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Showing 1-30 of 80 results for "SCC064" within Papers
Huan Liu et al.
Biochemical and biophysical research communications, 514(3), 913-918 (2019-05-16)
Liver fibrosis is a common consequence of various chronic hepatitis and liver injuries. The myofibroblasts, through the accumulation of extracellular matrix (ECM) proteins, are closely associated with the progression of liver fibrosis. However, the molecular mechanisms underlying transcriptional regulation of
Yong Rao et al.
British journal of pharmacology, 176(16), 2877-2893 (2019-05-22)
Non-alcoholic hepatic fatty liver disease (NAFLD) is a manifestation of the metabolic syndrome in the liver and non-alcoholic steatohepatitis (NASH) represents its advanced stage. R17 derived from bouchardatine, shows benefits in the metabolic syndrome, but has not been tested in
Hyomin Park et al.
Free radical biology & medicine, 204, 195-206 (2023-05-06)
The important pathway toward liver fibrosis is the TGF-β1-induced activation of hepatic stellate cells (HSCs). To discover chemicals to inhibit liver fibrosis, we screened 3000 chemicals using cell array system where human HSCs line LX2 cells are activated with TGF-β1.
Yiqiao Luo et al.
Cancers, 13(4) (2021-03-07)
Pancreatic ductal adenocarcinoma (PDAC) is extremely malignant and the therapeutic options available usually have little impact on survival. Great hope is placed on new therapeutic targets, including long noncoding RNAs (lncRNAs), and on the development of new drugs, based on
Yetao Xu et al.
Cell reports, 30(5), 1310-1318 (2020-02-06)
Pathological activation of TGF-β signaling is universal in fibrosis. Aberrant TGF-β signaling in conjunction with transdifferentiation of hepatic stellate cells (HSCs) into fibrogenic myofibroblasts plays a central role in liver fibrosis. Here we report that the DNA demethylase TET3 is
Preethi Vijayaraj et al.
Cell reports, 29(11), 3488-3505 (2019-12-12)
Progressive organ fibrosis accounts for one-third of all deaths worldwide, yet preclinical models that mimic the complex, progressive nature of the disease are lacking, and hence, there are no curative therapies. Progressive fibrosis across organs shares common cellular and molecular
Kristy Kwan-Shuen Chan et al.
Hepatology communications, 6(12), 3473-3486 (2022-09-28)
Liver cirrhosis represents an advanced stage of chronic liver disease and is associated with significant morbidity, mortality, and risk of cancer development. While sex disparity of liver diseases has been observed, understanding at a genetic level awaits more thorough investigation.
Ming Tong et al.
Cell cycle (Georgetown, Tex.), 20(7), 676-688 (2021-03-19)
Liver fibrosis is a critical health issue in the world due to its rapidly increasing prevalence. It is of great demand to develop effective drugs for the treatment of liver fibrosis. 5-methoxytryptophan (5-MTP) has been reported to play an important
Defu Kong et al.
Stem cell research & therapy, 14(1), 288-288 (2023-10-06)
Liver fibrosis is prevalent among chronic diseases of the liver and represents a major health burden worldwide. Growth differentiation factor 7 (GDF7), a member of the TGFβ protein superfamily, has been recently investigated for its role in repair of injured
Olga Pivovarova-Ramich et al.
Cells, 10(5) (2021-05-06)
Liver fibrosis is a critical complication of obesity-induced fatty liver disease. Wnt1 inducible signaling pathway protein 1 (WISP1/CCN4), a novel adipokine associated with visceral obesity and insulin resistance, also contributes to lung and kidney fibrosis. The aim of the present
Genetic characteristics of the human hepatic stellate cell line LX-2.
Weiskirchen, Ralf, et al.
Testing, 8, e75692-e75692 (2013)
Hongwei Han et al.
iScience, 24(10), 103165-103165 (2021-10-26)
Persistent activation of fibroblasts and resistance of myofibroblasts to turnover play important roles in organ-tissue fibrosis development and progression. The mechanism that mediates apoptosis resistance of myofibroblasts is not understood. Here, we report that myofibroblasts express and secrete PKM2. Extracellular PKM2
Alessandro Cherubini et al.
Nature medicine, 29(10), 2643-2655 (2023-09-26)
Fatty liver disease (FLD) caused by metabolic dysfunction is the leading cause of liver disease and the prevalence is rising, especially in women. Although during reproductive age women are protected against FLD, for still unknown and understudied reasons some develop
William E Plautz et al.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 33(1), 14-24 (2021-12-11)
Acute kidney injury (AKI) is common after trauma, but contributory factors are incompletely understood. Increases in plasma von Willebrand Factor (vWF) with concurrent decreases in ADAMTS13 are associated with renal microvascular thrombosis in other disease states, but similar findings have
Epigenetic regulation of connective tissue growth factor by microRNA-214 delivery in exosomes from mouse or human hepatic stellate cells.
Chen, Li, et al.
Hepatology (2013)
Shadi Sawalha et al.
Nanoscale advances, 5(21), 5974-5982 (2023-10-26)
Carbon nanodots, a family of carbon-based nanomaterials, have been synthesized through different methods from various resources, affecting the properties of the resulting product and their application. Herein, carbon nanodots (CNDs) were synthesized with a green and simple hydrothermal method from
Courtney Sakolish et al.
Toxicology, 463, 152954-152954 (2021-09-21)
Predicting human hepatic clearance remains a fundamental challenge in both pharmaceutical drug development and toxicological assessments of environmental chemicals, with concerns about both accuracy and precision of in vitro-derived estimates. Suggested sources of these issues have included differences in experimental
STAT3 is Activated by CTGF-mediated Tumor-stroma Cross Talk to Promote HCC Progression.
Makino, et al.
Cellular and molecular gastroenterology and hepatology, 15, 99-119 (2023)
Sachiyo Yoshio et al.
Hepatology research : the official journal of the Japan Society of Hepatology, 51(7), 803-812 (2021-05-18)
In patients with liver cirrhosis, high levels of serum myostatin are associated with poor prognosis. We aimed to clarify the influence of myostatin on the prognosis of patients with non-alcoholic fatty liver disease-hepatocellular carcinoma (NAFLD-HCC) without cirrhosis and on the
Qi-Tao Chen et al.
Nature metabolism, 4(10), 1306-1321 (2022-10-04)
Extracellular vesicles play crucial roles in intercellular communication in the tumor microenvironment. Here we demonstrate that in hepatic fibrosis, TGF-β stimulates the palmitoylation of hexokinase 1 (HK1) in hepatic stellate cells (HSCs), which facilitates the secretion of HK1 via large extracellular
Kevin J Paavola et al.
Cancer immunology research, 9(11), 1283-1297 (2021-08-25)
Suppressive myeloid cells inhibit antitumor immunity by preventing T-cell responses. Immunoglobulin-like transcript 3 (ILT3; also known as LILRB4) is highly expressed on tumor-associated myeloid cells and promotes their suppressive phenotype. However, the ligand that engages ILT3 within the tumor microenvironment
Li Deng et al.
Oncology letters, 20(6), 287-287 (2020-10-06)
The formation of the pre-metastatic niche (PMN), which precedes the establishment of tumor lesions, plays a critical role in cancer recurrence and metastasis. Hepatic stellate cells (HSCs), a critical liver stromal cell component, can be induced to facilitate metastasis by
Frauke Liebelt et al.
Cell reports, 26(1), 236-249 (2019-01-04)
The role of stress-induced increases in SUMO2/3 conjugation during the heat shock response (HSR) has remained enigmatic. We investigated SUMO signal transduction at the proteomic and functional level during the HSR in cells depleted of proteostasis network components via chronic
Expression of Septin4 in human hepatic stellate cells LX-2 stimulated by LPS.
Sun, Xiaolei, et al.
Inflammation, 36, 539-548 (2013)
Natalia Smith-Cortinez et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 35(2), e21219-e21219 (2020-11-26)
Liver fibrosis is characterized by the accumulation of extracellular matrix proteins, mainly composed of collagen. Hepatic stellate cells (HSCs) mediate liver fibrosis by secreting collagen. Vitamin C (ascorbic acid) is a cofactor of prolyl-hydroxylases that modify newly synthesized collagen on
Clint M Upchurch et al.
Science advances, 8(28), eabn0050-eabn0050 (2022-07-21)
Oxidized phosphatidylcholines (OxPCs) are implicated in chronic tissue damage. Hyperlipidemic LDL-R--deficient mice transgenic for an OxPC-recognizing IgM fragment (scFv-E06) are protected against nonalcoholic fatty liver disease (NAFLD). To examine the effect of OxPC elimination at different stages of NAFLD progression
Paloma Gallego et al.
Foods (Basel, Switzerland), 10(8) (2021-08-28)
Liver fibrosis can be caused by non-alcoholic steatohepatitis (NASH), among other conditions. We performed a study to analyze the effects of a nontoxic, water-soluble extract of the edible mushroom Agaricus bisporus (AB) as a potential inhibitor of fibrosis progression in
Michal Segal-Salto et al.
JHEP reports : innovation in hepatology, 2(1), 100064-100064 (2020-02-11)
C-C motif chemokine ligand 24 (CCL24) is a chemokine that regulates inflammatory and fibrotic activities through its receptor, C-C motif chemokine receptor (CCR3). The aim of the study was to evaluate the involvement of the CCL24-CCR3 axis in liver fibrosis
Natalia Smith-Cortinez et al.
Cells, 9(11) (2020-11-15)
Upon liver injury, hepatic stellate cells (HSCs) transdifferentiate to migratory, proliferative and extracellular matrix-producing myofibroblasts (e.g., activated HSCs; aHSCs) causing liver fibrosis. HSC activation is associated with increased glycolysis and glutaminolysis. Here, we compared the contribution of glycolysis, glutaminolysis and
Murali Ganesan et al.
Biomolecules, 9(12) (2019-12-15)
In an era of improved survival due to modern antiretroviral therapy, liver disease has become a major cause of morbidity and mortality, resulting in death in 15-17% of human immunodeficiency virus (HIV)-infected patients. Alcohol enhances HIV-mediated liver damage and promotes
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