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Showing 1-30 of 362 results for "S8282" within Papers
I C Lawrance et al.
Digestive diseases and sciences, 58(4), 926-935 (2012-10-26)
Bowel-cleansing studies are frequently underpowered, poorly designed, and with subjective assessments. Consensus on tolerability of the bowel-cleansing agents is thus lacking. This study developed and validated a bowel-preparation tolerability questionnaire and used it to assess the tolerability of three bowel-cleansing
Stephan H K Eder et al.
PloS one, 9(9), e107356-e107356 (2014-09-19)
The ferrimagnetic mineral magnetite Fe3O4 is biomineralized by magnetotactic microorganisms and a diverse range of animals. Here we demonstrate that confocal Raman microscopy can be used to visualize chains of magnetite crystals in magnetotactic bacteria, even though magnetite is a
Valentina Bosi et al.
Analytical and bioanalytical chemistry, 407(18), 5405-5415 (2015-05-10)
We present a capillary electrophoresis method for determining two different C8-conjugated deoxyadenosines, and for oligonucleotides containing them, in which a psoralen or an acridine molecule is bonded to the base via a short alkyl chain containing sulfur ethers at both
Raquel Bridi et al.
Journal of food science, 80(6), C1188-C1195 (2015-05-07)
Propolis has been proposed as a polyphenolic-rich natural product potentially able to be used for human consumption or even for medicinal proposes. To guarantee a minimum phenolic and flavonoid content and as consequence of their related-biological activities, international requirements of
Raffaello Mazzaro et al.
ChemistryOpen, 4(3), 268-273 (2015-08-08)
Graphene-metal composites have potential as novel catalysts due to their unique electrical properties. Here, we report the synthesis of a composite material comprised of monodispersed platinum nanoparticles on high-quality graphene obtained by using two different exfoliation techniques. The material, prepared
Aditya Iyer et al.
Biochimica et biophysica acta, 1840(9), 2935-2943 (2014-06-18)
Tagging a luminescent quantum dot (QD) with a biological like enzyme (Enz) creates value-added entities like quantum dot-enzyme bioconjugates (QDEnzBio) that find utility as sensors to detect glucose or beacons to track enzymes in vivo. For such applications, it is
Diego A Fernández et al.
Toxicon : official journal of the International Society on Toxinology, 91, 23-34 (2014-09-03)
Cylindrospermopsin is a freshwater and widespread cyanotoxin considered hazardous for human health. Climate change and eutrophication are the main factors influencing the increasing presence of cylindrospermopsin producers that can contaminate human and animal drinking waters, leading to a rise in
Shuai Qian et al.
International journal of pharmaceutics, 477(1-2), 442-453 (2014-12-03)
Tacrine (THA), as the first approved acetylcholinesterase (AChE) inhibitors for the treatment of Alzheimer's disease (AD), has been extensively investigated in last seven decades. After dimerization of THA via a 7-carbon alkyl spacer, bis(7)-tacrine (B7T) showed much potent anti-AChE activity
Arpana Patil-Gadhe et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(1), 169-177 (2014-08-01)
The aim of the present study was to establish the potential of montelukast loaded nanostructured lipid carrier (MNLC) for pulmonary application. The formulated nanoparticles were evaluated in vitro for aerodynamic characterization and in vivo for pulmokinetics in Wistar rats. The
Anh T Vu et al.
Journal of separation science, 38(16), 2819-2825 (2015-06-06)
Hydrophobic interaction membrane chromatography has gained interest due to its excellent performance in the purification of humanized monoclonal antibodies. The membrane material used in hydrophobic interaction membrane chromatography has typically been commercially available polyvinylidene fluoride. In this contribution, newly developed
Shou-Lun Lee et al.
Biochemical pharmacology, 95(1), 71-79 (2015-03-17)
Previous studies have reported that aspirin significantly reduced the first-pass metabolism (FPM) of ethanol in humans thereby increasing adverse effects of alcohol. The underlying causes, however, remain poorly understood. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), principal enzymes responsible for
Shijie Wei et al.
Malaria journal, 14, 432-432 (2015-11-06)
Artemisinin (ART) is an efficacious and safe anti-malarial drugs but has low oral bioavailability and auto-induction profiles during multiple dosing. The pharmacokinetic disadvantages have been found to partially depend on the induction of cytochrome P-450 enzymes by ART and resulted
Johannes Felsenberg et al.
Cell, 175(3), 709-722 (2018-09-25)
Accurately predicting an outcome requires that animals learn supporting and conflicting evidence from sequential experience. In mammals and invertebrates, learned fear responses can be suppressed by experiencing predictive cues without punishment, a process called memory extinction. Here, we show that extinction
M Shokrzadeh et al.
Drug research, 65(6), 281-286 (2014-03-29)
This study was undertaken to evaluate the protective effects of melatonin against cyclophosphamide (CP)-induced oxidative lung toxicity in mice. Mice were pre-treated with various doses of melatonin for 7 consecutive days and were then injected with CP (200 mg/kg b.
Matteo M Pusceddu et al.
Psychoneuroendocrinology, 58, 79-90 (2015-05-13)
Stressful life events, especially those in early life, can exert long-lasting changes in the brain, increasing vulnerability to mental illness especially in females. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) play a critical role in the development and function of the
Marijke C C Sachweh et al.
Oncotarget, 6(18), 16488-16506 (2015-06-02)
Malignant melanoma is the most dangerous type of skin cancer. Although recent progress in treatment has been achieved, lack of response, drug resistance and relapse remain major problems. The tumor suppressor p53 is rarely mutated in melanoma, yet it is
Antonis Myridakis et al.
Analytical and bioanalytical chemistry, 407(9), 2509-2518 (2015-02-04)
Phthalates, bisphenol A (BPA) and parabens (PBs), organic chemicals widely used in everyday products, are considered to be endocrine disruptors. We propose a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the determination of seven phthalate metabolites, six PBs and BPA
Michelle S Antunes et al.
Hormones and behavior, 73, 56-63 (2015-07-01)
Depression is one of the most common mental disorders and a primary cause of disability. To better treat patients suffering this illness, elucidation of the underlying psychopathological and neurobiological mechanisms is urgently needed. Based on the above-mentioned evidence, we sought
Olga Tyurikova et al.
Journal of neurochemistry, 156(1), 48-58 (2020-05-18)
Brain function relies on vesicular release of neurotransmitters at chemical synapses. The release probability depends on action potential-evoked presynaptic Ca2+ entry, but also on the resting Ca2+ level. Whether these basic aspects of presynaptic calcium homeostasis show any consistent trend
Ruiting Zuo et al.
Food chemistry, 182, 242-245 (2015-04-07)
Creatinine (Cr), uric (UA) and ascorbic acid (AA) are common constituents in human fluids. Their abnormal concentrations in human fluids are associated with various diseases. Thus, apart from the endogenous formation in human body, it is also important to examine
Jie Zhang et al.
Food chemistry, 165, 256-261 (2014-07-21)
Beta-lactoglobulin (β-LG), the principal whey protein, possesses multiple sites for binding ligands. Most studies of β-LG-ligand interactions have focused on the formation and dissociation of protein complexes with single ligands, such as α-tocopherol, resveratrol or folic acid. In this study
Ambily Ravindran Nair et al.
Archives of toxicology, 89(12), 2273-2289 (2014-11-13)
Cadmium (Cd(2+)) induces oxidative stress that ultimately defines cell fate and pathology. Mitochondria are the main energy-producing organelles in mammalian cells, but they also have a central role in formation of reactive oxygen species, cell injury, and death signaling. As
Luca Casettari et al.
Carbohydrate polymers, 91(2), 597-602 (2012-11-06)
The physicochemical and rheological properties of chitosan and two different inorganic sodium phosphate dispersions (NaH(2)PO(4) and Na(3)PO(4)) were investigated in order to elucidate the role of different factors, such as ratios between polymer and sodium inorganic phosphates, different pHs and
D N Nguyen et al.
International journal of pharmaceutics, 475(1-2), 214-226 (2014-09-03)
This study was the first investigation into the potential of a fixed dose combination of ritonavir and darunavir in the form of dispersible powders prepared by spray drying. A common polymer (hydroxypropyl methylcellulose, polyvinylpyrrolidone, and polyvinylpyrrolidone-vinyl acetate 64) was formulated
Elena V Piletska et al.
The Analyst, 140(9), 3113-3120 (2015-03-10)
Curcumin is a versatile anti-inflammatory and anti-cancer agent known for its low bioavailability, which could be improved by developing materials capable of binding and releasing drug in a controlled fashion. The present study describes the preparation of magnetic nano-sized Molecularly
Elena V Parfenyuk et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(3), 1038-1045 (2014-10-02)
Biodegradable, controlled-release carrier materials with non-toxic degradation products are very valuable for delivery of cardiovascular drugs. This study is a part of development of novel form of vasodilator molsidomine to improve pharmacokinetic and consumer properties of the drug. It focuses
Danial Barati et al.
Langmuir : the ACS journal of surfaces and colloids, 31(18), 5130-5140 (2015-04-17)
Carboxylate-rich organic acids play an important role in controlling the growth of apatite crystals and the extent of mineralization in the natural bone. The objective of this work was to investigate the effect of organic acids on calcium phosphate (CaP)
Dennis Åsberg et al.
Journal of chromatography. A, 1401, 52-59 (2015-05-25)
The importance of the generated temperature and pressure gradients in ultra-high-pressure liquid chromatography (UHPLC) are investigated and compared to high-pressure liquid chromatography (HPLC). The drug Omeprazole, together with three other model compounds (with different chemical characteristics, namely uncharged, positively and
Madiha F Khan et al.
Colloids and surfaces. B, Biointerfaces, 132, 216-224 (2015-06-10)
Silicone surfactants are used in a variety of applications, however, limited data is available on the relationship between surfactant structure and biological activity. A series of seven nonionic, silicone polyether surfactants with known structures was tested for in vitro antibacterial
Wenying Fan et al.
Journal of chromatography. A, 1418, 36-44 (2015-10-05)
Graphene oxide (GO) is an ideal adsorbent for polar and less polar compounds due to its hexagonal carbon network structure with oxygen-containing groups, while its strong hydrophilicity and water solubility limited its application in sample pretreatment techniques. Herein, GO was
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