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Showing 1-30 of 109 results for "S106" within Papers
Giulia Quattrocolo et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(13), 5486-5498 (2013-03-29)
Cajal-Retzius cells are a class of neurons believed to play critical roles during cortical development. However, their network computational functions remain poorly understood. Although work in the neocortex and hippocampus has shown that Cajal-Retzius cells receive predominantly, if not exclusively
G Mark Freeman et al.
Neuron, 78(5), 799-806 (2013-06-15)
Systems of coupled oscillators abound in nature. How they establish stable phase relationships under diverse conditions is fundamentally important. The mammalian suprachiasmatic nucleus (SCN) is a self-sustained, synchronized network of circadian oscillators that coordinates daily rhythms in physiology and behavior.
Kyoko Tossell et al.
The European journal of neuroscience, 53(6), 1722-1737 (2021-02-02)
The activity of midbrain dopamine neurons is strongly regulated by fast synaptic inhibitory γ-Aminobutyric acid (GABA)ergic inputs. There is growing evidence in other brain regions that low concentrations of ambient GABA can persistently activate certain subtypes of GABAA receptor to
Raunak Sinha et al.
Current biology : CB, 31(19), 4314-4326 (2021-08-26)
Developing neural circuits, including GABAergic circuits, switch receptor types. But the role of early GABA receptor expression for establishment of functional inhibitory circuits remains unclear. Tracking the development of GABAergic synapses across axon terminals of retinal bipolar cells (BCs), we
Georg M Stettner et al.
Journal of applied physiology (Bethesda, Md. : 1985), 114(1), 119-130 (2012-10-30)
The perifornical (PF) region of the posterior hypothalamus promotes wakefulness and facilitates motor activity. In anesthetized rats, local disinhibition of PF neurons by GABA(A) receptor antagonists activates orexin (OX) neurons and elicits a systemic response, including increases of hypoglossal nerve
Ji-Hye Lee et al.
Nature neuroscience, 26(2), 259-273 (2022-12-24)
While initial encoding of contextual memories involves the strengthening of hippocampal circuits, these memories progressively mature to stabilized forms in neocortex and become less hippocampus dependent. Although it has been proposed that long-term storage of contextual memories may involve enduring
Hannah J Seong et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(31), 10516-10521 (2012-08-03)
Dopamine modulation in the prefrontal cortex is important for cognitive processing and disrupted in diverse neuropsychiatric diseases. Activation of D1 receptors is thought to enable working memory by enhancing the firing properties of pyramidal neurons. However, these receptors are only
G C Gregoriou et al.
Molecular pharmacology, 98(4), 454-461 (2020-07-02)
Endogenous opioid peptides in the amygdala regulate many of our behaviors and emotional responses. In particular, the endogenous opioid enkephalin plays a significant role in regulating amygdala activity, but its action is strongly limited by peptidases, which degrade enkephalin into
Amanda L Zimmerman et al.
Neuron, 102(2), 420-434 (2019-03-04)
Presynaptic inhibition (PSI) of primary sensory neurons is implicated in controlling gain and acuity in sensory systems. Here, we define circuit mechanisms and functions of PSI of cutaneous somatosensory neuron inputs to the spinal cord. We observed that PSI can
Edmund Cauley et al.
American journal of physiology. Heart and circulatory physiology, 309(8), H1281-H1287 (2015-09-16)
Hypertension, cardiac hypertrophy, and heart failure (HF) are widespread and debilitating cardiovascular diseases that affect nearly 23 million people worldwide. A distinctive hallmark of these cardiovascular diseases is autonomic imbalance, with increased sympathetic activity and decreased parasympathetic vagal tone. Recent
Emily Johnson et al.
iScience, 26(1), 105914-105914 (2023-01-25)
The action potential and its all-or-none nature is fundamental to neural communication. Canonically, the action potential is initiated once voltage-activated Na+ channels are activated, and their rapid kinetics of activation and inactivation give rise to the action potential's all-or-none nature.
Rebecca Lethbridge et al.
PloS one, 7(4), e35024-e35024 (2012-04-13)
Rat pup odor preference learning follows pairing of bulbar beta-adrenoceptor activation with olfactory input. We hypothesize that NMDA receptor (NMDAR)-mediated olfactory input to mitral cells is enhanced during training, such that increased calcium facilitates and shapes the critical cAMP pattern.
Quentin Gaucher et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(26), 10713-10728 (2013-06-28)
In all sensory modalities, intracortical inhibition shapes the functional properties of cortical neurons but also influences the responses to natural stimuli. Studies performed in various species have revealed that auditory cortex neurons respond to conspecific vocalizations by temporal spike patterns
Mark van den Hurk et al.
NPJ Parkinson's disease, 8(1), 134-134 (2022-10-19)
Complex genetic predispositions accelerate the chronic degeneration of midbrain substantia nigra neurons in Parkinson's disease (PD). Deciphering the human molecular makeup of PD pathophysiology can guide the discovery of therapeutics to slow the disease progression. However, insights from human postmortem
Vladislav Sekulić et al.
Frontiers in cellular neuroscience, 14, 277-277 (2020-10-24)
Determining biophysical details of spatially extended neurons is a challenge that needs to be overcome if we are to understand the dynamics of brain function from cellular perspectives. Moreover, we now know that we should not average across recordings from
Jason V Thompson et al.
Journal of neurophysiology, 109(3), 721-733 (2012-11-17)
Changes in inhibition during development are well documented, but the role of inhibition in adult learning-related plasticity is not understood. In songbirds, vocal recognition learning alters the neural representation of songs across the auditory forebrain, including the caudomedial nidopallium (NCM)
Kotaro Takano et al.
Analytical and bioanalytical chemistry, 412(17), 4037-4043 (2020-04-25)
A convenient analytical system for protein-ligand interactions under crude conditions was developed using native mass spectrometry (MS). As a model protein, Escherichia coli (E. coli) dihydrofolate reductase (DHFR) with and without a histidine tag was used for the study. First
Violeta G López-Huerta et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(11), 4964-4975 (2013-03-15)
Inhibitory connections among striatal projection neurons (SPNs) called "feedback inhibition," have been proposed to endow the striatal microcircuit with computational capabilities, such as motor sequence selection, filtering, and the emergence of alternating network states. These properties are disrupted in models
Ian Duguid et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(32), 11132-11143 (2012-08-10)
Tonic inhibition is a key regulator of neuronal excitability and network function in the brain, but its role in sensory information processing remains poorly understood. The cerebellum is a favorable model system for addressing this question as granule cells, which
Betty Jurek et al.
Annals of neurology, 86(5), 656-670 (2019-07-22)
Maternal autoantibodies are a risk factor for impaired brain development in offspring. Antibodies (ABs) against the NR1 (GluN1) subunit of the N-methyl-d-aspartate receptor (NMDAR) are among the most frequently diagnosed anti-neuronal surface ABs, yet little is known about effects on
Lorcan P Browne et al.
Cell reports, 41(10), 111750-111750 (2022-12-09)
Successful neuronal regeneration requires the reestablishment of synaptic connectivity. This process requires the reconstitution of presynaptic neurotransmitter release, which we investigate here in a model of entirely natural regeneration. After toxin-induced injury, olfactory sensory neurons in the adult mouse olfactory
Petr Unichenko et al.
Cerebral cortex (New York, N.Y. : 1991), 28(8), 2873-2886 (2017-11-07)
Neuroligin-4 (Nlgn4) is a cell adhesion protein that regulates synapse organization and function. Mutations in human NLGN4 are among the causes of autism spectrum disorders. In mouse, Nlgn4 knockout (KO) perturbs GABAergic synaptic transmission and oscillatory activity in hippocampus, and
M Heaulme et al.
Brain research, 384(2), 224-231 (1986-10-08)
An arylaminopyridazine derivative of gamma-aminobutyric acid (GABA), SR 95103, has been shown to be a selective antagonist of GABA at the GABAA receptor site. Subsequent structure-activity studies showed that suppressing the methyl in the 4-position of the pyridazine ring, and
Ping Liu et al.
Nature communications, 11(1), 5076-5076 (2020-10-10)
Proper threat-reward decision-making is critical to animal survival. Emerging evidence indicates that the motor system may participate in decision-making but the neural circuit and molecular bases for these functions are little known. We found in C. elegans that GABAergic motor
Sergey N Kolbaev et al.
Scientific reports, 10(1), 18399-18399 (2020-10-29)
Activation of GABAA receptors causes in immature neurons a functionally relevant decrease in the intracellular Cl- concentration ([Cl-]i), a process termed ionic plasticity. Amount and duration of ionic plasticity depends on kinetic properties of [Cl-]i homeostasis. In order to characterize
Nicholas M George et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 42(8), 1491-1509 (2022-01-14)
The axon initial segment (AIS), nodes of Ranvier, and the oligodendrocyte-derived myelin sheath have significant influence on the firing patterns of neurons and the faithful, coordinated transmission of action potentials (APs) to downstream brain regions. In the olfactory bulb (OB)
Amanda Borgquist et al.
Journal of neurophysiology, 113(3), 904-914 (2014-11-14)
Since estradiol attenuates cannabinoid-induced increases in energy intake, energy expenditure, and transmission at proopiomelanocortin (POMC) synapses in the hypothalamic arcuate nucleus (ARC), we tested the hypothesis that neuronal nitric oxide synthase (nNOS) plays an integral role. To this end, whole
Yan-Hua Bing et al.
Die Pharmazie, 70(2), 129-134 (2015-05-23)
Cerebellar Purkinje cells (PCs) respond to sensory stimulation via climbing fiber and mossy fiber-granule cell pathways, and generate motor-related outputs according to internal rules of integration and computation. However, the dynamic properties of sensory information processed by PC in mouse
Daniel A Llano et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(46), 16141-16148 (2012-11-16)
Flavoprotein autofluorescence imaging was used to examine auditory cortical synaptic responses in aged animals with behavioral evidence of tinnitus and hearing loss. Mice were exposed to noise trauma at 1-3 months of age and were assessed for behavioral evidence of
Gubbi Govindaiah et al.
eNeuro, 7(6) (2020-10-25)
Retinofugal synapses serve as models for understanding how sensory signals from the periphery are relayed to the brain. Past studies have focused primarily on understanding the postsynaptic glutamatergic receptor subtypes involved in signal transmission, but the mechanisms underlying glutamate release
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