CN
Search Within
RDD002
Applied Filters:
Keyword:'RDD002'
Showing 1-30 of 4117 results for "RDD002" within Papers
Beatriz Escudero-Pérez et al.
PLoS pathogens, 10(11), e1004509-e1004509 (2014-11-21)
During Ebola virus (EBOV) infection a significant amount of surface glycoprotein GP is shed from infected cells in a soluble form due to cleavage by cellular metalloprotease TACE. Shed GP and non-structural secreted glycoprotein sGP, both expressed from the same
David R Janero et al.
ACS chemical neuroscience, 6(8), 1400-1410 (2015-05-16)
The cannabinoid 1 receptor (CB1R) is one of the most abundant G protein-coupled receptors (GPCRs) in the central nervous system. CB1R involvement in multiple physiological processes, especially neurotransmitter release and synaptic function, has made this GPCR a prime drug discovery
J H Foley et al.
Journal of thrombosis and haemostasis : JTH, 13(4), 610-618 (2015-01-06)
The plasmin(ogen) and complement systems are simultaneously activated at sites of tissue injury, participating in hemostasis, wound healing, inflammation and immune surveillance. In particular, the C3 proteolytic fragment, iC3b, and its degradation product C3dg, which is generated by cleavage by
Zi-Zhen Zhang et al.
Molecular cancer therapeutics, 14(5), 1162-1170 (2015-01-24)
The objective of this study was to evaluate the role of HOTAIR long noncoding RNA in gastric cancer metastasis. We analyzed HOTAIR expression levels by real-time reverse transcription PCR and Northern blot analysis in 100 gastric tissues (50 gastric cancer
Yuji Ishitsuka et al.
The journal of physical chemistry. B, 119(22), 6611-6619 (2015-05-16)
Fluorescence resonance energy transfer (FRET) is a superb technique for measuring conformational changes of proteins on the single molecule level (smFRET) in real time. It requires introducing a donor and acceptor fluorophore pair at specific locations on the protein molecule
O Kassaar et al.
Journal of thrombosis and haemostasis : JTH, 13(1), 101-110 (2014-10-30)
Histidine-rich glycoprotein (HRG) regulates coagulation through its ability to bind and neutralize heparins. HRG associates with Zn(2+) to stimulate HRG-heparin complex formation. Under normal conditions, the majority of plasma Zn(2+) associates with human serum albumin (HSA). However, free fatty acids
Michael Weichhaus et al.
Oncology letters, 8(1), 374-378 (2014-06-25)
Leptin is a hormone secreted by white fat tissue and signals the amount of overall body fat to the hypothalamus. The circulating concentration of leptin correlates with the level of obesity. Breast cancer risk is higher in obese postmenopausal women
Na N Guan et al.
British journal of pharmacology, 172(16), 4024-4037 (2015-04-29)
We have described a urothelium-dependent release of PGD2 -like activity which had inhibitory effects on the motility of guinea pig urinary bladder. Here, we have pharmacologically characterized the receptors involved and localized the sites of PGD2 formation and of its
Yanqing Huang et al.
The Journal of biological chemistry, 290(29), 17745-17752 (2015-06-03)
Prostate stem cells (P-SCs) are capable of giving rise to all three lineages of prostate epithelial cells, including basal, luminal, and neuroendocrine cells. Multiple methods have been used to identify P-SCs in adult prostates. These include in vivo renal capsule
Claire Soudais et al.
Journal of immunology (Baltimore, Md. : 1950), 194(10), 4641-4649 (2015-04-15)
Mucosal-associated invariant T (MAIT) cells recognize microbial compounds presented by the MHC-related 1 (MR1) protein. Although riboflavin precursor derivatives from Gram-positive bacteria have been characterized, some level of ligand heterogeneity has been suggested through the analysis of the MAIT cell
Ru-Juan Zuo et al.
The Journal of biological chemistry, 290(35), 21280-21291 (2015-07-17)
Decidualization is an essential process of maternal endometrial stromal cells to support pregnancy. Although it is known that enhanced glucose influx is critical for decidualization, the underlying mechanism in regulating glucose metabolism in decidua remains insufficiently understood. Here, we demonstrate
Maryam Ghafari et al.
Brain structure & function, 220(4), 2209-2221 (2014-05-09)
Reduced daily intake of magnesium (Mg(2+)) is suggested to contribute to depression. Indeed, preclinical studies show dietary magnesium restriction (MgR) elicits enhanced depression-like behaviour establishing a causal relationship. Amongst other mechanisms, Mg(2+) gates the activity of N-methyl-D-asparte (NMDA) receptors; however
Zohra Madani et al.
Molecular medicine reports, 12(5), 7017-7026 (2015-09-24)
The current study investigated whether sardine protein mitigates the adverse effects of fructose on plasma glucagon‑like peptide-1 (GLP-1) and oxidative stress in rats. Rats were fed casein (C) or sardine protein (S) with or without high‑fructose (HF) for 2 months.
Tamara Lozano-Fernández et al.
Nanomedicine : nanotechnology, biology, and medicine, 10(6), 1301-1310 (2014-03-22)
The impact of metal oxide nanoparticles (NPs) on the immune system has been studied in vitro using human peripheral blood lymphocytes (PBLs). Metal oxide NPs (ZnO, CeO2, TiO2 and Al2O3) induced changes in the expression levels of adhesion molecules and
Yang Chen et al.
Biochimica et biophysica acta, 1853(2), 396-408 (2014-12-03)
Inflammasomes play a critical role in the development of vascular diseases. However, the molecular mechanisms activating the inflammasome in endothelial cells and the relevance of this inflammasome activation is far from clear. Here, we investigated the mechanisms by which an
Jieun Yun et al.
Journal of cellular physiology, 230(12), 3115-3127 (2015-06-03)
p53 and Notch-1 play important roles in breast cancer biology. Notch-1 inhibits p53 activity in cervical and breast cancer cells. Conversely, p53 inhibits Notch activity in T-cells but stimulates it in human keratinocytes. Notch co-activator MAML1 binds p53 and functions
Rahul Bhowmick et al.
Virus research, 210, 344-354 (2015-09-20)
Cytoplasmic Processing bodies (P bodies), the RNA-protein aggregation foci of translationally stalled and potentially decaying mRNA, have been reported to be differentially modulated by viruses. Rotavirus, the causative agent of acute infantile gastroenteritis is a double stranded RNA virus which
Venkataswarup Tiriveedhi et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 20(23), 5964-5975 (2014-12-03)
Mammaglobin-A (MAM-A) is overexpressed in 40% to 80% of primary breast cancers. We initiated a phase I clinical trial of a MAM-A DNA vaccine to evaluate its safety and biologic efficacy. Patients with breast cancer with stable metastatic disease were
Shu Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 43(5), 743-748 (2015-03-01)
Farnesoid X receptor (FXR) functions as a regulator of bile acid and lipid homeostasis and is recognized as a promising therapeutic target for metabolic diseases. The biologic function of FXR is mediated in part by a small heterodimer partner (SHP);
Krzysztof M Mrozik et al.
British journal of haematology, 171(3), 387-399 (2015-07-22)
Elevated expression of the cell adhesion molecule N-cadherin (cadherin 2, type 1, N-cadherin (neuronal); CDH2) is associated with poor prognosis in newly-diagnosed multiple myeloma (MM) patients. In this study, we investigated whether targeting of N-cadherin represents a potential treatment for
Naoko Iwata-Yoshikawa et al.
Journal of virology, 88(15), 8597-8614 (2014-05-23)
Severe acute respiratory syndrome-related coronavirus (SARS-CoV) is an emerging pathogen that causes severe respiratory illness. Whole UV-inactivated SARS-CoV (UV-V), bearing multiple epitopes and proteins, is a candidate vaccine against this virus. However, whole inactivated SARS vaccine that includes nucleocapsid protein
Zhenxi Zhang et al.
Journal of biomedical optics, 20(5), 51043-51043 (2015-05-30)
There are three possible mechanisms for 5-aminolevulinic acid (5-ALA) conjugated gold nanoparticles (GNPs) through electrostatic bonding for photodynamic therapy (PDT) of cancer: GNPs delivery function,singlet oxygen generation (SOG) by GNPs irradiated by light, and surface resonance enhancement (SRE) of SOG.
Masashi Higuchi et al.
Cell and tissue research, 361(2), 557-565 (2015-03-22)
We have recently shown that cells positive for the paired-related homeobox transcription factors PRRX1 and PRRX2 occur in the rat pituitary, and that they are derived from two different origins: pituitary-derived cells positive for stem cell marker SOX2 and extra-pituitary-derived
L A Black et al.
Australian veterinary journal, 93(11), 420-423 (2015-09-29)
To determine the in vitro susceptibilities of koala isolates of Chlamydia pecorum to enrofloxacin and chloramphenicol, which are frequently used to treat koalas with chlamydiosis, and florfenicol, a derivative of chloramphenicol. The in vitro susceptibilities were determined by culturing three
F Henry et al.
Theriogenology, 83(8), 1373-1380 (2015-03-05)
From many endangered or threatened species which are expected to profit from assisted reproduction techniques, mainly epididymal sperm of dead or freshly castrated males are available. These sperm had contact to epididymal secretion products but not to seminal fluid components.
Bin Lou et al.
PloS one, 9(7), e102641-e102641 (2014-07-18)
Sphingomyelin synthase (SMS) plays an important role in plasma atherogenic lipoprotein metabolism, inflammation, and the development of atherosclerosis. To understand whether the impaired apoB secretion and inflammation response is a direct result from lack of SMS activity, in this study
R Brooks et al.
Stem cells (Dayton, Ohio), 33(3), 848-858 (2014-11-18)
Promoting the expansion of adult stem cell populations offers the potential to ameliorate radiation or chemotherapy-induced bone marrow failure and allows for expedited recovery for patients undergoing these therapies. Previous genetic studies suggested a pivotal role for SH2 domain-containing inositol-5-phosphatase
A M de Lucas Cerrillo et al.
Gene therapy, 22(5), 365-373 (2015-02-27)
Erythropoietin (EPO) is critical for red blood cell production and is also an effective neuroprotective agent. However, it may contribute to pathological angiogenesis. Here we investigate the angiogenic potential of EPO and a mutant form with attenuated erythropoietic activity, EPO-R76E
Robert K Amanfu et al.
Molecular pharmacology, 86(2), 222-230 (2014-05-29)
β-Adrenergic receptor blockers (β-blockers) are commonly used to treat heart failure, but the biologic mechanisms governing their efficacy are still poorly understood. The complexity of β-adrenergic signaling coupled with the influence of receptor polymorphisms makes it difficult to intuit the
Mohamed Aittaleb et al.
Journal of cell science, 128(20), 3744-3756 (2015-09-04)
Rapsyn, a scaffold protein, is required for the clustering of acetylcholine receptors (AChRs) at contacts between motor neurons and differentiating muscle cells. Rapsyn is also expressed in cells that do not express AChRs. However, its function in these cells remains
Page 1 of 138