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Showing 1-30 of 10905 results for "S6546" within Papers
Andrew M Phillips et al.
PLoS genetics, 11(8), e1005443-e1005443 (2015-08-06)
Flagella are assembled sequentially from the inside-out with morphogenetic checkpoints that enforce the temporal order of subunit addition. Here we show that flagellar basal bodies fail to proceed to hook assembly at high frequency in the absence of the monotopic
Yunqi Li et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(22), 8038-8042 (2015-04-23)
Hollow bioactive glass spheres with mesoporous shells were prepared by using dual soft templates, a diblock co-polymer poly(styrene-b-acrylic acid) (PS-b-PAA) and a cationic surfactant cetyltrimethylammonium bromide (CTAB). Hollow mesoporous bioactive glass (HMBG) spheres comprise the large hollow interior with vertical
Hui Cai et al.
Journal of virology, 89(12), 6391-6405 (2015-04-10)
Human metapneumovirus (hMPV) is a member of the Pneumovirinae subfamily in the Paramyxoviridae family that causes respiratory tract infections in humans. Unlike members of the Paramyxovirinae subfamily, the polymerase complex of pneumoviruses requires an additional cofactor, the M2-1 protein, which
Verena Wahl et al.
International journal of pharmaceutics, 484(1-2), 95-102 (2015-02-24)
The purpose of this work was to investigate the influence of water content on the secondary structure of a freeze-dried protein (fibrinogen) after a storage period of two weeks. To that end, attenuated reflectance Fourier transformed infrared (ATR-FTIR) and Raman
Adriana Sierra Assencio Almeida Barbosa et al.
Mycoses, 58(9), 522-530 (2015-07-15)
There are no studies investigating the role of nutritional status and immunity associated with Jorge Lobo's disease. The objective of this study was to evaluate the effects of protein-calorie malnutrition on the immune response of BALB/c mice inoculated with Lacazia
Yongjian Qiu et al.
The Plant cell, 27(5), 1409-1427 (2015-05-07)
Phytochromes (phys) are red and far-red photoreceptors that control plant development and growth by promoting the proteolysis of a family of antagonistically acting basic helix-loop-helix transcription factors, the PHYTOCHROME-INTERACTING FACTORs (PIFs). We have previously shown that the degradation of PIF1
Tingting Zhu et al.
Carbohydrate research, 402, 189-199 (2014-12-17)
Abnormal glycosphingolipids (GSLs) are expressed in many human tumors. These tumor-associated GSLs may have important roles in tumor progression. However, they are hard to be detected because of their low concentration and the limited availability of antibodies and lectins that
Nicholas J Izzo et al.
PloS one, 9(11), e111898-e111898 (2014-11-13)
Synaptic dysfunction and loss caused by age-dependent accumulation of synaptotoxic beta amyloid (Abeta) 1-42 oligomers is proposed to underlie cognitive decline in Alzheimer's disease (AD). Alterations in membrane trafficking induced by Abeta oligomers mediates reduction in neuronal surface receptor expression
L Garcia-Valdes et al.
International journal of obesity (2005), 39(4), 571-578 (2015-01-24)
Obesity is associated with decreased iron status, possibly due to a rise in hepcidin, an inflammatory protein known to reduce iron absorption. In animals, we have shown that maternal iron deficiency is minimised in the foetus by increased expression of
Wei Hong et al.
Acta pharmacologica Sinica, 36(12), 1487-1496 (2015-11-26)
Apolipoprotein E (ApoE) plays an important role in the transport and metabolism of lipids. Recent studies show that bone mass is increased in young apoE(-/-) mice. In this study we investigated the bone phenotype and metabolism in aged apoE(-/-) mice.
Julio César España Amórtegui et al.
Food chemistry, 182, 14-22 (2015-04-07)
The most relevant parameters of a multimode inlet were optimized to increase the injection volume up to 25 μL using solvent vent mode in order to improve the sensitivity of the gas chromatography-mass spectrometry system. Consequently, the implementation of a
Tom Ashmore et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(3), 1102-1112 (2014-11-26)
In mammals, hypoxia-triggered erythropoietin release increases red blood cell mass to meet tissue oxygen demands. Using male Wistar rats, we unmask a previously unrecognized regulatory pathway of erythropoiesis involving suppressor control by the NO metabolite and ubiquitous dietary component nitrate.
Maria Hayashi et al.
Journal of nutritional science and vitaminology, 61(5), 369-374 (2015-12-08)
Thiamin pyrophosphate is an essential cofactor in all living systems. In its biosynthesis, the thiamin structure is initially formed as thiamin phosphate from a thiazole and a pyrimidine moiety, and then thiamin pyrophosphate is synthesized from thiamin phosphate. Many eubacterial
Xiao-ou Hou et al.
Acta pharmacologica Sinica, 36(11), 1300-1307 (2015-09-15)
Parkin has been shown to exert protective effects against 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in different models of Parkinson disease. In the present study we investigated the molecular mechanisms underlying the neuroprotective action of parkin in vitro. HEK293, HeLa and PC12 cells
Simona Kavaliauskiene et al.
The Biochemical journal, 470(1), 23-37 (2015-08-08)
2-Deoxy-D-glucose (2DG) is a structural analogue of glucose with well-established applications as an inhibitor of glycolysis and N-glycosylation. Importantly, 2DG has been shown to improve the efficacy of several cancer chemotherapeutic agents in vivo and thus it is in clinical
Qing Wu et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(12), 4989-5005 (2015-08-28)
Talin (tln) binds and activates integrins to couple extracellular matrix-bound integrins to the cytoskeleton; however, its role in heart development is not well characterized. We identified the defective gene and the resulting cardiovascular phenotypes in zebrafish tln1(fl02k) mutants. The ethylnitrosourea-induced
Christina Preising et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 37(1), 1-13 (2015-08-19)
Recently, we gained evidence that impairment of rOat1 and rOat3 expression induced by ischemic acute kidney injury (AKI) is mediated by COX metabolites and this suppression might be critically involved in renal damage. (i) Basolateral organic anion uptake into proximal
Filipe Nascimento et al.
Purinergic signalling, 11(4), 471-480 (2015-09-04)
Amyotrophic lateral sclerosis (ALS) is a disease leading to neuromuscular transmission impairment. A2A adenosine receptor (A2AR) function changes with disease stage, but the role of the A(1) receptors (A1Rs) is unknown and may have a functional cross-talk with A2AR. The
R Hernanz et al.
British journal of pharmacology, 172(12), 3159-3176 (2015-02-26)
Toll-like receptor 4 (TLR4) signalling contributes to inflammatory cardiovascular diseases, but its role in hypertension and the associated vascular damage is not known. We investigated whether TLR4 activation contributed to angiotensin II (AngII)-induced hypertension and the associated vascular structural, mechanical
S Watanabe et al.
Cell death & disease, 5, e1497-e1497 (2014-10-31)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the selective and progressive loss of motor neurons. Cystatin C (CysC), an endogenous cysteine protease inhibitor, is a major protein component of Bunina bodies observed in the spinal motor
Kyoung-Jin Jang et al.
Nature communications, 6, 6750-6750 (2015-04-11)
During immune reactions, functionally distinct B-cell subsets are generated by stochastic processes, including class-switch recombination (CSR) and plasma cell differentiation (PCD). In this study, we show a strong association between individual B-cell fates and mitochondrial functions. CSR occurs specifically in
Simon Henriet et al.
Nucleic acids research, 43(7), 3701-3711 (2015-03-18)
Selective pressure to maintain small genome size implies control of transposable elements, and most old classes of retrotransposons are indeed absent from the very compact genome of the tunicate Oikopleura dioica. Nonetheless, two families of retrotransposons are present, including the
Hiroki Saijo et al.
Laboratory investigation; a journal of technical methods and pathology, 95(7), 728-748 (2015-05-06)
Ulcerative colitis (UC) is a representative clinical manifestation of inflammatory bowel disease that causes chronic gastrointestinal tract inflammation. Dextran sulfate sodium (DSS)-induced colitis mice have been used to investigate UC pathogenesis, and in this UC model, disturbance and impairment of
Claudia Carissimi et al.
Biochimie, 107 Pt B, 319-326 (2014-10-12)
microRNAs (miRNAs) are a class of small non-coding RNAs acting as post-transcriptional regulators of gene expression and play fundamental roles in regulating immune response and autoimmunity. We show that memory T-lymphocytes express higher levels of miR-21 compared to naïve T-lymphocytes
I Kovács et al.
Free radical research, 48(10), 1190-1199 (2014-07-06)
Robust production of reactive oxygen species (ROS) by phagocyte NADPH oxidase (phox) during the respiratory burst (RB) is a characteristic feature of eosinophil and neutrophil granulocytes. In these cells the voltage-gated proton channel (Hv1) is now considered as an ancillary
Jeanine Alterio et al.
Traffic (Copenhagen, Denmark), 16(9), 978-993 (2015-06-17)
Yif1B is an intracellular membrane-bound protein belonging to the Yip family, shown previously to control serotonin 5-HT1A receptor targeting to dendrites. Because some Yip proteins are involved in the intracellular traffic between the ER and the Golgi, here we investigated
Shinichiro Fuma et al.
Molecular vision, 21, 883-892 (2015-09-01)
Photobiomodulation is the treatment with light in the far-red to near-infrared region of the spectrum and has been reported to have beneficial effects in various animal models of disease, including an age-related macular degeneration (AMD) mouse model. Previous reports have
Laurens Pauwels et al.
Plant physiology, 169(2), 1405-1417 (2015-09-01)
Jasmonate (JA) signaling in plants is mediated by the JASMONATE ZIM-DOMAIN (JAZ) proteins that repress the activity of several transcription factors regulating JA-inducible gene expression. The hormone JA-isoleucine triggers the interaction of JAZ repressor proteins with the F-box protein CORONATINE
Kristen E Rennoll-Bankert et al.
PLoS pathogens, 11(8), e1005115-e1005115 (2015-08-21)
Bacterial Sec7-domain-containing proteins (RalF) are known only from species of Legionella and Rickettsia, which have facultative and obligate intracellular lifestyles, respectively. L. pneumophila RalF, a type IV secretion system (T4SS) effector, is a guanine nucleotide exchange factor (GEF) of ADP-ribosylation
P-F Wu et al.
Physiological research, 64(4), 523-530 (2014-12-04)
In this study, lipoic acid and heat shock treatments were applied to C(2)C(12) myotubes and Sprague-Dawley rats to investigate changes in the heat shock protein 70 (HSP70) and glucose transporter 4 (GLUT4) in 4 different skeletal muscle groups. The results
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