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Showing 1-30 of 362 results for "S8282" within Papers
Fei Wang et al.
Current biology : CB, 30(19), 3749-3760 (2020-08-17)
The mating decisions of Drosophila melanogaster females are primarily revealed through either of two discrete actions: opening of the vaginal plates to allow copulation, or extrusion of the ovipositor to reject the male. Both actions are triggered by the male
Elena V Piletska et al.
The Analyst, 140(9), 3113-3120 (2015-03-10)
Curcumin is a versatile anti-inflammatory and anti-cancer agent known for its low bioavailability, which could be improved by developing materials capable of binding and releasing drug in a controlled fashion. The present study describes the preparation of magnetic nano-sized Molecularly
Shuai Qian et al.
International journal of pharmaceutics, 477(1-2), 442-453 (2014-12-03)
Tacrine (THA), as the first approved acetylcholinesterase (AChE) inhibitors for the treatment of Alzheimer's disease (AD), has been extensively investigated in last seven decades. After dimerization of THA via a 7-carbon alkyl spacer, bis(7)-tacrine (B7T) showed much potent anti-AChE activity
Itzel Jatziri Contreras-García et al.
Brain sciences, 11(5) (2021-05-01)
Synaptic vesicle protein 2A (SV2A), the target of the antiepileptic drug levetiracetam (LEV), is expressed ubiquitously in all synaptic terminals. Its levels decrease in patients and animal models of epilepsy. Thus, changes in SV2A expression could be a critical factor
I C Lawrance et al.
Digestive diseases and sciences, 58(4), 926-935 (2012-10-26)
Bowel-cleansing studies are frequently underpowered, poorly designed, and with subjective assessments. Consensus on tolerability of the bowel-cleansing agents is thus lacking. This study developed and validated a bowel-preparation tolerability questionnaire and used it to assess the tolerability of three bowel-cleansing
Raquel Bridi et al.
Journal of food science, 80(6), C1188-C1195 (2015-05-07)
Propolis has been proposed as a polyphenolic-rich natural product potentially able to be used for human consumption or even for medicinal proposes. To guarantee a minimum phenolic and flavonoid content and as consequence of their related-biological activities, international requirements of
Valentina Bosi et al.
Analytical and bioanalytical chemistry, 407(18), 5405-5415 (2015-05-10)
We present a capillary electrophoresis method for determining two different C8-conjugated deoxyadenosines, and for oligonucleotides containing them, in which a psoralen or an acridine molecule is bonded to the base via a short alkyl chain containing sulfur ethers at both
Stephan H K Eder et al.
PloS one, 9(9), e107356-e107356 (2014-09-19)
The ferrimagnetic mineral magnetite Fe3O4 is biomineralized by magnetotactic microorganisms and a diverse range of animals. Here we demonstrate that confocal Raman microscopy can be used to visualize chains of magnetite crystals in magnetotactic bacteria, even though magnetite is a
Shou-Lun Lee et al.
Biochemical pharmacology, 95(1), 71-79 (2015-03-17)
Previous studies have reported that aspirin significantly reduced the first-pass metabolism (FPM) of ethanol in humans thereby increasing adverse effects of alcohol. The underlying causes, however, remain poorly understood. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), principal enzymes responsible for
Matteo M Pusceddu et al.
Psychoneuroendocrinology, 58, 79-90 (2015-05-13)
Stressful life events, especially those in early life, can exert long-lasting changes in the brain, increasing vulnerability to mental illness especially in females. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) play a critical role in the development and function of the
Shijie Wei et al.
Malaria journal, 14, 432-432 (2015-11-06)
Artemisinin (ART) is an efficacious and safe anti-malarial drugs but has low oral bioavailability and auto-induction profiles during multiple dosing. The pharmacokinetic disadvantages have been found to partially depend on the induction of cytochrome P-450 enzymes by ART and resulted
Johannes Felsenberg et al.
Cell, 175(3), 709-722 (2018-09-25)
Accurately predicting an outcome requires that animals learn supporting and conflicting evidence from sequential experience. In mammals and invertebrates, learned fear responses can be suppressed by experiencing predictive cues without punishment, a process called memory extinction. Here, we show that extinction
Diego A Fernández et al.
Toxicon : official journal of the International Society on Toxinology, 91, 23-34 (2014-09-03)
Cylindrospermopsin is a freshwater and widespread cyanotoxin considered hazardous for human health. Climate change and eutrophication are the main factors influencing the increasing presence of cylindrospermopsin producers that can contaminate human and animal drinking waters, leading to a rise in
Raffaello Mazzaro et al.
ChemistryOpen, 4(3), 268-273 (2015-08-08)
Graphene-metal composites have potential as novel catalysts due to their unique electrical properties. Here, we report the synthesis of a composite material comprised of monodispersed platinum nanoparticles on high-quality graphene obtained by using two different exfoliation techniques. The material, prepared
Aditya Iyer et al.
Biochimica et biophysica acta, 1840(9), 2935-2943 (2014-06-18)
Tagging a luminescent quantum dot (QD) with a biological like enzyme (Enz) creates value-added entities like quantum dot-enzyme bioconjugates (QDEnzBio) that find utility as sensors to detect glucose or beacons to track enzymes in vivo. For such applications, it is
Arpana Patil-Gadhe et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 88(1), 169-177 (2014-08-01)
The aim of the present study was to establish the potential of montelukast loaded nanostructured lipid carrier (MNLC) for pulmonary application. The formulated nanoparticles were evaluated in vitro for aerodynamic characterization and in vivo for pulmokinetics in Wistar rats. The
Anh T Vu et al.
Journal of separation science, 38(16), 2819-2825 (2015-06-06)
Hydrophobic interaction membrane chromatography has gained interest due to its excellent performance in the purification of humanized monoclonal antibodies. The membrane material used in hydrophobic interaction membrane chromatography has typically been commercially available polyvinylidene fluoride. In this contribution, newly developed
M Shokrzadeh et al.
Drug research, 65(6), 281-286 (2014-03-29)
This study was undertaken to evaluate the protective effects of melatonin against cyclophosphamide (CP)-induced oxidative lung toxicity in mice. Mice were pre-treated with various doses of melatonin for 7 consecutive days and were then injected with CP (200 mg/kg b.
Marijke C C Sachweh et al.
Oncotarget, 6(18), 16488-16506 (2015-06-02)
Malignant melanoma is the most dangerous type of skin cancer. Although recent progress in treatment has been achieved, lack of response, drug resistance and relapse remain major problems. The tumor suppressor p53 is rarely mutated in melanoma, yet it is
Cynthia L Morris-Kukoski et al.
Journal of analytical toxicology, 38(9), 628-636 (2014-08-08)
Samples from a self-proclaimed cocaine (COC) user, from 19 drug users (postmortem) and from 27 drug chemists were extensively washed and analyzed for COC, benzoylecgonine, norcocaine (NC), cocaethylene (CE) and aryl hydroxycocaines by liquid chromatography-tandem mass spectrometry. Published wash criteria
Marjorie Brand et al.
Nature protocols, 3(3), 398-409 (2008-03-08)
Chromatin immunoprecipitation (ChIP) is routinely used to examine epigenetic modification of histones at specific genomic locations. However, covalent modifications of histone tails can serve as docking sites for chromatin regulatory factors. As such, association of these regulatory factors with chromatin
U Eletxigerra et al.
Biosensors & bioelectronics, 70, 34-41 (2015-03-21)
A highly sensitive amperometric magnetoimmunosensor for the determination of ErbB2 protein, a well-known biomarker related to high-impact high-incidence diseases such as breast cancer, is described. A sandwich format involving the covalent immobilization of a specific capture antibody onto magnetic beads
Agnieszka Kosińska-Cagnazzo et al.
Food chemistry, 170, 288-294 (2014-10-13)
Strawberry fruits are highly valued for their taste and nutritional value. However, results describing the bioaccessibility and intestinal absorption of phenolic compounds from strawberries are still scarce. In our study, a combined in vitro digestion/Caco-2 absorption model was used to
Dennis Åsberg et al.
Journal of chromatography. A, 1401, 52-59 (2015-05-25)
The importance of the generated temperature and pressure gradients in ultra-high-pressure liquid chromatography (UHPLC) are investigated and compared to high-pressure liquid chromatography (HPLC). The drug Omeprazole, together with three other model compounds (with different chemical characteristics, namely uncharged, positively and
Brendan J Holland et al.
Analytica chimica acta, 842, 35-41 (2014-08-17)
Sodium polyphosphate is commonly used to enhance chemiluminescence reactions with acidic potassium permanganate through a dual enhancement mechanism, but commercially available polyphosphates vary greatly in composition. We have examined the influence of polyphosphate composition and concentration on both the dual
Wenying Fan et al.
Journal of chromatography. A, 1418, 36-44 (2015-10-05)
Graphene oxide (GO) is an ideal adsorbent for polar and less polar compounds due to its hexagonal carbon network structure with oxygen-containing groups, while its strong hydrophilicity and water solubility limited its application in sample pretreatment techniques. Herein, GO was
F Kazazi-Hyseni et al.
Acta biomaterialia, 22, 141-154 (2015-05-02)
Subcapsular renal injection is a novel administration method for local delivery of therapeutics for the treatment of kidney related diseases. The aim of this study was to investigate the feasibility of polymeric microspheres for sustained release of protein therapeutics in
Danial Barati et al.
Langmuir : the ACS journal of surfaces and colloids, 31(18), 5130-5140 (2015-04-17)
Carboxylate-rich organic acids play an important role in controlling the growth of apatite crystals and the extent of mineralization in the natural bone. The objective of this work was to investigate the effect of organic acids on calcium phosphate (CaP)
Sreejith Raveendran et al.
International journal of biological macromolecules, 76, 310-319 (2015-03-10)
Polysaccharides that show finest bioactivities and physicochemical properties are always promising for bionanoscience applications. Mauran is such a macromolecule extracted from halophilic bacterium, Halomonas maura for biotechnology and nanoscience applications. Antioxidant properties of MR/CH nanoparticles were studied using biochemical assays
Mansoor Khan et al.
Talanta, 146, 130-137 (2015-12-24)
Magnetic allylamine modified graphene oxide-poly(vinyl acetate-co-divinylbenzene) (MGO-DVB-VA) was synthesized and used for magnetic solid phase extraction of Pb(II), Cd(II), Cu(II), Ni(II) and Co(II) prior to their determination by flame atomic absorption spectroscopy. The adsorbent surface functional group was characterized by
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