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Showing 1-30 of 1841 results for "ruthenium" within Papers
Lianne Pope et al.
Cell chemical biology, 27(5), 511-524 (2020-02-16)
The trinuclear ruthenium amine ruthenium red (RuR) inhibits diverse ion channels, including K2P potassium channels, TRPs, the calcium uniporter, CALHMs, ryanodine receptors, and Piezos. Despite this extraordinary array, there is limited information for how RuR engages targets. Here, using X-ray
Srabanti Ghosh et al.
Journal of hazardous materials, 402, 123788-123788 (2020-12-02)
Ruthenium coordination compounds have demonstrated a promising anticancer and antibacterial activity, but their poor water solubility and low stability under physiological conditions may limit their therapeutic applications. Physical encapsulation or covalent conjugation with polymers may overcome these drawbacks, but generally
Batthula Srinivas et al.
Carbohydrate research, 406, 86-92 (2015-02-16)
A highly efficient and convenient C-glycosylation method was developed using ruthenium(III) chloride for the synthesis of 2,3-unsaturated C-glycosides. Various nucleophiles such as allyl trimethylsilane, triethylsilane, trimethylsilyl cyanide, trimethylsilyl azide and heterocycles such as thiophene and furan reacted smoothly with glycals
Serena Berardi et al.
ChemSusChem, 8(21), 3688-3696 (2015-10-02)
Mastering the light-induced four-electron oxidation of water to molecular oxygen is a key step towards the achievement of overall water splitting to produce alternative solar fuels. In this work, we report two rugged molecular pyrazolate-based diruthenium complexes that efficiently catalyze
Erin Wachter et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 22(2), 550-559 (2015-11-13)
Recognition and regulation of G-quadruplex nucleic acid structures is an important goal for the development of chemical tools and medicinal agents. The addition of a bromo-substituent to the dipyridylphenazine (dppz) ligands in the photophysical "light switch", [Ru(bpy)2 dppz](2+) , and
Anna Notaro et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 26(22), 4997-5009 (2020-02-18)
Cancer is one of the main causes of death worldwide. Chemotherapy, despite its severe side effects, is to date one of the leading strategies against cancer. Metal-based drugs present several potential advantages when compared to organic compounds and they have
Maxime Bessières et al.
Current protocols in nucleic acid chemistry, 59, 14-14 (2014-12-17)
The detailed synthetic protocol for the straightforward, efficient synthesis of various alkenyl acyclonucleosides, including challenging trisubstituted alkenyl acyclonucleoside phosphonates, is described. The key step of those syntheses is an olefin cross-metathesis reaction between two olefins selected based on their reactivity
Walaa Khushaim et al.
Biosensors, 12(10) (2022-10-28)
Two-dimensional (2D) layered materials functionalized with monometallic or bimetallic dopants are excellent materials to fabricate clinically useful biosensors. Herein, we report the synthesis of ruthenium nanoparticles (RuNPs) and nickel molybdate nanorods (NiMoO4 NRs) functionalized porous graphitic carbon nitrides (PCN) for
Michał Łomzik et al.
Journal of inorganic biochemistry, 175, 80-91 (2017-07-25)
Two ruthenium(II) complexes Ru1 and Ru2 bearing as a one ligand 2,2'-bipyridine substituted by a semicarbazone 2-formylopyridine moiety (bpySC: 5-(4-{4'-methyl-[2,2'-bipyridine]-4-yl}but-1-yn-1-yl)pyridine-2-carbaldehyde semicarbazone) and as the others 2,2'-bipyridine (bpy) and 4,7-diphenyl-1,10-phenanthroline (dip), respectively, as auxiliary ligands have been prepared. Their biological activity
Hui-juan Yu et al.
Journal of inorganic biochemistry, 149, 80-87 (2015-03-24)
Two new Ru(II) complexes [Ru(tpy)(dpoq)Cl](+)1 and [Ru(tpy)(dpoq)CH3CN](2+)2 (tpy = 2,2':6',2''-terpyridine; dpoq = dipyrido[1,2,5]oxadiazolo[3,4-b]quinoxaline) have been synthesized and characterized by elemental analysis, (1)H NMR, electrospray ionization mass spectra (ESI-MS) and X-ray crystallographic study. The experimental results of spectra titration, thermal denaturation
Mayara S Bertolini et al.
International journal of molecular sciences, 21(23) (2020-12-11)
The mitochondrial Ca2+ uptake in trypanosomatids shares biochemical characteristics with that of animals. However, the composition of the mitochondrial Ca2+ uniporter complex (MCUC) in these parasites is quite peculiar, suggesting lineage-specific adaptations. In this work, we compared the inhibitory activity
Dmytro Havrylyuk et al.
European journal of medicinal chemistry, 156, 790-799 (2018-07-29)
8-Hydroxyquinolines (HQ), including clioquinol, possess cytotoxic properties and are widely used as ligands for metal-based anticancer drug research. The number and identity of substituents on the HQ can have a profound effect on activity for a variety of inorganic compounds.
Gideon K Yawson et al.
Journal of inorganic biochemistry, 214, 111303-111303 (2020-11-10)
Alzheimer's disease (AD) is the most common form of dementia, characterized by extracellular protein deposits, comprised primarily of the peptide amyloid-beta (Aβ), are a pathological indicator of the disease. Commonly known as Aβ plaques, these deposits contain a relatively high
Luca Conti et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 25(45), 10606-10615 (2019-05-21)
A comparative study between two novel, highly water soluble, ruthenium(II) polypyridyl complexes, [Ru(phen)2 L'] and [Ru(phen)2 Cu(II)L'] (L and L-CuII ), containing the polyaazamacrocyclic unit 4,4'-(2,5,8,11,14-pentaaza[15])-2,2'-bipyridilophane (L'), is herein reported. L and L-CuII interact with calf-thymus DNA and efficiently cleave
Katia M Oliveira et al.
Journal of inorganic biochemistry, 214, 111289-111289 (2020-11-03)
The preparation of two new Ru(II)/diphosphine complexes containing Lapachol (Lap) and Lawsone (Law): (1) [Ru(Lap)(dppm)2]PF6 and (2) [Ru(Law)(dppm)2]PF6, where dppm = bis(diphenylphosphino)methane, is reported here. The complexes were synthetized and fully characterized by elemental analyses, molar conductivity, UV-Vis, IR, 31P{1H}, 1H and
Bart Pauwels et al.
The Journal of pharmacy and pharmacology, 67(9), 1263-1271 (2015-04-14)
Over the past few years, ruthenium has been under attention for development of organometallic drugs with various therapeutic applications. Because of its favourable characteristics, ruthenium is perfectly suitable for drug design. Ruthenium-containing complexes exert a wide range of biological effects.
Yuchen Wang et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 26(66), 15170-15182 (2020-07-09)
In this study, we newly designed and synthesized a small library of ten structurally related C,N-cyclometalated ruthenium(II) complexes containing various pyridine-functionalized NHC ligand and chelating bipyridyl ligands (e.g., 2,2'-bipyridine, 5,5'-dimethyl-2,2'-bipyridine, and 1,10-phenanthroline (phen)). The complexes were well characterized by NMR
Ho-Geun Jegal et al.
The Journal of reproduction and development, 66(4), 377-386 (2020-04-24)
Ruthenium red (RR) inhibits calcium (Ca2+) entry from the cytoplasm to the mitochondria, and is involved in maintenance of Ca2+ homeostasis in mammalian cells. Ca2+ homeostasis is very important for further embryonic development of fertilized oocytes. However, the effect of
Sara Rojas et al.
Journal of inorganic biochemistry, 166, 87-93 (2016-11-14)
Two novel anthracene-based half-sandwich organometallic Ru(II) compounds, namely, [Ru(p-cymene)(L
Grzegorz Szczepaniak et al.
ChemSusChem, 8(24), 4139-4148 (2015-11-12)
Three isocyanides containing a tertiary nitrogen atom were investigated for use as small-molecule ruthenium scavenging agents in the workup of olefin metathesis reactions. The proposed compounds are odorless, easy to obtain, and highly effective in removing metal residues, sometimes bringing
Juliano Andreoli Miyake et al.
Anticancer research, 34(4), 1901-1911 (2014-04-03)
Gliomas are primary brain tumours. Gamma-linolenic acid (GLA) exerts anti-proliferative effects. Several ruthenium-containing complexes have antiproliferative effects and can be used as adjuvant therapies in cisplatin-resistant cancer. The present study reports on the anti-proliferative properties and effects on tumour morphology
Cynthia Licona et al.
Oncotarget, 8(2), 2568-2584 (2016-12-10)
Ruthenium complexes are considered as potential replacements for platinum compounds in oncotherapy. Their clinical development is handicapped by a lack of consensus on their mode of action. In this study, we identify three histones (H3.1, H2A, H2B) as possible targets
Harsh Vardhan et al.
Molecules (Basel, Switzerland), 24(12) (2019-06-30)
Coordination-driven self-assembly is an effective synthetic tool for the construction of spatially and electronically tunable supramolecular coordination complexes (SCCs), which are useful in various applications. Herein, we report the synthesis of a two-dimensional discrete metalla-rectangle [(η6-p-cymene)4Ru4(C6H2O4)2(2)2](CF3SO3)4 (3) by the reaction
Aviva Levina et al.
Metallomics : integrated biometal science, 1(6), 458-470 (2009-11-01)
Interest in Ru anticancer drugs has been growing rapidly since NAMI-A ((ImH(+))[Ru(III)Cl(4)(Im)(S-dmso)], where Im = imidazole and S-dmso = S-bound dimethylsulfoxide) or KP1019 ((IndH(+))[Ru(III)Cl(4)(Ind)(2)], where Ind = indazole) have successfully completed phase I clinical trials and an array of other
Samuel A Kemp et al.
Molecules (Basel, Switzerland), 25(2) (2020-01-16)
Metallation of biomacromolecular species forms the basis for the anticancer activity of many metallodrugs. A major limitation of these compounds is that their reactivity is indiscriminate and can, in principle, occur in healthy tissue as well as cancerous tissue, potentially
Govindan Prakash et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 129, 352-358 (2014-04-22)
Schiff base disulfide ligands (H2L(1-6)) were synthesized from the condensation of cystamine with salicylaldehyde(H2L(1)), 5-chlorosalicylaldehyde(H2L(2)), o-vanillin(H2L(3)), 2-hydroxyacetophenone(H2L(4)), 3-methyl-2-hydroxyacetophenone(H2L(5)), and 2-hydroxy-1-naphthaldehyde(H2L(6)). H2L(1-6) reacts with the ruthenium precursor complex [RuHCl(CO)(PPh3)3] in benzene giving rise to six new ruthenium(II) complexes of general formula
Nikolay V Gromov et al.
Bioresource technology, 319, 124122-124122 (2020-09-25)
The aim of this work was to study the one-pot synthesis of sorbitol via hydrolysis-hydrogenation of cellulose in the presence of Ru-containing composites based on H3PW12O40 supported on ZrO2 and Nb2O5 (Ru-PW/ZrO2 and Ru-PW/Nb2O5). The main parameters impacted the reaction
Tomasz Respondek et al.
ChemMedChem, 9(6), 1306-1315 (2014-04-15)
Light-activated inhibition of cathepsin activity was demonstrated in a cell-based assay. Inhibitors of cathepsin K, Cbz-Leu-NHCH2 CN (2) and Cbz-Leu-Ser(OBn)-CN (3), were caged within the complexes cis-[Ru(bpy)2 (2)2 ]Cl2 (4) and cis-[Ru(bpy)2 (3)2 ](BF4 )2 (5) (bpy=2,2'-bipyridine) as 1:1 mixtures
Yoshihide Usami et al.
Molecules (Basel, Switzerland), 24(2) (2019-01-18)
Three types of pyrazole-fused heterobicycles, i.e., 1,5-, 1,7-, and 2,5-dihydropyrano[3,2-c]pyrazoles, were synthesized from 4-allyloxy-1H-pyrazoles. A sequence of the Claisen rearrangement of 4-allyloxy-1H-pyrazoles, ruthenium-hydride-catalyzed double bond migration, O-allylation, and ring-closing metathesis was employed in this study.
Yu Lin et al.
Journal of inorganic biochemistry, 146, 44-51 (2015-03-15)
Electrospray ionization mass spectrometry (ESI-MS) has been widely used to identify binding sites of metal complexes to proteins. However, the MS quantification of the metal-protein coordination remains a challenge. We have recently demonstrated by ESI-MS analysis that organometallic ruthenium complexes
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