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Showing 1-30 of 268 results for "S2626" within Papers
C W Tabor et al.
Annual review of biochemistry, 45, 285-306 (1976-01-01)
As is evident from the above summary of the recent literature, plus many other papers not cited here, there is an extensive literature indicating the physiological significance of these amines. The most important studies can be summarized as follows. (a)
Daniela A Parodi et al.
Reproductive toxicology (Elmsford, N.Y.), 54, 66-75 (2014-12-30)
Early life exposure to estrogens and estrogen like contaminants in the environment is thought to contribute to the early onset of puberty and consequently increases the risk of developing breast cancer in the exposed female. The results of this study
Josias B Frazão et al.
Journal of cellular biochemistry, 116(9), 2008-2017 (2015-03-11)
The human CYBB gene encodes the gp91-phox component of the phagocyte oxidase enzyme complex, which is responsible for generating superoxide and other downstream reactive oxygen species essential to microbial killing. In the present study, we have identified by sequence analysis
Norin Nabil Hamouda et al.
The Journal of biological chemistry, 296, 100182-100182 (2020-12-15)
Polyamines, such as putrescine, spermidine, and spermine, are physiologically important polycations, but the transporters responsible for their uptake in mammalian cells remain poorly characterized. Here, we reveal a new component of the mammalian polyamine transport system using CHO-MG cells, a
Masayuki Ikeda et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(36), 12029-12038 (2014-09-05)
The hypothalamic suprachiasmatic nucleus (SCN) plays a pivotal role in the mammalian circadian clock system. Bmal1 is a clock gene that drives transcriptional-translational feedback loops (TTFLs) for itself and other genes, and is expressed in nearly all SCN neurons. Despite
Gilbert Eriani et al.
PloS one, 10(6), e0130042-e0130042 (2015-06-13)
Aminoacyl-tRNA synthetases (AARSs) constitute a family of RNA-binding proteins, that participate in the translation of the genetic code, by covalently linking amino acids to appropriate tRNAs. Due to their fundamental importance for cell life, AARSs are likely to be one
Michael P Greenwood et al.
Endocrinology, 156(8), 2905-2917 (2015-05-12)
The polyamines spermidine and spermine are small cations present in all living cells. In the brain, these cations are particularly abundant in the neurons of the paraventricular (PVN) and supraoptic nuclei (SON) of the hypothalamus, which synthesize the neuropeptide hormones
Etienne Delangre et al.
Cell death & disease, 12(12), 1136-1136 (2021-12-09)
Glucocorticoids (GCs) are widely prescribed for their anti-inflammatory and immunosuppressive properties as a treatment for a variety of diseases. The use of GCs is associated with important side effects, including diabetogenic effects. However, the underlying mechanisms of GC-mediated diabetogenic effects
Milena Popović et al.
Nucleic acids research, 43(14), 7070-7082 (2015-07-02)
In vitro evolution experiments have long been used to evaluate the roles of RNA in both modern and ancient biology, and as a tool for biotechnology applications. The conditions under which these experiments have been conducted, however, do not reflect
Marie-Christin Wierich et al.
Experimental gerontology, 119, 82-88 (2019-02-01)
Ageing is associated with cardiovascular disease and reduced cardiac function. This cardiac functional decline is accompanied by cardiac remodeling and alterations in cardiomyocyte composition. Recently, it was shown that the natural polyamine spermidine preserves cardiac function and cardiomyocyte composition in
Shungo Kobori et al.
Nucleic acids research, 43(13), e85-e85 (2015-04-02)
Self-cleaving ribozymes are found in all domains of life and are believed to play important roles in biology. Additionally, self-cleaving ribozymes have been the subject of extensive engineering efforts for applications in synthetic biology. These studies often involve laborious assays
Clémence Hurni et al.
PLoS genetics, 18(8), e1009903-e1009903 (2022-08-04)
In eukaryotes, RNA is synthesised in the nucleus, spliced, and exported to the cytoplasm where it is translated and finally degraded. Any of these steps could be subject to temporal regulation during the circadian cycle, resulting in daily fluctuations of
In vitro Reconstitution Assay of miRNA Biogenesis by Arabidopsis DCL1.
Wang T
Bio-protocol, 5(8), e1454-e1454 (2015)
Radhika Jain et al.
Molecular microbiology, 82(1), 39-53 (2011-09-03)
The saprophytic fungus Aspergillus fumigatus is the most important air-borne fungal pathogen. The cell wall of A. fumigatus has been studied intensively as a potential target for development of effective antifungal agents. A major role in maintaining cell wall integrity
Kevin Guo et al.
Analytical chemistry, 81(10), 3919-3932 (2009-03-25)
We report a new quantitative metabolome profiling technique based on differential (12)C-/(13)C-isotope dansylation labeling of metabolites, fast liquid chromatography (LC) separation and electrospray ionization Fourier-transform ion cyclotron resonance mass spectrometry (ESI-FTICR MS) detection. An isotope reagent, (13)C-dansyl chloride, can be
Hagit Hak et al.
Virology, 477, 56-60 (2015-02-04)
Tomato yellow leaf curl virus (TYLCV), a major tomato pathogen causing extensive crop losses, is a whitefly-transmitted geminivirus. V2 mutants of TYLCV-Is and related viruses tend to induce symptomless infection with attenuated viral DNA levels, while accumulating close to wild-type
Kihyoun Park et al.
Autophagy, 19(5), 1444-1458 (2022-10-11)
Macroautophagy/autophagy or mitophagy plays crucial roles in the maintenance of pancreatic β-cell function. PPP3/calcineurin can modulate the activity of TFEB, a master regulator of lysosomal biogenesis and autophagy gene expression, through dephosphorylation. We studied whether PPP3/calcineurin inhibitors can affect the
Swati Mandal et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(6), 2169-2174 (2013-01-25)
The polyamines, putrescine, spermidine, and spermine, are essential polycations, intimately involved in the regulation of cellular proliferation. Although polyamines exert dynamic effects on the conformation of nucleic acids and macromolecular synthesis in vitro, their specific functions in vivo are poorly
Gordana Bjelaković et al.
Journal of basic and clinical physiology and pharmacology, 24(1), 67-72 (2013-02-22)
Glucocorticoids (GCs) exert a wide range of anti-inflammatory, immunosuppressive, and antineoplastic activities. The aim of our investigation was to elucidate the effect of dexamethasone, a synthetic GC, on polyamine metabolism in the rat thymus. Male albino Wistar rats, weighing 180-230
Asif Hameed et al.
International journal of systematic and evolutionary microbiology, 63(Pt 12), 4790-4796 (2013-09-03)
A Gram-staining-negative, strictly aerobic, rod-shaped, non-flagellated, non-spore-forming and gliding marine bacterium designated strain CC-AMZ-301(T) was isolated from coastal surface seawater near Taichung harbour, Taiwan. Strain CC-AMZ-301(T) predominantly synthesized zeaxanthin and thus formed yellow colonies on marine agar. The novel strain
Tina C Roeske et al.
PloS one, 9(11), e111722-e111722 (2014-11-14)
All-trans retinoic acid (ATRA), the main active metabolite of vitamin A, is a powerful signaling molecule that regulates large-scale morphogenetic processes during vertebrate embryonic development, but is also involved post-natally in regulating neural plasticity and cognition. In songbirds, it plays
Xueyan Li et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 37(1), 153-161 (2015-08-26)
The causative factors of the vaginitis are not fully understood yet. Epithelial barrier dysfunction plays a critical role in the pathogenesis of vaginitis. This study aims to investigate the role of prolactin (PRL) in the causing the vaginal epithelial barrier
Benjamin S Waldman et al.
Cell, 180(2), 359-372 (2020-01-21)
Toxoplasma gondii chronically infects a quarter of the world's population, and its recrudescence can cause life-threatening disease in immunocompromised individuals and recurrent ocular lesions in the immunocompetent. Acute-stage tachyzoites differentiate into chronic-stage bradyzoites, which form intracellular cysts resistant to immune
Zdena Kristofikova et al.
Neurochemical research, 40(8), 1709-1718 (2015-07-21)
It has been suggested that advanced glycation end (AGE) products, via cognate receptor activation, are implicated in several diseases, including Alzheimer's disease. The NMDA receptor-nitric oxide pathway appears to be influenced by AGE products and involved in the pathogenesis of
Kazuko Yoshida et al.
Plant physiology, 167(3), 693-710 (2015-01-28)
Trees in the genus Populus (poplar) contain phenolic secondary metabolites including the proanthocyanidins (PAs), which help to adapt these widespread trees to diverse environments. The transcriptional activation of PA biosynthesis in response to herbivory and ultraviolet light stress has been
Fabrice Jean-Pierre et al.
Microbiology (Reading, England), 161(9), 1889-1896 (2015-08-25)
RsmA is a post-transcriptional RNA-binding protein that acts as a pleiotropic global regulator of mRNAs in the opportunistic pathogen Pseudomonas aeruginosa. Upon binding to its target, RsmA impedes the translation of the mRNA by the ribosome. The RsmA regulon affects
Polyamines spermidine and spermine as modulators of calcium-dependent immune processes.
T C Theoharides
Life sciences, 27(9), 703-713 (1980-09-01)
P A Mirzoian et al.
Ukrainskii biokhimicheskii zhurnal (1978), 51(5), 474-476 (1979-09-01)
It is shown that in the tissue of the human brain glial tumours the content of putrescine depends on the degree of the tumour malignization. In malignant gliomas (glioblastomas), as compared to the benign (astrocytomas), the content of putrescine is
Ramesh M Ray et al.
Cellular signalling, 27(9), 1850-1859 (2015-06-21)
Tissue polyamine levels are largely determined by the activity of ornithine decarboxylase (ODC, EC 4.1.17), which catalyzes the conversion of ornithine to the diamine putrescine. The activity of the enzyme is primarily regulated by a negative feedback mechanism involving ODC
Anja Mezger et al.
New biotechnology, 32(5), 504-510 (2015-02-15)
We show for the first time that monomerized rolling circle amplification (RCA) products can be directly detected with the Luminex suspension bead array readout without the need of PCR amplification. Furthermore, using monomerized RCA products to guide ligation of the
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