RAB0005

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Showing 1-30 of 53 results for "RAB0005" within Papers

Pharmacological activation of AMPK ameliorates perivascular adipose/endothelial dysfunction in a manner interdependent on AMPK and SIRT1.

Yan Sun et al.

Pharmacological research, 89, 19-28 (2014-08-12)

Adipose and endothelial dysfunction is tightly associated with cardiovascular diseases in obesity and insulin resistance. Because perivascular adipose tissue (PVAT) surrounds vessels directly and influences vessel functions through paracrine effect, and AMP-activated protein kinase (AMPK) and sirtuin 1 (SIRT1) show

Adiponectin profile and Irisin expression in Italian obese children: Association with insulin-resistance.

Ersilia Nigro et al.

Cytokine, 94, 8-13 (2017-04-08)

Adiponectin (Acrp30), its high molecular weight (HMW) oligomers, and Irisin are molecules involved in several metabolic processes. To investigate if these cytokines could represent new metabolic markers, we evaluated the expression of Acrp30 and Irisin in serum of obese children

Positive interaction between prebiotics and thiazolidinedione treatment on adiposity in diet-induced obese mice.

Maud Alligier et al.

Obesity (Silver Spring, Md.), 22(7), 1653-1661 (2014-03-04)

To investigate whether inulin-type fructan (ITF) prebiotics could counteract the thiazolidinedione (TZD, PPARγ activator) induced-fat mass gain, without affecting its beneficial effect on glucose homeostasis, in high-fat (HF) diet fed mice. Male C57bl6/J mice were fed a HF diet alone

Intracellular IL-37b interacts with Smad3 to suppress multiple signaling pathways and the metastatic phenotype of tumor cells.

C Luo et al.

Oncogene, 36(20), 2889-2899 (2017-01-17)

Multiple signaling pathways that promote tumor cell metastasis are differentially activated in low/non-metastatic and metastatic tumor cells, resulting in the differential expression of metastasis-related genes. The underlying mechanism may involve the alterations of the intrinsic negative regulation in tumor cells.

The Circulating Levels of Complement-C1q/TNF-Related Protein 13 (CTRP13) in Patients with Type 2 Diabetes and its Association with Insulin Resistance.

Abolfazl Afrookhteh et al.

Clinical laboratory, 63(2), 327-333 (2017-02-10)

Complement-C1q/TNF-related protein 13 (CTRP13) is a novel adipokine involved in the regulation of energy metabolism. Here, we sought to evaluate serum levels of CTRP13 and adiponectin in patients with type 2 diabetes (T2D) (n = 40) and healthy subjects (n

Association between HMW adiponectin, HMW-total adiponectin ratio and early-onset coronary artery disease in Chinese population.

Ying Wang et al.

Atherosclerosis, 235(2), 392-397 (2014-06-16)

Adiponectin is an adipose-secreting protein that shows atheroprotective property and has inverse relation with coronary artery disease (CAD). High-molecular weight (HMW) adiponectin is reported as the active form of adiponectin. In the present study, we aimed to investigate the association

Central adiponectin administration reveals new regulatory mechanisms of bone metabolism in mice.

Yuwei Wu et al.

American journal of physiology. Endocrinology and metabolism, 306(12), E1418-E1430 (2014-05-02)

Adiponectin (APN), the most abundant adipocyte-secreted adipokine, regulates energy homeostasis and exerts well-characterized insulin-sensitizing properties. The peripheral or central effects of APN regulating bone metabolism are beginning to be explored but are still not clearly understood. In the present study

Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome.

Hao Wu et al.

Autophagy, 15(11), 1882-1898 (2019-03-23)

There is overwhelming evidence for an association between impaired mitochondrial function and metabolic syndrome. Mitophagy, a process that selectively removes damaged mitochondria via a specialized form of autophagy, is essential for mitochondrial quality control (mitochondrial QC) and metabolic homeostasis. We

Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians.

Heid IM

Diabetes (2006)

The opposing effects of ghrelin on hypothalamic and systemic inflammatory processes are modulated by its acylation status and food intake in male rats.

Cristina García-Cáceres et al.

Endocrinology, 155(8), 2868-2880 (2014-05-23)

Ghrelin is an endogenous hormone that stimulates appetite and adipose tissue accrual. Both the acylated (AG) and non-acylated (DAG) isoforms of this hormone are also reported to exert anti-inflammatory and protective effects systemically and in the central nervous system. As

Leptin deficiency in rats results in hyperinsulinemia and impaired glucose homeostasis.

Anna M D'souza et al.

Endocrinology, 155(4), 1268-1279 (2014-01-29)

Leptin, an adipocyte-derived hormone, has well-established anorexigenic effects but is also able to regulate glucose homeostasis independent of body weight. Until recently, the ob/ob mouse was the only animal model of global leptin deficiency. Here we report the effects of

Long-acting glucose-dependent insulinotropic polypeptide ameliorates obesity-induced adipose tissue inflammation.

Chen Varol et al.

Journal of immunology (Baltimore, Md. : 1950), 193(8), 4002-4009 (2014-09-14)

Obesity induces low-grade chronic inflammation, manifested by proinflammatory polarization of adipose tissue innate and adaptive resident and recruited immune cells that contribute to insulin resistance (IR). The glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone that mediates postprandial insulin secretion

The absorption and metabolism of a single L-menthol oral versus skin
administration: Effects on thermogenesis and metabolic rate

Angelica V

Food And Chemical Toxicology (2015)

Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients.

Hotta K

Arteriosclerosis, Thrombosis, and Vascular Biology (2000)

White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection.

Seong-Ji Han et al.

Immunity, 47(6), 1154-1168 (2017-12-10)

White adipose tissue bridges body organs and plays a fundamental role in host metabolism. To what extent adipose tissue also contributes to immune surveillance and long-term protective defense remains largely unknown. Here, we have shown that at steady state, white

New insights into serum/extracellular thioredoxin in regulating hepatic insulin receptor activation.

Yun Bai et al.

Biochimica et biophysica acta. General subjects, 1864(8), 129630-129630 (2020-05-08)

Serum thioredoxin of type-2 diabetic patients is significantly higher than that of healthy people. Pathophysiological significance is unclear. Effects of serum/extracellular thioredoxin on phosphorylation (activation) of hepatic insulin receptor (IR) were investigated by using methods in biochemistry, cell/molecular biology and

Adiponectin promotes muscle regeneration through binding to T-cadherin.

Yoshimitsu Tanaka et al.

Scientific reports, 9(1), 16-16 (2019-01-11)

Skeletal muscle has remarkable regenerative potential and its decline with aging is suggested to be one of the important causes of loss of muscle mass and quality of life in elderly adults. Metabolic abnormalities such as obesity were linked with

Anti-inflammatory effects of hepatocyte growth factor on the vicious cycle of macrophages and adipocytes.

Hiroshi Kusunoki et al.

Hypertension research : official journal of the Japanese Society of Hypertension, 37(6), 500-506 (2014-03-14)

The paracrine loop involving inflammatory cytokines between adipocytes and macrophages establishes a vicious cycle that aggravates pro-inflammatory changes in adipose tissue. The serum level of hepatocyte growth factor (HGF) is increased in metabolic syndrome, but whether HGF is beneficial or

Association of Serum Retinol-Binding Protein 4 Concentration With Risk for and Prognosis of Amyotrophic Lateral Sclerosis.

Angela Rosenbohm et al.

JAMA neurology, 75(5), 600-607 (2018-02-27)

Knowledge about the metabolic states of patients with amyotrophic lateral sclerosis (ALS) may provide a therapeutic approach. To investigate the association between the onset and prognosis of ALS and serum retinol-binding protein 4 (RBP4) concentration as a biomarker for insulin

Relationship between adiposity, adipokines, inflammatory markers and lipid profile in hemodialysis patients.

A Markaki et al.

European review for medical and pharmacological sciences, 18(10), 1496-1498 (2014-06-06)

Our aim is to study the correlations of leptin and adiponectin with inflammation markers, body composition and lipid profile in end stage renal disease (ESRD) patients. Phase angle values and fat mass as calculated using BIA, Malnutrition-Inflammation Score (MIS), leptin

Association of intracellular lipid accumulation in subcutaneous adipocyte precursors and plasma adipokines in bariatric surgery candidates.

Ioana Hristov et al.

Lipids in health and disease, 18(1), 141-141 (2019-06-14)

The adipocyte expansion is a critical process with implications in the pathogenesis of obesity associated metabolic syndrome. Impaired adipogenesis leads to dysfunctional, hypertrophic adipocytes, local inflammation and peripheric insulin resistance. We assessed the relationship between the adipogenic differentiation capacity of

Photoreceptor glucose metabolism determines normal retinal vascular growth.

Zhongjie Fu et al.

EMBO molecular medicine, 10(1), 76-90 (2017-11-29)

The neural cells and factors determining normal vascular growth are not well defined even though vision-threatening neovessel growth, a major cause of blindness in retinopathy of prematurity (ROP) (and diabetic retinopathy), is driven by delayed normal vascular growth. We here

Metabolic phenotype of male obesity-related secondary hypogonadism pre-replacement and post-replacement therapy with intra-muscular testosterone undecanoate therapy.

Georgios K Dimitriadis et al.

Endocrine, 60(1), 175-184 (2018-02-06)

To explore the metabolic phenotype of obesity-related secondary hypogonadism (SH) in men pre-replacement and post-replacement therapy with long-acting intramuscular (IM) testosterone undecanoate (TU). A prospective observational pilot study on metabolic effects of TU IM in male obesity-related SH (hypogonadal [HG]

Aerobic exercise and nano-curcumin supplementation improve inflammation in elderly females with metabolic syndrome.

Ali Osali

Diabetology & metabolic syndrome, 12, 26-26 (2020-04-08)

Aging, inflammation, oxidative stress, and metabolic syndrome are the main important factors in brain-derived neurotrophic factor (BDNF) level. The aim of this research was to investigate the effect of 6-week aerobic exercise with moderate intensity and consumption of nano-curcumin on

Fisetin up-regulates the expression of adiponectin in 3T3-L1 adipocytes via the activation of silent mating type information regulation 2 homologue 1 (SIRT1)-deacetylase and peroxisome proliferator-activated receptors (PPARs).

Taewon Jin et al.

Journal of agricultural and food chemistry, 62(43), 10468-10474 (2014-10-07)

Adiponectin, an adipokine, has been described as showing physiological benefits against obesity-related malfunctions and vascular dysfunction. Several natural compounds that promote the expression and secretion of adipokines in adipocytes could be useful for treating metabolic disorders. This study investigated the

Adipocyte cell size, free fatty acids and apolipoproteins are associated with non-alcoholic liver injury progression in severely obese patients.

Alexander Wree et al.

Metabolism: clinical and experimental, 63(12), 1542-1552 (2014-10-01)

Obesity is a modern pandemic with continuous expansion and represents an independent risk factor for non-alcoholic fatty liver disease (NAFLD), the most common liver disease in westernized countries. The crosstalk between adipose tissue and the liver is key to the

Human amnion-derived mesenchymal stem cells induced osteogenesis and angiogenesis in human adipose-derived stem cells via ERK1/2 MAPK signaling pathway.

Yuli Wang et al.

BMB reports, 51(4), 194-199 (2018-02-13)

Mesenchymal stem cells (MSCs) have shown great potential in treating bone deficiency. Human adipose-derived stem cells (HASCs) are multipotent progenitor cells with multi-lineage differentiation potential. Human amnion-derived mesenchymal stem cells (HAMSCs) are capable of promoting osteogenic differentiation of MSCs. In

A RAGE-antagonist peptide potentiates polymeric micelle-mediated intracellular delivery of plasmid DNA for acute lung injury gene therapy.

Chunxian Piao et al.

Nanoscale, 12(25), 13606-13617 (2020-06-20)

Acute lung injury (ALI) is a severe inflammatory lung disease. A high mobility group box-1 (HMGB-1) derived RAGE-antagonist peptide (RAP) was previously developed for anti-inflammatory therapy for ALI. Due to its specific binding to RAGE on the surface of inflammatory

Tofogliflozin, a sodium/glucose cotransporter 2 inhibitor, attenuates body weight gain and fat accumulation in diabetic and obese animal models.

M Suzuki et al.

Nutrition & diabetes, 4, e125-e125 (2014-07-08)

Tofogliflozin, a highly selective inhibitor of sodium/glucose cotransporter 2 (SGLT2), induces urinary glucose excretion (UGE), improves hyperglycemia and reduces body weight in patients with Type 2 diabetes (T2D). The mechanisms of tofogliflozin on body weight reduction were investigated in detail

Homeostatic model assessment of adiponectin (HOMA-Adiponectin) as a surrogate measure of insulin resistance in adolescents: Comparison with the hyperglycaemic clamp and homeostatic model assessment of insulin resistance.

Cleliani de Cassia da Silva et al.

PloS one, 14(3), e0214081-e0214081 (2019-03-26)

Studies on adults have reported inverse association between the homeostatic model assessment (HOMA) of adiponectin (HOMA-Adiponectin) and the insulin resistance assessed by the glucose clamp technique. To our knowledge, in the pediatric population this association has not been previously investigated.

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