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Showing 1-30 of 31 results for "RAB0273" within Papers
Hui Huang et al.
Annals of translational medicine, 9(18), 1460-1460 (2021-11-05)
Pancreatic cancer (PC) is one of the worst prognostic cancers. Here, we probed the anti-cancer activity of wogonoside (Wog), a flavonoid isolated from Scutellaria baicalensis Georgi, on PC, as well as potential molecular mechanism. Following Wog stimulation, the viability, proliferation
Haisong Wang et al.
Medical science monitor : international medical journal of experimental and clinical research, 26, e921618-e921618 (2020-05-18)
BACKGROUND Intestinal ischemia-reperfusion injury is a serious intestinal disease, with main symptoms of inflammatory reaction and severe oxidative damage. In addition, GTS-21-induced alpha7 nAChR has been shown to exert anti-inflammatory effects and anti-oxidation effects in various organs. However, whether alpha7
Qiancheng Luo et al.
International journal of molecular medicine, 42(2), 1161-1167 (2018-05-12)
The mechanism underlying sepsis‑induced cardiomyopathy (SICM) remains unclear. The aim of the present study was therefore to illuminate the mechanisms and effects of apelin on SICM, using both patient clinical features and a sepsis rat model. A total of 73 adult
Hyo Geun Kim et al.
Canadian journal of physiology and pharmacology, 92(6), 429-437 (2014-05-14)
Microglia-mediated inflammation is a major pathological mechanism contributing to Alzheimer's disease (AD), and has been proposed as a potential therapeutic target. Chunghyuldan (CHD; Qingxue-dan in Chinese and Daio-Orengedokuto in Japanese) possesses wide-ranging biological effects, including anti-hyperlipidemic, anti-stroke, anti-inflammatory, and antioxidant
Muhammad Ihtisham Umar et al.
Pharmaceutical biology, 52(11), 1411-1422 (2014-07-16)
Azadirachta indica A. Juss. (Meliaceaes) leaves have been used traditionally to treat swelling and rheumatism in Indian cultures. To fractionate A. indica leaf extracts using bioactivity guided manner for identification of the active anti-inflammatory principles. Polarity-gradient sequential extracts (petroleum ether
Qiwu Zhao et al.
Clinical and translational medicine, 12(2), e727-e727 (2022-02-21)
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive tumours. We previously confirmed that apatinib has potential therapeutic effects on ATC via regulated cell death (RCD). As a newly identified RCD, pyroptosis demonstrates direct antitumour activity different from apoptosis
RuiJin Xie et al.
Artificial cells, nanomedicine, and biotechnology, 47(1), 1877-1887 (2019-05-14)
Hepatitis is a severe liver disease with worldwide distribution. This study explored the anti-inflammatory influence of Emodin on LPS-triggered liver injury in vitro and in vivo. In vitro, we discovered that LPS treatment triggered L-02 cell and primary hepatocyte inflammatory
Tao Gu et al.
African health sciences, 14(2), 356-363 (2014-10-17)
An early differentiation of malignant from benign solitary pulmonary nodules (SPNs) is essential for management and prognosis of lung cancer. Here we investigated whether measurement of circulating sex hormones could be useful for an early detection of malignancy among patients
Jie Liu et al.
The Journal of international medical research, 49(3), 300060521996564-300060521996564 (2021-03-27)
Porphyromonas gingivalis (Pg) plays a critical role in the occurrence and development of atherosclerosis. Lipopolysaccharide from Pg (Pg-LPS) could lead to pyroptosis of vascular smooth muscle cells (VSMCs) and induce instability of atherosclerotic plaque. Therefore, pyroptosis of VSMCs could promote
Interleukin 1 beta (IL1?) rs16944 genetic variant as a genetic marker of severe renal manifestations and renal sequelae in Henoch-Schonlein purpura.
Lopez-Mejias R
Clinical and Experimental Rheumatology, 34(3 Suppl 97), S84-S88 (2016)
Yuri L Boteon et al.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 25(7), 1007-1022 (2019-03-02)
Strategies to increase the use of steatotic donor livers are required to tackle the mortality on the transplant waiting list. We aimed to test the efficacy of pharmacological enhancement of the lipid metabolism of human livers during ex situ normothermic
Jia Shen et al.
Experimental and therapeutic medicine, 24(3), 564-564 (2022-08-19)
The aim of the present study was to investigate the effects of microRNA (miR)-374a-5p on sepsis-induced acute lung injury (ALI) and the associated mechanism. Lipopolysaccharide (LPS)-induced human pulmonary microvascular endothelial cells (HPMVECs) were used to construct the cellular model of
Ana Hagiu et al.
Clinical oral investigations, 24(7), 2375-2383 (2019-10-28)
This in vitro study aimed to analyze the anti-inflammatory and wound healing potential of green tea extract (GTE) in human gingival epithelial keratinocytes (HGEK) treated with lipopolysaccharides (LPS). A cell viability assay was conducted using MTT to determine nontoxic levels
Motoyasu Onishi et al.
Vaccine, 32(25), 3004-3009 (2014-04-12)
Synthetic hemozoin (sHZ, also known as β-hematin) from monomeric heme is a particle adjuvant which activates antigen-presenting cells (APCs), such as dendritic cells and macrophages, and enhances humoral immune responses to several antigens, including ovalbumin, human serum albumin, and serine
Andrea L Armstead et al.
International journal of nanomedicine, 11, 6195-6206 (2016-12-07)
Identifying the toxicity of nanoparticles (NPs) is an important area of research as the number of nanomaterial-based consumer and industrial products continually rises. In addition, the potential inflammatory effects resulting from pulmonary NP exposure are emerging as an important aspect
Bin Li et al.
The American journal of Chinese medicine, 42(5), 1229-1244 (2014-09-03)
Amomum tsao-ko Crevost et Lemaire, used as a spice in Asia, is an important source of Chinese cuisine and traditional Chinese medicines. A. tsao-ko is reported to exert a variety of biological and pharmacological activities, including anti-proliferative, anti-oxidative and neuroprotective
Nathella Pavan Kumar et al.
The Journal of infectious diseases, 210(10), 1670-1678 (2014-06-08)
Diabetes mellitus type 2 (DM) is known to be a major risk factor for the development of active tuberculosis, although its influence on latent Mycobacterium tuberculosis infection (hereafter, "latent infection") remains poorly characterized. We examined circulating plasma cytokine levels in
Long-Qing Li et al.
International journal of molecular sciences, 22(5) (2021-03-07)
The purpose of this work was to fractionate the complex exopolysaccharide (EPS) from a medicinal fungus Ophiocordyceps sinensis Cs-HK1 based on the molecular weight (MW) range and to assess the in vitro anti-inflammatory activity of different EPS fractions in THP-1
Differential regulation of monocyte matrix metalloproteinase and TIMP-1 production by TNF-alpha, granulocyte-macrophage CSF, and IL-1 beta through prostaglandin-dependent and -independent mechanisms.
Zhang Y
Journal of Immunology, 161(6), 3071-3076 (1998)
Fei Zheng et al.
Mediators of inflammation, 2014, 507208-507208 (2014-07-08)
The role of the NLRP3 inflammasome in atherosclerosis remains controversial. The aim of this study was to determine whether inhibition of NLRP3 signaling by lentivirus-mediated RNA interference could reduce atherosclerosis and stabilizes plaques. We also tried to explore the mechanisms
Faith Nutter et al.
Endocrine-related cancer, 21(2), 327-341 (2014-01-15)
Advanced breast cancer is associated with the development of incurable bone metastasis. The two key processes involved, tumour cell homing to and subsequent colonisation of bone, remain to be clearly defined. Genetic studies have indicated that different genes facilitate homing
Junrui Cheng et al.
Frontiers in nutrition, 8, 723480-723480 (2021-10-15)
Background: Carotenoids are naturally occurring pigments accounting for the brilliant colors of fruits and vegetables. They may display antioxidant and anti-inflammatory properties in humans besides being precursors to vitamin A. There is a gap of knowledge in examining their role
Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis.
Kolb M
The Journal of Clinical Investigation, 107(12), 1529-1536 (2001)
Weiwei Sheng et al.
European journal of haematology, 93(3), 214-223 (2014-03-29)
Severe aplastic anemia (SAA) is a rare immune-regulated disease characterized by severe pancytopenia and bone marrow failure, caused by destruction of hematopoietic cells by the activated T lymphocytes. Linker for activation of T cells (LAT), a transmembrane adaptor protein, plays
Hui Wang et al.
Mediators of inflammation, 2014, 858763-858763 (2014-09-13)
Diabetic retinopathy (DR) is a major microvascular complication in diabetics, and its mechanism is not fully understood. Toll-like receptor 4 (TLR4) plays a pivotal role in the maintenance of the inflammatory state during DR, and the deletion of TLR4 eventually
Zetao Ma et al.
Journal of orthopaedic surgery and research, 15(1), 284-284 (2020-07-30)
Inflammation and apoptosis of chondrocytes are the pathological bases of osteoarthritis. Autophagy could alleviate the symptoms of inflammation and apoptosis. Previous study has shown that BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) can induce the occurrence and development of autophagy.
Rongfeng Cao et al.
Inflammation, 37(5), 1453-1458 (2014-04-20)
Kaempferol isolated from the root of Zingiberaceae plants galangal and other Chinese herbal medicines have been reported to have anti-inflammatory properties. However, the anti-inflammatory effects of kaempferol on lipopolysaccharide (LPS)-induced mastitis are unknown and their underlying molecular mechanisms remain to
Zhao Gao et al.
BMC ophthalmology, 20(1), 134-134 (2020-04-08)
Inflammation of RPE cells led to different kinds of eye diseases and affected the normal function of the retina. Furthermore, higher levels of ROCK1 and ROCK2 induced injury of endothelial cells and many inflammatory diseases of the eyes. Ripasudil, which
Proinflammatory cytokines detectable in synovial fluids from patients with temporomandibular disorders.
Takahashi T
Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 85(2), 135-141 (1998)
Strain- and host species-specific inflammasome activation, IL-1? release, and cell death in macrophages infected with uropathogenic Escherichia coli.
Schaale K
Mucosal Immunology, 9(1), 124-136 (2016)
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