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Showing 1-28 of 28 results for "S7899" within Papers
Tomas Erban et al.
Scientific reports, 7(1), 5084-5084 (2017-07-13)
Honeybee (Apis mellifera L.) workers act as passive vectors of Paenibacillus larvae spores, which cause the quarantine disease American foulbrood (AFB). We assessed the relative proportions of P. larvae within the honeybee microbiome using metabarcoding analysis of the 16 S rRNA
Li-Ping Gong et al.
EMBO reports, 21(10), e49689-e49689 (2020-08-14)
Cancer stem cells (CSCs) are cancer-initiating cells that are not only a source of tumorigenesis but also the cause of tumour progression, metastasis and therapy resistance. EBV-associated gastric cancer (EBVaGC) is a distinct subtype of gastric cancer with unique clinicopathological
Lily Agranat-Tamir et al.
Cell, 181(5), 1146-1157 (2020-05-30)
We report genome-wide DNA data for 73 individuals from five archaeological sites across the Bronze and Iron Ages Southern Levant. These individuals, who share the "Canaanite" material culture, can be modeled as descending from two sources: (1) earlier local Neolithic
Amanda Bentley-DeSousa et al.
mBio, 12(5), e0099421-e0099421 (2021-09-22)
Polyphosphates (polyP) are energy-rich polymers of inorganic phosphates assembled into chains ranging from 3 residues to thousands of residues in length. They are thought to exist in all cells on earth and play roles in an eclectic mix of functions
Saika Siddiqui et al.
Molecules (Basel, Switzerland), 26(1) (2021-01-07)
E. coli O157:H7 is a pathogenic bacterium producing verotoxins that could lead to serious complications such as hemolytic uremia syndrome. Fast detection of such pathogens is important. For rapid detection, aptamers are quickly gaining traction as alternative biorecognition molecules besides
Jaspreet Kaur et al.
Antimicrobial agents and chemotherapy, 55(2), 659-666 (2010-12-01)
In this study we utilized the concept of rational drug design to identify novel compounds with optimal selectivity, efficacy and safety, which would bind to the target enzyme pteridine reductase 1 (PTR1) in Leishmania parasites. Twelve compounds afforded from Baylis-Hillman
Ons M'Saad et al.
Nature communications, 11(1), 3850-3850 (2020-08-02)
Resolving the distribution of specific proteins at the nanoscale in the ultrastructural context of the cell is a major challenge in fluorescence microscopy. We report the discovery of a new principle for an optical contrast equivalent to electron microscopy (EM)
M Strupp
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft, 110(1), 7-15 (2013-01-05)
The spectrum of diagnoses of patients with dizziness as the leading symptom who consult a neurologist does not differ greatly from the spectrum of those who consult ear nose and throat (ENT) specialists or general practitioners (GP). The most frequent
Nathan Nakatsuka et al.
Cell, 181(5), 1131-1145 (2020-05-11)
There are many unanswered questions about the population history of the Central and South Central Andes, particularly regarding the impact of large-scale societies, such as the Moche, Wari, Tiwanaku, and Inca. We assembled genome-wide data on 89 individuals dating from
Vasant Shinde et al.
Cell, 179(3), 729-735 (2019-09-10)
We report an ancient genome from the Indus Valley Civilization (IVC). The individual we sequenced fits as a mixture of people related to ancient Iranians (the largest component) and Southeast Asian hunter-gatherers, a unique profile that matches ancient DNA from
Ronald Lulijwa et al.
Metabolites, 11(8) (2021-08-27)
Ocean warming and extreme sea surface temperature anomalies are threatening wild and domesticated fish stocks in various regions. Understanding mechanisms for thermotolerance and processes associated with divergent growth performance is key to the future success of aquaculture and fisheries management.
Xavier Roca-Rada et al.
iScience, 24(6), 102553-102553 (2021-06-19)
The Southern Cone of South America (SCSA) is a key region for investigations about the peopling of the Americas. However, little is known about the eastern sector, the Argentinian Pampas. We analyzed 18 mitochondrial genomes-7 of which are novel-from human
Abdulyezir A Badmos et al.
Journal of biomedical optics, 22(2), 27003-27003 (2017-02-09)
Enzyme-functionalized dual-peak long-period fiber grating (LPFG) inscribed in 80 - ? m -cladding B/Ge codoped single-mode fiber is presented for sugar-level and specific glucose detection. Before enzyme functionalization, the dual-peak LPFG was employed for refractive index sensing and sugar-level detection
Sambrook, J., and Russell, D.W.
Molecular Cloning: A Laboratory Manual, A1-A1 (2001)
Tong Ihn Lee et al.
Nature protocols, 1(2), 729-748 (2007-04-05)
Genome-wide location analysis, also known as ChIP-Chip, combines chromatin immunoprecipitation and DNA microarray analysis to identify protein-DNA interactions that occur in living cells. Protein-DNA interactions are captured in vivo by chemical crosslinking. Cell lysis, DNA fragmentation and immunoaffinity purification of
Raul Torres-Ruiz et al.
STAR protocols, 2(3), 100631-100631 (2021-07-15)
Chromosomal instability (CIN), a type of genomic instability, favors changes in chromosome number and structure and it is associated with the progression and initiation of multiple diseases, including cancer. Therefore, CIN identification and analysis represents a useful tool for cancer
Sena Bluemel et al.
Gut microbes, 11(3), 265-275 (2019-04-16)
Alcohol-induced liver disease is closely related to translocation of bacterial products and bacteria from the intestine to the liver. However, it is not known whether bacterial translocation to the liver depends on certain intestinal microbiota changes that would predispose bacteria
He Yu et al.
Cell, 181(6), 1232-1245 (2020-05-22)
Modern humans have inhabited the Lake Baikal region since the Upper Paleolithic, though the precise history of its peoples over this long time span is still largely unknown. Here, we report genome-wide data from 19 Upper Paleolithic to Early Bronze Age
Yujie Zhang et al.
STAR protocols, 2(2), 100447-100447 (2021-04-20)
mRNA degradation is connected to the translation process up to the degree that 5'-3' mRNA degradation follows the last translating ribosome. To study 5'-3'co-translational mRNA decay and the associated ribosome dynamics, here we present an improved high-throughput 5'P degradome RNA
Emma Bondy-Chorney et al.
Cell reports, 33(4), 108318-108318 (2020-10-29)
Polyphosphates (polyPs) are long chains of inorganic phosphates linked by phosphoanhydride bonds. They are found in all kingdoms of life, playing roles in cell growth, infection, and blood coagulation. Unlike in bacteria and lower eukaryotes, the mammalian enzymes responsible for
Nadin Rohland et al.
Nature protocols, 13(11), 2447-2461 (2018-10-17)
DNA preserved in ancient bones, teeth and sediments is typically highly fragmented and present only in minute amounts. Here, we provide a highly versatile silica-based DNA extraction protocol that enables the retrieval of short (≥35 bp) or even ultrashort (≥25
Xiaofeng Wang et al.
Autophagy, 16(1), 154-166 (2019-04-23)
Damaged or redundant peroxisomes and their luminal cargoes are removed by pexophagy, a selective autophagy pathway. In yeasts, pexophagy depends mostly on the pexophagy receptors, such as Atg30 for Pichia pastoris and Atg36 for Saccharomyces cerevisiae, the autophagy scaffold proteins
Robin Ganesan et al.
Methods (San Diego, Calif.), 155, 58-67 (2018-12-30)
Ribosomes associated with nonsense-mediated decay factors Upf1, Upf2, or Upf3 were purified by immunoprecipitation, and enrichment and stoichiometry of Upf factors and ribosomal proteins were analyzed by western blot and mass spectrometry. Using a small RNA library preparation protocol that
Chunxiao Hu et al.
IEEE transactions on bio-medical engineering, 67(9), 2417-2426 (2020-02-06)
Early stage diagnosis of sepsis without overburdening health services is essential to improving patient outcomes. A fast and simple-to-use platform that combines an integrated circuit with paper microfluidics for simultaneous detection of multiple-metabolites appropriate for diagnostics was presented. Paper based
Jaspreet Kaur et al.
The Journal of antimicrobial chemotherapy, 65(8), 1742-1748 (2010-06-04)
Using the pteridine reductase (PTR1) enzyme of Leishmania as the target, the objective of our study was to find a drug candidate that can enter the clinical development process after being evaluated for safety and efficacy in animals. Monastrol (R)
Yaroslav A Kainov et al.
Nature communications, 11(1), 361-361 (2020-01-19)
Eukaryotic gene expression relies on extensive crosstalk between transcription and RNA processing. Changes in this composite regulation network may provide an important means for shaping cell type-specific transcriptomes. Here we show that the RNA-associated protein Srrt/Ars2 sustains embryonic stem cell
Chun-Chun Chen et al.
Journal of visualized experiments : JoVE, (62)(62), doi:10-doi:10 (2012-05-09)
Knowing the timing, level, cellular localization, and cell type that a gene is expressed in contributes to our understanding of the function of the gene. Each of these features can be accomplished with in situ hybridization to mRNAs within cells.
Wahyu Widowati et al.
Tropical life sciences research, 31(3), 127-144 (2020-11-21)
Skin aging is a complex natural process characterised by gradual diminishment of structural integrity and physiological imbalance of the skin tissue. Since the oxidative stress is tightly corelated to the skin aging process, the usage of antioxidant may serve as
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