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Showing 31-60 of 11064 results for "S7653" within Papers
Kaitlin C Murphy et al.
Annals of biomedical engineering, 43(8), 2010-2021 (2014-12-21)
Mesenchymal stem/stromal cells (MSCs) are under examination for use in cell therapies to repair bone defects resulting from trauma or disease. MSCs secrete proangiogenic cues and can be induced to differentiate into bone-forming osteoblasts, yet there is limited evidence that
Pallichera Vijayan Shahana et al.
Protein expression and purification, 113, 35-43 (2015-05-12)
Japanese Encephalitis (JE) is a mosquito borne arboviral infection caused by Japanese Encephalitis Virus (JEV). It is a major cause of viral encephalitis in Asian countries including India. In the present study, we have used a Tymovirus [i.e. Physalis Mottle
Hong-Tao Xu et al.
Antimicrobial agents and chemotherapy, 59(6), 3189-3196 (2015-03-18)
Compound A is a novel nucleotide-competing HIV-1 reverse transcriptase (RT) inhibitor (NcRTI) that selects for a unique W153L substitution that confers hypersusceptibility to tenofovir, while the K65R substitution in RT confers resistance against tenofovir and enhances susceptibility to NcRTIs. Although
Lusine Danielyan et al.
Cell transplantation, 23 Suppl 1, S123-S139 (2014-10-11)
In view of the rapid preclinical development of cell-based therapies for neurodegenerative disorders, traumatic brain injury, and tumors, the safe and efficient delivery and targeting of therapeutic cells to the central nervous system is critical for maintaining therapeutic efficacy and
Huili Yu et al.
Journal of biotechnology, 214, 77-82 (2015-09-22)
Antimicrobial peptides (AMPs) are small molecules which serve as essential components of the innate immune system in various organisms. AMPs possess a broad spectrum of antimicrobial activities. However, the scaled production of such peptides in Escherichia coli faces many difficulties
Jing Zhou et al.
Autophagy, 11(8), 1259-1279 (2015-06-27)
Autophagy inhibition has been widely accepted as a promising therapeutic strategy in cancer, while the lack of effective and specific autophagy inhibitors hinders its application. Here we found that liensinine, a major isoquinoline alkaloid, inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome
Corey P Parlet et al.
Journal of leukocyte biology, 97(4), 769-778 (2015-01-22)
Alcoholics are at increased risk of Staphylococcus aureus skin infection and serious sequelae, such as bacteremia and death. Despite the association between alcoholism and severe S. aureus skin infection, the impact of EtOH on anti-S. aureus cutaneous immunity has not
Dandan Zhang et al.
The Plant cell, 26(7), 2939-2961 (2014-07-19)
Tapetal programmed cell death (PCD) is a prerequisite for pollen grain development in angiosperms, and cysteine proteases are the most ubiquitous hydrolases involved in plant PCD. We identified a papain-like cysteine protease, CEP1, which is involved in tapetal PCD and
S A Kim et al.
Journal of food protection, 78(12), 2233-2239 (2015-11-29)
This study investigated changes in the microbial composition of microbrewed beer during the manufacturing processes and identified potential microbial hazards, effective critical quality control points, and potential contamination routes. Comprehensive quantitative (aerobic plate count, lactic acid bacteria, fungi, acetic acid
Kiranj K Chaudagar et al.
Clinical and experimental hypertension (New York, N.Y. : 1993), 36(8), 557-566 (2014-02-05)
Telmisartan possesses endothelial protective effects due to angiotensin II type 1 receptor antagonist, peroxisome proliferator-activated receptor γ (PPARγ) agonist and antioxidant action. Therefore, our objective was to study effect of telmisartan on angiogenic responsiveness of coronary endothelial cells (cECs) of
Béatrice Dirat et al.
Molecular cancer therapeutics, 14(2), 586-596 (2014-12-21)
Cell migration is a critical step in the progression of prostate cancer to the metastatic state, the lethal form of the disease. The antidiabetic drug metformin has been shown to display antitumoral properties in prostate cancer cell and animal models;
M C Pérez et al.
Applied microbiology and biotechnology, 99(1), 19-32 (2014-05-07)
The removal of styrene was studied using two biofilters packed with peat and coconut fibre (BF1-P and BF2-C, respectively) and one biotrickling filter (BTF) packed with plastic rings. Two inoculation procedures were applied: an enriched culture with strain Pseudomonas putida
Ailin Xiao et al.
Scientific reports, 5, 16086-16086 (2015-11-05)
H2S is produced mainly by two enzymes:cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE), using L-cysteine (L-Cys) as the substrate. In this study, we investigated the role of H2S in gastric accommodation using CBS(+/-) mice, immunohistochemistry, immunoblot, methylene blue assay, intragastric pressure (IGP)
Juan Zhou et al.
Microvascular research, 101, 33-37 (2015-06-28)
Toll like receptor 4 (TLR4) represents a critical cellular link for endotoxin-induced pathology. The aim of this study was to evaluate the potential role of TLR4 inhibition on the intestinal microcirculation during experimental endotoxemia. The intestinal microcirculation was studied by
Hwee Ling Poh et al.
Chemistry (Weinheim an der Bergstrasse, Germany), 21(22), 8130-8136 (2015-04-17)
Covalently functionalized graphene materials with well-defined stoichiometric composition are of a very high importance in the research of 2D carbon material family due to their well-defined properties. Unfortunately, most of the contemporary graphene-functionalized materials do not have this kind of
Yasong Wu et al.
Nature cell biology, 17(6), 715-725 (2015-05-20)
We describe robust induction of autophagy during the reprogramming of mouse fibroblasts to induced pluripotent stem cells by four reprogramming factors (Sox2, Oct4, Klf4 and c-Myc), henceforth 4F. This process occurs independently of p53 activation, and is mediated by the
Munawar Hussain et al.
Talanta, 147, 1-7 (2015-11-26)
We present a fast, robust and straightforward spin force assisted surface imprinting approach for activated platelets and demonstrate that Heparin induced thrombocytopenia (HIT) platelet aggregation can be measured by this approach. A critical and challenging step in functional assays for
Matthias Hillenbrand et al.
Proceedings of the National Academy of Sciences of the United States of America, 112(11), E1181-E1190 (2015-03-04)
Agonist binding to G-protein-coupled receptors (GPCRs) triggers signal transduction cascades involving heterotrimeric G proteins as key players. A major obstacle for drug design is the limited knowledge of conformational changes upon agonist binding, the details of interaction with the different
Abhishek Chauhan et al.
SpringerPlus, 4, 582-582 (2015-11-07)
The Larsemann Hills is an ice-free area of approximately 50 km(2), located halfway between the Vestfold Hills and the Amery Ice Shelf on the south-eastern coast of Prydz Bay, Princess Elizabeth Land, East Antarctica (69º30'S, 76º19'58″E). The ice-free area consists of
Takuya Yashiro et al.
PloS one, 10(9), e0137699-e0137699 (2015-09-12)
The transcription factor PU.1 is predominantly expressed in dendritic cells (DCs) and is essential for DC differentiation. Although there are several reports that PU.1 positively regulates the expression of DC-specific genes, whether PU.1 also has a suppressive effect on DCs
Kevin C Gough et al.
Respiratory research, 16, 86-86 (2015-07-16)
Human lung mast cells (HLMCs) infiltrate the airway epithelium and airway smooth muscle (ASM) in asthmatic airways. The mechanism of HLMC adhesion to both cell types is only partly defined, and adhesion is not inhibited by function-blocking anti-Kit and anti-stem
An oil-soluble extract of Rubus idaeus cells enhances hydration and water homeostasis in skin cells.
A Tito et al.
International journal of cosmetic science, 37(6), 588-594 (2015-05-06)
Raspberry plants, belonging to the species of Rubus idaeus, are known for their excellent therapeutic properties as they are particularly rich in compounds with strong antioxidant activity, which promote health and well-being of human cells. Besides their high content of
Mei Yang et al.
Journal of cancer research and clinical oncology, 141(6), 1037-1047 (2014-11-30)
Nuclear apoptosis-inducing factor 1 (NAIF1) could induce apoptosis in gastric cancer cells. Previously, we have reported that the expression of NAIF1 protein is down-regulated in gastric cancer tissues compared with the adjacent normal tissues. However, the role of NAIF1 in
Suresh Subramanian et al.
Nuclear medicine communications, 36(8), 848-853 (2015-05-02)
In-situ sentinel lymph node (SLN) detection is an important component in staging cancers of various origins. At present, technetium-99m (Tc)-labeled nanoparticle formulations like sulfur colloid and human serum albumin (HSA) nanocolloid are used in the clinic as SLN tracers. In
K A Taylor et al.
Journal of thrombosis and haemostasis : JTH, 12(6), 987-998 (2014-03-25)
Pannexin-1 (Panx1) forms an anion-selective channel with a permeability up to ~1 kDa and represents a non-lytic, non-vesicular ATP release pathway in erythrocytes, leukocytes and neurons. Related connexin gap junction proteins have been reported in platelets; however, the expression and
Jack Chai et al.
Biophysical journal, 109(2), 407-414 (2015-07-23)
Embryonic morphogenesis takes place via a series of dramatic collective cell movements. The mechanisms that coordinate these intricate structural transformations across an entire organism are not well understood. In this study, we used gentle mechanical deformation of developing zebrafish embryos
Human recombinant truncated RNASET2, devoid of RNase activity; A potential cancer therapeutic agent.
Liron Nesiel-Nuttman et al.
Oncotarget, 5(22), 11464-11478 (2014-11-27)
Human RNASET2 has been implicated in antitumorigenic and antiangiogenic activities, independent of its ribonuclease capacities. We constructed a truncated version of human RNASET2, starting at E50 (trT2-50) and devoid of ribonuclease activity. trT2-50 maintained its ability to bind actin and
Susanne Herbst et al.
EMBO molecular medicine, 7(3), 240-258 (2015-02-01)
Transplant recipients on calcineurin inhibitors are at high risk of invasive fungal infection. Understanding how calcineurin inhibitors impair fungal immunity is a key priority for defining risk of infection. Here, we show that the calcineurin inhibitor tacrolimus impairs clearance of
Takashi Hosono et al.
Journal of Alzheimer's disease : JAD, 48(1), 149-162 (2015-09-25)
It is believed that the amyloid β-protein (Aβ) plays a causative role in the development of Alzheimer's disease (AD). The amyloid-β protein precursor (AβPP), a substrate of Aβ, and β-secretase and γ-secretase complex proteins, which process AβPP to generate Aβ
Shuying Huo et al.
Dalton transactions (Cambridge, England : 2003), 43(41), 15328-15336 (2014-07-31)
L-Selenomethionine (SeMet), the predominant form of selenium acquired from the diet by humans, has been used as a supplement, and exhibit some important functions like cancer prevention and antioxidative defense. Its interactions with Pt(II) anticancer drugs have been characterized, but
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