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Showing 1-30 of 319 results for "S7547" within Papers
Stephanie B M Miller et al.
The EMBO journal, 34(6), 778-797 (2015-02-13)
Disruption of the functional protein balance in living cells activates protective quality control systems to repair damaged proteins or sequester potentially cytotoxic misfolded proteins into aggregates. The established model based on Saccharomyces cerevisiae indicates that aggregating proteins in the cytosol
Andreas von Bohl et al.
Malaria journal, 14, 435-435 (2015-11-06)
During development in human erythrocytes, Plasmodium falciparum parasites display a remarkable number of adhesive proteins on their plasma membrane. In the invasive merozoites, these include members of the PfMSP1 and PfAMA1/RON complexes, which facilitate contact between merozoites and red blood
Johannes Numrich et al.
Journal of cell science, 128(13), 2278-2292 (2015-05-23)
Membrane fusion at the vacuole depends on a conserved machinery that includes SNAREs, the Rab7 homolog Ypt7 and its effector HOPS. Here, we demonstrate that Ypt7 has an unexpected additional function by controlling membrane homeostasis and nutrient-dependent signaling on the
Simona Capone et al.
Microbial cell factories, 14, 101-101 (2015-07-15)
Recombinant protein production in the yeast Pichia pastoris is usually based on the alcohol oxidase promoters pAOX1 and pAOX2, which are regulated by methanol and strongly repressed by other C-sources, like glycerol and glucose. However, the use of methanol brings
Christine S Gibhardt et al.
Scientific reports, 5, 13861-13861 (2015-09-10)
Ionizing radiation is a universal tool in tumor therapy but may also cause secondary cancers or cell invasiveness. These negative side effects could be causally related to the human-intermediate-conductance Ca2+-activated-K+-channel (hIK), which is activated by X-ray irradiation and affects cell
Crystal A West et al.
American journal of physiology. Renal physiology, 309(1), F63-F70 (2015-05-01)
Pregnancy is characterized by plasma volume expansion due to Na(+) retention, driven by aldosterone. The aldosterone-responsive epithelial Na(+) channel is activated in the kidney in pregnancy. In the present study, we investigated the aldosterone-responsive Na(+)-Cl(-) cotransporter (NCC) in mid- and
Nicholas P Evans et al.
Journal of food protection, 78(7), 1266-1271 (2015-07-22)
Salmonella is an important economic and public health concern for the poultry industry. Fresh ground product has been linked with multiple salmonellosis outbreaks in humans. Exposure can be controlled by proper handling and preparation by consumers; however, the industry desires
Gloria Bárzana et al.
Plant, cell & environment, 38(8), 1613-1627 (2015-01-30)
The arbuscular mycorrhizal (AM) symbiosis alters host plant physiology under drought stress, but no information is available on whether or not the AM affects respond to drought locally or systemically. A split-root system was used to obtain AM plants with
M A Raskind et al.
Biological psychiatry, 46(6), 756-765 (1999-09-24)
High cerebrospinal fluid (CSF) norepinephrine (NE) concentrations in aging and Alzheimer's disease (AD) could reflect decreased NE clearance from central nervous system (CNS) extracellular fluid or increased release of NE into CNS extracellular fluid. Measuring CSF concentrations of the intraneuronal
Yanjie Tang et al.
PloS one, 9(8), e105272-e105272 (2014-08-20)
Shiga-toxin producing Escherichia coli (STEC) have emerged as important foodborne pathogens, among which seven serogroups (O26, O45, O103, O111, O121, O145, O157) are most frequently implicated in human infection. The aim was to determine if a light scattering sensor can
M O Kristensen et al.
Acta neurologica Scandinavica, 87(6), 475-481 (1993-06-01)
The cobalamin status was evaluated in Alzheimer dementia (n = 26), other dementias (n = 24), various gerontopsychiatric disorders (n = 25), and in neuro-psychiatrically healthy controls (n = 20). Supplementing serum cobalamin we measured methylmalonic acid (MMA), a metabolite
Nor Afiqah Aleng et al.
PloS one, 10(8), e0135603-e0135603 (2015-08-20)
Mild heat stress promotes thermotolerance and protection against several different stresses in aquatic animals, consequences correlated with the accumulation of heat shock protein 70 (Hsp70). The purpose of this study was to determine if non-lethal heat shock (NLHS) of the
Do-Kyun Kim et al.
Journal of food protection, 78(7), 1380-1386 (2015-07-22)
This study was undertaken to compare the effect of the spindle and stomacher for detaching microorganisms from fresh vegetables. The spindle is an apparatus for detaching microorganisms from food surfaces, which was developed in our laboratory. When processed with the
Simon R Harris et al.
Genome research, 25(9), 1360-1371 (2015-07-15)
Strangles, the most frequently diagnosed infectious disease of horses worldwide, is caused by Streptococcus equi. Despite its prevalence, the global diversity and mechanisms underlying the evolution of S. equi as a host-restricted pathogen remain poorly understood. Here, we define the
Raúl García et al.
BMC genomics, 16, 683-683 (2015-09-06)
The fungal cell wall forms a compact network whose integrity is essential for cell morphology and viability. Thus, fungal cells have evolved mechanisms to elicit adequate adaptive responses when cell wall integrity (CWI) is compromised. Functional genomic approaches provide a
George S Brush
BMC research notes, 8, 275-275 (2015-07-01)
Histone H1, referred to as the linker histone, associates with the nucleosome core particle. While there is indication that the budding yeast version of histone H1 (Hho1) contributes to regulation of chromatin structure and certain chromatin-related processes, such as DNA
Taicheng Zhu et al.
Journal of industrial microbiology & biotechnology, 40(2), 183-189 (2013-01-12)
Heterologous protein expression using Pichia pastoris causes metabolic stress on the physiology of host cells, which may compromise the yields of secreted foreign proteins. Thus, understanding these metabolic stresses during secretory expression allows us to circumvent these undesirable effects. We
Huiying Miao et al.
Journal of experimental botany, 64(4), 1097-1109 (2013-01-19)
The effects of glucose on aliphatic glucosinolate biosynthesis in Arabidopsis thaliana were investigated in this study by using mutants related to aliphatic glucosinolate biosynthesis and regulation, as well as glucose signalling. The results showed that glucose significantly increased the contents
Sumana Raychaudhuri et al.
The Journal of biological chemistry, 290(23), 14430-14440 (2015-04-29)
Layers of quality control ensure proper protein folding and complex formation prior to exit from the endoplasmic reticulum. The fission yeast Dsc E3 ligase is a Golgi-localized complex required for sterol regulatory element-binding protein (SREBP) transcription factor activation that shows
Samira Khodayari et al.
PloS one, 8(1), e54025-e54025 (2013-01-26)
Diapause is a common feature in several arthropod species that are subject to unfavorable growing seasons. The range of environmental cues that trigger the onset and termination of diapause, in addition to associated hormonal, biochemical, and molecular changes, have been
Chongyang Han et al.
Journal of neurophysiology, 113(9), 3172-3185 (2015-03-20)
Although species-specific differences in ion channel properties are well-documented, little has been known about the properties of the human Nav1.8 channel, an important contributor to pain signaling. Here we show, using techniques that include voltage clamp, current clamp, and dynamic
Arun Sreekumar et al.
Nature, 457(7231), 910-914 (2009-02-13)
Multiple, complex molecular events characterize cancer development and progression. Deciphering the molecular networks that distinguish organ-confined disease from metastatic disease may lead to the identification of critical biomarkers for cancer invasion and disease aggressiveness. Although gene and protein expression have
Laura Bryant et al.
BMC plant biology, 15, 175-175 (2015-07-15)
MS-based proteomics was applied to the analysis of the medicinal plant Artemisia annua, exploiting a recently published contig sequence database (Graham et al. (2010) Science 327, 328-331) and other genomic and proteomic sequence databases for comparison. A. annua is the
Ali O Azghani et al.
Microbiology (Reading, England), 160(Pt 3), 547-555 (2014-01-05)
Receptor tyrosine kinases, including the epidermal growth factor receptors (EGFR), are able to activate the mitogen-activated protein kinases (MAPK) via several adaptor proteins and protein kinases such as Raf. EGFR can be activated by a variety of extracellular stimuli including
María Inés Espinoza et al.
Journal of agricultural and food chemistry, 62(49), 11797-11804 (2014-11-14)
Stevia rebaudiana is known for its sweet-tasting ent-kaurene diterpenoid glycosides. Several manufacturing strategies are currently employed to obtain Stevia sweeteners with the lowest possible off-flavors. The chemical composition of four commercial S. rebaudiana extracts, obtained by different technologies, was characterized
Alvaro Mongui et al.
Malaria journal, 14, 233-233 (2015-06-05)
The chemical treatment of Plasmodium falciparum for human infections is losing efficacy each year due to the rise of resistance. One possible strategy to find novel anti-malarial drugs is to access the largest reservoir of genomic biodiversity source on earth
Mariana Brizuela et al.
Molecular and cellular neurosciences, 66(Pt B), 129-140 (2015-02-17)
Neuronal cytoskeletal alterations, in particular the loss and misalignment of microtubules, are considered a hallmark feature of the degeneration that occurs after traumatic brain injury (TBI). Therefore, microtubule-stabilizing drugs are attractive potential therapeutics for use following TBI. The best-known drug
H U Shetty et al.
Clinical chemistry, 42(2), 298-302 (1996-02-01)
Previous studies suggest the presence of increased concentrations of cerebral myo-inositol in Alzheimer disease (AD). To characterize this abnormality further, we quantified myo-inositol and several other polyols in cerebrospinal fluid (CSF) and plasma from 10 AD subjects and 10 healthy
Fábio Netto Ferreira et al.
Experimental eye research, 115, 140-143 (2013-07-16)
Diabetic retinopathy (DR) is a common chronic complication of diabetes and remains the leading cause of blindness in working-aged people. Hyperglycemia increases glucose flux through the polyol pathway, in which aldose reductase converts glucose into intracellular sorbitol, which is subsequently
Azam Fatahi Sadeghabadi et al.
Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences, 19(Suppl 1), S51-S55 (2014-07-09)
Antibiotic resistance of enteric pathogens particularly Shigella species, is a critical world-wide problem and monitoring their resistant pattern is essential, because the choice of antibiotics is absolutely dependent on regional antibiotic susceptibility patterns. During summer 2013, an unusual increase in
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