SCC043

Applied Filters:

Keyword:'SCC043'

Showing 1-10 of 10 results for "SCC043" within Papers

Rapamycin-PLGA microparticles prevent senescence, sustain cartilage matrix production under stress and exhibit prolonged retention in mouse joints.

Kaamini M Dhanabalan et al.

Biomaterials science, 8(15), 4308-4321 (2020-07-01)

Osteoarthritis (OA) is a joint disease characterized by progressive damage of articular cartilage and the adjoining subchondral bone. Chondrocytes, the primary cells of the cartilage, have limited regenerative capacity and when they undergo stress due to trauma or with aging

Cytoprotective Effects of Delphinidin for Human Chondrocytes against Oxidative Stress through Activation of Autophagy.

Dong-Yeong Lee et al.

Antioxidants (Basel, Switzerland), 9(1) (2020-01-23)

Antioxidant enzymes are decreased in osteoarthritis (OA) patients, implying the role of oxidative stress in osteoarthritis pathogenesis. The aim of this study was to evaluate the cytoprotective effects of delphinidin, a potent antioxidant, in human chondrocytes and the underlying mechanisms.

C-28/I2 and T/C-28a2 chondrocytes as well as human primary articular chondrocytes express sex hormone and insulin receptors--Useful cells in study of cartilage metabolism.

Horst Claassen et al.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft, 193(1), 23-29 (2010-10-26)

Sex hormones and insulin have been implicated in articular cartilage metabolism. To supplement previous findings on the regulation of matrix synthesis with 17β-estradiol and insulin and to find a possible model to study cartilage metabolism in vitro, we evaluated the

Culture of immortalized chondrocytes and their use as models of chondrocyte function.

Mary B Goldring

Methods in molecular medicine, 100, 37-52 (2004-07-29)

Immortalization of chondrocytes increases life span and proliferative capacity but does not necessarily stabilize the differentiated phenotype. Expansion of chondrocyte cell lines in continuous monolayer culture may result in the loss of phenotype, particularly if high cell density is not

Interleukin-1 beta-modulated gene expression in immortalized human chondrocytes.

M B Goldring et al.

The Journal of clinical investigation, 94(6), 2307-2316 (1994-12-01)

Immortalized human chondrocytes were established by transfection of primary cultures of juvenile costal chondrocytes with vectors encoding simian virus 40 large T antigen and selection in suspension culture over agarose. Stable cell lines were generated that exhibited chondrocyte morphology, continuous

Celecoxib prevents tumor necrosis factor-α (TNF-α)-induced cellular senescence in human chondrocytes.

Qunli Wang et al.

Bioengineered, 12(2), 12812-12820 (2021-12-14)

Osteoarthritis (OA) is a cartilage degenerative disease commonly observed in the elderly population and significantly impacts the normal life of OA patients. It has been reported that the development of pathological cell senescence in chondrocytes is involved in the pathogenesis

Controlled Self-Assembly of DNA-Mimicking Nanotubes to Form a Layer-by-Layer Scaffold for Homeostatic Tissue Constructs.

Libo Zhou et al.

ACS applied materials & interfaces, 13(43), 51321-51332 (2021-10-20)

Various biomaterial scaffolds have been developed for improving stem cell anchorage and function in tissue constructs for in vitro and in vivo uses. Growth factors are typically applied to scaffolds to mediate cell differentiation. Conventionally, growth factors are not strictly

Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation.

Sinthu Pathmanapan et al.

Cell reports, 42(6), 112578-112578 (2023-06-02)

Chondrosarcomas are the most common malignancy of cartilage and are associated with somatic mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 genes. Somatic IDH mutations are also found in its benign precursor lesion, enchondromas, suggesting that IDH mutations are early

MLN4924, a Protein Neddylation Inhibitor, Suppresses the Growth of Human Chondrosarcoma through Inhibiting Cell Proliferation and Inducing Endoplasmic Reticulum Stress-Related Apoptosis.

Meng-Huang Wu et al.

International journal of molecular sciences, 20(1) (2018-12-28)

Chondrosarcoma, a heterogeneous malignant bone tumor, commonly produces cartilage matrix, which generally has no response to conventional therapies. Studies have reported that MLN4924, a NEDD8-activating enzyme inhibitor, achieves antitumor effects against numerous malignancies. In this study, the suppressive effects of

Downregulation of BIRC2 hinders the progression of rheumatoid arthritis through regulating TRADD.

Yanting Rao et al.

Immunity, inflammation and disease, 11(10), e978-e978 (2023-10-31)

Rheumatoid arthritis (RA) is a chronic inflammation mediated by an autoimmune response. Baculoviral IAP repeat-containing 2 (BIRC2) and tumor necrosis factor receptor 1-associated death domain protein (TRADD) have been reported to be highly expressed in RA, while their specific roles

Page 1 of 1