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Showing 31-60 of 10987 results for "S3014" within Papers
Yiwei Li et al.
Lab on a chip, 15(15), 3203-3210 (2015-07-02)
Active control over the cell gradient is essential for understanding biological systems and the reconstitution of the functionality of many types of tissues, particularly for organ-on-a-chip. Here, we propose a three-dimensional (3D) microfluidic strategy for generating controllable cell gradients. In
Richard J Giannone et al.
Analytical chemistry, 87(15), 7720-7728 (2015-06-26)
The marine archaeon Nanoarchaeum equitans is dependent on direct physical contact with its host, the hyperthermophile Ignicoccus hospitalis. As this interaction is thought to be membrane-associated, involving a myriad of membrane-anchored proteins, proteomic efforts to better characterize this difficult to
Reina N Fuji et al.
Science translational medicine, 7(273), 273ra15-273ra15 (2015-02-06)
Inhibition of the kinase activity of leucine-rich repeat kinase 2 (LRRK2) is under investigation as a possible treatment for Parkinson's disease. However, there is no clinical validation as yet, and the safety implications of targeting LRRK2 kinase activity are not
Jung-Yoon Choe et al.
Apoptosis : an international journal on programmed cell death, 20(1), 38-49 (2014-11-16)
The aim of this study is to clarify the effect of oxidative stress on monosodium urate (MSU)-mediated apoptosis of renal cells. Quantitative real-time polymerase chain reaction and immunoblotting for Bcl-2, caspase-9, caspase-3, iNOS, cyclooxygenase-2 (COX-2), interleukin-1β (IL-1β), IL-18, TNF receptor-associated
Ananda Malta et al.
The Journal of endocrinology, 221(2), 285-295 (2014-03-07)
Nutritional insults during developmental plasticity have been linked with metabolic diseases such as diabetes in adulthood. We aimed to investigate whether a low-protein (LP) diet at the beginning of adulthood is able to program metabolic disruptions in rats. While control
Michelle E Diodati et al.
Foodborne pathogens and disease, 12(3), 235-243 (2015-02-07)
Escherichia coli serogroup O111 is among the six most commonly reported non-O157:H7 Shiga toxin-producing E. coli (STEC), which are emerging as important foodborne pathogens. We have assembled a collection of environmental and clinical strains of E. coli O111 from diverse
Jisun Kim et al.
Applied microbiology and biotechnology, 99(24), 10611-10626 (2015-08-25)
Two-dimensional gel electrophoresis was conducted to investigate the effect of H2O2 on whole protein expression in Acinetobacter oleivorans DR1. Functional classification of 13 upregulated proteins using MALDI-TOF mass spectrometry showed relationships with oxidative stress, energy production and conversion, nucleotide and
Mauro Siragusa et al.
Science signaling, 8(390), ra81-ra81 (2015-08-20)
Endothelial nitric oxide synthase (eNOS) catalyzes the conversion of l-arginine and molecular oxygen into l-citrulline and nitric oxide (NO), a gaseous second messenger that influences cardiovascular physiology and disease. Several mechanisms regulate eNOS activity and function, including phosphorylation at Ser
Marko A Popovic et al.
Nature communications, 6, 8436-8436 (2015-10-06)
Thousands of dendritic spines on individual neurons process information and mediate plasticity by generating electrical input signals using a sophisticated assembly of transmitter receptors and voltage-sensitive ion channel molecules. Our understanding, however, of the electrical behaviour of spines is limited
Ricardo Rodríguez-Calvo et al.
PPAR research, 2015, 785783-785783 (2015-12-10)
Here we studied the impact of 5-aminoimidazole-4-carboxamide riboside (AICAR), a well-known AMPK activator, on cardiac metabolic adaptation. AMPK activation by AICAR was confirmed by increased phospho-Thr(172)-AMPK and phospho-Ser(79)-ACC protein levels in HL-1 cardiomyocytes. Then, cells were exposed to AICAR stimulation
Vassiliki Stamatopoulou et al.
Nature protocols, 13(10), 2387-2406 (2018-09-27)
Ribosome biogenesis is initiated in the nucleolus, a cell condensate essential to gene expression, whose morphology informs cancer pathologists on the health status of a cell. Here, we describe a protocol for assessing, both qualitatively and quantitatively, the involvement of
R Serafini et al.
Theriogenology, 84(5), 833-837 (2015-06-25)
Unilateral orchiectomy (UO) may interfere with thermoregulation of the remaining testis caused by inflammation surrounding the incision site, thus altering normal spermatogenesis and consequently sperm quality. Two measures of sperm DNA quality (neutral comet assay and the sperm chromatin structure
Peili Chen et al.
PloS one, 10(4), e0125490-e0125490 (2015-04-29)
Dysregulated homeostasis of epithelial cells resulting in disruption of mucosal barrier function is an important pathogenic mechanism in inflammatory bowel diseases (IBD). We have characterized a novel gastric protein, Antrum Mucosal Protein (AMP)-18, that has pleiotropic properties; it is mitogenic
Yetrib Hathout et al.
Human molecular genetics, 23(24), 6458-6469 (2014-07-17)
It is expected that serum protein biomarkers in Duchenne muscular dystrophy (DMD) will reflect disease pathogenesis, progression and aid future therapy developments. Here, we describe use of quantitative in vivo stable isotope labeling in mammals to accurately compare serum proteomes
Ayse Nur Polat et al.
Journal of proteome research, 14(9), 4087-4098 (2015-08-14)
Cytokinesis is the last step of the cell cycle that requires coordinated activities of the microtubule cytoskeleton, actin cytoskeleton, and membrane compartments. Aurora B kinase is one of the master regulatory kinases that orchestrate multiple events during cytokinesis. To reveal
Xiaoli Wang et al.
American journal of cancer research, 5(9), 2590-2604 (2015-11-27)
Early stages of melanoma can be successfully treated by surgical resection of the tumor, but there is still no effective treatment once it is progressed to metastatic phases. Although growing family of both melanoma metastasis promoting and metastasis suppressor genes
Anca M Paşca et al.
Nature methods, 12(7), 671-678 (2015-05-26)
The human cerebral cortex develops through an elaborate succession of cellular events that, when disrupted, can lead to neuropsychiatric disease. The ability to reprogram somatic cells into pluripotent cells that can be differentiated in vitro provides a unique opportunity to
HSV-2 increases TLR4-dependent phosphorylated IRFs and IFN-β induction in cervical epithelial cells.
Hongya Liu et al.
PloS one, 9(4), e94806-e94806 (2014-04-12)
Our previous studies demonstrated that HSV-2 infection up-regulates TLR4 expression and induces NF-kB activity, thereby facilitating innate immune response in human cervical epithelial cells. This process requires involvement of TLR4 adaptors, Mal and MyD88. In the current study, we found
Liang Deng et al.
Oncology letters, 10(5), 3323-3331 (2016-01-02)
Various human cancers have been revealed to contain cancer stem-like cells (CSCs) and the spherical colonies that possess stem-like properties and cancer-initiating abilities. Malignant fibrous histiocytoma (MFH) is a common soft-tissue sarcoma, and is considered to be a myxoma due
Jeffery Chen et al.
The Journal of biological chemistry, 290(34), 21101-21113 (2015-07-15)
The human ether-a-go-go-related gene (hERG) encodes the pore-forming subunit of the rapidly activating delayed rectifier potassium channel (IKr). A reduction in the hERG current causes long QT syndrome, which predisposes affected individuals to ventricular arrhythmias and sudden death. We reported
Aven Lee et al.
American journal of physiology. Renal physiology, 308(7), F784-F792 (2015-01-15)
ClC-5 is a chloride/proton exchanger that plays an obligate role in albumin uptake by the renal proximal tubule. ClC-5 forms an endocytic complex with the albumin receptor megalin/cubilin. We have identified a novel ClC-5 binding partner, cytosolic aspartyl aminopeptidase (DNPEP;
José R Cussiol et al.
The EMBO journal, 34(12), 1704-1717 (2015-04-22)
In response to DNA damage, checkpoint signalling protects genome integrity at the cost of repressing cell cycle progression and DNA replication. Mechanisms for checkpoint down-regulation are therefore necessary for proper cellular proliferation. We recently uncovered a phosphatase-independent mechanism for dampening
Andrew J Schwab et al.
PloS one, 9(7), e103112-e103112 (2014-07-24)
Spinal muscular atrophy (SMA) is an autosomal recessive disorder leading to paralysis and early death due to reduced SMN protein. It is unclear why there is such a profound motor neuron loss, but recent evidence from fly and mouse studies
Fangjia Lu et al.
Journal of controlled release : official journal of the Controlled Release Society, 204, 51-59 (2015-03-10)
The use of nanoparticles for delivery of vaccine antigens and as vaccine adjuvants is appealing because their size allows efficient uptake by dendritic cells and their biological properties can be tailored to the desired function. Here, we report the effect
Intae Kim et al.
Sensors (Basel, Switzerland), 15(6), 12513-12525 (2015-05-30)
In whole-cell based biosensors, spectrophotometry is one of the most commonly used methods for detecting organophosphates due to its simplicity and reliability. The sensor performance is directly affected by the cell immobilization method because it determines the amount of cells
Jenna L Terebetski et al.
AAPS PharmSciTech, 15(5), 1334-1344 (2014-06-13)
To maximize the pharmacological effect of a pain reliever such as ibuprofen, early onset of action is critical. Unfortunately, the acidic nature of ibuprofen minimizes the amount of drug that can be solubilized under gastric conditions and would be available
Amal A Al-Dossary et al.
The Journal of biological chemistry, 290(29), 17710-17723 (2015-05-30)
Oviductosomes ((OVS), exosomes/microvesicles), which deliver the Ca(2+) efflux pump, plasma membrane Ca(2+)ATPase 4 (PMCA4), to sperm are likely to play an important role in sperm fertilizing ability (Al-Dossary, A. A., Strehler, E. E., and Martin-DeLeon, P. A. (2013) PloS one
T S Anirudhan et al.
Journal of colloid and interface science, 456, 22-31 (2015-06-19)
A novel adsorbent, 2-mercaptobenzamide modified itaconic acid-grafted-magnetite nanocellulose composite [P(MB-IA)-g-MNCC] was synthesized for adsorbing mercury(II) [Hg(II)] ions selectively from aqueous solutions. Fourier transforms infrared spectroscopy, X-ray diffraction, scanning electron microscopy and thermogravimetric studies were performed to characterize the adsorbent. The
Sarah Hammer et al.
Neural development, 9, 16-16 (2014-07-12)
Mouse visual thalamus has emerged as a powerful model for understanding the mechanisms underlying neural circuit formation and function. Three distinct nuclei within mouse thalamus receive retinal input, the dorsal lateral geniculate nucleus (dLGN), the ventral lateral geniculate nucleus (vLGN)
Milena R Simic et al.
Archiv der Pharmazie, 348(2), 100-112 (2015-02-11)
Cytoprotective compounds such as amifostine play an important role in chemo- and radiotherapy due to their ability to reduce the side effects of these treatments. Our work was initiated with the intention to design, synthesise and test a new class
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