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Showing 1-30 of 416 results for "s0900000" within Papers
Mónica Narváez-Rivas et al.
Analytica chimica acta, 954, 140-150 (2017-01-14)
The confident identification and in-depth profiling of molecular lipid species remain to be a challenge in lipidomics analysis. In this work, an off-line two-dimensional mixed-mode and reversed-phase liquid chromatography (RPLC) method combined with high-field quadrupole orbitrap mass spectrometer (Q Exactive
Alexander S Tatikolov et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 216, 190-201 (2019-03-23)
Spectral-fluorescent properties of polymethine dye probes anionic 3,3'-di(sulfopropyl)-4,5,4',5'-dibenzo-9-ethylthiacarbocyanine-betaine (DEC) and cationic 3,3',9-trimethylthiacarbocyanine iodide (Cyan 2) in the presence of biological surfactants, bile salts sodium cholate (NaC), sodium deoxycholate (NaDC) and sodium taurocholate (NaTC), as well as sodium dodecyl sulfate (SDS)
Yupeng Yan et al.
Molecular medicine reports, 16(6), 8471-8476 (2017-10-11)
Severe acute pancreatitis (SAP) has a rapid onset and may cause multiple organ dysfunction syndrome (MODS), which has high mortality. Nucleotide binding oligomerization domain (NOD) receptor and Toll‑like receptor 9 (TLR9), a pattern recognition receptor in innate immunity, are involved
Aleksandra V Bukhovets et al.
Polymers, 12(7) (2020-07-08)
Interpolymer complexes (IPC) based on Eudragit® EPO and Eudragit® S100 were investigated as potential carriers for oral controlled drug delivery to the colon. IPC samples were prepared by mixing copolymer solutions in organic solvents (ethanol, isopropanol:acetone mixture (60:40, % v/v)
Yipshu Pui et al.
Molecular pharmaceutics, 15(7), 2754-2763 (2018-05-22)
Amorphous solid dispersion (ASD) is one of the most versatile supersaturating drug delivery systems to improve the dissolution rate and oral bioavailability of poorly water-soluble drugs. PVP based ASD formulation of nimodipine (NMD) has been marketed and effectively used in
Philipp A Elvang et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 120, 61-72 (2018-04-29)
Colloidal phases (self-assemblies) in aqueous dispersions of selected binary bile salt/phospholipid blends were studied utilizing the combined analytical approach of asymmetrical flow field-flow fractionation (AF4) and multi-angle laser light scattering (MALLS) in order to resolve the co-existence of different colloidal
Flavia D Toledo et al.
Archives of toxicology, 91(6), 2391-2403 (2016-12-04)
In previous studies, we showed that the pro-oxidant model agent tert-butyl hydroperoxide (tBuOOH) induces alterations in hepatocanalicular secretory function by activating Ca
Maureen A Williams et al.
Oecologia, 194(1-2), 65-74 (2020-09-03)
Parasites are ecologically ubiquitous and, by modifying the physiology and behavior of their host organisms, act as key regulators of the dynamics and stability of ecosystems. It is, however, as yet unclear how parasitic relationships will act to moderate or
Peter P Rainer et al.
Heart (British Cardiac Society), 99(22), 1685-1692 (2013-07-31)
High bile acid serum concentrations have been implicated in cardiac disease, particularly in arrhythmias. Most data originate from in vitro studies and animal models. We tested the hypotheses that (1) high bile acid concentrations are arrhythmogenic in adult human myocardium
Fei-Hu Zhang et al.
The Journal of surgical research, 256, 295-302 (2020-07-28)
To explore the mechanism of Shenmai injection (SMI) on severe acute pancreatitis (SAP) through heme oxygenase-1 (HO-1) signaling. A total of 40 male Sprague-Dawley (SD) rats (220-260 g) were grouped into the following four categories (n = 10): SAP + SMI + Zinc protoporphyrin (ZnPP), SAP + SMI
Alison B Kohan et al.
American journal of physiology. Gastrointestinal and liver physiology, 311(4), G648-G654 (2016-08-16)
It is not well understood how monosodium glutamate (MSG) affects gastrointestinal physiology, especially regarding the absorption and the subsequent transport of dietary lipids into lymph. Thus far, there is little information about how the ingestion of MSG affects the lipid
Huan Yan et al.
Journal of virology, 87(14), 7977-7991 (2013-05-17)
Human hepatitis B virus (HBV) and its satellite virus, hepatitis D virus (HDV), primarily infect humans, chimpanzees, or tree shrews (Tupaia belangeri). Viral infections in other species are known to be mainly restricted at the entry level since viral replication
Liang Sun et al.
Molecular medicine reports, 18(4), 3818-3824 (2018-08-15)
The aim of the present study was to investigate the effects of Toll‑like receptor (TLR) 9 and CpG oligodeoxynucleotide (CpG‑ODN)1826 on sodium taurocholate‑induced acute pancreatitis (AP) rats at different time points. Pathological examination indicated that the severity of pancreatic tissue
Can Yu et al.
Molecular medicine reports, 14(6), 5507-5513 (2016-11-24)
High-motility group box protein 1 (HMGB1) has an important role in autophagy; however, its exact role in acute necrotizing pancreatitis (ANP) remains unknown. The present study aimed to investigate the expression pattern of HMGB1 in ANP, and to determine its association
Muhammad Imran Sohail et al.
Molecular pharmacology, 92(4), 401-413 (2017-08-09)
The bile salt export pump (BSEP/ABCB11) transports bile salts from hepatocytes into bile canaliculi. Its malfunction is associated with severe liver disease. One reason for functional impairment of BSEP is systemic administration of drugs, which as a side effect inhibit
Juan Li et al.
BMC gastroenterology, 14, 115-115 (2014-07-01)
Acute pancreatitis (AP) is a common inflammatory disease of the pancreas accompanied by serious metabolic disturbances. Nevertheless, the specific metabolic process of this disease is still unclear. Characterization of the metabolome may help identify biomarkers for AP. To identify potential
Xiaozheng Yu et al.
Pancreas, 47(7), 892-897 (2018-06-19)
The aim of this study was to investigate the effects of emodin on attenuating autophagy response in acute pancreatitis (AP) models. Acute pancreatitis was induced in Wistar rats by injecting 3% sodium taurocholate into the biliopancreatic duct. Emodin (40 mg/kg
Chan Hee Moon et al.
Cornea, 36(4), 497-501 (2016-12-13)
To compare the therapeutic and preventive effects of topically administered 7-taurocholic acid-conjugated low-molecular-weight heparin (LHT7) and bevacizumab in experimentally induced corneal neovascularization (CoNV). CoNV was induced using sutures in the right eyes of 24 mice. To investigate the therapeutic effects
Regulation of bile acid metabolism: new insights from inside.
Pablo Quintero et al.
Hepatology (Baltimore, Md.), 58(5), 1850-1853 (2013-06-19)
Dominika Trzilova et al.
PLoS pathogens, 16(8), e1008708-e1008708 (2020-08-14)
The intestinal pathogen Clostridioides difficile exhibits heterogeneity in motility and toxin production. This phenotypic heterogeneity is achieved through phase variation by site-specific recombination via the DNA recombinase RecV, which reversibly inverts the "flagellar switch" upstream of the flgB operon. A
Chan Hee Moon et al.
International journal of ophthalmology, 11(9), 1435-1439 (2018-09-19)
To investigate the ocular biodistribution and clearance of topically administered 7-taurocholic acid conjugated low-molecular weight heparin (LHT7) in a neovascularized mouse cornea using an in vivo optical imaging system. A total of 10 eyes of 6 to 8-week-old BALB/c mice
Jean-Louis Delaunay et al.
Hepatology (Baltimore, Md.), 65(2), 560-570 (2016-12-25)
ABCB4 (MDR3) is an adenosine triphosphate (ATP)-binding cassette (ABC) transporter expressed at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine (PC) secretion. Variations in the ABCB4 gene are responsible for several biliary diseases, including progressive familial intrahepatic cholestasis type
Xuefei Yang et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 125, 110024-110024 (2020-03-20)
Acute kidney injury (AKI), characterized by an increase of serum creatinine and urea, is a severe complication of severe acute pancreatitis (SAP) with high mortality. Endoplasmic reticulum (ER) stress has been considered as a key pathologic process in AKI. Chaiqin
Andrea C Boaglio et al.
PloS one, 7(11), e49255-e49255 (2012-11-21)
The endogenous, cholestatic metabolite estradiol 17ß-D-glucuronide (E(2)17G) induces endocytic internalization of the canalicular transporters relevant to bile formation, Bsep and Mrp2. We evaluated here whether MAPKs are involved in this effect. ERK1/2, JNK1/2, and p38 MAPK activation was assessed by
Z-G Luan et al.
Clinical and experimental immunology, 172(3), 417-426 (2013-04-23)
In this study, we examined the effect of ethyl pyruvate (EP) on pulmonary inflammation in rats with severe pancreatitis-associated acute lung injury (ALI). Severe acute pancreatitis (SAP) was induced in rats by the retrograde injection of 5% sodium taurocholate into
Bin Wang et al.
Molecular medicine reports, 23(4) (2021-03-03)
Severe acute pancreatitis (SAP) is a common acute abdominal disease accompanied by systemic inflammatory response syndrome, which may be complicated by acute kidney injury (AKI). Isoacteoside (ISO) is the active ingredient of Monochasma savatieri Franch. ex Maxim and has been reported to have
Yiping Zhang et al.
Journal of pharmaceutical and biomedical analysis, 164, 155-163 (2018-11-06)
Previous studies have indicated that dietary fucoxanthin is mainly converted into fucoxanthinol (the deacetylated form) in mammals, but the pharmacokinetics of fucoxanthinol remains unknown. In this study, after intravenous (i.v.) and intragastric gavage (i.g.) administration of fucoxanthinol to rats at
Johan Linders et al.
Laboratory investigation; a journal of technical methods and pathology, 100(12), 1618-1630 (2020-07-28)
Neutrophil extracellular traps (NETs) play a key role in the development of acute pancreatitis (AP). In the present study, we studied the role of extracellular cold-inducible RNA-binding protein (eCIRP), a novel damage-associated-molecular-pattern molecule, in severe AP. C57BL/6 mice underwent retrograde
R L Anisimov et al.
Protein expression and purification, 170, 105573-105573 (2020-01-26)
Antibodies specific to β-Glucocerebrosidase were selected from phage displayed naïve scFv libraries. Biopannings were performed against recombinant human protein β-Glucocerebrosidase immobilized on polystyrene surface, specific phages were eluted with 50% ethylene glycol in citrate buffer (pH 6.0). Several specific binders
Kristine Bach Korsholm Knudsen et al.
Nutrients, 13(2) (2021-02-03)
Efficient lipid digestion in formula-fed infants is required to ensure the availability of fatty acids for normal organ development. Previous studies suggest that the efficiency of lipid digestion may depend on whether lipids are emulsified with soy lecithin or fractions
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