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Showing 1-30 of 339 results for "R8004" within Papers
Feng-Ying Guan et al.
Molecular medicine reports, 12(1), 371-376 (2015-03-05)
Astragaloside is one of the most common traditional Chinese medicines and is derived from Astragalus membranaceus. Astragaloside IV (AsIV) is a monomer located in an extract of astragaloside. The current study investigated the protective effects of AsIV against hydrogen peroxide
Xiao-Long Hu et al.
Environmental toxicology and pharmacology, 40(1), 230-240 (2015-07-15)
Oxidative stress mediates the cell damage in several neurodegenerative diseases, including multiple sclerosis, Alzheimer's disease (AD) and Parkinson's disease (PD). This study aimed at investigating the protective effects of Kukoamine B (KuB) against hydrogen peroxide (H2O2) induced cell injury and
Clara F Alves-Pereira et al.
Nature communications, 5, 5623-5623 (2014-12-18)
How the vast majority of B cells express only one of the two alleles at their immunoglobulin loci remains a biological puzzle. Here, in mice reconstituted with a single haematopoietic stem cell, we demonstrate that each of the two immunoglobulin
Olatz Arteaga et al.
PloS one, 10(11), e0142424-e0142424 (2015-11-07)
Despite advances in neonatal care, hypoxic-ischemic brain injury is still a serious clinical problem, which is responsible for many cases of perinatal mortality, cerebral palsy, motor impairment and cognitive deficits. Resveratrol, a natural polyphenol with important anti-oxidant and anti-inflammatory properties
Shweta Hegde et al.
Pesticide biochemistry and physiology, 167, 104588-104588 (2020-06-13)
Methyl parathion (MP) is a commonly used organophosphorus insecticide in commercial farming. It is well known that MP exposure can affect the function of nervous, respiratory, cardiovascular and reproductive systems. In our previous report we have demonstrated that MP exposure
Ying Li et al.
PloS one, 10(6), e0128693-e0128693 (2015-06-06)
Candida albicans, which is the most common human fungal pathogen, causes high mortality among immunocompromised patients. Antifungal drug resistance becomes a major challenge for the management of Candida infection. Diorcinol D (DD), a diphenyl ether derivative isolated from an endolichenic
Alessandra Capasso et al.
Oncotarget, 6(37), 40202-40222 (2015-10-17)
CDC25 phosphatases are important regulators of the cell cycle and represent promising targets for anticancer drug discovery. We recently identified NSC 119915 as a new quinonoid CDC25 inhibitor with potent anticancer activity. In order to discover more active analogs of
Le Qu et al.
Neuropharmacology, 144, 291-300 (2018-10-22)
Rosmarinic acid (RA) is a naturally occurring polyphenolic compound. In this study, we demonstrated that RA could protect against the degeneration of the nigrostriatal dopaminergic system in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of Parkinson's disease (PD). In addition, RA could inhibit
Hyo Hyun Yang et al.
Archives of pharmacal research, 38(5), 876-884 (2014-07-06)
Cellular senescence influences tumor suppression and progress, tissue repair and regeneration, tissue and organismal aging, and age-related diseases. Aging intervention might be an advantageous target for prevention and treatment of diverse age-related diseases. In this study, we investigated whether (-)-loliolide
Shashank Jain et al.
Pharmaceutical development and technology, 20(4), 473-489 (2014-02-05)
The objective of this study was to fabricate and understand ethosomal formulations of diclofenac (DF) for enhanced anti-inflammatory activity using quality by design approach. DF-loaded ethosomal formulations were prepared using 4 × 5 full-factorial design with phosphatidylcholine:cholesterol (PC:CH) ratios ranging
Chia-Chia Chao et al.
Pharmacological reports : PR, 66(4), 576-584 (2014-06-21)
Strong P2X7 receptor (P2X7R) activation causes Ca(2+) overload and consequent cell death. We previously showed that depletion of Ca(2+) stores and endoplasmic reticulum (ER) stress in differentiated NG108-15 neuronal cells contributed to P2X7R-mediated cytotoxicity. In this work, we assessed whether
Yanlin Wang et al.
Journal of neurochemistry, 119(3), 555-568 (2011-08-19)
St. John's wort has been found to be an effective and safe herbal treatment for depression in several clinical trials. However, the underlying mechanism of its therapeutic effects is unclear. Recent studies show that the loss and malfunction of oligodendrocytes
Yao-Tsung Yeh et al.
Free radical biology & medicine, 74, 1-13 (2014-06-22)
Phenethyl isothiocyanate (PEITC) is a naturally occurring cruciferous vegetable-derived compound that inhibits cell growth and induces apoptosis in oral cancer cells. However, the exact mechanism of PEITC action has not been fully elucidated. This study investigated the molecular mechanism and
Afzal Hussain et al.
Drug development and industrial pharmacy, 41(5), 780-790 (2014-03-25)
To characterize the enhanced stability and permeation potential of amphotericin B nanoemulsion comprising sefsol-218 oil at varying pH and temperature of aqueous continuous phase. Several batches of amphotericin B loaded nanoemulsion were prepared and evaluated for their physical and chemical
Ester Casanova et al.
Biochimica et biophysica acta, 1837(6), 783-791 (2014-02-04)
Skeletal muscle is a key organ of mammalian energy metabolism, and its mitochondria are multifunction organelles that are targets of dietary bioactive compounds. The goal of this work was to examine the regulation of mitochondrial dynamics, functionality and cell energy
Jae Yun Han et al.
Toxicology and applied pharmacology, 287(1), 77-85 (2015-06-02)
The chalcone compound isosalipurposide (ISPP) has been successfully isolated from the native Korean plant species Corylopsis coreana Uyeki (Korean winter hazel). However, the therapeutic efficacy of ISPP remains poorly understood. This study investigated whether ISPP has the capacity to activate
Yangxiao Wu et al.
Tissue engineering. Part A, 21(13-14), 2001-2012 (2015-03-27)
Small-diameter tissue-engineered blood vessels (TEBVs) have been associated with low, long-term patency rates primarily because of acute thrombosis in early stages and an inability to achieve early endothelialization. Platelets and endothelial progenitor cells (EPCs) play a key role in these
Yan Wang et al.
Environmental toxicology, 29(12), 1437-1451 (2013-06-19)
Benzene-induced erythropoietic depression has been proposed to be due to the production of toxic metabolites. Presently, the cytotoxicities of benzene metabolites, including phenol, catechol, hydroquinone, and 1,2,4-benzenetriol, to erythroid progenitor-like K562 cells were investigated. After exposure to these metabolites, K562
Mirjam Hemmelmann et al.
Journal of controlled release : official journal of the Controlled Release Society, 163(2), 170-177 (2012-09-18)
The successful non-invasive treatment of diseases associated with the central nervous system (CNS) is generally limited by poor brain permeability of various developed drugs. The blood-brain barrier (BBB) prevents the passage of therapeutics to their site of action. Polymeric drug
Dana Alms et al.
Pharmaceutical research, 31(6), 1588-1604 (2014-01-31)
The expression of P-glycoprotein (Pgp) is increased in brain capillary endothelial cells (BCECs) of patients with pharmacoresistant epilepsy. This may restrict the penetration of antiepileptic drugs (AEDs) into the brain. However, the mechanisms underlying increased Pgp expression in epilepsy patients
Victor Maso et al.
Cancer prevention research (Philadelphia, Pa.), 7(12), 1240-1250 (2014-10-09)
This study proposes to investigate quercetin antitumor efficacy in vitro and in vivo, using the P39 cell line as a model. The experimental design comprised leukemic cells or xenografts of P39 cells, treated in vitro or in vivo, respectively, with
Apoptosis-inducing effects of Melissa officinalis L. essential oil in glioblastoma multiforme cells.
Rafaela Muniz de Queiroz et al.
Cancer investigation, 32(6), 226-235 (2014-04-22)
Current therapies for glioblastoma multiforme (GBM) are not effective. This study investigated the activity of the M. officinalis essential oil (EO) and its major component (citral) in GBM cell lines. Both EO and citral decreased the viability and induced apoptosis
Aeyung Kim et al.
PloS one, 10(5), e0127898-e0127898 (2015-05-29)
Jaeumganghwa-tang (JGT, Zi-yin-jiang-huo-tang in Chinese and Jiin-koka-to in Japanese) is an oriental herbal formula that has long been used as a traditional medicine to treat respiratory and kidney diseases. Recent studies revealed that JGT exhibited potent inhibitory effects on allergies
Chi-Chiu Lee et al.
Journal of applied toxicology : JAT, 35(4), 407-417 (2014-07-23)
This study reports on a cytotoxic toxin derived from the venom of the crown-of-thorns starfish Acanthaster planci (CAV). The protein toxin was isolated through both ion-exchange and gel-filtration chromatography, and characterized by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and mass
Sarah E Lacher et al.
The Journal of pharmacology and experimental therapeutics, 348(2), 336-345 (2013-12-04)
Genetic variation in the multidrug resistance gene ABCB1, which encodes the efflux transporter P-glycoprotein (P-gp), has been associated with Parkinson disease. Our goal was to investigate P-gp transport of paraquat, a Parkinson-associated neurotoxicant. We used in vitro transport models of
Tianxiao Zhao et al.
Canadian journal of physiology and pharmacology, 93(1), 33-38 (2014-11-27)
The overexpression of P-glycoprotein (P-gp) in tumors leads to multidrug resistance (MDR), which is a significant obstacle in clinical cancer chemotherapy. The co-administration of anticancer drugs and MDR modulators is a promising strategy for overcoming this problem. Our study aimed
Xuan Wang et al.
Environmental toxicology and pharmacology, 39(3), 1099-1106 (2015-04-23)
Di-(2-ethylhexyl) phthalate (DEHP) is commonly employed as a plasticizer. We have found that exposure of human embryonic kidney cell line 293 (HEK-293) to DEHP resulted in a crucial dose-dependent increase of DNA strand breaks in a comet assay. To elucidate
Gerardo Ramos-Mandujano et al.
Stem cell research, 12(3), 690-702 (2014-04-01)
Taurine was previously reported to increase the proliferation of neural precursor cells (NPCs) from subventricular zone of the mouse brain. The results of a study that aimed to understand the mechanisms of this effect are presented here. Because taurine was
Xuezhong Gong et al.
Archives of toxicology, 89(7), 1057-1070 (2014-06-26)
Although kidney is a target organ of arsenic cytotoxicity, the underlying mechanisms of arsenic-induced nephrotoxicity remain poorly understood. As tetramethylpyrazine (TMP) has recently been found to be a renal protectant in multiple kidney injuries, we hypothesize that TMP could suppress
Alice Rossi et al.
Cell reports, 30(7), 2332-2348 (2020-02-23)
Mitochondria are key organelles for brain health. Mitochondrial alterations have been reported in several neurodegenerative disorders, including Alzheimer's disease (AD), and the comprehension of the underlying mechanisms appears crucial to understand their relationship with the pathology. Using multiple genetic, pharmacological
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