20(19) (2020-10-03)
Functionalized fluorescent silica nanoparticles were designed and synthesized to selectively target cancer cells for bioimaging analysis. The synthesis method and characterization of functionalized fluorescent silica nanoparticles (50-60 nm), as well as internalization and subcellular localization in HeLa cells is reported
Double-liposome-based dual-drug delivery system as vectors for effective management of peptic ulcer.
Ashish K Jain et al.
Journal of liposome research, 22(3), 205-214 (2012-08-15)
The aim of the present investigation was to prepare and evaluate a vesicular dual-drug delivery system for effective management of the mucosal ulcer. Inner encapsulating and double liposomes were prepared by the glass-bead and reverse-phase evaporation methods, respectively. The formulation
Julien Le Roux et al.
Environmental science & technology, 46(20), 11095-11103 (2012-09-13)
The kinetics of decomposition of the pharmaceutical ranitidine (a major precursor of NDMA) during chloramination was investigated and some decomposition byproducts were identified by using high performance liquid chromatography coupled with mass spectrometry (HPLC-MS). The reaction between monochloramine and ranitidine
Zachary Barrett-O'Keefe et al.
Experimental physiology, 98(1), 268-277 (2012-08-01)
A sustained postexercise vasodilatation, which is histamine receptor mediated, has been observed following single bouts of whole-body exercise, but the mechanisms that regulate activation of histamine receptors following exercise are undefined. Exploration of vasodilatation after small muscle-mass dynamic or resistance
Gaia Rocchitta et al.
Analytical chemistry, 84(16), 7072-7079 (2012-07-25)
Ethanol is one of the most widespread psychotropic agents in western society. While its psychoactive effects are mainly associated with GABAergic and glutamatergic systems, the positive reinforcing properties of ethanol are related to activation of mesolimbic dopaminergic pathways resulting in
Tian Xie et al.
Neuroscience research, 158, 30-36 (2019-09-19)
We aimed to demonstrate the effects of microRNA (miR)-101 on neuropathic pain and explore the underlying mechanisms. Rat spinal microglia cells were isolated and inflammatory condition was stimulated by 24-h incubation with lipopolysaccharide (LPS). Rats were divided into 4 groups:
Marzena Jamrógiewicz et al.
Journal of pharmaceutical and biomedical analysis, 76, 177-182 (2013-01-22)
Ranitidine (RAN) is on top of the list of prescribed drugs, due to its popularity as a selective H2-receptor antagonist, which efficiently decreases the amount of acid produced in the stomach. RAN is not stable both in a solid state
Ruqiao Shen et al.
Water research, 47(2), 802-810 (2012-11-28)
N-nitrosodimethylamine (NDMA) is an emerging disinfection by-product (DBP) which can be formed via the chloramination of amine-based precursors. The formation of NDMA is mainly determined by the speciation of chloramines and the precursor amine groups, both of which are highly
Andy Rorie et al.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 112(4), 376-382 (2014-02-11)
Observational reports have linked vitamin D with chronic urticaria, yet no randomized controlled trial has been conducted. To determine whether high-dose vitamin D supplementation would decrease Urticaria Symptom Severity (USS) scores and medication burden in patients with chronic urticaria. In
Effects of levamisole and ranitidine on antibody-forming responses induced by killed Mycoplasma vaccine antigens in Saanen goats.
E M Temizel et al.
The Veterinary record, 171(23), 597-597 (2012-11-03)
Charlene Galea et al.
Journal of pharmaceutical and biomedical analysis, 111, 333-343 (2015-01-30)
Supercritical fluid chromatography (SFC) is drawing considerable interest as separation technique in the pharmaceutical industry. The technique is already well established in chiral separations both analytically and on a preparative scale. The use of SFC as a technique for drug
Shuang Zhang et al.
PloS one, 7(12), e51148-e51148 (2012-12-20)
Stress contributes to a variety of diseases and disorders such as depression and peptic ulcer. The present study aimed to investigate the correlation between stress ulcer and depression in pathogenesis and treatment by using chronic stress depression (CSD), chronic psychological
Zaim Gashi et al.
Medical archives (Sarajevo, Bosnia and Herzegovina), 66(4), 236-239 (2012-08-28)
Nowadays PPI present cornerstone in the medical therapy of bleeding peptic ulcer. Controlled pantoprazole data in peptic ulcer bleeding are few. To compare the effect of intravenous (iv) pantoprazole (PPI) with iv ranitidine (H2RA) for bleeding peptic ulcers after endoscopic
Mahmut Özer et al.
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, 23(5), 438-443 (2012-11-20)
The aim of this study was to investigate the effects of the H2 receptor antagonists famotidine and ranitidine on lower esophageal sphincter pressure in the rat isolated lower esophageal sphincter preparation contracted with carbachol. Lower esophageal sphincter tissues of eight
M Boyce et al.
Alimentary pharmacology & therapeutics, 36(2), 181-189 (2012-05-23)
Nonclinical studies have shown netazepide (YF476) to be a potent, selective, competitive and orally active gastrin receptor antagonist. To administer to humans for the first time single oral doses of netazepide, to assess their tolerability, safety, pharmacokinetics and effect on
Flushing, fatigue, and recurrent anaphylaxis: a delayed diagnosis of mastocytosis.
Theo Gülen et al.
Lancet (London, England), 383(9928), 1608-1608 (2014-05-06)
Morteza Piri et al.
Pharmacology, biochemistry, and behavior, 102(3), 391-399 (2012-06-13)
Histaminergic receptors and neuronal nitric oxide synthase (nNOS) are co-expressed at high levels in the hippocampal neurons and alter anxiety-like behaviors in rodents. Since the dorsal hippocampus may be involved in modulation of anxiety-like behaviors, the aim of the present
Ana Oliveira et al.
Life sciences, 109(2), 104-110 (2014-06-27)
Morphine is extensively metabolized to neurotoxic morphine-3-glucuronide (M3G) and opioid agonist morphine-6-glucuronide (M6G). Due to these different roles, interindividual variability and co-administration of drugs that interfere with metabolism may affect analgesia. The aim of the study was to investigate the
L Tian et al.
Neuroscience research, 36(1), 61-66 (2000-03-18)
Recent neuroanatomical studies have revealed a direct hypothalamocerebellar histaminergic pathway. However, the functional significance of the histaminergic fibers in the cerebellum is not yet clear. In this study, the effects of histamine on the firing of cerebellar Purkinje cells (PCs)
Ahmad Bani-Jaber et al.
Archives of pharmacal research, 35(7), 1159-1168 (2012-08-07)
The aim of this study was to prepare fatty acid salts of chitosan (CS) and to evaluate the salts as matrices for sustained drug release and prolonged gastric retention. CS-laurate and CS-palmitate were formed by mixing saturated CS solution and
Hiroshi Satoh et al.
The Journal of pharmacology and experimental therapeutics, 348(2), 227-235 (2013-11-21)
Antisecretory drugs such as histamine H₂-receptor antagonists and proton pump inhibitors are commonly used for the treatment of upper gastrointestinal mucosal lesions induced by nonsteroidal anti-inflammatory drugs (NSAIDs). However, it has recently been reported that these drugs exacerbate NSAID-induced small
Imre Laszlo Szabó et al.
Current pharmaceutical design, 19(1), 84-89 (2012-09-06)
Actions of various drugs have been tested on the gastric acid basal secretion and on the drug (Indomethacin)- induced gastric mucosal damage; however their physiological and pharmacological mechanisms have not been compared. The effects of capsaicinoids, atropine, cimetidine, omeprazole, famotidine
Michael J Dolton et al.
Antimicrobial agents and chemotherapy, 56(11), 5503-5510 (2012-08-15)
Posaconazole has an important role in the prophylaxis and salvage treatment of invasive fungal infections (IFIs), although poor and variable bioavailability remains an important clinical concern. Therapeutic drug monitoring of posaconazole concentrations has remained contentious, with the use of relatively
Peter J Kahrilas et al.
Chest, 143(3), 605-612 (2012-11-03)
Epidemiologic and physiologic studies suggest an association between gastroesophageal reflux disease (GERD) and chronic cough. However, the benefit of antireflux therapy for chronic cough remains unclear, with most relevant trials reporting negative findings. This systematic review aimed to reevaluate the
Milena Marsoni et al.
Ecotoxicology and environmental safety, 108, 52-57 (2014-07-22)
Pharmaceutically active compounds (PACs) are continuously dispersed into the environment due to human and veterinary use, giving rise to their potential accumulation in edible plants. In this study, Eruca sativa L. and Zea mays L. were selected to determine the
Lin Lin et al.
Biochemical and biophysical research communications, 463(3), 434-439 (2015-06-04)
Histamine and TGF-β, major mediators secreted by mast cells, are involved in skin inflammation and play critical roles in the pathogenesis of systemic sclerosis. However, the roles of signaling mechanisms in the development of skin fibrosis remain largely unclear. Here
Nageh A El-Mahdy et al.
Journal of immunotoxicology, 10(1), 9-16 (2012-07-17)
Histamine, involved in many inflammatory reactions and immune responses, is reported to suppress--via H4R stimulation--injury concomitant with the late phase of warm hepatic ischemia/re-perfusion (I/R). The current study investigated the possible effects of histamine on the acute phase of hepatic
Fuat Bicer et al.
American journal of physiology. Renal physiology, 308(2), F103-F113 (2014-09-12)
The cause of chronic pelvic pain in interstitial cystitis/painful bladder syndrome (IC/PBS) remains unclear; autoimmunity is a possible etiology. We have recently shown that injection of a single immunogenic peptide of uroplakin 3A (UPK3A 65-84) induces experimental autoimmune cystitis (EAC)
P W Bliss et al.
Alimentary pharmacology & therapeutics, 13(12), 1669-1674 (1999-12-14)
Gastrin release by Helicobacter pylori may be an important step in the pathway leading to duodenal ulceration. A histamine H3-receptor agonist was found to release gastrin from antral mucosal fragments; this was interpreted as being due to suppression of somatostatin
L Antonicelli et al.
European annals of allergy and clinical immunology, 44(6), 253-255 (2013-02-28)
We report the case of a 18-year old male who developed intraoperative anaphylaxis. The presence of specific IgE to ranitidine was documented This case confirms the possibility of anaphylaxis at first exposure.
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