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Showing 1-30 of 43 results for "RAB0537" within Papers
Shan Wu et al.
Life sciences, 253, 117539-117539 (2020-03-14)
Lipopolysaccharide (LPS)-induced intestinal injury is a common clinical feature of sepsis. Aggravated inflammation and higher sensitivity to infection are associated with high-fat diet (HFD) in patients with type 2 diabetes and/or obesity. However, the mechanism by which HFD exacerbates LPS-induced
Rosalie H Bartels et al.
Scientific reports, 9(1), 2304-2304 (2019-02-21)
Intestinal pathology in children with complicated severe acute malnutrition (SAM) persists despite standard management. Given the similarity with intestinal pathology in non-IgE mediated gastrointestinal food allergy and Crohn's disease, we tested whether therapeutic feeds effective in treating these conditions may
A novel approach to the nutrigenetics and nutrigenomics of obesity and weight management.
Joffe Y T and Christine A H
Current Oncology Reports, 18(7), 43-43 (2016)
Elisa Karhu et al.
European journal of applied physiology, 117(12), 2519-2526 (2017-10-17)
Athletes frequently experience gastrointestinal (GI) symptoms during training and competition. Although the prevalence of exercise-induced GI symptoms is high, the mechanisms leading to GI distress during exercise are not fully understood. The aim of this study was to identify running-induced
Christopher Storm-Larsen et al.
AIDS (London, England), 33(4), 645-653 (2018-12-12)
Translocation of microbial products such as lipopolysaccharides (LPS) from the gut may contribute to chronic inflammation in HIV-infected individuals. Recent studies indicate that differences in degree of acylation of gut-bacterial-derived LPS may explain variable immune effects, with hexa-acylated rather than
Natalia Drabińska et al.
Nutrients, 12(6) (2020-06-14)
Abnormalities in the intestinal barrier are a possible cause of celiac disease (CD) development. In animal studies, the positive effect of prebiotics on the improvement of gut barrier parameters has been observed, but the results of human studies to date
Derrick R Samuelson et al.
PLoS pathogens, 13(6), e1006426-e1006426 (2017-06-13)
Chronic alcohol consumption perturbs the normal intestinal microbial communities (dysbiosis). To investigate the relationship between alcohol-mediated dysbiosis and pulmonary host defense we developed a fecal adoptive transfer model, which allows us to investigate the impact of alcohol-induced gut dysbiosis on
Daniela Paganini et al.
Gut, 66(11), 1956-1967 (2017-08-05)
Iron-containing micronutrient powders (MNPs) reduce anaemia in African infants, but the current high iron dose (12.5 mg/day) may decrease gut In a 4-month, controlled, double-blind trial, we randomised Kenyan infants aged 6.5-9.5 months (n=155) to receive daily (1) a MNP without
Salma A Khattab et al.
Journal of diabetes, 9(9), 821-826 (2016-10-26)
Intestinal fatty acid-binding protein 2 (FABP2) is expressed in enterocytes and binds saturated and unsaturated long-chain fatty acids. The FABP2 Ala54Thr polymorphism has been reported to effect lipid metabolism. The aim of the present study was to assess the relationship
Jean-Paul Decuypere et al.
International journal of molecular sciences, 21(19) (2020-10-03)
Renal ischemia-reperfusion (IR) injury leading to cell death is a major cause of acute kidney injury, contributing to morbidity and mortality. Autophagy counteracts cell death by removing damaged macromolecules and organelles, making it an interesting anchor point for treatment strategies.
Ozge Surmeli Onay et al.
European journal of pediatrics, 179(4), 561-570 (2019-12-20)
We aimed to investigate the role of hypoxia-ischemia in the pathophysiology of early NEC/NEC like disease (ENEC) and classic NEC/NEC like disease (CNEC) in preterm infants. In this pilot study, preterm infants who developed the clinical symptoms and signs of
H A G Ducray et al.
Journal of applied microbiology, 128(4), 1163-1178 (2019-12-10)
To characterize efficacy of the Bacillus subtilis BSB3 (BSB3) strain in the prevention of excessive exercise-induced side effects and in maintaining stability of the gut microbiota. Rats were pretreated by oral gavage with B. subtilis BSB3 (BSB3) or with phosphate-buffered
Donghao Li et al.
Pharmacognosy magazine, 13(52), 677-682 (2017-12-05)
To investigate the effect of berberine (BBR) on intestinal barrier function in nonalcoholic fat liver disease (NAFLD) in rats. Rats were divided into three groups: normal diet group (control group [CON group]), high-fat diet feeding group (HFD group), and HFD
Michael Reid et al.
AIDS (London, England), 31(3), 385-393 (2017-01-13)
HIV/hepatitis C virus (HCV) coinfection is associated with insulin resistance, but the mechanism is unclear. We hypothesized that intestinal epithelial damage and the consequent monocyte/macrophage activation and inflammation explain this perturbation. Cross-sectional study of 519 adults (220 HIV+/HCV-; 64 HIV-/HCV+;
Can Kong et al.
Annals of translational medicine, 7(16), 388-388 (2019-09-27)
The aim of this prospective study was to screen and combine effective biomarkers to improve their diagnostic performance in detecting intestinal barrier dysfunction in patients after major abdominal surgery. Patients undergoing major abdominal surgery were enrolled after signing informed consent
Takeshi Kitai et al.
Clinical biochemistry, 50(9), 491-495 (2017-02-25)
Venous congestion has become increasingly recognized as a potential contributor to end-organ dysfunction in heart failure. Elevated I-FABP, which is excreted specifically from damaged intestinal epithelial cells, has been found in patients with abdominal hypertension and intestinal ischemia. We hypothesize
Konstantin A Krychtiuk et al.
Resuscitation, 155, 32-38 (2020-06-12)
Current guidelines suggest the use of epinephrine in patients with cardiac arrest (CA). However, evidence for increased survival in good neurological condition is lacking. In experimental settings, epinephrine-induced impairment of microvascular flow was shown. The aim of our study was
Sara J Kuik et al.
Pediatric research, 87(5), 903-909 (2019-10-28)
Intestinal recovery after NEC is difficult to predict in individuals. We evaluated whether several biomarkers predict intestinal recovery after NEC in preterm infants. We measured intestinal tissue oxygen saturation (rintSO2) and collected urinary intestinal-fatty acid binding protein (I-FABPu) levels 0-24 h and
Leila B Giron et al.
Mucosal immunology, 13(5), 753-766 (2020-03-11)
An emerging paradigm suggests that gut glycosylation is a key force in maintaining the homeostatic relationship between the gut and its microbiota. Nevertheless, it is unclear how gut glycosylation contributes to the HIV-associated microbial translocation and inflammation that persist despite
Catherine Lalande et al.
Diabetology & metabolic syndrome, 12, 31-31 (2020-04-16)
Evidence suggests that pathophysiological conditions such as obesity and type 2 diabetes (T2D) are associated with morphologic and metabolic alterations in the small intestinal mucosa. Exploring these alterations generally requires invasive methods, limiting data acquisition to subjects with enteropathies or
Brynjulf Mortensen et al.
Gastroenterology, 157(3), 637-646 (2019-05-17)
Enteropathy and small-intestinal ulcers are common adverse effects of nonsteroidal anti-inflammatory drugs such as acetylsalicylic acid (ASA). Safe, cytoprotective strategies are needed to reduce this risk. Specific bifidobacteria might have cytoprotective activities, but little is known about these effects in
Alena Kokesova et al.
PloS one, 14(1), e0210797-e0210797 (2019-01-15)
We analyzed the capacity of urinary Intestinal fatty acid-binding protein (I-FABP) to quantify the degree of mucosal injury in neonates with gastroschisis (GS) and to predict the speed of their clinical recovery after surgery. In this prospective study, we collected
Sophie Novelli et al.
EBioMedicine, 62, 103129-103129 (2020-11-29)
Interpretation of the increase in certain inflammatory markers in virally suppressed HIV-infected individuals must rely on an appropriate uninfected control group well characterized for non-HIV-related factors that contribute to chronic inflammation, e.g. smoking, alcohol consumption, or being overweight. We compared
Beatrice Amadi et al.
EBioMedicine, 22, 191-199 (2017-07-29)
Intestinal damage in malnutrition constitutes a threat to the survival of many thousands of children globally. We studied children in Lusaka, Zambia, with severe acute malnutrition (SAM) and persistent diarrhea using endoscopy, biopsy and analysis of markers and protective proteins
Doungnapa Kantamala et al.
Cytokine, 136, 155257-155257 (2020-08-30)
Individuals residing in areas with high prevalence of foodborne infection could have a higher risk of gut microbial translocation which may affect monocyte activation, gut immune recovery and intestinal epithelial cell damage. We aimed to measure alterations in microbial translocation
Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets.
Furuhashi M and Gokhan S H
Nature Reviews. Drug Discovery, 7(6), 489-489 (2008)
Nicole U Stoffel et al.
The Lancet. Haematology, 4(11), e524-e533 (2017-10-17)
Current guidelines to treat iron deficiency recommend daily provision of ferrous iron divided through the day to increase absorption. However, daily dosing and split dosing might increase serum hepcidin and decrease iron absorption from subsequent doses. Our study aim was
Intestinal FABP2 A54T polymorphism: association with insulin resistance and obesity in women.
Albala C, et al.
Obesity Research, 12(2), 340-345 (2004)
Diana E Matei et al.
Med (New York, N.Y.), 2(7), 864-883 (2021-07-24)
Evidence suggests an important role for gut-microbiota dysbiosis in the development of rheumatoid arthritis (RA). The link between changes in gut bacteria and the development of joint inflammation is missing. Here, we address whether there are changes to the gut
Luca Maccioni et al.
Gut microbes, 12(1), 1782157-1782157 (2020-06-27)
Animal data suggest a role of the gut-liver axis in progression of alcoholic liver disease (ALD), but human data are scarce especially for early disease stages. We included patients with alcohol use disorder (AUD) who follow a rehabilitation program and
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