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Showing 1-30 of 10902 results for "S0817" within Papers
Julia Müller et al.
Basic research in cardiology, 109(6), 440-440 (2014-09-23)
Interleukin-6 (IL-6) is a multifunctional cytokine that orchestrates the immune response to a wide variety of pathophysiologic challenges but also contributes to tissue homeostasis. Furthermore, IL-6 is elevated in patients with acute myocardial infarction. Hyaluronan (HA) is an extracellular carbohydrate
G L Erre et al.
Clinical rheumatology, 33(12), 1725-1729 (2014-05-27)
Little is known regarding the environmental factors at play in igniting rheumatoid arthritis (RA) autoimmunity, although an association between Mycobacteria and RA has been documented. This pilot study focused on examining a possible involvement of Mycobacterium tuberculosis (MTB) and Mycobacterium
Vicente Ferreira et al.
Journal of chromatography. A, 1407, 30-41 (2015-07-15)
SPME is extremely sensitive to experimental parameters affecting liquid-gas and gas-solid distribution coefficients. Our aims were to measure the weights of these factors and to design a multivariate strategy based on the addition of a pool of internal standards, to
Stephen M Hinshaw et al.
eLife, 4, e06057-e06057 (2015-06-04)
The cohesin ring holds newly replicated sister chromatids together until their separation at anaphase. Initiation of sister chromatid cohesion depends on a separate complex, Scc2(NIPBL)/Scc4(Mau2) (Scc2/4), which loads cohesin onto DNA and determines its localization across the genome. Proper cohesin
Eduardo Parra et al.
Oncology reports, 33(1), 413-418 (2014-10-30)
Inhibition of basal Jun kinase (JNK) activity by small interfering RNAs (siRNAs) enhances cisplatin sensitivity and decreases DNA repair in T98G glioblastoma cells. Although the JNK pathway has been extensively studied in recent years, little is known concerning the signaling
Anja Bauermeister et al.
PloS one, 9(4), e94265-e94265 (2014-04-17)
Bioburden encapsulated in spacecraft polymers (such as adhesives and coatings) poses a potential risk to jeopardize scientific exploration of other celestial bodies. This is particularly critical for spacecraft components intended for hard landing. So far, it remained unclear if polymers
Ragna Berthelsen et al.
International journal of pharmaceutics, 473(1-2), 356-365 (2014-07-06)
The aim of this study was to develop a sensitive and discriminative in vitro-in silico model able to simulate the in vivo performance of three fenofibrate immediate release formulations containing different surfactants. In addition, the study was designed to investigate
Martha Estela Salcido-Neyoy et al.
Environmental pollution (Barking, Essex : 1987), 203, 175-182 (2015-04-25)
The carcinogenic potential of urban particulate matter (PM) has been partly attributed to polycyclic aromatic hydrocarbons (PAHs) content, which activates the aryl hydrocarbon receptor (AhR). Here we report the effect of PM with an aerodynamic size of 10 μm (PM10)
Zhiqiang Zhao et al.
Scientific reports, 5, 11094-11094 (2015-06-10)
Direct interspecies electron transfer (DIET) between Geobacter species and Methanosaeta species is an alternative to interspecies hydrogen transfer (IHT) in anaerobic digester, which however has not been established in anaerobic sludge digestion as well as in bioelectrochemical systems yet. In
Sang Eun Kim et al.
Biochemical and biophysical research communications, 463(3), 205-210 (2015-05-23)
Pancreatic ductal adenocarcinomas are an extremely aggressive and devastating type of cancer with high mortality. Given the dense stroma and poor vascularization, accessibility to nutrients is limited in the tumor microenvironment. Here, we aimed to elucidate the role of autophagy
Masayuki Tanaka et al.
The Journal of surgical research, 194(2), 571-580 (2014-12-17)
High-mobility group box 1 (HMGB1) has recently been identified as an important mediator of various kinds of acute and chronic inflammation. The protein encoded by the box-A domain of the HMGB1 gene is known to act as a competitive inhibitor
Young-Jun Kim et al.
PLoS genetics, 11(2), e1004988-e1004988 (2015-02-28)
Stabilization of neurotransmitter receptors at postsynaptic specializations is a key step in the assembly of functional synapses. Drosophila Neto (Neuropillin and Tolloid-like protein) is an essential auxiliary subunit of ionotropic glutamate receptor (iGluR) complexes required for the iGluRs clustering at
Zita Rovó et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(21), 7137-7147 (2014-05-23)
GABA-A receptors (GABA-ARs) are typically expressed at synaptic or nonsynaptic sites mediating phasic and tonic inhibition, respectively. These two forms of inhibition conjointly control various network oscillations. To disentangle their roles in thalamocortical rhythms, we focally deleted synaptic, γ2 subunit-containing
Fabiano Di Marco et al.
Anesthesia and analgesia, 120(2), 373-380 (2014-11-02)
An increased alveolar-arterial oxygen tension difference is frequent in anesthetized patients. In this study, we evaluated the effect on the lung of anesthesia, muscle paralysis, and a brief course of mechanical ventilation. Lung diffusion for carbon monoxide (DLCO), including pulmonary
Kyunghee Lee et al.
Biochemical and biophysical research communications, 453(4), 793-797 (2014-12-03)
Vascular calcification is an active cell-mediated process that reduces elasticity of blood vessels and increases blood pressure. Until now, the molecular basis of vascular calcification has not been fully understood. We previously reported that microtubule disturbances mediate vascular calcification. Here
Paula Solar et al.
Journal of nanobiotechnology, 13, 14-14 (2015-04-18)
Advances in nanostructure materials are leading to novel strategies for drug delivery and targeting, contrast media for magnetic resonance imaging (MRI), agents for hyperthermia and nanocarriers. Superparamagnetic iron oxide nanoparticles (SPIONs) are useful for all of these applications, and in
Ryan C Hill et al.
Molecular & cellular proteomics : MCP, 14(4), 961-973 (2015-02-11)
The use of extracellular matrix (ECM) scaffolds, derived from decellularized tissues for engineered organ generation, holds enormous potential in the field of regenerative medicine. To support organ engineering efforts, we developed a targeted proteomics method to extract and quantify extracellular
Sedigheh Kamran et al.
Amino acids, 47(12), 2483-2493 (2015-07-08)
In this paper, nanoparticles of Fe3O4 as well as their modified forms with different ionic liquids (IL-Fe3O4) were prepared and used for adsorption of lysozyme. The mean size and the surface morphology of the nanoparticles were characterized by TEM, XRD
M-F Wu et al.
Free radical research, 48(7), 794-805 (2014-04-01)
One major pathological hallmark of Alzheimer's disease (AD) is accumulation of senile plaques in patients' brains, mainly composed of amyloid beta-peptide (Aβ). Nicotinamide adenine dinucleotide (NAD) has emerged as a common mediator regulating energy metabolism, mitochondrial function, aging, and cell
Sujung Yeo et al.
Genetics and molecular biology, 38(1), 115-127 (2015-05-20)
Parkinson's disease (PD) is a neurodegenerative disorder characterized by the death of dopamine-generating cells in the substantia nigra (SN). Acupuncture stimulation results in an enhanced survival of dopaminergic neurons in the SN in Parkinsonism animal models. The present study investigated
Ahmadreza Sardarian et al.
Toxicology mechanisms and methods, 25(2), 98-104 (2014-11-25)
Cyclosporine A (CsA) is an immunosuppressive agent administered to transplant patients. A well-known reported oral side effect of CsA consumption is gingival overgrowth (GO). Changes in the expression of integrins occurring in the gingiva following CsA treatment have been reported
Malik Mukhtar et al.
Environmental monitoring and assessment, 187(8), 482-482 (2015-07-02)
The present studies were carried out to observe the dissipation pattern of chlorpyrifos on apple in Kashmir Valley. Persistence of chlorpyrifos in apple was studied following two applications rates of chlorpyrifos (Dursban 20 EC) at 200 g a.i. ha(-1) (single dose
Volker Winstel et al.
Applied and environmental microbiology, 81(7), 2481-2488 (2015-01-27)
Genetic manipulation of emerging bacterial pathogens, such as coagulase-negative staphylococci (CoNS), is a major hurdle in clinical and basic microbiological research. Strong genetic barriers, such as restriction modification systems or clustered regularly interspaced short palindromic repeats (CRISPR), usually interfere with
Carolina Parra et al.
Journal of nanobiotechnology, 13, 82-82 (2015-11-18)
Biofouling, the colonization of artificial and natural surfaces by unwanted microorganisms, has an important economic impact on a wide range of industries. Low cost antifouling strategies are typically based on biocides which exhibit a negative environmental impact, affecting surrounding organisms
Yang Xu et al.
Behavioural brain research, 286, 1-10 (2015-02-28)
BRD7 is a bromodomain-containing protein (BCP), and recent evidence implicates the role of BCPs in the initiation and development of neurodevelopmental disorders. However, few studies have investigated the biological functions of BRD7 in the central nervous system. In our study
Stefan Spulber et al.
PloS one, 9(4), e94227-e94227 (2014-04-18)
Perfluorooctane sulfonate (PFOS) is a widely spread environmental contaminant. It accumulates in the brain and has potential neurotoxic effects. The exposure to PFOS has been associated with higher impulsivity and increased ADHD prevalence. We investigated the effects of developmental exposure
Andrea Groß et al.
Bioorganic & medicinal chemistry, 23(14), 4050-4055 (2015-03-25)
The chemokine receptor CXCR4 belongs to the family of seven-transmembrane G-protein coupled receptors (GPCRs). It is activated by its natural ligand SDF-1α. In addition, CXCR4, along with CCR5, serve as coreceptors during HIV-1 entry into its target cell. Recently, we
Manouela V Valtcheva et al.
The journal of pain : official journal of the American Pain Society, 16(4), 346-356 (2015-02-03)
Chronic pruritic conditions are often associated with dry skin and loss of epidermal barrier integrity. In this study, repeated application of acetone and ether followed by water (AEW) to the cheek skin of mice produced persistent scratching behavior with no
Susana Matamouros et al.
mBio, 6(3), e00616-e00615 (2015-05-28)
HAMP domains are α-helical coiled coils that often transduce signals from extracytoplasmic sensing domains to cytoplasmic domains. Limited structural information has resulted in hypotheses that specific HAMP helix movement changes downstream enzymatic activity. These hypotheses were tested by mutagenesis and
Pallichera Vijayan Shahana et al.
Protein expression and purification, 113, 35-43 (2015-05-12)
Japanese Encephalitis (JE) is a mosquito borne arboviral infection caused by Japanese Encephalitis Virus (JEV). It is a major cause of viral encephalitis in Asian countries including India. In the present study, we have used a Tymovirus [i.e. Physalis Mottle
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