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Showing 1-30 of 109 results for "S106" within Papers
M Heaulme et al.
Brain research, 384(2), 224-231 (1986-10-08)
An arylaminopyridazine derivative of gamma-aminobutyric acid (GABA), SR 95103, has been shown to be a selective antagonist of GABA at the GABAA receptor site. Subsequent structure-activity studies showed that suppressing the methyl in the 4-position of the pyridazine ring, and
Betty Jurek et al.
Annals of neurology, 86(5), 656-670 (2019-07-22)
Maternal autoantibodies are a risk factor for impaired brain development in offspring. Antibodies (ABs) against the NR1 (GluN1) subunit of the N-methyl-d-aspartate receptor (NMDAR) are among the most frequently diagnosed anti-neuronal surface ABs, yet little is known about effects on
Lorcan P Browne et al.
Cell reports, 41(10), 111750-111750 (2022-12-09)
Successful neuronal regeneration requires the reestablishment of synaptic connectivity. This process requires the reconstitution of presynaptic neurotransmitter release, which we investigate here in a model of entirely natural regeneration. After toxin-induced injury, olfactory sensory neurons in the adult mouse olfactory
Amanda L Zimmerman et al.
Neuron, 102(2), 420-434 (2019-03-04)
Presynaptic inhibition (PSI) of primary sensory neurons is implicated in controlling gain and acuity in sensory systems. Here, we define circuit mechanisms and functions of PSI of cutaneous somatosensory neuron inputs to the spinal cord. We observed that PSI can
Ping Liu et al.
Nature communications, 11(1), 5076-5076 (2020-10-10)
Proper threat-reward decision-making is critical to animal survival. Emerging evidence indicates that the motor system may participate in decision-making but the neural circuit and molecular bases for these functions are little known. We found in C. elegans that GABAergic motor
Petr Unichenko et al.
Cerebral cortex (New York, N.Y. : 1991), 28(8), 2873-2886 (2017-11-07)
Neuroligin-4 (Nlgn4) is a cell adhesion protein that regulates synapse organization and function. Mutations in human NLGN4 are among the causes of autism spectrum disorders. In mouse, Nlgn4 knockout (KO) perturbs GABAergic synaptic transmission and oscillatory activity in hippocampus, and
G Mark Freeman et al.
Neuron, 78(5), 799-806 (2013-06-15)
Systems of coupled oscillators abound in nature. How they establish stable phase relationships under diverse conditions is fundamentally important. The mammalian suprachiasmatic nucleus (SCN) is a self-sustained, synchronized network of circadian oscillators that coordinates daily rhythms in physiology and behavior.
Sergey N Kolbaev et al.
Scientific reports, 10(1), 18399-18399 (2020-10-29)
Activation of GABAA receptors causes in immature neurons a functionally relevant decrease in the intracellular Cl- concentration ([Cl-]i), a process termed ionic plasticity. Amount and duration of ionic plasticity depends on kinetic properties of [Cl-]i homeostasis. In order to characterize
Kyoko Tossell et al.
The European journal of neuroscience, 53(6), 1722-1737 (2021-02-02)
The activity of midbrain dopamine neurons is strongly regulated by fast synaptic inhibitory γ-Aminobutyric acid (GABA)ergic inputs. There is growing evidence in other brain regions that low concentrations of ambient GABA can persistently activate certain subtypes of GABAA receptor to
Georg M Stettner et al.
Journal of applied physiology (Bethesda, Md. : 1985), 114(1), 119-130 (2012-10-30)
The perifornical (PF) region of the posterior hypothalamus promotes wakefulness and facilitates motor activity. In anesthetized rats, local disinhibition of PF neurons by GABA(A) receptor antagonists activates orexin (OX) neurons and elicits a systemic response, including increases of hypoglossal nerve
Giulia Quattrocolo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(13), 5486-5498 (2013-03-29)
Cajal-Retzius cells are a class of neurons believed to play critical roles during cortical development. However, their network computational functions remain poorly understood. Although work in the neocortex and hippocampus has shown that Cajal-Retzius cells receive predominantly, if not exclusively
Jason V Thompson et al.
Journal of neurophysiology, 109(3), 721-733 (2012-11-17)
Changes in inhibition during development are well documented, but the role of inhibition in adult learning-related plasticity is not understood. In songbirds, vocal recognition learning alters the neural representation of songs across the auditory forebrain, including the caudomedial nidopallium (NCM)
Vladislav Sekulić et al.
Frontiers in cellular neuroscience, 14, 277-277 (2020-10-24)
Determining biophysical details of spatially extended neurons is a challenge that needs to be overcome if we are to understand the dynamics of brain function from cellular perspectives. Moreover, we now know that we should not average across recordings from
Ji-Hye Lee et al.
Nature neuroscience, 26(2), 259-273 (2022-12-24)
While initial encoding of contextual memories involves the strengthening of hippocampal circuits, these memories progressively mature to stabilized forms in neocortex and become less hippocampus dependent. Although it has been proposed that long-term storage of contextual memories may involve enduring
Raunak Sinha et al.
Current biology : CB, 31(19), 4314-4326 (2021-08-26)
Developing neural circuits, including GABAergic circuits, switch receptor types. But the role of early GABA receptor expression for establishment of functional inhibitory circuits remains unclear. Tracking the development of GABAergic synapses across axon terminals of retinal bipolar cells (BCs), we
Hannah J Seong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(31), 10516-10521 (2012-08-03)
Dopamine modulation in the prefrontal cortex is important for cognitive processing and disrupted in diverse neuropsychiatric diseases. Activation of D1 receptors is thought to enable working memory by enhancing the firing properties of pyramidal neurons. However, these receptors are only
Kotaro Takano et al.
Analytical and bioanalytical chemistry, 412(17), 4037-4043 (2020-04-25)
A convenient analytical system for protein-ligand interactions under crude conditions was developed using native mass spectrometry (MS). As a model protein, Escherichia coli (E. coli) dihydrofolate reductase (DHFR) with and without a histidine tag was used for the study. First
Emily Johnson et al.
iScience, 26(1), 105914-105914 (2023-01-25)
The action potential and its all-or-none nature is fundamental to neural communication. Canonically, the action potential is initiated once voltage-activated Na+ channels are activated, and their rapid kinetics of activation and inactivation give rise to the action potential's all-or-none nature.
Rebecca Lethbridge et al.
PloS one, 7(4), e35024-e35024 (2012-04-13)
Rat pup odor preference learning follows pairing of bulbar beta-adrenoceptor activation with olfactory input. We hypothesize that NMDA receptor (NMDAR)-mediated olfactory input to mitral cells is enhanced during training, such that increased calcium facilitates and shapes the critical cAMP pattern.
Ian Duguid et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(32), 11132-11143 (2012-08-10)
Tonic inhibition is a key regulator of neuronal excitability and network function in the brain, but its role in sensory information processing remains poorly understood. The cerebellum is a favorable model system for addressing this question as granule cells, which
Quentin Gaucher et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(26), 10713-10728 (2013-06-28)
In all sensory modalities, intracortical inhibition shapes the functional properties of cortical neurons but also influences the responses to natural stimuli. Studies performed in various species have revealed that auditory cortex neurons respond to conspecific vocalizations by temporal spike patterns
Edmund Cauley et al.
American journal of physiology. Heart and circulatory physiology, 309(8), H1281-H1287 (2015-09-16)
Hypertension, cardiac hypertrophy, and heart failure (HF) are widespread and debilitating cardiovascular diseases that affect nearly 23 million people worldwide. A distinctive hallmark of these cardiovascular diseases is autonomic imbalance, with increased sympathetic activity and decreased parasympathetic vagal tone. Recent
Mark van den Hurk et al.
NPJ Parkinson's disease, 8(1), 134-134 (2022-10-19)
Complex genetic predispositions accelerate the chronic degeneration of midbrain substantia nigra neurons in Parkinson's disease (PD). Deciphering the human molecular makeup of PD pathophysiology can guide the discovery of therapeutics to slow the disease progression. However, insights from human postmortem
Marvin R Diaz et al.
PloS one, 8(1), e55673-e55673 (2013-02-06)
Cerebellar granule cells (CGNs) are one of many neurons that express phasic and tonic GABAergic conductances. Although it is well established that Golgi cells (GoCs) mediate phasic GABAergic currents in CGNs, their role in mediating tonic currents in CGNs (CGN-I(tonic))
Gubbi Govindaiah et al.
eNeuro, 7(6) (2020-10-25)
Retinofugal synapses serve as models for understanding how sensory signals from the periphery are relayed to the brain. Past studies have focused primarily on understanding the postsynaptic glutamatergic receptor subtypes involved in signal transmission, but the mechanisms underlying glutamate release
Daniel A Llano et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(46), 16141-16148 (2012-11-16)
Flavoprotein autofluorescence imaging was used to examine auditory cortical synaptic responses in aged animals with behavioral evidence of tinnitus and hearing loss. Mice were exposed to noise trauma at 1-3 months of age and were assessed for behavioral evidence of
Bridget M McKay et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(13), 5499-5506 (2013-03-29)
Learning-related intrinsic excitability changes of pyramidal neurons via modulation of the postburst afterhyperpolarization (AHP) have been repeatedly demonstrated in multiple brain regions (especially the hippocampus), after a variety of learning tasks, and in multiple species. While exciting and important, the
Yu-Ting Mao et al.
Neural plasticity, 2013, 530651-530651 (2013-11-30)
Loss of sensory input from peripheral organ damage, sensory deprivation, or brain damage can result in adaptive or maladaptive changes in sensory cortex. In previous research, we found that auditory cortical tuning and tonotopy were impaired by cross-modal invasion of
Anna Cavaccini et al.
Neuron, 98(4), 801-816 (2018-05-01)
Monoaminergic modulation of cortical and thalamic inputs to the dorsal striatum (DS) is crucial for reward-based learning and action control. While dopamine has been extensively investigated in this context, the synaptic effects of serotonin (5-HT) have been largely unexplored. Here
Giulia Puia et al.
Frontiers in neural circuits, 6, 94-94 (2012-12-13)
The balance between glutamate- and GABA-mediated neurotransmission in the brain is fundamental in the nervous system, but it is regulated by the "tonic" release of a variety of endogenous factors. One such important group of molecules are the neurosteroids (NSs)
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