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Showing 1-30 of 10902 results for "S0817" within Papers
Deirdre R Ducken et al.
PloS one, 10(6), e0129309-e0129309 (2015-06-17)
Anaplasma marginale is a tick-borne rickettsial pathogen of cattle with a worldwide distribution. Currently a safe and efficacious vaccine is unavailable. Outer membrane protein (OMP) extracts or a defined surface protein complex reproducibly induce protective immunity. However, there are several
Malte Butzlaff et al.
Human molecular genetics, 24(13), 3623-3637 (2015-03-22)
The gene mapt codes for the microtubule-associated protein Tau. The R406W amino acid substitution in Tau is associated with frontotemporal dementia with parkinsonism linked to chromosome 17 (FTDP-17) characterized by Tau-positive filamentous inclusions. These filamentous Tau inclusions are present in
Bryan D Monesson-Olson et al.
PloS one, 9(5), e96641-e96641 (2014-05-06)
Vertebrate hair cells are responsible for the high fidelity encoding of mechanical stimuli into trains of action potentials (spikes) in afferent neurons. Here, we generated a transgenic zebrafish line expressing Channelrhodopsin-2 (ChR2) under the control of the hair-cell specific myo6b
António Pagarete et al.
Viruses, 7(7), 3937-3953 (2015-07-21)
Numbering in excess of 10 million per milliliter of water, it is now undisputed that aquatic viruses are one of the major factors shaping the ecology and evolution of Earth's microbial world. Nonetheless, environmental viral diversity and roles remain poorly
Ling Lian et al.
Poultry science, 94(11), 2616-2621 (2015-10-27)
Marek's disease (MD), caused by Marek's disease virus (MDV), is a lymphoproliferative neoplastic disease of chickens and is characterized by MD lymphoma in multiple visceral organs of chicken. It causes great damage to poultry health. Recently, miRNA has been reported
Dominika Drulis-Fajdasz et al.
Oncotarget, 6(16), 14065-14081 (2015-06-24)
Recent studies emphasized crucial role of astrocytic glycogen metabolism in regulation of synaptic transmission and plasticity in young animals. However, the interplay between age-related synaptic plasticity impairments and changes in energetic metabolism remains obscure. To address this issue, we investigated
Ryo Nemoto et al.
Molecules (Basel, Switzerland), 20(5), 8094-8106 (2015-05-08)
The effect of a chum salmon egg lectin (CSL3) on tight junction (TJ) of Caco-2 cell monolayers was investigated. The lectin opened TJ as indicated by the decrease of the transepithelial electrical resistance (TER) value and the increase of the
Tariq A Tahir et al.
Cellular signalling, 26(7), 1379-1384 (2014-03-20)
Angiopoietin-1 (Ang1) is a ligand for the receptor tyrosine kinase Tie2 and has key roles in the development of the vascular system and vascular protection. In a screen to define signalling pathways regulated by Ang1 in endothelial cells we found
Andrew S Gilder et al.
The Journal of biological chemistry, 290(24), 14798-14809 (2015-04-04)
Genomic heterogeneity is characteristic of glioblastoma (GBM). In many GBMs, the EGF receptor gene (EGFR) is amplified and may be truncated to generate a constitutively active form of the receptor called EGFRvIII. EGFR gene amplification and EGFRvIII are associated with
Hyo Hyun Yang et al.
Archives of pharmacal research, 38(5), 876-884 (2014-07-06)
Cellular senescence influences tumor suppression and progress, tissue repair and regeneration, tissue and organismal aging, and age-related diseases. Aging intervention might be an advantageous target for prevention and treatment of diverse age-related diseases. In this study, we investigated whether (-)-loliolide
Megan M Jones et al.
Infection and immunity, 82(11), 4758-4766 (2014-08-27)
Moraxella catarrhalis is a strict human pathogen that causes otitis media in children and exacerbations of chronic obstructive pulmonary disease in adults, resulting in significant worldwide morbidity and mortality. M. catarrhalis has a growth requirement for arginine; thus, acquiring arginine
Maria Gagliardi et al.
Journal of cell science, 127(Pt 22), 4918-4926 (2014-09-23)
A key step in the canonical Wnt signalling pathway is the inhibition of GSK3β, which results in the accumulation of nuclear β-catenin (also known as CTNNB1), and hence regulation of target genes. Evidence suggests that endocytosis is required for signalling
Kazushi Aoto et al.
Human molecular genetics, 24(3), 698-713 (2014-10-09)
Congenital brain and craniofacial defects often occur together as a consequence of their developmental dependency on common progenitor tissue interactions and signaling pathways during embryogenesis. A classic example of this is perturbation of midline embryo development, and disruption of Hedgehog
Marina Campos Rocha et al.
PloS one, 10(8), e0135195-e0135195 (2015-08-22)
Aspergillus fumigatus is an opportunistic human pathogen, which causes the life-threatening disease, invasive pulmonary aspergillosis. In fungi, cell wall homeostasis is controlled by the conserved Cell Wall Integrity (CWI) pathway. In A. fumigatus this signaling cascade is partially characterized, but
Kevin Moreau et al.
Nature communications, 6, 8045-8045 (2015-08-21)
Autophagy is an important degradation pathway, which is induced after starvation, where it buffers nutrient deprivation by recycling macromolecules in organisms from yeast to man. While the classical pathway mediating this response is via mTOR inhibition, there are likely to
Jian Li et al.
Analytical and bioanalytical chemistry, 407(20), 6137-6148 (2015-06-07)
Benzophenone-type UV filters (BPs) are ubiquitous in the environment. Transformation products (TPs) of BPs with suspected toxicity are likely to be produced during disinfection of water by chlorination. To quickly predict the toxicity of TPs, in this study, a novel
Víctor M Castillo-Acosta et al.
PLoS neglected tropical diseases, 9(3), e0003612-e0003612 (2015-03-10)
Trypanosoma brucei variant surface glycoproteins (VSG) are glycosylated by both paucimannose and oligomannose structures which are involved in the formation of a protective barrier against the immune system. Here, we report that the stinging nettle lectin (UDA), with predominant N-acetylglucosamine-binding
Sofia Jurgensen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 35(43), 14681-14687 (2015-10-30)
Mutations in the human gene encoding contactin-associated protein-like 2 (CNTNAP2) have been strongly associated with autism spectrum disorders (ASDs). Cntnap2(-/-) mice recapitulate major features of ASD, including social impairment, reduced vocalizations, and repetitive behavior. In addition, Cntnap2(-/-) mice show reduced
Angela Schlipp et al.
Cardiovascular research, 104(2), 245-257 (2014-09-13)
We determined the contribution of the desmosomal cadherin desmoglein-2 to cell-cell cohesion in cardiomyocytes. In the intercalated disc, providing mechanical strength and electrical communication between adjacent cardiomyocytes, desmoglein-2 is closely associated with N-cadherin and gap junctions. We studied intercalated discs
Yuhong Qin et al.
Journal of chromatography. A, 1385, 1-11 (2015-02-11)
In this study, dispersive-Solid Phase Extraction (d-SPE) cleanup and multi-plug filtration cleanup (m-PFC) methods were compared for 25 representative pesticides in six matrices (wheat, spinach, carrot, apple, citrus and peanut) by QuEChERS-LC-ESI-MS/MS detection. The type of sorbents in dispersive-SPE (d-SPE)
Sobhi M Gomha et al.
Chemical biology & drug design, 86(5), 1292-1303 (2015-06-03)
Type 2 diabetes mellitus is a vast growing progressive disease that almost affects one person among every twelve globally. Regardless the availability of wide variety of oral hypoglycemics, only one-third of patients achieves proper glycemic control. With the advantage of
Kosei Nakajima et al.
Neoplasia (New York, N.Y.), 16(11), 939-949 (2014-11-27)
Patients with bone cancer metastasis suffer from unbearable pain and bone fractures due to bone remodeling. This is caused by tumor cells that disturb the bone microenvironment. Here, we have investigated the role of tumor-secreted sugar-binding protein, i.e., galectin-3, on
Kirsten A Wunderlich et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 4815-4828 (2015-08-08)
Vimentin (Vim) and glial fibrillary acidic protein (GFAP) are important components of the intermediate filament (IF) (or nanofilament) system of astroglial cells. We conducted full-field electroretinogram (ERG) recordings and found that whereas photoreceptor responses (a-wave) were normal in uninjured GFAP(-/-)Vim(-/-)
Sebastian Daum et al.
Biological chemistry, 395(7-8), 801-812 (2014-07-09)
As shape transformations of membranes are vital for intracellular trafficking, it is crucial to understand both the mechanics and the biochemistry of these processes. The interplay of these two factors constitutes an experimental challenge, however, because biochemical experiments are not
Dareen M Abdelaziz et al.
Breast cancer research and treatment, 153(1), 9-20 (2015-07-26)
Patients with breast cancer metastasis to bone suffer from inadequate pain relief. Animal models provide increased understanding of cancer-induced bone and sensory alterations. The objective of this study was to investigate the measures of pain at distant non-tumor-bearing sites in
Susan M Armstrong et al.
Cardiovascular research, 108(2), 268-277 (2015-09-04)
Retention of low-density lipoprotein (LDL) cholesterol beneath the arterial endothelium initiates an inflammatory response culminating in atherosclerosis. Since the overlying endothelium is healthy and intact early on, it is likely that LDL passes through endothelial cells by transcytosis. However, technical
Roberto B Pontes et al.
American journal of physiology. Renal physiology, 308(8), F848-F856 (2015-02-07)
Renal nerve stimulation at a low frequency (below 2 Hz) causes water and sodium reabsorption via α1-adrenoreceptor tubular activation, a process independent of changes in systemic blood pressure, renal blood flow, or glomerular filtration rate. However, the underlying mechanism of
Jie Yang et al.
Chemosphere, 133, 97-102 (2015-05-08)
Model fly ash (MFA) containing activated carbon (AC) as source of carbon, NaCl as source of chlorine and either NiO or NiCl2 as de novo catalyst, was heated for 1h at 350 °C in a carrier gas flow composed of
Mariela B Nolly et al.
Journal of applied physiology (Bethesda, Md. : 1985), 118(9), 1154-1160 (2015-03-10)
We examined the effect of specific and local silencing of sodium/hydrogen exchanger isoform 1 (NHE1) with a small hairpin RNA delivered by lentivirus (L-shNHE1) in the cardiac left ventricle (LV) wall of spontaneously hypertensive rats, to reduce cardiac hypertrophy. Thirty
Niraj S Desai et al.
Journal of neurophysiology, 114(2), 1331-1345 (2015-06-19)
Automation has been an important part of biomedical research for decades, and the use of automated and robotic systems is now standard for such tasks as DNA sequencing, microfluidics, and high-throughput screening. Recently, Kodandaramaiah and colleagues (Nat Methods 9: 585-587
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